Granulomatous reactions at sites of previous cutaneous herpes zosier lesions occur, but their etiology is not known. Three tissue specimens from 5 cases identified clinically and hislologically as post‐zosteric granulomatous reactions were studied for the presence of varicella‐zoster virus (VZV) deoxyribonucleic acid (DNA) by the polymerase chain reaction using specific primers For VZV. VZV DNA was detected in 1 of 3 cases where the granulomatous reaction occurred immediately in the wake of resolving vesicular herpes zoster lesions. Finding viral DNA in earlier reactions probably represents residue from the active herpetic process. VZV DNA was not identified in granulomatous reactions arising between 1 month and up to 4 years after resolved herpes zoster. The negative result in these cases supports the hypothesis that there is no association between persistence of VZV DNA and granuloma formation. How long VZV DNA is detectable at sites of resolved herpes zoster lesions could be the subject of further studies.
A 45-year-old Chinese man had begun to show asymmetry of the face 30 years previously. Subsequently, he developed visual extinction of the right eye, slight numbness, and weakness of the left extremities. Simultaneously, multiple atrophic brownish patches occurred on his side. He denied prior trauma or tick bites at those sites. There was no report of preceding redness, induration, or a history of trauma. The atrophic lesions extended and enlarged slowly. Ten years previously, some brownish patches with normal texture had appeared on the right side of the trunk. There was no further progression of the lesions. In November 2010, the patient consulted our department for the final diagnosis and prognosis of his disease. He did not suffer from epileptic seizures and had no history of a tick bite or Lyme disease.
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Tan C, Zhu W. Case reportPointillist melanotic macules: a new clinical entity?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2012;29(6):475-479. doi:10.5114/pdia.2012.32398. APA Tan, C., & Zhu, W. (2012). Case reportPointillist melanotic macules: a new clinical entity?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 29(6), 475-479. https://doi.org/10.5114/pdia.2012.32398 Chicago Tan, Cheng, and Wen-Yuan Zhu. 2012. "Case reportPointillist melanotic macules: a new clinical entity?". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 29 (6): 475-479. doi:10.5114/pdia.2012.32398. Harvard Tan, C., and Zhu, W. (2012). Case reportPointillist melanotic macules: a new clinical entity?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 29(6), pp.475-479. https://doi.org/10.5114/pdia.2012.32398 MLA Tan, Cheng et al. "Case reportPointillist melanotic macules: a new clinical entity?." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 29, no. 6, 2012, pp. 475-479. doi:10.5114/pdia.2012.32398. Vancouver Tan C, Zhu W. Case reportPointillist melanotic macules: a new clinical entity?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2012;29(6):475-479. doi:10.5114/pdia.2012.32398.
Abstract Background. A viral etiology has been suspected in papillomatosis of the external auditory canal ( peac ), but virus particles have not been detected so far, although they are easily demonstrable in skin warts. The purpose of the study was to solve this discrepancy by the use of polymerase chain reaction ( pcr ). Materials and Methods. Specimens from the external auditory canal of 14 patients with PEAC, but no human papilloma virus infection of the genital areas, were examined histologically by light and electron microscopy, as well as by PCR to detect viral dna . Results. Histologically, papillomatosis was present in all specimens. Vacuolated cells were found in the upper part of the stratum malpighii in five cases. On electron microscopy, the numbers of perichromatin and interchromatin granules were increased, but no viral granules were observed. In all specimens, dna of hpv 6 was detected using PCR, but there was no evidence of DNA of other hpv . Conclusions. Papilloma of the external auditory canal is produced by infection with hpv 6.
Imiquimod is a small molecule with adjuvant pro-inflammatory effects that can be topically delivered as a cream for treating external genital and perianal warts. In our report, two Chinese males at the ages of 25 and 22 years were treated with imiquimod 5% cream for recurrent condyloma accuminatum, three times per week for 18 and 12. weeks, respectively. Depigmentation were noted and gradually enlarged in the treated areas after the two patients discontinued imiquimod. Therefore, clinicians should be made aware of the possible pigmentary changes associated with application of this cream.
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