Peihua Liu

China National Petroleum Corporation (China)

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i-10 index

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Xiongbing Zu

Xiangya Hospital Central South University

Xiaodong Liu

China Pharmaceutical University

Li Liu

China Pharmaceutical University

Nancy S. Goroff

Stony Brook University

Jinbo Chen

Xiangya Hospital Central South University

Liang Zhu

West China Hospital of Sichuan University

Huihuang Li

Central South University

Longfei Liu

Xiangya Hospital Central South University

J.A. Webb

Naval Air Warfare Center Weapons Division

Anze Yu

The First Affiliated Hospital, Sun Yat-sen University

Cooperative Institutions

Central South University

Xiangya Hospital Central South University

China Pharmaceutical University

Chinese Academy of Sciences

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Southern Medical University

Wuhan University

University of Chinese Academy of Sciences

Zhejiang University

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Synthesis and biological activity evaluation of sex attractant for Holcocerus arenicola (Lepidoptera: Cossidae).

Linye Kexue (2010)

Jing Xiao-Yuan Jintong Zhang Luo YouQing Shixiang Zong Peihua Liu

Arenicola

Saturniidae

Source

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Citations (2)

Semi-Mechanistic Modeling of HY-021068 Based on Irreversible Inhibition of Thromboxane Synthetase

Frontiers in Pharmacology (2020)

Ping Li Jie Huang Donghao Geng Peihua Liu Zhaoxing Chu

Background: HY-021068 [4-(2-(1H-imidazol-1-yl) ethoxy)-3-methoxybenzoate], developed by Hefei Industrial Pharmaceutical Institute Co., Ltd. (Anhui, China), is a potential thromboxane synthetase inhibitor under development as an anti-platelet agent for the treatment of stroke. A semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model was developed to characterize the PK of HY-021068 and its platelet aggregation inhibitory effect in beagle dogs. Method: Beagle dogs received single oral administration of 2.5 mg/kg HY-021068 or consecutively oral administration of 5 mg/kg HY-021068 once daily for 7 days. The plasma concentration of HY-021068 and the platelet aggregation rate (PAR) were determined by liquid chromatography tandem-mass spectrometry (LC‐MS/MS) assay and a photometric method, respectively. The PK/PD data was sequentially fitted by Phoenix NLME. The PK/PD parameters of HY-021068 in beagle dogs were estimated by 2.5 and 5 mg/kg dosing on the 1st day, and then used to simulate the PAR of HY-021068 on the 7th day after 5 mg/kg dosing daily. Result: A one-compartment model with saturable Michaelis-Menten elimination was best fitted to the PK of HY-021068. A mechanistic PD model based on irreversible inhibition of thromboxane synthetase was constructed to describe the relationship between plasma concentration of HY-021068 and PAR. Diagnostic plots showed no obvious bias. Visual predictive check confirmed the stability and reliability of the model. Most of PK/PD observed data on the 7th day after 5 mg/kg dosing fell in the 90% prediction interval. Conclusion: We established a semi-mechanistic PK/PD model for characterizing the PK of HY-021068 and its anti-platelet effect in beagle dogs. The model can be used to predict the concentration and PAR under different dosage regimen of HY-021068, and might be served as a reference for dose design in the future clinical studies.

Beagle

Pharmacodynamics

Thromboxane B2

10.3389/fphar.2020.588286

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Citations (1)

Development and validation of a predictive nomogram for the risk of recurrence in patients with cystitis glandularis

Annals of Translational Medicine (2020)

Jiao Hu Chao Li Xi Guo Huihui Zhang Huihuang Li

Most patients with cystitis glandularis (CG) suffer from recurrence after primary treatment. Therefore, we performed this multicenter study to clarify the recurrent risk factors and constructed a predictive nomogram for the risk of recurrence. Also, we try to investigate the correlation between CG and bladder cancer.Consecutive patients with pathologically confirmed CG were divided into training and validation sets. Clinicopathological characters were collected from electronic medical records. Uni- and multivariate logistic regression analyses were used to identify independent risk factors of CG recurrence in the training set. The predictive nomogram was developed by incorporating these independent factors and histological subtype. The performance of the nomogram was assessed and validated with respects to its calibration, discrimination, and clinical usefulness. The risk of developing subsequent bladder cancer was analyzed from the follow-up data.Ultimately, 278 eligible patients were included and were allocated to a training set (n=190) and a validation set (n=88). Of them, 165 (59.35%) patients experienced CG recurrence, and none showed evidence of subsequent bladder carcinoma during a median (IQR) follow-up time of 27 months (14-57 months). Results of multivariate analysis showed that urinary infections, long-term indwelling catheter usage, urinary calculus, squamous metaplasia, and atypical hyperplasia were independent risk factors of CG recurrence. The C-index (95% CI) of the nomogram was 0.76 (0.69-0.83) in the training set and 0.72 (0.61-0.83) in the validation set. A decision curve analysis (DCA) demonstrated that this predictive nomogram was clinically useful.We developed and validated a nomogram to predict the individualized risk of CG recurrence. Also, we demonstrated that neither intestinal nor typical CG increased the consequent risk of bladder cancer during the follow-up period.

