Bo Jiang

Shanxi Provincial Cancer Hospital

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Fada Xia

Xiangya Hospital Central South University

Xinying Li

Xiangya Hospital Central South University

Xiangmin Shen

Second Xiangya Hospital of Central South University

Yan-Hui Fu

Hainan Normal University

Hainan Zhang

Yangzhou University

Lei Yao

Harbin Medical University

Chunyu Wang

Second Xiangya Hospital of Central South University

Liming Tan

Huaihua University

Beisha Tang

Xiangya Hospital Central South University

Lixia Qin

Shanxi Agricultural University

Cooperative Institutions

Central South University

Xiangya Hospital Central South University

Second Xiangya Hospital of Central South University

Chinese Academy of Sciences

Shanghai Jiao Tong University

Peking University

Nanchang University

Chinese Academy of Medical Sciences & Peking Union Medical College

Hebei Medical University

Shanxi Provincial Cancer Hospital

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Chemical constituents from Clausena excavata and their inhibitory activities against proliferation of synoviocytes

China Journal of Chinese Materia Medica (2021)

Jiaming Guo Xiaomei Yu Bo Jiang Qin-Ting Su Wenqing Cao

The chemical constituents from the stems and leaves of Clausena excavata were isolated and purified by column chromatography with silica gel, ODS, Sephadex LH-20 and RP-HPLC. The chemical structures of the isolated compounds were identified on the basis of physicochemical properties, spectroscopic analysis, as well as the comparisons with the data reported in literature. Nineteen compounds were isolated from the 90% ethanol extract of the stems and leaves of C. excavata, which were identified as methyl orsellinate(1), syringaresinol(2), lenisin A(3), scopoletin(4), osthenol(5), N-benzoyltyrarnine methyl ether(6), N-p-coumaroyltyramine(7), aurantiamide acetate(8), 1H-indole-3-carboxaldehyde(9), furostifoline(10), clausenalansine E(11), 3-formylcarbazole(12), clausine L(13), clausine E(14), methyl carbazole-3-carboxylate(15), glycosinin(16), murrayafoline A(17), clausine H(18) and 2,7-dihydroxy-3-formyl-1-(3'-methyl-2'-butenyl)carbazole(19). Among these isolated compounds, compounds 1-11 were isolated from C. excavata for the first time, and compounds 1, 2 and 10 were isolated from the genus Clausena for the first time. In addition, this study evaluated the anti-rheumatoid arthritis activities of compounds 1-19 by measuring their anti-proliferative effects on synoviocytes in vitro according to MTS method. Compounds 10-19 displayed remarkable anti-rheumatoid arthritis activities, which exhibited the inhibitory effects on the proliferation of MH7 A synovial fibroblast cells with the IC_(50) values ranging from(27.63±0.18) to(235.67±2.16) μmol·L~(-1).

Sephadex

scopoletin

Carbazole

10.19540/j.cnki.cjcmm.20210429.203

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The association between ferroptosis-related patterns and tumor microenvironment in colorectal cancer

International Immunopharmacology (2024)

Chengshan He Xuemei Gu Chengyuan Dong Zheng Xu Luyao Liu

Ferroptosis, a form of regulated cell death (RCD), exhibits distinct characteristics such as iron-dependence and lipid peroxidation accumulation (ROS), setting it apart from other types of cell death like apoptosis and necrosis. Its role in cancer biology is increasingly recognized, particularly its potential interaction with tumor microenvironment (TME) and CD8 T cells in cancer immunotherapy. However, the impact of ferroptosis on TME cell infiltration remains unclear. In this study, we conducted unsupervised clustering analysis on patient data from public databases, identifying three ferroptosis patterns with distinct TME cell infiltration characteristics: immune-inflamed, immune-excluded, and immune-desert phenotypes. We developed a ferroptosis score based on differentially expressed genes (DEGs) among these patterns, which correlated with various biological features including chemotherapy-resistance and immune cells infiltration. Despite patients with high ferroptosis scores exhibiting worse prognosis, they showed increased likelihood of benefiting from immunotherapy. Our findings highlight the importance of ferroptosis-related patterns in understanding TME cell infiltration and suggest novel strategies for drug combinations and immune-related therapies.

Association (psychology)

10.1016/j.intimp.2024.112258

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Effects of genistein on neuronal apoptosis, and expression of Bcl-2 and Bax proteins in the hippocampus of ovariectomized rats.

