Sandra Lopes

Hospital de São Bernardo

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Pedro Figueiredo

Hospitais da Universidade de Coimbra

Francisco Portela

University of Coimbra

Hermano Gouveia

Hospital Dr. Nélio Mendonça

Carlos Sofia

University of Verona

Nuno Almeida

University of Coimbra

Maria Augusta Cipriano

Hospitais da Universidade de Coimbra

Paulo Freire

University of Coimbra

Sofia Mendes

Unidade Hospitalar de Bragança

Maximino Correia Leitão

Hospitais da Universidade de Coimbra

Fernando Magro

Universidade do Porto

Cooperative Institutions

Hospitais da Universidade de Coimbra

University of Coimbra

Universidade do Porto

University of Surrey

Hospital de São João

Administração Regional de Saúde de Lisboa e Vale do Tejo

University Gastroenterology

Instituto Português de Oncologia Francisco Gentil

University of Lisbon

Centro Hospitalar do Porto

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P511 Epstein-Barr Virus in inflammatory bowel disease – correlation with different therapeutic regimens

Journal of Crohn s and Colitis (2013)

Fernando Magro João Santos‐Antunes A. Albuquerque Filipe Vilas‐Boas G. Macedo

10.1016/s1873-9946(13)60532-2

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P502 Correlation between soluble suppression of tumorigenicity 2 (sST2) and endoscopic activity in patients with moderate to severe ulcerative colitis under golimumab treatment: results of the EVOLUTION study

Journal of Crohn s and Colitis (2019)

Fernando Magro Sandra Lopes Marina Pequeno Camargo Da Silva R Coelho Francisco Portela

Suppressor of Tumorigenicity 2 (ST2) is an IL33 receptor detected in mucosa and serum of ulcerative colitis (UC) patients. We aimed to evaluate soluble ST2 (sST2) as a surrogate biomarker of disease activity and therapeutic response in subjects with moderately to severely active UC under golimumab and to compare with standard biomarkers such as faecal calprotectin (FC) and C-reactive protein (CRP). Open-label single-arm multi-centre prospective study. At screening/baseline, Week 6 (W6) and Week 16 (W16), clinical and endoscopic activity (total Mayo score), histological activity (Geboes index) and biomarkers were evaluated. Biomarkers levels by UC activity were compared using Mann–Whitney test and t-test. Receiver-operating characteristic curves (ROC), Wilcoxon signed rank test and Spearman correlations (rs) were also used (α = 0.05). Thirty-four patients (89.5%) completed W6 and 29 (76.3%) completed W16. Mean ± sd age was 34.6 ± 12.6 years; 55.9% were female. At W16, 62.1% (18/29) achieved clinical response by total Mayo score. At W6, sST2 levels correlated with endoscopic activity (rs=0.45, p = 0.007) but not with histological activity (rs = 0.25, p = 0.151). W16 correlations were not significant. Patients with endoscopic activity at W6 had higher sST2 baseline levels: median, 24.5 vs. 18.7 ng/ml (p = 0.026) and showed no decrease of sST2 levels (median change, 0.8 vs. −2.7, p = 0.029). The best sST2 cut-off for endoscopic activity was 16.9 ng/ml (specificity=71%; sensitivity=85%). sST2 did not correlate with FC nor with CRP (Table 1). Accuracy of sST2, FC and CRP measurement to predict endoscopic and histological activity at Week 6. sST2 may be a surrogate biomarker of UC activity and therapeutic response. sST2, FC and CRP may be biomarkers of different components of the UC inflammatory process during early treatment with golimumab.

Golimumab

Faecal calprotectin

10.1093/ecco-jcc/jjy222.626

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Dose‐dependent inhibitory effects of proton pump inhibitors on human osteoclastic and osteoblastic cell activity

FEBS Journal (2013)

João Costa‐Rodrigues Sara Reis Sónia Teixeira Sandra Lopes Maria Helena Fernandes

Proton pump inhibitors (PPIs), a class of molecules that are used to decrease gastric acid production, might have adverse effects on bone metabolism. The aim of this study was to characterize the concentration-dependent and time-dependent effects of three PPIs (omeprazole, esomeprazole, and lansoprazole) on human osteoclast precursor cells isolated from peripheral blood, and on human mesenchymal stem cells (osteoblast precursors). Cell cultures were characterized for total protein content, apoptosis, and several osteoclastic/osteoblastic features, and also for the involvement of some intracellular signaling pathways. PPIs caused a dose-dependent decrease in cellular density, which correlated with an increase in the apoptosis rate, effects that became statistically significant at concentrations ≥ 10(-5) m. They also inhibited phenotype-related gene expression and functional parameters. For both cell types, cellular function, i.e. osteoclastic resorption and the formation of mineralized deposits by osteoblastic cells, was more affected than proliferation-related parameters. The three PPIs showed similar qualitative and quantitative effects, but displayed some differences in the underlying intracellular signaling pathways. These results suggest that PPIs might have a direct deleterious effect on bone cells, with the possibility of decreased bone turnover.

