Abstract Background: Central obesity is strongly associated with obesity-related and metabolic diseases, which is a common health problem in sedentary adults, particularly in women, but the mechanisms remain unclear. This study aimed to investigate the prevalence and factors associated with central obesity in white-collar workers Chinese population, and explore potential sex differences. Methods: A cross-sectional study was conducted between 2017 and 2019 at two large general hospitals in northern and southern China. Totally 6,081 white-collar workers underwent a physical examination and completed an online health self-report questionnaire, which included demographic variables, lifestyle factors and blood lipid test. Multilevel logistic regression analysis was performed to assess the prevalence and factors of central obesity. Results: A total of 4,973 male and 1,108 female white-collar workers were included in this study, and the incidence of central obesity was 67.5% and 30.1%, respectively. In male white-collar workers, increasing age, chronic disease, higher levels of total cholesterol, salt intake and BEE, social engagement, eating spicy food and animal offal were risk factors for central obesity, while a higher HDL-C level, eating fish, and high vegetable intake were protective factors. In female white-collar workers, increasing age, higher total cholesterol level, higher BEE, and overeating were risk factors for central obesity, while a higher HDL-C level, and drinking milk were protective factors. Conclusions: Central obesity was a significant public health concern and the prevalence was high in Chinese adults. Healthy lifestyles and dietary measures to control the rates of central obesity should be undertaken to circumvent the growing disease burden in Chinese people..
Ustekinumab is a biological therapy that has been approved for treating moderate-to-severe psoriasis. Although injection site reactions, nasopharyngitis, headaches, and infections are the common adverse events associated with ustekinumab, the development of bullous pemphigoid (BP) is also thought to be related to ustekinumab. Given that psoriasis itself can be complicated by BP, it is worthwhile to investigate the relationship between ustekinumab, psoriasis, and BP. Here we report a case of a male patient who developed BP twice after psoriasis treatment with ustekinumab. The patient's psoriasis and BP were brought under control by discontinuing ustekinumab and administering methotrexate, minocycline, and topical corticosteroids. Because of the increasing use of biologics in patients with psoriasis, BP should be considered a potential adverse event associated with ustekinumab.
Background . Occult psoriatic arthritis (PsA) refers to a subset of psoriasis patients showing lesions on imaging but do not exhibit arthritis symptoms. Objective . This study was aimed to discover a simple biomarker that could be easily incorporated in clinical practice to identify occult PsA patients, defined as psoriasis patients with lesions on imaging but without arthritis symptoms, among silent psoriasis (PsO) patients, defined as psoriasis patients without any arthritis symptoms. Methods . A total of 149 silent PsO patients, including 83 PsO alone patients, defined as psoriasis patients without any arthritis symptoms and evidence of lesions on imaging, and 66 occult PsA patients, were enrolled in this cross‐sectional study, and they all underwent blood tests to determine hematological inflammation biomarkers. Results . Occult PsA patients had a higher derived neutrophil‐to‐lymphocyte ratio (dNLR) (1.6 (1.3–2.2) vs. 1.3 (0.9–1.8), p < 0.001), body mass index (BMI) (25.2 (23.7–28.1) vs. 24.0 (21.9–26.0), p = 0.002), diabetes mellitus (DM) rate (30.3% vs. 7.2%, p < 0.001), and nail involvement rate (65.2% vs. 41.0%, p = 0.003) than patients with PsO alone. A prediction nomogram was established, and the area under the curve (AUC) was 0.843. The sensitivity and specificity of the model for identifying occult PsA patients were 77.3% and 81.9%, respectively. Conclusion . Our findings suggest that dNLR is a valuable diagnostic biomarker for occult PsA, and our prediction nomogram could provide clinicians with a useful tool for differentiating occult PsA patients from PsO alone patients.
The mechanism of 4.1 family in human cancer has not been elucidated. In this study we investigate the value as a prognostic factor of mRNA expression of 4.1 family in non-small cell lung cancer (NSCLC).A survival analysis was carried out through the Kaplan-Meier plotter (KM plotter) database. KM's method was used to estimate the prognostic value of 4.1 mRNA expression in NSCLC.Expression of four members are linked to overall survival (OS) in NSCLC patients, among which 4.1G, 4.1B, 4.1R are concerned with first progression (FP), and 4.1G, 4.1R are correlated with post progression survival (PPS) besides. Only 4.1B expression is associated with OS in squamous cell carcinoma, as four members with OS in adenocarcinoma. What's more, 4.1G, 4.1N high mRNA are linked to better FP in adenocarcinoma, and 4.1R overexpression is linked to better PPS. The expression of 4.1G is associated with the prognosis in female, whereas 4.1R in male. Furthermore, 4.1G and 4.1B play as protective roles in non-smoking populations, while 4.1N overexpression is related to poorer PPS. All the four family members are associated with early stage in NSCLC 4.1G, 4.1B and 4.1R are closely related to surgical resection, yet 4.1N has no prognostic significance in patients receiving treatments. However, the results need to be verified in clinical trials further.Our results offer new opinion about the prognostic value of 4.1 protein family in NSCLC, which may contribute to the development of new therapy for NSCLC.
Objective: To study the features in the pulse waves of women during pregnancy. Methods: To collect the pulse waves of pregnant women in different stage and compare them with normal women's. We choose continuous cycles waves with different period length and then do the LSQ regression by 12 harmonics fitting to build mathematical model and extract 193 parameters after pretreatment, then do classification and identification to find the features. Result: There are significant difference between pregnant women's pulse waves and the normal women's and the accurate is 86% to identify, the features distribute at different places in radial artery called "cun" "guan" "chi" in pulse-diagnosis of TCM. The identification accurate of first trimester is 86%, and second trimester's is 89%, 94% is the third's. Features of each stage focus on the special place of radial artery. Conclusion: Physiological changes of pregnant women can embody in pulse waves we collected from the radial artery and the characters change regularly during the different stage of pregnancy. This research can offer some scientific basis for diagnosing pregnancy by taking pulse in TCM and also for the method of pulse-taking to feel different places in radial artery.
Psoriatic arthritis (PsA) is an immune-mediated form of chronic inflammatory arthritis associated with psoriasis (PsO). It constitutes a significant comorbidity of PsO and is distinguished by the presence of widespread musculoskeletal inflammation.
Abstract Cancer mutations play essential roles in tumor development by promote cell proliferation or immune evasion. However, some recent researches indicate that cancer cells with these mutation burden also expose their vulnerability to immune-based therapies such as checkpoint blockade. Here we performed comprehensive CRISPR knockout library screens in syngeneic mouse models on cancer driver mutation genes. We identified a set of genes including Kmt2d, Arid2, Rhob, Eloc, Ptpn11 and Xpo1, which have high frequency mutation in several human cancer types and their deficiency made tumor cells better respond to anti-PD-1 treatment. Furthermore, some of these deletions were validated to sensitize the tumor cells to cytotoxic T cells by in vitro co-culture with CD8+ T cells. The findings of Kmt2d was in accordance with a recent report for its role as a sensitizing modulator of immune checkpoint blockade from mouse model and patient prediction. These findings provide a new insight for understanding the interaction between the tumor heterogeneity and microenvironment. These results revealed CRISPR in vivo screen as a robust tool for both context and target discovery for tumor immunotherapy. Citation Format: Wenrong Zhou, Zhengang Peng, Dawei Huang, Min Long, Tianyu Song, Siyuan Ni, Yong Cang. Cancer driver screens identifyregulators of immune checkpoint blockade therapy response [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1600.
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