Fuyan Wang

Hunan Cancer Hospital

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Zhaoyang Zeng

Central South University

Wei Xiong

Central South University

Qijia Yan

Xiangya Hospital Central South University

Guiyuan Li

Central South University

Yongzhen Mo

Central South University

Can Guo

Central South University

Yumin Wang

Central South University

Zhaojian Gong

Second Xiangya Hospital of Central South University

Qianjin Liao

Hunan Normal University

Bo Xiang

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Cooperative Institutions

Central South University

138

Hunan Cancer Hospital

Xiangya Hospital Central South University

Second Xiangya Hospital of Central South University

Third Xiangya Hospital

Sichuan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Anhui Medical University

Huazhong University of Science and Technology

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Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA

Science China Life Sciences (2022)

Mengyao Zhao Yian Wang Fenghua Tan Lingyun Liu Xiangchan Hou

10.1007/s11427-021-2089-8

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Citations (16)

Predictors of students’ global competence in China, Germany, Turkey, and Mexico: A cross-cultural comparative study

International Journal of Educational Development (2025)

Zhang Hong Hanwei Tang Qianyu Zhou Fuyan Wang

Cross-Cultural

10.1016/j.ijedudev.2025.103203

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Citations (0)

The role of alternative splicing in human cancer progression.

PubMed (2021)

Jiawei Ouyang Yijie Zhang Fang Xiong Shanshan Zhang Zhaojian Gong

In eukaryotes, alternative splicing refers to a process via which a single precursor RNA (pre-RNA) is transcribed into different mature RNAs. Thus, alternative splicing enables the translation of a limited number of coding genes into a large number of proteins with different functions. Although, alternative splicing is common in normal cells, it also plays an important role in cancer development. Alteration in splicing mechanisms and even the participation of non-coding RNAs may cause changes in the splicing patterns of cancer-related genes. This article reviews the latest research on alternative splicing in cancer, with a view to presenting new strategies and guiding future studies related to pathological mechanisms associated with cancer.

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IGF-1 promotes the development and cytotoxic activity of human NK cells

Nature Communications (2013)

Fang Ni Rui Sun Binqing Fu Fuyan Wang Chuang Guo

Insulin-like growth factor 1 (IGF-1) is a critical regulator of many physiological functions, ranging from longevity to immunity. However, little is known about the role of IGF-1 in natural killer cell development and function. Here, we identify an essential role for IGF-1 in the positive regulation of human natural killer cell development and cytotoxicity. Specifically, we show that human natural killer cells have the ability to produce IGF-1 and that differential endogenous IGF-1 expression leads to disparate cytotoxicity in human primary natural killer cells. Moreover, miR-483-3p is identified as a critical regulator of IGF-1 expression in natural killer cells. Overexpression of miR-483-3p has an effect similar to IGF-1 blockade and decreased natural killer cell cytotoxicity, whereas inhibition of miR-483-3p has the opposite effect, which is reversible with IGF-1 neutralizing antibody. These findings indicate that IGF-1 and miR-483-3p belong to a new class of natural killer cell functional modulators and strengthen the prominent role of IGF-1 in innate immunity. Insulin-like growth factor (IGF)-1 regulates many physiological functions including growth and metabolism. Ni et al.show that human natural killer cells secrete IGF-1 and that IGF-1 enhances the development and cytotoxicity of these cells.

Lymphokine-activated killer cell

10.1038/ncomms2484

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Two novel neutralizing antigenic epitopes of the s1 subunit protein of a QX-like avian infectious bronchitis virus strain Sczy3 as revealed using a phage display peptide library

Veterinary Immunology and Immunopathology (2015)

Nianli Zou Jing Xia Fuyan Wang Zhenzhen Duan Dan Miao

Conformational epitope

10.1016/j.vetimm.2015.08.008

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Exploring the Reliability of Compressed Sensing Cardiac MR Cine in Heart Failure: Evidence from Varied MR Field Strengths and Vendors

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2024)

Siying Ma Fuyan Wang Junjie Zhou Lingjie Zhang Chengbin He

Motivation: The challenge of obtaining high-quality CMR cine images in patients with heart failure (HF) due to difficulties in breath-holding and arrhythmia. Goal(s): Explore the feasibility of utilizing compressed sensing cardiac cine with varying levels of acceleration to acquire comparable cine images in HF patients. Approach: We compare cardiac function, strain parameters, and image quality between bSSFP and CS images in both HF patients and healthy participants, utilizing MRI systems from different vendors. Results: Our findings demonstrate a high level of consistency in most cardiac function and strain parameters between the two sequences. CS cardiac cine images exhibit comparable quality to bSSFP images. Impact: This study offers prospective validation for the use of CS cardiac cine sequences in HF patients, addressing issues related to lengthy scanning durations and artifacts. It expands the eligible population for CMR scanning while optimizing image quality.