Lansoprazole

Bone remodeling

Bone cell

10.1111/febs.12478

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Citations (88)

Doença celíaca no adulto e invaginação intestinal - A propósito de um caso clínico

Jornal Português de Gastrenterologia (2009)

Sandra Lopes Sofia Broco Daniela Vieira O Mota Francisco Portela

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Biomechanical Basis of Bone Fracture and Fracture Osteosynthesis in Small Animals

IntechOpen eBooks (2023)

Nuno Alexandre Gonçalo Simões Sandra Lopes Tarcísio Guerra Guimarães Bruna Lopes

The mastery of concepts related to biomechanics in bone fracture is crucial for the surgical success of osteosynthesis. The understanding of the basics of bone fracture is a skill fundamental to the choice of the correct method of osteosynthesis. Deep knowledge of implants, namely, their mechanic characteristics, and the correct technical use following the recommended guidelines for each type are crucial factors to decrease surgical failure and complications rate. This chapter reviews the biomechanical parameters of fracture repair that influence construct stiffness and strength. The authors also provided practical examples of the biomechanics concepts applied in clinical practice during this chapter. Metal alloys used in orthopedic implants are also fundamentally reviewed in their physical properties during this chapter. Fracture patterns vary hugely among patients and contributed to the difficult understanding of forces acting in fracture lines. However, fracture biomechanics basic knowledge and how osteosynthesis methods counteract the forces acting on fractures are key to surgical success.

Biomechanics

Osteosynthesis

Bone pathology

10.5772/intechopen.112777

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Whipple Disease: An Atypical Diagnosis by Capsule Endoscopy in an Oldest-Old Patient

GE Portuguese Journal of Gastroenterology (2021)

C Macedo Elisa Gravito‐Soares Marta Gravito‐Soares Sandra Lopes Rui Caetano-Oliveira

10.1159/000514713

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Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis

BMJ Case Reports (2015)

Ana Torres Oliveira Sandra Lopes Maria Augusta Cipriano Carlos Sofia

A 33-year-old woman with multiple sclerosis, medicated with high doses of methylprednisolone, cyclophosphamide and glatiramer acetate, was referred to our department due to acute liver injury. The laboratory investigation was normal except for weakly positive antinuclear antibodies. Cyclophosphamide and glatiramer acetate were suspended, and intravenous immunoglobulin with maintenance of high doses of methylprednisolone was initiated. The patient developed another episode of acute hepatitis so the immunoglobulin was stopped. After that, she had three more episodes of elevation of liver enzymes with no hepatic insufficiency while medicated only with high doses of methylprednisolone. At this time, liver biopsy showed focal centrilobubar hepatocyte necrosis with minimal interface hepatitis. After the high doses of methylprednisolone were suspended, the patient remained asymptomatic, with normal hepatic enzymes. This case emphasises that, although rare, induced liver injury after high doses of methylprednisolone can occur.

Glatiramer acetate

Methylprednisolone acetate

10.1136/bcr-2015-210722

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E-Learning and Digital Education in the Twenty-First Century

IntechOpen eBooks (2020)

Igor Balaban Miran Zlatović Željko Hutinski Jowati Juhary Dominique Verpoorten

E-learning and digital education approaches are evolving and changing the landscape of teaching and learning at all levels of education throughout the world. Innovation of emerging learning technologies is assisting e-learning and digital education to meet the needs of the 21st century. Due to the digital transformation of everyday practice, the process of learning and education has become more self-paced and accessible at any time from anywhere. The new generations of digital natives are growing up with a set of skills through their engagement with the digital world. In this context, this book includes a collection of chapters to facilitate continuous improvements including flexibility and accessibility in e-learning and digital education by exploring the challenges and opportunities of innovative approaches through the lenses of current theories, policies, and practices.

Digital Learning

10.5772/intechopen.87797

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Educação patrimonial e suas relações com a patrimonialização subalterna na Amazônia

DELOS Desarrollo Local Sostenible (2024)

Francisco Perpetuo Santos Diniz Marion Costa Iramaia Muniz Damasceno Nazaré do Socorro Cordeiro do Vale Milene Vieira Barata

O presente trabalho discute relações que envolvem a educação patrimonial no contexto da patrimonialização global e da construção e reconhecimento de patrimônios que concebemos como subalternos. Em um primeiro momento, evidenciamos a educação patrimonial no contexto das conferências globais que trataram do patrimônio, especialmente as promovidas pela Organização das Nações Unidas para Educação Ciência e Cultura (UNESCO), em que damos destaque para a “pedagogia da instrução”. Posteriormente, destacamos como a noção de paisagem serve aos interesses do processo patrimonializador. No terceiro tópico, damos destaque à educação não normativa, desenvolvida no processo de patrimonialização e suas relações com as noções de paisagem e dialética. Por último, discutimos a possibilidade de construção de uma educação patrimonial alternativa frente à ação patrimonializadora na Amazônia ao considerarmos paisagens visíveis e invisíveis como processo contraditório e relacionado a patrimonialização subalterna. O referencial teórico está baseado na discussão da noção de paisagem, sendo explicada pelo princípio dialético que envolve aparência e essência. A metodologia utilizada tem caráter qualitativo, baseada em pesquisas bibliográficas e os resultados demonstraram que a pedagogia da patrimonialização global prioriza formas paisagísticas arquitetônicas feitas de “pedra e cal”, e expressa símbolos, ícones e objetos da cultura colonizadora europeia, e que no contexto amazônico as paisagens enquanto patrimônios exaltados em práticas educativas subalternas são edificadas por processos territoriais conflituosos que demarcam o apelo à memória, à resistência identitária e reforça os traços culturais singulares locais.

10.55905/rdelosv17.n60-150

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Glycogenic acanthosis of the esophagus: an unusually endoscopic appearance

Revista Española de Enfermedades Digestivas (2010)

Sandra Lopes Pedro Figueiredo Pedro Amaro Paulo Freire Sónia Alves

Acanthosis Nigricans

10.4321/s1130-01082010000500013

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Citations (2)