Wei Li

Huashan Hospital

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i-10 index

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Shugang Ma

Hebei University of Economics and Business

Kay Yaw Tay

Tan Tock Seng Hospital

Yan-peng He

Hebei University of Economics and Business

Hwee Lan Ng

Parkinson's Foundation

Shermyn Neo

Tan Tock Seng Hospital

Xu Yao

Chinese Academy of Medical Sciences & Peking Union Medical College

Zheyu Xu

Tan Tock Seng Hospital

Wing Lok Au

Tan Tock Seng Hospital

Louis C.S. Tan

Tan Tock Seng Hospital

Seyed Ehsan Saffari

Tan Tock Seng Hospital

Cooperative Institutions

National Neuroscience Institute

Chinese Academy of Medical Sciences & Peking Union Medical College

Nanjing University of Chinese Medicine

Peking University

Fudan University

Capital Medical University

Shanghai Jiao Tong University

Duke-NUS Medical School

Chinese Academy of Sciences

Nanjing Medical University

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Freemium of Digital Products with Small-World Network

Mathematical Problems in Engineering (2020)

Wei Li

“ Freemium ” is a popular business model adopted by the vendors of digital products, and it has aroused extensive attention in the academia. The existing research studies commonly explore the business model from the perspective of network effect, but lack the attention to the small-world features of network effect. In order to explore the effect of the small-world network, the current work presents a two-period optimization model of monopolist. The optimization model is incorporating with the Freemium model and the small-world feature of consumer base. The optimization model is solved analytically, and the comparative static results show that if the integrating network effect caused by the strong and weak relationship group is sufficiently high (or the small-world feature of the user group is prominent), the user group network exerts a positive effect; if the integrating network effect is not sufficiently high (or the small-world feature of the user group is not prominent), the user group network exerts a negative effect; especially, if the integrating network effect is low or moderate, the premium product is supposed to be free for the consumers. The conclusions enrich the understanding on the operation of digital products firms in the academia and industry.

Feature (linguistics)

Small-world network

10.1155/2020/6367051

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Mathematical Optimization on Hybrid Channel Pricing Digital Products in Two-Sided Market with Network Effect

Journal of Applied Mathematics (2023)

Wei Li Yan-peng He Shugang Ma

In the two-sided market where the third-party platforms connect the providers and consumers, the online platforms become the significant distribution channel of digital products; therefore, the digital product firms face the hybrid channel pricing problem in the two-sided market in which the products are launched through the platform channel and the existing direct channel. Because the network externality effect is the significant economic characteristic of digital products and services, the current work presents the models of consumers’ utility obtained by adopting digital products from the direct and platform channels, and the utility models use the network effect in the direct and platform channels as the parameters. The optimization model on pricing is derived from the utility models and solved mathematically. The closed-form solutions show that the price in the direct channel is supposed to be lower than that in the platform channel, while the prices of digital products would be affected by the network effect only when the products are distributed through the direct channel. The comparative statics analysis on the network effect illustrates that the network effect in the direct channel and the platform channel would, respectively, have the positive and negative impact on the products’ prices and the firms’ profit. The current work explores the hybrid channel pricing problem and provides insights for the digital product firms on the optimal pricing decision in the context of the emerging platform economy.

Comparative statics

Complementary good

Pricing strategies

Direct Selling

10.1155/2023/4456931

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[Effect of calming the liver and suppressing the hyperactive YANG drugs on lymphocyte protein in hypertension patients with hyperactivity of liver-YANG].

Zhongnan Daxue xuebao. Yixue ban (2008)

Guangwei Zhong Wei Li Yanhong Luo Guo‐Lin Chen Zhen-jia Yi

To explore the effect of calming the liver and suppressing the hyperactive YANG drugs on the lymphocyte protein and clinical efficacy in the hypertension patients with hyperactivity of liver-YANG, and to identify the therapy.Twenty-six hypertension patients with hyperactivity of liver-YANG were treated by calming the liver and suppressing the hyperactive YANG drugs for 2 courses. Symptoms of Chinese medicine and blood pressure were observed, and the separated lymphocyte total protein of normal and hypertensions before and after the treatment were examined by the solid-state pH gradient 2-dimensional gel electrophoresis. The differences of the protein expression were analyzed by ImageMaster 2DE analysis software with two-way patterns.The total efficiency rate of calming the liver and suppressing the hyperactive YANG drugs was 88.5%, and the drugs could significantly relieve the symptoms, such as headache, dizziness, dry mouth, irritability, etc. Calming the liver and suppressing the hyperactive YANG drugs could also remarkably reduce the blood pressure,with significant different between pre-treatment and post-treatment (P<0.05). The average spots of lymphocyte gel proteins in the normal and the hypertension patients with syndrome of hyperactivity of liver-YANG before and after the treatment were 527+/-41,559+/-62, and 543+/-59, respectively. Compared with normal people, the expression of 15 proteins was down-regulated, and 10 up-regulated in the hypertension patients with syndrome of hyperactivity of liver-YANG. Compared with the pre-treatment, the expression of 12 proteins was increased in the 15 down-regulated proteins, and 6 decreased in the 10 up-regulated proteins after the treatment in the hypertension patients with syndrome of the hyperactivity of liver-YANG.Calming the liver and suppressing the hyperactive yang drugs may mildly depress the blood pressure and improve the symptoms of Chinese medicine. The effect of drugs in treating hypertension may probably be associated with regulating the expression of some proteins in lymphocytes.