10.58530/2024/1651

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Extrachromosomal Circular DNA: A New Target in Cancer

Frontiers in Oncology (2022)

Pan Wu Yuhang Liu Ruijia Zhou Lingyun Liu Hong-Li Zeng

Genomic instability and amplification are intrinsically important traits determining the development and heterogeneity of tumors. The role of extrachromosomal circular DNA (eccDNA) in tumors has recently been highlighted. EccDNAs are unique genetic materials located off the chromosomal DNA. They have been detected in a variety of tumors. This review analyzes the mechanisms involved in the formation of eccDNAs and their genetic characteristics. In addition, the high-copy number and transcriptional levels of oncogenes located in eccDNA molecules contribute to the acceleration of tumor evolution and drug resistance and drive the development of genetic heterogeneity. Understanding the specific genomic forms of eccDNAs and characterizing their potential functions will provide new strategies for tumor therapy. Further research may yield new targets and molecular markers for the early diagnosis and treatment of human cancer.

Extrachromosomal DNA

Chromosome instability

10.3389/fonc.2022.814504

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N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies

Journal of Experimental & Clinical Cancer Research (2021)

Fenghua Tan Mengyao Zhao Fang Xiong Yumin Wang Shanshan Zhang

Abstract The N6-methyladenosine (m6A) modification is a dynamic and reversible epigenetic modification, which is co-transcriptionally deposited by a methyltransferase complex, removed by a demethylase, and recognized by reader proteins. Mechanistically, m6A modification regulates the expression levels of mRNA and nocoding RNA by modulating the fate of modified RNA molecules, such as RNA splicing, nuclear transport, translation, and stability. Several studies have shown that m6A modification is dysregulated in the progression of multiple diseases, especially human tumors. We emphasized that the dysregulation of m6A modification affects different signal transduction pathways and involves in the biological processes underlying tumor cell proliferation, apoptosis, invasion and migration, and metabolic reprogramming, and discuss the effects on different cancer treatment.

Demethylase

N6-Methyladenosine

Reprogramming

10.1186/s13046-021-01952-4

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Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis‐Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment

Advanced Science (2024)

Yuan Zhi Qian Wang Moxin Zi Shanshan Zhang Junshang Ge

Abstract In South and Southeast Asia, the habit of chewing betel nuts is prevalent, which leads to oral submucous fibrosis (OSF). OSF is a well‐established precancerous lesion, and a portion of OSF cases eventually progress to oral squamous cell carcinoma (OSCC). However, the specific molecular mechanisms underlying the malignant transformation of OSCC from OSF are poorly understood. In this study, the leading‐edge techniques of Spatial Transcriptomics (ST) and Spatial Metabolomics (SM) are integrated to obtain spatial location information of cancer cells, fibroblasts, and immune cells, as well as the transcriptomic and metabolomic landscapes in OSF‐derived OSCC tissues. This work reveals for the first time that some OSF‐derived OSCC cells undergo partial epithelial–mesenchymal transition (pEMT) within the in situ carcinoma (ISC) region, eventually acquiring fibroblast‐like phenotypes and participating in collagen deposition. Complex interactions among epithelial cells, fibroblasts, and immune cells in the tumor microenvironment are demonstrated. Most importantly, significant metabolic reprogramming in OSF‐derived OSCC, including abnormal polyamine metabolism, potentially playing a pivotal role in promoting tumorigenesis and immune evasion is discovered. The ST and SM data in this study shed new light on deciphering the mechanisms of OSF‐derived OSCC. The work also offers invaluable clues for the prevention and treatment of OSCC.

Oral submucous fibrosis

Malignant Transformation

10.1002/advs.202306515

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Comparison of the Protective Efficacy of Neutralizing Epitopes of 2009 Pandemic H1N1 Influenza Hemagglutinin

Frontiers in Immunology (2017)

Bo Peng Na Peng Yanan Zhang Fenghua Zhang Xuguang Li

The 2009 H1N1 influenza (Pdm09) pandemic has been referred to as the first influenza pandemic of the twenty-first century. There is a marked difference in antigenicity between the pandemic H1N1 virus and past seasonal H1N1 viruses, which allowed the pandemic virus to spread rapidly in humans. Antibodies (Abs) against hemagglutinin (HA), especially neutralizing Abs against epitopes in the head of HA, play critical roles in defending the host against the virus. Some preexisting neutralizing Abs that recognize neutralizing epitopes of Pdm09 HA, thereby affording cross-protection, have been reported. To better understand the protective effects of epitopes in Pdm09 HA, we constructed a series of plasmid DNAs (DNA vaccines) by cloning various combinations of Pdm09 neutralizing epitopes into the HA backbone derived from A/PR/8/1934 (H1N1). We subsequently compared the protective immune responses induced by these various forms of HA in a mouse model. We found that the plasmid DNAs with epitope substitutions provided better protection against lethal virus challenge and induced higher strain-specific antibody titers, with epitope Sa being the most effective. Moreover, the combination of epitopes Sa and Sb provided almost complete protection in mice. These findings provide new insights into the protective efficacy of neutralizing epitopes of influenza HA.

Pandemic

Pandemic influenza

10.3389/fimmu.2017.01070

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Citations (7)