Minghui Zhang

Johns Hopkins University

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Nilanjan Chatterjee

Johns Hopkins University

Meng Ru

Icahn School of Medicine at Mount Sinai

Jingning Zhang

Regeneron (United States)

Kala Visvanathan

Johns Hopkins University

Mehrnoosh M. Soori

Johns Hopkins University

David Couper

University of North Carolina at Chapel Hill

Corinne E. Joshu

Johns Hopkins University

Elizabeth A. Platz

Johns Hopkins University

Jiayun Lu

Johns Hopkins University

Anna E. Prizment

University of Minnesota

Cooperative Institutions

Sun Yat-sen University

Northeast Agricultural University

Chinese Academy of Sciences

Beijing Academy of Food Sciences

Harbin Medical University

Johns Hopkins University

Chinese Academy of Agricultural Sciences

Zhejiang University

Rice Research Institute

Ministry of Education of the People's Republic of China

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The RNA‐binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA

Cancer Medicine (2024)

Yafei Li Shuoshuo Wang Guoli Li Chunyang Gao Zihan Cui

The RNA-binding motif single-stranded interacting protein 3 (RBMS3) is a constituent of the RNA-binding motif (RBM) protein family, which assumes a pivotal role in governing cellular biogenesis processes such as the cell cycle and apoptosis. Despite an abundance of studies elucidating RBMS3's divergent roles in the genesis and advancement of various tumors, its involvement in colon cancer remains enigmatic. The present investigation employed data analysis from TCGA and GTEx to unveil that RBMS3 expression demonstrated a diminished presence in colon cancer tissues when juxtaposed with normal colon tissues. The effect of RBMS3 and LIM zinc finger domain 1 (LIMS1) on colon cancer was substantiated via animal models and cellular experiments. The connection between RBMS3 and LIM zinc finger domain 1 (LIMS1) was verified by molecular biology methods. The study conclusively ascertained that augmenting RBMS3 expression quells the proliferation, migration, and invasion of colon cancer cells. Furthermore, the inquiry unveiled a plausible mechanism through which RBMS3 impacts the expression of LIMS1 by modulating its mRNA stability. The investigation ascertained that RBMS3 inhibits the progression of colon cancer by regulating LIMS1. The inhibitory function of LIMS1 and RBMS3 is closely intertwined in colon cancer, with knocking down LIMS1 being able to rescue the inhibitory effect of RBMS3 overexpression on the functionality of colon cancer cell CONCLUSIONS: The discernments delineate RBMS3 as a novel suppressor of cancer via LIMS1, thereby bestowing fresh therapeutic possibilities and illuminating the intricacies of colon cancer.

10.1002/cam4.7129

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Supplementary Figure S3 from Alcohol Consumption Does not Modify the Polygenic Risk Score–Based Genetic Risk of Breast Cancer in Postmenopausal Women: Atherosclerosis Risk in Communities Study

Minghui Zhang Meng Ru Jingning Zhang Ziqiao Wang Jiayun Lu

Supplementary Figure S3: Natural logarithm hazard ratios of breast cancer for P-spline term scaled 313-SNP PRS with 4 degrees of freedom estimated by fully-adjusted Cox proportional hazards model in ARIC (1990-2015)

Polygenic risk score

10.1158/1940-6207.28333155

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Supplementary Table S5 from Alcohol Consumption Does not Modify the Polygenic Risk Score–Based Genetic Risk of Breast Cancer in Postmenopausal Women: Atherosclerosis Risk in Communities Study

Minghui Zhang Meng Ru Jingning Zhang Ziqiao Wang Jiayun Lu

Supplementary Table S5: The association between current ethanol intake and breast cancer incidence stratified by routine examinations frequency and by race in ARIC (1990-2015)

Polygenic risk score

Table (database)

Consumption

10.1158/1940-6207.28333131

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Effect of folA gene in human breast milk-derived Limosilactobacillus reuteri on its folate biosynthesis

Frontiers in Microbiology (2024)

Yu Jiang Xianping Li Wei Zhang Yadong Ji Kai Yang

Introduction Folate supplementation is crucial for the human body, and the chemically synthesized folic acid might have undesirable side effects. The use of molecular breeding methods to modify the genes related to the biosynthesis of folate by probiotics to increase folate production is currently a focus of research. Methods In this study, the folate-producing strain of Limosilactobacillus reuteri B1-28 was isolated from human breast milk, and the difference between B1-28 and folA gene deletion strain ΔFolA was investigated by phenotyping, in vitro probiotic evaluation, metabolism and transcriptome analysis. Results The results showed that the folate producted by the ΔFolA was 2–3 folds that of the B1-28. Scanning electron microscope showed that ΔFolA had rougher surface, and the acid-producing capacity ( p = 0.0008) and adhesion properties ( p = 0.0096) were significantly enhanced than B1-28. Transcriptomic analysis revealed that differentially expressed genes were mainly involved in three pathways, among which the biosynthesis of ribosome and aminoacyl-tRNA occurred in the key metabolic pathways. Metabolomics analysis showed that folA affected 5 metabolic pathways, involving 89 different metabolites. Discussion In conclusion, the editing of a key gene of folA in folate biosynthesis pathway provides a feasible pathway to improve folate biosynthesis in breast milk-derived probiotics.