Irritability

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Rheumatoid Arthritis Syndrome Differentiation Typing Experience

Wei Li

Rheumatoid arthritis is a traditional Chinese medicine Arthralgia category,this article will be divided into three types of differentiation:wind alpine-type governance comfortable and easy,and dehumidification Tongluo side with Juanbi decoction for treatment;Phlegm heattype of governance to blood stasis and phlegm,heat through contact,side by pairs of co-Tang treating;liver and kidney deficiency type governance in order to make up the liver and kidney,strengthening the bones,to use blood Wing ribs pills,tiger latent pill treatment.Clinical addition and subtraction,flexible medication,can achieve better efficacy.

Phlegm

Blood stasis

Pill

Blood circulation

Decoction

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Clinical effect observation of using glass ionomer to treat the early stage of children fissure caries

Modern Medicine Health (2010)

Wei Li

Objective:To evaluate the clinical effect of using Ketac-Molar glass ionomer to treat the early stage of children fissure caries.Methods:Using Ketac-Molar glass ionomer,light-curing composite resin,pit and fissure sealant respectively to treat the early stage of children fissure caries,meanwhile all children were followed up.Results:The successful rates of using Ketac-Molar glass ionomer,light-curing composite resin,pit and fissure sealant groups were 93.69% and 94.44%.When they were followed up for one year,they had no significant difference on statistics.When they were followed up for two years,the successful rates were 91.86% and 92.37%,with no significant difference(P0.05).Conclusion:Ketac-Molar glass ionomer is a kind of good materials to treat the early stage of fissure caries.In a word,it is worth while to extend in clinical using.

Glass ionomer cement

Fissure

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Channel Management for Digital Products in the Two-sided Market with Network Externality Effects

Discrete Dynamics in Nature and Society (2023)

Wei Li Yan-peng He Shugang Ma

Channel selection is a critical trade-off for digital products firms whose products are characterized by network externality. This work develops the models of consumers’ utility impacted by the network externality for two channel strategies of the digital product firms in the two-sided market: direct channel strategy and platform channel strategy. Deriving from the consumers’ utility, the optimization models of the two channel strategies are presented. The optimization models are solved through the Lagrangian method, and the comparative statics analysis is conducted to investigate the effect of network externality on optimality. Mathematical results show that if the intensity of network externality in the online platform surpasses that in the direct channel, the platform channel strategy dominates the other channel strategy; otherwise, the direct channel strategy is the firms’ optimal decision. In addition, the two channels share the equal optimal price, and the firms’ profit (and demand) would be positively impacted by the network effect and the products’ features but negatively impacted by the consumers’ learning cost. This work provides decision support for the digital product firms on channel selection in the context of the two-sided market.

Comparative statics

Externality

10.1155/2023/3461050

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Receiver Operating Characteristics Curve of Acute Levodopa Challenge Test in Parkinson Disease

Zhongguo kangfu lilun yu shijian (2007)

Wei Li

Objective To establish a new protocol and receiver operator characteristic curves of acute levodopa challenge test with consecutive dosage of levodopa in Parkinson disease (PD). Methods The levodopa responsiveness was analyzed in 151 parkinsonian patients, including 102 with a clinical diagnosis of PD and 49 with non-PD parkinsonian syndrome. All patients received consecutive dosage of oral levodopa/benserazide (50/12.5 mg, 100/25 mg, 150/37.5 mg, 200/50 mg, 300/75 mg) every morning in 5 days. The UPDRS part Ⅲ scores were evaluated every 30 min until 6 h after administration. The maximum improvement of UPDRS part Ⅲ scores was compared between patients with PD and those with non-PD. The receiver operating characteristics curves were plotted comparing PD vs non-PD. The cutoff of improvement was defined as the value with maximal diagnostic sensitivity and maximal specificity. Results The sensitivity and specificity of the test were over 80% with selective cut-off point were 150/37.5 mg, 200/50 mg and 300/75 mg of levodopa/benserazide. The sensitivity was 97.1% when the cut-off point was set at 28.5% with 300/75 mg of levodopa/benserazide. The specificity was 93.2% when the cut-off point was set at 22.5% with 150/37.5 mg of levodopa/benserazide. Conclusion The acute levodopa challenge test with consecutive dosage of levodopa/benserazide should be used to assess the levodopa responsiveness. The cutoff of improvements may be useful in diagnosis of PD.

