Jee Eun Han

Kyungpook National University

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Jin Woo Jun

Seoul National University Hospital

Se Chang Park

Seoul National University

Ji Hyung Kim

Gachon University

Sang Phil Shin

Kongju National University

Casiano H. Choresca

Research & Development Institute

Donald V. Lightner

University of Arizona

Kathy F.J. Tang

University of North Texas

Carlos R. Pantoja

University of Arizona

Ji Young Chai

Bundang Jesaeng Hospital

Jun‐Seob Kim

Incheon National University

Cooperative Institutions

Kyungpook National University

Seoul National University

Daegu Gyeongbuk Institute of Science and Technology

University of Arizona

Queensland University of Technology

Jeju National University

Yonsei University

Hanyang University

Chungbuk National University

Korea Research Institute of Bioscience and Biotechnology

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Isolation, Molecular Characterization, and Antibiotic Susceptibility ofVibrio parahaemolyticusin Korean Seafood

Foodborne Pathogens and Disease (2012)

Jin Woo Jun Ji Hyung Kim Casiano H. Choresca Sang Phil Shin Jee Eun Han

The principal objective of this study was to investigate the incidence, risk assessment, antibiotic resistance, and genotyping of Vibrio parahaemolyticus in Korean seafood. The incidence of V. parahaemolyticus in seafood obtained from several fish markets in Korea was investigated from May to December of 2009, except between July and September. Two selective mediums (TCBS [thiosulfate, citrate, bile salts, and sucrose] agar and CHROMagar™ Vibrio) were used, and the V. parahaemolyticus strains were identified via polymerase chain reaction (PCR) amplification (Vp. flaE, tl, and toxR). 16S rRNA gene sequencing and their virulence were analyzed via the detection of tdh, trh, ORF8, toxRS/old, and toxRS/new genes. We collected 24 strains of V. parahaemolyticus: 19 seafood isolates, three environmental isolates, and two clinical (human) isolates. Among these strains, two tdh+ strains, two ORF8+ strains, 16 toxRS/old+ strains, and one toxRS/new+ strain were isolated. Twenty-two commercial antibiotics were used to assess the antibiotic susceptibility of isolates, and all the strains evidenced resistance to more than four antibiotics. The strains harboring antibiotic-resistant genes such as TetA (25%) and strB (4.16%) were detected via PCR. Repetitive extragenic palindromic sequence (REP)–PCR analysis revealed differences in the V. parahaemolyticus strains from other species and intraspecific strains.

10.1089/fpd.2011.1018

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Citations (65)

Successful Pregnancy by ICSI using Spermatozoa Banked Prior to Bone Marrow Transplantation for Severe Apalstic Anemia and Chronic Myelogenous Leukemia.

Korean Journal of Fertility and Sterility (2003)

Jee Eun Han Tae Gyu Chung Mi Kyung Chung Woo Sung Min Sook Hwan Lee

Chronic myelogenous leukemia

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Development of in situ hybridization and PCR assays for the detection of Enterocytozoon hepatopenaei (EHP), a microsporidian parasite infecting penaeid shrimp

Journal of Invertebrate Pathology (2015)

Kathy F.J. Tang Carlos R. Pantoja Rita M. Redman Jee Eun Han Loc H. Tran

Hepatopancreas

Penaeidae

Penaeus

Shrimp farming

10.1016/j.jip.2015.06.009

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Citations (155)

Bacteriophage Therapy of a Vibrio parahaemolyticus Infection Caused by a Multiple-Antibiotic–Resistant O3:K6 Pandemic Clinical Strain

The Journal of Infectious Diseases (2014)

Jin Woo Jun Tae Hoon Shin Ji Hyung Kim Sang Phil Shin Jee Eun Han

Background. Recently isolated Vibrio parahaemolyticus strains have displayed multiple antibiotic resistance. Alternatives to conventional antibiotics are needed, especially for the multiple-antibiotic–resistant V. parahaemolyticus pandemic strain. Methods. A bacteriophage, designated pVp-1, showed effective infectivity for multiple-antibiotic–resistant V. parahaemolyticus and V. vulnificus, including V. parahaemolyticus pandemic strains. The therapeutic potential of the phage was studied in a mouse model of experimental infection using a multiple-antibiotic–resistant V. parahaemolyticus pandemic strain. We monitored the survivability and histopathological changes, quantified the bacterial and phage titers during phage therapy, and observed the immune response induced by phage induction. Results. Phage-treated mice displayed protection from a V. parahaemolyticus infection and survived lethal oral and intraperitoneal bacterial challenges. Conclusions. To the best of our knowledge, this is the first report of phage therapy in a mouse model against a multiple-antibiotic–resistant V. parahaemolyticus pandemic strain infection.

Phage therapy

Infectivity

10.1093/infdis/jiu059

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Citations (110)

Draft Genome Sequence of Vibrio parahaemolyticus SNUVpS-1 Isolated from Korean Seafood

Genome Announcements (2013)

Jin Woo Jun Ji Hyung Kim Casiano H. Choresca Sang Phil Shin Jee Eun Han

Vibrio parahaemolyticus is the leading cause of food-borne diseases, and several pathogenic strains cause global gastroenteritis outbreaks. Here, we report a draft genome sequence of V. parahaemolyticus SNUVpS-1, which was isolated from seafood in a fishery market in the Republic of Korea and contained TL, toxR, and toxRS(old) genes. The current draft genome sequence will contribute to the effort to monitor the spread of V. parahaemolyticus seafood isolates and clinical isolates.