10.3389/fmicb.2024.1402654

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Physiological differentiation and races distribution of Setosphaeria turcica in China.

Yumi kexue (2011)

Minghui Zhang Xu XiuDe Liu Kejie Dong Huai-yu Yu Jiang

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Supplementary Figure S5 from Alcohol Consumption Does not Modify the Polygenic Risk Score–Based Genetic Risk of Breast Cancer in Postmenopausal Women: Atherosclerosis Risk in Communities Study

Minghui Zhang Meng Ru Jingning Zhang Ziqiao Wang Jiayun Lu

Supplementary Figure S5: Natural logarithm hazard ratios of breast cancer for P-spline term scaled 313-SNP PRS with 4 degrees of freedom estimated by fully-adjusted Cox proportional hazards model stratified by alcohol consumption category among White women in ARIC (1990-2015)

Polygenic risk score

10.1158/1940-6207.28333149

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Glandular trichomes: the factory of artemisinin biosynthesis

Medicinal Plant Biology (2024)

Qiaojuan Zhao Mingyu Li Minghui Zhang Hexin Tan

Plant glandular trichomes serve as a crucial secretory organ, responsible for the production, modification, and storage of a variety of vital secondary metabolites, including medicinal natural products, while also playing a role in plant defense mechanisms. Artemisia annua L. (A. annua) stands as a significant herb in Chinese traditional medicine because of its primary active compound, artemisinin, the most potent antimalarial agent. The glandular trichomes of A. annua are closely related to the synthesis and accumulation of artemisinin. As research in the field of medicinal plants progresses, the significance of glandular trichomes in the study of plant secondary metabolites has notably escalated. Given their pivotal role in artemisinin biosynthesis, the growth and development of A. annua glandular trichomes directly influence the yield and quality of artemisinin. This paper presents a comprehensive review of the latest research advancements regarding A. annua glandular trichomes, encompassing their morphology, function, growth, and developmental influencing factors, and the artemisinin biosynthesis pathway. The aim is to provide substantial support for ongoing investigations into the growth and development of A. annua glandular trichomes and the underlying mechanisms of metabolic regulation.

Artemisia annua

Trichome

10.48130/mpb-0024-0018

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Identification of SSR primer numbers for analyzing genetic diversity of Chinese soybean cultivated soybean

Molecular plant breeding (2003)

Biao Wang Ruzhen Chang Yan Li Tao Li Guang Rongxia

The traditional way was applied to define genetic diversity of abundant Chinese soybean accessions according to agronomic traits, but those traits were affected by environmental and unnatural factors Genetic diversity of soybean germplasmand resources should be further studied from the DNA level because phenotype traits had not enough to expound their relationships among over 20,000 genotypes with cultivars increased 190 experimental materials were a standard sample obtained from Chinese soybean primary core collection 606 alleles were found in 60 loci, with each locus having a mean of 10 alleles, and the mean of gene diversity scores was 0 83, with a range of 0 55～0 99 Standard error of similarity matrices was analyzed with SSR primers increased, and the change of standard error appeared few fluctuations after the number of SSR loci reached 50 The correlation among cophenetic matrices was also examined using Mantel correlation test There was good fit among those matrices if alleles raised over 570 Analyzing the correlation of cophenetic matrices originated from a small sample of North East Spring Planting Soybean from experimental materials showed the similar results The truly genetic relationship of Chinese soybean cultivars (G max) could be obtained from enough alleles using SSR markers The scope of genetic diversity was reduced to a relatively smaller range, and the number of alleles used to study relationships among accessions became correspondently fewer The core SSR primers might be selected according to distribution of the SSR loci in the soybean genome and gene diversity scores The objectively genetic relationships of Chinese soybean cultivars could be reflected using over 570 alleles

Gene pool

Germ plasm

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Supplementary Figure S4 from Alcohol Consumption Does not Modify the Polygenic Risk Score–Based Genetic Risk of Breast Cancer in Postmenopausal Women: Atherosclerosis Risk in Communities Study

Minghui Zhang Meng Ru Jingning Zhang Ziqiao Wang Jiayun Lu

Supplementary Figure S4: Natural logarithm hazard ratios of breast cancer for P-spline term current ethanol intake with 4 degrees of freedom estimated by fully-adjusted Cox proportional hazards model in ARIC (1990-2015)

Polygenic risk score

10.1158/1940-6207.28333152

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The complete chloroplast genome of Pyrrosia calvata (Polypodiaceae), a traditional Chinese medicinal fern only restricted to Guangxi, China

Mitochondrial DNA Part B (2019)

Yihui Min Shicheng Cai Haoyun Xiao Minghui Zhang Yongfeng Hong

We reported the complete chloroplast genome of Pyrrosia calvata, a traditional Chinese medicinal fern only restricted to Guangxi, China. Its genome is 158,201 bp in length with 41.59% GC content and includes two inverted repeats (IRs) of 26,983 bp separated by LSC and SSC of 82,517 bp and 21,718 bp, respectively. A total of 131 genes are predicted, including 88 protein-coding genes, 34 tRNA genes, eight rRNA genes, and one pseudogene. ML tree indicates that P. calvata is sister to Lepisorus clathratu. This study provides a new perspective to explore the phylogenetic relationship of Pyrrosia.

Polypodiaceae

Inverted repeat

Pseudogene

Phylogenetic relationship

10.1080/23802359.2019.1610095

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