PubMed (2012)

Yun Peng Bo Jiang Huiling Wu Ru-Chun Dai Liming Tan

Genistein is one of several isoflavones that has a structure similar to 17β-estradiol, has a strong antioxidant effect, and a high affinity to estrogen receptors. At 15 weeks after ovariectomy, the expression of Bcl-2 in the hippocampus of rats decreased and Bax expression increased, with an obvious upregulation of apoptosis. However, intraperitoneal injection of genistein or 17β-estradiol for 15 consecutive weeks from the second day after operation upregulated Bcl-2 protein expression, downregulated Bax protein expression, and attenuated hippocampal neuron apoptosis. Our experimental findings indicate that long-term intervention with genistein can lead to a decrease in apoptosis in hippocampal neurons following ovariectomy, upregulate the expression of Bcl-2, and downregulate the expression of Bax. In addition, genistein and 17β-estradiol play equal anti-apoptotic and neuroprotective roles.

10.3969/j.issn.1673-5374.2012.36.004

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BAG5 Interacts with DJ‐1 and Inhibits the Neuroprotective Effects of DJ‐1 to Combat Mitochondrial Oxidative Damage

Oxidative Medicine and Cellular Longevity (2017)

Lixia Qin Jieqiong Tan Hainan Zhang Rizwana Kousar Jiahong Lu

Loss‐of‐function mutations in gene encoding DJ‐1 contribute to the pathogenesis of autosomal recessive early‐onset familial forms of Parkinson’s disease (PD). DJ‐1 is a multifunctional protein and plays a protective role against oxidative stress‐induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co‐IP) and immunofluorescence methods, we prove that Bcl‐2‐associated athanogene 5 (BAG5), a BAG family member, interacts with DJ‐1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ‐1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ‐1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ‐1.

10.1155/2017/5094934

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Synthesis and Antitumor Activities of Platinum(II) Complexes of Curcumin Analog

Acta Chimica Sinica (2011)

Zhou Shuang-sheng Xue Xuan Bo Jiang Chuanhua Lu Tian Yu-peng

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Liposomal irinotecan + 5-fluorouracil + leucovorin + bevacizumab as second-line therapy in metastatic colorectal cancer (IRIS): A multi-center, single-arm, prospective, phase II study.

Journal of Clinical Oncology (2025)

Xuhua Hu Bo Jiang Lu Hongxia Bin Yu Bo Yi

195 Background: In patients with advanced colorectal cancer (CRC), the recommended second-line treatment following first-line therapy with oxaliplatin-based regimens is irinotecan-based therapy. Liposomal irinotecan, a novel formulation of traditional irinotecan, has demonstrated potential to enhance efficacy while minimizing toxicity. This study aims to investigate the efficacy and safety of liposomal irinotecan in combination with 5-FU/LV and bevacizumab as a second-line treatment option for metastatic CRC. Methods: This is a multi-center, single-arm, prospective, phase II study. Patients with metastatic CRC who received oxaliplatin-based chemotherapy as first-line treatment were enrolled to receive liposomal irinotecan + 5-fluorouracil + leucovorin + bevacizumab regimen until disease progression and/or unacceptable toxicity. The primary endpoint is objective response rate (ORR), secondary endpoints include disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and safety. Results: A total of 50 patients were enrolled from Jan 2024 to Jul 2024 across 6 sites in China. The median age was 56.5 years (range: 30.0-76.0), with 58.0% male and 36.0% ECOG 0. Among the patients, 38.0% had left-sided colon cancer, 24.0% had right-sided colon cancer, and 38.0% had rectal cancer. As of Sept 14, 2024, 39 patients had at least one tumor assessment and 19 patients were still on treatment. ORR and DCR were 20.5% (8/39, 95% CI: 9.3%-36.5%) and 84.6% (33/39, 95% CI: 69.5%-94.1%), respectively. Eleven patients had disease progression and 5 patients died, and the median PFS and OS were not reached. The relative dose intensity of liposomal irinotecan and 5-fluorouracil were 92.8% (range: 23.6%-109.6%) and 89.5% (range: 13.3%-116.8%), respectively. During treatment, 43 (86.0%) patients had at least one adverse event (AE) and 24 (48.0%) had grade 3-4 AE. Most common (≥ 10%) grade 3-4 AEs were neutropenia (20.0%), leukocytopenia (16.0%) and diarrhea (10.0%). No unexpected toxicities observed in this study. Conclusions: These preliminary results reveled that liposomal irinotecan + 5-fluorouracil + leucovorin + bevacizumab after oxaliplatin-based treatment for metastatic CRC was well tolerated with encouraging clinical activity, which warrants further follow up. Clinical trial information: NCT06184698 .

