Shengjie Xu

Shanghai Jiao Tong University

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Wenkai Zhong

South China University of Technology

Lei Zhu

Shanghai Jiao Tong University

Xiaonan Xue

Beijing Solar Energy Research Institute

Feng Liu

Shanghai Jiao Tong University

Yanli Li

Kunming Medical University

Sufang Wu

Shanghai Jiao Tong University

Jiawei Deng

Shanghai Jiao Tong University

Rui Zeng

Shanghai Jiao Tong University

Xingyu Gao

Chinese Academy of Sciences

Yongming Zhang

Shanghai Jiao Tong University

Cooperative Institutions

Shanghai Jiao Tong University

Chinese Academy of Sciences

Shanghai First People's Hospital

University of Chinese Academy of Sciences

Beijing National Laboratory for Molecular Sciences

Institute of Chemistry

Beijing Normal University

Lawrence Berkeley National Laboratory

State Key Laboratory of Polymer Physics and Chemistry

Zhejiang University

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miR-98-5p contributes to cisplatin resistance in epithelial ovarian cancer by suppressing miR-152 biogenesis via targeting Dicer1

Cell Death and Disease (2018)

Yanan Wang Wei Bao Yuan Liu Shiyu Wang Shengjie Xu

Abstract Epithelial ovarian cancer (EOC) is a highly lethal gynecological malignancy, and cisplatin resistance is usually correlated with the poor prognosis of EOC. Increasing evidence indicates that the dysregulation of miRNAs is related to chemotherapy sensitivity. In this study, we revealed that miR-98-5p, a member of the let-7 family, was enriched in cisplatin-resistant EOC cells compared with cisplatin-sensitive cells, and could promote cisplatin resistance in EOC cells. Further studies showed that miR-98-5p could directly target the 3′-UTR of Dicer1 and suppress its expression, causing global miRNA downregulation. By miRNA array and qRT-PCR verification, we identified miR-152 as the vital downstream target of the miR-98-5p/Dicer1 axis in EOC cells. Moreover, we demonstrated that the ectopic expression of miR-152 reversed cisplatin resistance both in vitro and in vivo by targeting RAD51, a central member in homologous recombination. Importantly, miR-98-5p expression, as determined by in situ hybridization in tumor tissues, was associated with poor outcome of EOC patients. Together, these findings suggest the essential role of the miR-98-5p/Dicer1/miR-152 pathway in regulating cisplatin resistance of EOC cells and provide a potential target for EOC therapy.

Ectopic expression

10.1038/s41419-018-0390-7

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Citations (90)

Suppressing electron-phonon coupling in organic photovoltaics for high-efficiency power conversion

Nature Communications (2023)

Yuanyuan Jiang Yixin Li Feng Liu Wenxuan Wang Wenli Su

The nonradiative energy loss (∆Enr) is a critical factor to limit the efficiency of organic solar cells. Generally, strong electron-phonon coupling induced by molecular motion generates fast nonradiative decay and causes high ∆Enr. How to restrict molecular motion and achieve a low ∆Enr is a sticking point. Herein, the free volume ratio (FVR) is proposed as an indicator to evaluate molecular motion, providing new molecular design rationale to suppress nonradiative decay. Theoretical and experimental results indicate proper proliferation of alkyl side-chain can decrease FVR and restrict molecular motion, leading to reduced electron-phonon coupling while maintaining ideal nanomorphology. The reduced FVR and favorable morphology are simultaneously obtained in AQx-6 with pinpoint alkyl chain proliferation, achieving a high PCE of 18.6% with optimized VOC, JSC and FF. Our study discovered aggregation-state regulation is of great importance to the reduction of electron-phonon coupling, which paves the way to high-efficiency OSCs.

