Kai Fan

University of Science and Technology of China

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Xiaoming Tu

Central South University

Jiahai Zhang

Hefei National Center for Physical Sciences at Nanoscale

Shanhui Liao

University of Science and Technology of China

Zhi Hua Feng

Northwest A&F University

Mengmeng Kong

University of Science and Technology of China

Xuecheng Zhang

Shanghai University

Chao Xu

Hefei National Center for Physical Sciences at Nanoscale

Ruiqi Shi

University of Science and Technology of China

Zilong Feng

University of Science and Technology of China

Junjian Zhang

University of Science and Technology of China

Cooperative Institutions

University of Science and Technology of China

Tea Research Institute

Chinese Academy of Sciences

Hefei National Center for Physical Sciences at Nanoscale

Nanjing University

Sun Yat-sen University

University of Toronto

Nanjing General Hospital of Nanjing Military Command

Qingdao Agricultural University

University of Wollongong

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High-Throughput, Off-Chip Microdroplet Generator Enabled by a Spinning Conical Frustum

Analytical Chemistry (2019)

Shi‐Yang Tang Kun Wang Kai Fan Zilong Feng Yuxin Zhang

Although droplet-based microfluidics has been broadly used as a versatile tool in biology, chemistry, and nanotechnology, its rather complicated microfabrication process and the requirement of specialized hardware and operating skills hinder researchers fully unleashing the potential of this powerful platform. Here, we develop an integrated microdroplet generator enabled by a spinning conical frustum for the versatile production of near-monodisperse microdroplets in a high-throughput and off-chip manner. The construction and operation of this generator are simple and straightforward without the need of microfabrication, and we demonstrate that the generator is able to passively and actively control the size of the produced microdroplets. In addition to water microdroplets, this generator can produce microdroplets of liquid metal that would be difficult to produce in conventional microfluidic platforms as liquid metal has high surface tension. Moreover, we demonstrate that this generator can produce solid hydrogel microparticles and fibers using integrated ultraviolet (UV) light. In the end, we further explore the ability of this generator for forming double emulsions by coflowing two immiscible liquids. Given the remarkable abilities demonstrated by this platform and the tremendous potential of microdroplets, this user-friendly method may revolutionize the future of droplet-based chemical synthesis and biological analysis.

Microreactor

10.1021/acs.analchem.9b00093

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Citations (30)

Solution structure of HtrA PDZ domain from Streptococcus pneumoniae and its interaction with YYF–COOH containing peptides

Journal of Structural Biology (2011)

Kai Fan Jiahai Zhang Xuecheng Zhang Xiaoming Tu

PDZ domain

10.1016/j.jsb.2011.06.009

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Citations (9)

Solution structure of a PWWP doamin from Trypanosoma brucei

R. Wang Kai Fan Shanhui Liao J. Zhang Xiaoming Tu

10.2210/pdb2m1h/pdb

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Citations (0)

The small ubiquitin-like modifier (SUMO) is essential in cell cycle regulation in Trypanosoma brucei

Experimental Cell Research (2010)

Shanhui Liao Tao Wang Kai Fan Xiaoming Tu

10.1016/j.yexcr.2009.12.017

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Citations (42)

Additional file 3 of Fulvic acid ameliorates drought stress-induced damage in tea plants by regulating the ascorbate metabolism and flavonoids biosynthesis

Figshare (2020)

Jianhao Sun Chen Qiu Yiqian Ding Yu Wang Litao Sun

Additional file 3. The annotation of total reads.

Drought stress

Fulvic acid

10.6084/m9.figshare.12511412

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Ionic strength‐dependent conformations of a ubiquitin‐like small archaeal modifier protein (SAMP1) from Haloferax volcanii

Protein Science (2013)

Kaiqin Ye Shanhui Liao Wei Zhang Kai Fan Xuecheng Zhang

Eukaryotic ubiquitin and ubiquitin-like systems play crucial roles in various cellular biological processes. In this work, we determined the solution structure of SAMP1 from Haloferax volcanii by NMR spectroscopy. Under low ionic conditions, SAMP1 presented two distinct conformations, one folded β-grasp and the other disordered. Interestingly, SAMP1 underwent a conformational conversion from disorder to order with ion concentration increasing, indicating that the ordered conformation is the functional form of SAMP1 under the physiological condition of H. volcanii. Furthermore, SAMP1 could interact with proteasome-activating nucleotidase B, supposing a potential role of SAMP1 in the protein degradation pathway mediated by proteasome.

