Underweight, overweight and obesity are associated with increased mortality from several chronic diseases, including cancer. Self body weight misperceptions affect weight control. We monitored weight perception in Italy on a total of 14 135 individuals (6834 men, 7301 women), representative of the Italian adult population with available information on body mass index (BMI) derived by self-reported height and weight. Differences in misperception of BMI categories across subpopulations were analysed using unconditional multiple logistic regression models after adjustment for a number of covariates. Overall, 66.4% of individuals accurately perceived, 21.0% underestimated and 12.6% overestimated their category of BMI. In men, 27.2% underestimated and 5.0% overestimated their BMI category the corresponding estimates for women were 15.3% and 19.6%, respectively. The large majority of underweight (64.3%) and obese individuals (93.1%) overestimated and underestimated their weight, respectively. Overall, 13.5% of Italians misperceived (8.9% underestimated and 4.6% overestimated) their BMI category by more than 2 kg/m. By multivariate analysis, we observed significant differences in terms of sex, education, geographic area, marital status, smoking and drinking habit, year of survey and BMI category. In conclusion, misperception of body weight is frequent in Italy, paralleling findings from other countries with more unfavourable overweight and obesity patterns. The fact that one out of three Italian adults misperceive their weight is of great concern and indicates that media intervention campaigns aimed at explaining measurement and correct interpretation of BMI are required.
This study focuses on the development of a dry powder inhaler (DPI) formulation of simvastatin (SV), and the effects of SV on the respiratory epithelium.Micronised SV samples were prepared by dry jet-milling. The long-term chemical stability and physicochemical properties of the formulations were characterised in terms of particles size, morphology, thermal and moisture responses. Furthermore, in vitro aerosol depositions were performed. The formulation was evaluated for cell viability and its effect on cilia beat activity, using ciliated nasal epithelial cells in vitro. The formulation transport across an established air interface Calu-3 bronchial epithelial cells and its ability to reduce mucus secretion was also investigated.The particle size of the SV formulation and its aerosol performance were appropriate for inhalation therapy. Moreover, the formulation was found to be non-toxic to pulmonary epithelia cells and cilia beat activity up to a concentration of 10(-6) M. Transport studies revealed that SV has the ability to penetrate into airway epithelial cells and is converted into its active SV hydroxy acid metabolite. Single dose of SV DPI also decreased mucus production after 4 days of dosing.This therapy could potentially be used for the local treatment of diseases like chronic obstructive pulmonary disease, cystic fibrosis, and bronchiectasis given its anti-inflammatory effects and ability to reduce mucus production.
To monitor smoking prevalence and trends of young and adult populations in Italy. METHOD AND STUDY DESIGN: A survey on smoking was conducted during March-April 2009 on a sample of 3213 participants (1546 men and 1667 women), representative of the Italian population aged 15 years or over. Data from a simplified questionnaire were collected in an over-sample of 1010 young individuals, reaching a total of 1390 participants aged 15-24 years (713 males and 677 females).In 2009, 25.4% of Italians described themselves as current cigarette smokers (28.9% of men and 22.3% of women). Among young people, male smoking prevalence steadily declined from 38% in 2001 to 29% in 2009. Smoking prevalence in young females decreased from 30% in 2001 to 19% in 2008, but increased to 23% in 2009. Among both males and females aged 15-17 years, smoking prevalence was around 10%. This increased in the 18-24 year age group, with 37.6% of current smokers among males and 28.9% among females. Among young current smokers, 45.5% reported that they would reduce the number of cigarettes smoked per day, 11.1% would quit smoking, and 4.3% would switch to hand-rolled cigarettes, assuming that the minimum price of a pack of cigarettes increased to € 5.Our findings indicate that smoking prevalence has decreased over recent years, particularly in the young. Still, over one-fourth of Italian adults are smokers. An increase in cigarette price represents an effective strategy to control tobacco, particularly in the young.