10.1128/genomea.00132-12

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Veratramine Inhibits the Cell Cycle Progression, Migration, and Invasion via ATM/ATR Pathway in Androgen-Independent Prostate Cancer

The American Journal of Chinese Medicine (2023)

Hee Yeon Kim Seoung-Woo Lee Seong‐Kyoon Choi Janbolat Ashim Wansoo Kim

Prostate cancer (PC) is the second leading cause of cancer-related death among men. Treatment of PC becomes difficult after progression because PC that used to be androgen-dependent becomes androgen-independent prostate cancer (AIPC). Veratramine, an alkaloid extracted from the root of the Veratrum genus, has recently been reported to have anticancer effects that work against various cancers; however, its anticancer effects and the underlying mechanism of action in PC remain unknown. We investigated the anticancer effects of veratramine on AIPC using PC3 and DU145 cell lines, as well as a xenograft mouse model. The antitumor effects of veratramine were evaluated using the CCK-8, anchorage-independent colony formation, trans-well, wound healing assays, and flow cytometry in AIPC cell lines. Microarray and proteomics analyses were performed to investigate the differentially expressed genes and proteins induced by veratramine in AIPC cells. A xenograft mouse model was used to confirm the therapeutic response and in vivo efficacy of veratramine. Veratramine dose dependently reduced the proliferation of cancer cells both in vitro and in vivo. Moreover, veratramine treatment effectively suppressed the migration and invasion of PC cells. The immunoblot analysis revealed that veratramine significantly downregulated Cdk4/6 and cyclin D1 via the ATM/ATR and Akt pathways, both of which induce a DNA damage response that eventually leads to G1 phase arrest. In this study, we discovered that veratramine exerted antitumor effects on AIPC cells. We demonstrated that veratramine significantly inhibited the proliferation of cancer cells via G0/G1 phase arrest induced by the ATM/ATR and Akt pathways. These results suggest that veratramine is a promising natural therapeutic agent for AIPC.

DU145

10.1142/s0192415x2350060x

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Citations (1)

Genomic and histopathological characteristics of Vibrio parahaemolyticus isolated from an acute hepatopancreatic necrosis disease outbreak in Pacific white shrimp (Penaeus vannamei) cultured in Korea

Aquaculture (2020)

Jee Eun Han Seong‐Kyoon Choi Se‐Hyeon Han Seung Chan Lee Hye Jin Jeon

Hepatopancreas

Penaeus

Litopenaeus

10.1016/j.aquaculture.2020.735284

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Citations (33)

Biological Control ofAeromonas salmonicidasubsp.salmonicidaInfection in Rainbow Trout (Oncorhynchus mykiss) UsingAeromonasPhage PAS-1

Transboundary and Emerging Diseases (2013)

Ji Hyung Kim Casiano H. Choresca Sook Shin Jee Eun Han Jin Woo Jun

The potential control efficacy of Aeromonas phage PAS-1 was evaluated against Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) model in this study. The phage was co-cultured with the virulent A. salmonicida subsp. salmonicida strain AS05 that possesses the type III secretion system (TTSS) ascV gene, and efficient bacteriolytic activity was observed against the bacteria. The administration of PAS-1 in rainbow trout demonstrated that the phage was cleared from the fish within 200 h post-administration, and a temporal neutralizing activity against the phage was detected in the sera of phage-administrated fish. The administration of PAS-1 (multiplicity of infection: 10 000) in A. salmonicida subsp. salmonicida infected rainbow trout model showed notable protective effects, with increased survival rates and mean times to death. These results demonstrated that Aeromonas phage PAS-1 could be considered as an alternative biological control agent against A. salmonicida subsp. salmonicida infections in rainbow trout culture.

Aeromonas salmonicida

Clearance

Phage therapy

10.1111/tbed.12088

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Citations (49)

Antimicrobial effect of hypochlorous acid on pathogenic microorganisms

Journal of Preventive Veterinary Medicine (2013)

Sang Phil Shin Mun Sup Kim Sung Hee Cho Ji Hyung Kim Casiano H. Choresca

Disinfection is essential in terms of the public health or environmental hygiene. Hypochlorous acid (HOCI) solution was developed as a disinfectant in Korea. We evaluated the gemicidal activity of HOCI against various pathogenic microbes. Thirty-one ATCC strains were exposed to HOCI solution at various concentrations (20, 40 and 80 ppm) for 1 minute. All the strains of bacteria, yeasts and mycobacteria were killed at 80 ppm after exposure to HOCI. The results suggest that HOCI solution could be used to effectively disinfect public areas.

Hypochlorous acid

Disinfectant

Pathogenic bacteria

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Citations (7)

Potential application of bacteriophage pVp-1: Agent combating Vibrio parahaemolyticus strains associated with acute hepatopancreatic necrosis disease (AHPND) in shrimp

Aquaculture (2016)

Jin Woo Jun Jee Eun Han Kathy F.J. Tang Donald V. Lightner Jae-Hoon Kim

Infectivity

Vibrio Infections

10.1016/j.aquaculture.2016.02.018

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Citations (48)