Haloferax volcanii

10.1002/pro.2302

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Citations (6)

Electromagnetic design and analysis of high power density turbine permanent magnet generator

IET conference proceedings. (2025)

Ruini Li Jianxun Chen Yan Zhang Kai Fan Xiaoli Duan

Nacelle turbine generator systems are primarily used in the aviation field for hybrid electric propulsion systems of electric aircraft, requiring the turbine generators to have both high power density and high efficiency. To meet this requirement, based on the load characteristics of the nacelle turbine, this study conducts electromagnetic design research for a 290 kW turbine permanent magnet generator. Using finite element methods, an electromagnetic calculation model of the permanent magnet generator is established, analysing its no-load characteristics, load characteristics, and conducting loss and efficiency analysis, which proves the effectiveness of the design. The designed 290 kW generator achieves a power density of 4.9 kW/kg and a rated efficiency of 96%.

Power density

10.1049/icp.2024.3372

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A tuning fork gyroscope with drive-sense orthogonal thin-walled holes for high sensitivity

Review of Scientific Instruments (2023)

Ruiqi Shi Junjian Zhang Zilong Feng Kai Fan Mengmeng Kong

A tuning fork gyroscope (TFG) with orthogonal thin-walled round holes in the driving and sensing directions is proposed to improve sensitivity. The thin walls formed by through holes produce stress concentration, transforming the small displacement of tuning fork vibration into a large concentrated strain. When piezoelectric excitation or detection is carried out here, the driving vibration displacement and detection output voltage can be increased, thereby improving sensitivity. Besides, quadrature coupling can be suppressed because the orthogonal holes make the optimal excitation and detection positions in different planes. The finite element method is used to verify the benefits of the holes, and the parameters are optimized for better performance. The experimental results show that the sensitivity of the prototype gyroscope with a driving frequency of 890.68 Hz is 100.32 mV/(°/s) under open-loop driving and detection, and the rotation rate can be resolved at least 0.016 (°/s)/Hz, which is about 6.7 times better than that of the conventional TFG. In addition, the quadrature error is reduced by 2.7 times. The gyroscope has a simple structure, high reliability, and effectively improves sensitivity, which is helpful to guide the optimization of piezoelectric gyroscopes and derived MEMS gyroscopes.

Tuning fork

10.1063/5.0153518

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Backbone and side-chain NMR assignments for the bromodomain of mouse BAZ1A (ACF1)

Biomolecular NMR Assignments (2015)

Kai Fan Shengrong Chen Yi‐Feng Ge Kaiqin Ye Qi Yao

Side chain

Transcription

10.1007/s12104-015-9651-x

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Citations (2)

Ionic strength-dependent conformations of a ubiquitin-like small archaeal modifier protein (SAMP2) from Haloferax volcanii

Scientific Reports (2013)

Shanhui Liao Wei Zhang Kai Fan Kaiqin Ye Xuecheng Zhang

Ubiquitin-like proteins play important roles in diverse biological processes. In this study, we present an unexpected finding that a ubiquitin-like small archaeal modifier protein (SAMP2) from Haloferax volcanii adopts two distinct states under low ionic condition. One of these is similar to the β-grasp structure conserved in ubiquitin-like proteins from eukaryotes; the other is disordered, like prokaryotic ubiquitin-like protein, Pup. Furthermore, our study reveals that the conformation of SAMP2 is dependent on ionic strength. With the increase of ion concentration, SAMP2 undergoes a conformational conversion from disorder to order, indicating that the ordered conformation is the functional form of SAMP2 under the physiological condition of H. volcanii.

Haloferax volcanii

10.1038/srep02136

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Citations (9)