10.1038/s41467-023-40806-9

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MARCH1 silencing suppresses growth of oral squamous cell carcinoma through regulation of PHLPP2

Clinical & Translational Oncology (2022)

L Liu Bin Guo Yudong Han Shengjie Xu S. Liu

10.1007/s12094-021-02769-5

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Citations (9)

Role of the Gp91 Phox Homologues Nox1 and Nox4 in Atherosclerosis

Journal of Investigative Medicine (2004)

Shengjie Xu Francis J. Miller

NOX1

NOX4

10.1177/108155890405202s69

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γ-Glutamyl cyclotransferase contributes to endometrial carcinoma malignant progression and upregulation of PD-L1 expression during activation of epithelial-mesenchymal transition

International Immunopharmacology (2019)

Shengjie Xu Ye Yang Xiaoyun Wang Xiangnan Liu Chengjuan Jin

10.1016/j.intimp.2019.106039

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Construction of Linear Tetramer‐type Acceptors for High‐efficiency and High‐stability Organic Solar Cells

Angewandte Chemie (2025)

Rui Zeng Jiawei Deng Xiaonan Xue Senke Tan Lixuan Kan

The photovoltaic conversion efficiency (PCE) of organic solar cells (OSCs) has exceeded 20%, which has met the requirements for commercialisation. In the current stage, the main focus is to balance the performance and stability. It has been shown that all‐polymer formulation can improve device stability, however, PCE is not in satifsfaction, and the batch‐to‐batch variation leads to quality control issues. In this work, we constructed monodispersed tetramer NFA materials named G‐1 and G‐2, to best integrate the merits of small molecule and polymer. It was revealed that different connecting units at the centre could significantly affect the molecular planarity and thin film morphology. The alkene‐bonded tetramer G‐1 had a more regioregular structure, leading to better molecular planarity, and more ordered packing in thin film. More importantly, the oligomeration induced a favourable face‐on orientation, achieved a lower binding energy and a higher photoluminescence yield. As a result, the exciton and charge carrier kinetics was optimized with reduced non‐radiative energy loss. The OSC based on PM6:G‐1 achieved a PCE of 19.6%, which is the highest PCE reported so far for oligomer‐based binary OSC. In addition, the device stability was largely improved, showing a lifetime over 10000 hours in the inverted OSC device.

Tetramer

10.1002/ange.202420453

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Achieving 19% efficiency in non-fused ring electron acceptor solar cells via solubility control of donor and acceptor crystallization

Nature Energy (2024)

Rui Zeng Ming Zhang Xiaodong Wang Lei Zhu Bonan Hao

Acceptor

Electron acceptor

Electron donor

10.1038/s41560-024-01564-0

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Citations (18)

Progress of organic photovoltaics towards 20% efficiency

Nature Reviews Electrical Engineering (2024)

Lei Zhu Ming Zhang Zichun Zhou Wenkai Zhong Tianyu Hao

10.1038/s44287-024-00080-3

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Citations (8)

Achieving 20.8% organic solar cells via additive-assisted layer-by-layer fabrication with bulk p-i-n structure and improved optical management

Joule (2024)

Lei Zhu Ming Zhang Guanqing Zhou Zaiyu Wang Wenkai Zhong

10.1016/j.joule.2024.08.001

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Citations (45)

LSD1 silencing contributes to enhanced efficacy of anti-CD47/PD-L1 immunotherapy in cervical cancer

Cell Death and Disease (2021)

Shengjie Xu Xiaoyun Wang Yongbing Yang Yanli Li Sufang Wu

Abstract Anti-CD47/PD-L1 immunotherapies aiming to enhance antitumor immunity are being intensively investigated and show promising results in cancer therapy; however, not all patients treated with these new drugs respond. Thus, developing new immunotherapy agents or combination treatments to enhance the efficacy of immunotherapy is an urgent challenge. Here, we found that LSD1 knockdown directly downregulated the expression of CD47 and PD-L1 through upregulating H3K4me2 levels in the CD47 and CD274 promoter regions. In addition, the LSD1/wild-type p53/miR-34a signaling axis was also involved in the regulation of CD47/PD-L1 expression by targeting the 3′ untranslated regions (3′UTRs) of CD47 / PD-L1 . Further, the results showed that an LSD1 inhibitor (ORY-1001) combined with anti-CD47/PD-L1 monoclonal antibodies inhibited tumor growth in an established subcutaneous xenograft model more effectively than a single blockade strategy. Collectively, these findings indicate that LSD1 inhibition enhances the therapeutic efficacy of PD-L1/CD47 blockade by reducing CD47 and PD-L1 expression in cervical cancer.

CD47

Cancer Immunotherapy

Immune checkpoint

10.1038/s41419-021-03556-4

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Citations (40)