Benserazide

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[Research progress on chemical constituents, pharmacological mechanism and clinical application of Guizhi decoction].

PubMed (2017)

Hai-Jian Yuan Wei Li Jian‐Ming Jin Jingjing Chen Jun Jiang

Guizhi Decoction was one of the most commonly used traditional Chinese Medicine which possesses the effects of "jie-ji-fa-biao, regulating Ying and Wei". It was mainly used to treat mind-cold due to exogenous evils such as fever, headache, sweating, hate the wind, et al. Modern studies indicated that the chemical constituents of Guizhi decoction mainly include phenylpropanoid, monoterpenes, organic acids, flavonoids, triterpenoid saponins and so on. Pharmacological experimental studies had shown that Guizhi decoction could play a big role in dual-directional regulation on sweat gland, body temperature, immune function, gastrointestinal peristalsis, and blood pressure, and could also play the role of anti-inflammatory, antibacterial, antiviral, anti-allergic, analgesic, hypoglycemic, and cardiovascular protection. Many diseases such as internal, external, gynecological and pediatric diseases were treated in the clinical by using Guizhi decoction and its analogous formulae involving circulatory, immune, urinary, reproductive, endocrine, digestive, nervous and other systems. This article reviews the latest research progress of Guizhi decoction from three aspects: chemical constituents, pharmacological mechanism and clinical application. It will provide reference for further research and development of Guizhi decoction.

Decoction

10.19540/j.cnki.cjcmm.20170928.010

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Postoperative astigmatism and vision changes of phacoemulsification and the routine extracapsular cataract extraction

Yanke xinjinzhan (1998)

Wei Li

Objective To investigate the influence of different in cision styles of cataract extraction on the vision and astigmatism during postoperation. Methods The 29 cases (35 eyes ) dealed with extra capsular cataract extraction (ECCE ) of the routine incision style of 10mm width in the limbus were compared with 35 cases (44 eyes) with phacoemulsification of the antsuper ciliary arch tunnel incision style of 6mm width on the post operative vision and comeal astigmatism on 7th day, lst month and 3st month, respectoively.Results The postoperative vision of phacoemulsification was abviously improved than that of the ECCE with routine limbus incision style, and the astigmatism of the former were evidently decreased(P0. 05 ). With time going on. the difference between them were gradually reduced due to restoration, and showed no significant difference in their vision 3 months later(P0. 05).Conclusion The phacoemulsification operation with tunnel incision style of 6mm width can effectly improved the vision and cut down the degree of corneal astigmatism in the early stage of postoperation.

Astigmatism

Cataract extraction

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Research the Distribution Rule of SOD and MDA in Different oragens of Hyperlipemia Rat Model by Acupuncture on Fenglong(ST.40) Acupoint and It's Combination Acupoints

Zhonghua zhongyiyao xuekan (2008)

Wei Li

Objective:To observe the different regulative effects on SOD and MDA of hyperlipemia rat model and the mechanism by acupuncture on Fenglong(ST.40) acupoint and it's Combination Acupoints,and validate that the inbeing of acupoint offect is the distribution of the life matters between the correlational oragans,the passages are meridians.Methods:The model was fed with high fat diet.40 SD rats were randomly divided into 4 groups with 10 rats in each group: blank control group,model group,Fenglong(ST.40) group and combination of acupoints group(ST40,RN4,.PC6) Rats in the blank control group were fed with basic diet everyday,while the rest groups were fed with high fat diet everyday.After two weeks,the rats in the Fenglong(ST.40) acupoint group and combination of acupoints group were treated with acupuncture respectively.After 5 weeks of treatment,liver,spleen and lung were selected for test of SOD and MDA.Results:In spleen and lung,the SOD in Fenglong(ST.40) group and combination of acupoints group ascended greater than the model group(P0.01).The SOD in Fenglong(ST.40) group ascended greater than the combination of acupoints group(P0.01).And in lung,the MDA in Fenglong(ST.40) group descended greater than the combination of acupoints group(P0.01).In liver,the three groups(model group,Fenglong(ST.40) group and combination of acupoints group) had not difference(P0.05).Conclusion:The inbeing of acupoint offect is the distribution of the life matters between the correlational oragans,and the rules of the distribution correlate to the net relations between the meridians and oragans,and the relations of the cooperation and restriction oragans effect on the way of the substances and energys go between the correlational oragans.

Zusanli

Rat model

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