10.1200/jco.2025.43.4_suppl.195

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[Determination of adenosine in food by high performance anion exchange chromatography].

PubMed (2009)

Xiaoli Zou Hongyan Zeng Yuanqian Li Tang-Lin Mei Bo Jiang

To establish a high performance anion chromatography method for the determination of adenosine in food.Adenosine in the food sample was extracted with Acetonitrile-water, and separated with Amino PAC PA10 Amino acid-separation column, with 0.25 mol/L NaOH as the mobile phase. A pulse ampere detector with Au as working electrode was used throughout the experiment.A good linear result was produced for adenosine in the range of 1.00-20.00 microg/mL. The inner-day RSD of peak area and retention time for the standard adenosine solution were 4.97% and 0.47%, respectively. The intra-day RSD of peak area and retention time for the standard adenosine solution were 6.08% and 0.52%, respectively. The proposed method was applied to food and satisfactory results were obtained, with and average recoveries of 93.3%-106.7% and 8.86% of RSD.The high performance anion exchange chromatography method is a simple, accurate, and reliable method for measuring adenosine in food, which can be completed within 10 minutes.

Ion chromatography

Linear range

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miR93 regulates epithelial-to-mesenchymal transition process in metastatic colorectal cancer by targeting EphA4

Annals of Oncology (2017)

Sheng Gao Bo Jiang Hui‐rong Liu Su‐I Hou Liming Wu

Ectopic expression

10.1093/annonc/mdx679.002

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Anti-tumor effect of iodine-131 labeled 17-AAG on H460 human non-small lung cancer bearing nude mice

Jin Sun Lu Liu Wen Gao Xin Jiang Bo Jiang

Human lung

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Identifying the Transcriptional Regulatory Network Associated With Extrathyroidal Extension in Papillary Thyroid Carcinoma by Comprehensive Bioinformatics Analysis

Frontiers in Genetics (2020)

Yong Chen Bo Jiang Wenlong Wang Duntao Su Fada Xia

Extrathyroidal extension (ETE) affects papillary thyroid cancer (PTC) prognosis. The objective of this study was to identify biomarkers for ETE and explore the mechanisms controlling its development in PTC. We performed a comprehensive bioinformatics analysis using several datasets. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) on 58 paired PTC samples from The Cancer Genome Atlas (TCGA) were used to detect ETE-related mRNA and long noncoding (lnc)RNA modules and construct a lncRNA/mRNA network. An independent TCGA dataset containing 438 samples was utilized to validate and characterize the WGCNA results. Functional annotation was used to identify the biological functions and related pathways of ETE modules. Two independent RNA sequencing datasets were combined to crossvalidate relationships between lncRNAs and mRNAs by Pearson correlation analysis. Transcription factors (TFs) for affected genes were predicted using the binding motif data from Ensembl Biomart to construct a TF/lncRNA/mRNA network. Other two independent datasets were used to crossvalidate TF-mRNA associations. Finally, receiver operating characteristic, survival analyses and Cox proportional hazard regression model were performed to explore the significance of hub genes in ETE diagnosis and PTC prognosis. Three mRNA modules and two lncRNA modules were significantly associated with ETE. Enrichment analysis showed extracellular matrix (ECM) changes was closely related to the development of ETE. A TF/lncRNA/mRNA regulatory network was constructed containing 33 validated hub genes, 64 lncRNAs, and 64 TFs, all differentially expressed between ETE and non-ETE samples. Unc-5 family C-terminal like (area under the curve (AUC): 0.711), sushi repeat containing protein X-linked 2 (AUC: 0.706), lysyl oxidase (AUC: 0.704), collagen type I alpha 1 chain (AUC: 0.704), and collagen type X alpha 1 chain (AUC: 0.704) were the most highly significant hub genes for ETE diagnosis. The Cox proportional hazard regression model constructed with hub genes showed significant survival differences between low- and high- risk groups(p=0.00025) and performed good prediction for PTC prognosis(AUC=0.794;C-index=0.895). The identification of 33 biomarkers and TF/lncRNA/mRNA regulatory network would provide new insights into the molecular mechanisms of ETE besides the prognosis model may have important clinical implications in the improvement of PTC risk stratification, therapeutic decision-making, and prognosis prediction.

Gene regulatory network

Ensembl

10.3389/fgene.2020.00453

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Citations (4)