To investigate the effects of graphene (Gra) modified by 1-hexadecyl-3-methylimidazolium bromide (IL) on the crystallization kinetics behaviour of PVDF, a series of PVDF/IL blend, PVDF/Gra and PVDF/IL/Gra nanocomposites were prepared.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Background Lacunes, a characteristic feature of cerebral small vessel disease (CSVD), are critical public health concerns, especially in the aging population. Traditional neuroimaging techniques often fall short in early lacune detection, prompting the need for more precise predictive models. Methods In this retrospective study, 587 patients from the Neurology Department of the Affiliated Hospital of Hebei University who underwent cranial MRI were assessed. A nomogram for predicting lacune incidence was developed using LASSO regression and binary logistic regression analysis for variable selection. The nomogram’s performance was quantitatively assessed using AUC-ROC, calibration plots, and decision curve analysis (DCA) in both training ( n = 412) and testing ( n = 175) cohorts. Results Independent predictors identified included age, gender, history of stroke, carotid atherosclerosis, hypertension, creatinine, and homocysteine levels. The nomogram showed an AUC-ROC of 0.814 (95% CI: 0.791–0.870) for the training set and 0.805 (95% CI: 0.782–0.843) for the testing set. Calibration and DCA corroborated the model’s clinical value. Conclusion This study introduces a clinically useful nomogram, derived from binary logistic regression, that significantly enhances the prediction of lacunes in patients undergoing brain MRI for various indications, potentially advancing early diagnosis and intervention. While promising, its retrospective design and single-center context are limitations that warrant further research, including multi-center validation.
Abstract A facile method for the synthesis of fused, multifunctionalized salicylaldehydes and salicylketones by a one‐pot, three‐step cascade hexadehydro‐Diels–Alder (HDDA) reaction of tetraynes followed by an intermolecular aldehyde/ketone reaction and hydroxylation is reported. Target compounds were prepared by the condensation of malonates with 3‐bromo‐1‐propyne, and the resulting 2,2‐di(1‐propyn‐3‐yl)malonates underwent cross‐coupling with phenylethynyl bromides to afford 2,2‐di(5‐phenyl‐2,4‐pentadiynyl)malonates, which underwent intramolecular cyclization to produce bicyclic salicylaldehydes. The overall transformation involves the formation of four new C−C bonds and one new C aryl −O bond through both intramolecular and intermolecular reactions. The reaction is easy to perform, proceeds under mild conditions, and exhibits excellent regioselectivity. Water, a simple and readily available reagent, was employed as the OH source. A plausible reaction mechanism is proposed for this new annulation based on isotopic substitution experiments.
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