Nomogram

10.21037/atm.2020.02.102

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Citations (11)

CCDC 214878: Experimental Crystal Structure Determination

The Cambridge Structural Database (2005)

Peihua Liu Lei Li J.A. Webb Yi Zhang Nancy S. Goroff

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/cc76lkk

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Spatial Layout and Accessibility Evaluation of COVID-19 Vaccination Sites Based on Three Optimization Models: A Case Study of Tianhe District, Guangzhou

Journal of Disaster Research (2023)

Danni Wang Peihua Liu Ziqian Xu Chongyang Wang Yun Song

The outbreak of COVID-19 poses a serious threat to global public health, and vaccination is an effective means of prevention. Studying the spatial layout and accessibility of COVID-19 vaccination sites is of great significance. The study analyzes the spatial distribution characteristics and accessibility of vaccination sites in the early stage of mass vaccination in Tianhe District, Guangzhou, based on GIS technology and combines three location allocation models: the p-median model, maximum covering location problem (MCLP) model, and location set covering problem (LSCP) model to identify candidate COVID-19 vaccination sites for the proposed public service facilities. The study found that only 47 COVID-19 vaccination sites exist in the early stage, with a small overall number, uneven spatial distribution, and trend of high accessibility in the central but low accessibility in the north and south; after the proposed addition of 31 vaccination sites, the overall distribution showed an even and dense distribution in the central and western regions, sporadic distribution in other regions, consistent with the distribution characteristics of residential communities. The areas where the accessibility of vaccination sites increased by more than 500 m accounted for 41% of the total area, and the area served by vaccination sites increased by 18%. Therefore, using the existing public service facilities to reasonably add the vaccination sites can improve the efficiency of vaccination and safeguard the establishment of a herd immunity barrier.

Mass vaccination

Herd Immunity

10.20965/jdr.2023.p0531

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Citations (1)

CCDC 181226: Experimental Crystal Structure Determination

The Cambridge Structural Database (2002)

J.A. Webb Peihua Liu Olga L. Malkina Nancy S. Goroff

Crystal (programming language)

10.5517/cc62l0v

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Physicochemical characterization and cosmetic application of kelp blanching water polysaccharides

International Journal of Biological Macromolecules (2023)

Peihua Liu Jingjing Hu Qiangqiang Wang Tan Jian-hua Jian Wei

Blanching

Biopolymer

Alginic acid

Exopolymer

10.1016/j.ijbiomac.2023.125981

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Citations (7)

Vulnerability assessment of buildings adjacent to natural gas pipelines under explosion accident

Energy Sources Part A Recovery Utilization and Environmental Effects (2024)

Xinhong Li Xin Ning Ziqiang Xu Peihua Liu Ziyue Han

Gas explosion

Accident (philosophy)

Vulnerability

10.1080/15567036.2024.2402935

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Progression of research into the diagnosis and treatment of cystitis glandularis: a narrative review

Journal of Xiangya Medicine (2022)

Zhongyi Li Peihua Liu Xiongbing Zu Benyi Fan

Background and Objective: Cystitis glandularis (CG) is a frequent urological condition. The symptoms recur on a regular basis and are non-specific. The specific pathogenesis of CG is not yet clear. The gold standard is cystoscopy and biopsy. At present, there is currently no standard and uniform treatment plan. Common treatment plans include surgical treatment, non-surgical treatment, surgical treatment combined with drug treatment, etc. This article aims to summarize the research progress of CG and provide reference for clinical diagnosis and treatment. Methods: A search of publications before October 2021 was done. It was limited to publications in English. Searches were performed using PubMed, MEDLINE, Web of Science, and Google. The keywords used were: cystitis glandularis, cystitis cystica, bladder cancer, bladder lesions and bladder carcinoma. Key Content and Findings: This narrative review provides an overview of the research progress of diagnosis and treatment of CG in recent years, with the aim of providing reference for clinical practice. Conclusions: There are some debates and disagreements on the genesis and pathophysiology of CG, and no standardized protocol for clinical treatment. Treatment is still given priority to with surgical treatment. More further studies on CG are needed in order to provide more effective diagnosis and treatment strategies for clinic.

Gold standard (test)

Drug treatment

Narrative review

10.21037/jxym-22-5

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Citations (2)

Long-term follow-up and novel splice donor mutation in MEN1 in a Chinese family

Oncotarget (2017)

Minghao Li Qianqian Liu Peihua Liu Xiaoping Yi Xiao Guan

Heterozygous germline mutation of the MEN1 tumor suppressor gene is responsible for multiple endocrine neoplasia type 1. Parathyroid and thoracic neuroendocrine tumor specimens and DNA from two Han Chinese MEN1 family patients were analyzed using whole exome and Sanger sequencing. The proband (II-3) was sequentially diagnosed with pituitary adenoma, pancreatic tumor, adrenal cortical tumor, abdominal lipoma, and parathyroid adenoma during the 6-year follow-up. The son of the proband (III-6) was also diagnosed with a thoracic neuroendocrine tumor and a parathyroid adenoma during this period. Splice alterations were studied by RT-PCR and sequencing. The mutation impact was evaluated using bioinformatics. Sequence analysis revealed a novel splice donor mutation, MEN1 IVS9 + 1G > C, that changed the splicing mode of MEN1 to halt translation before two nuclear localization signals in the menin protein. Novel somatic mutations, MEN1 c.1402_1405delGAGG and c.286 C > T, were identified in the parathyroid adenoma of II-3 and thoracic neuroendocrine tumor of III-6, respectively, indicating a two-hit etiology of MEN1 syndrome. Our study revealed the clinical and genetic basis of MEN1 in this Han Chinese family and provides insight into MEN1 mechanisms, diagnosis, and management.

MEN1

splice

10.18632/oncotarget.23100

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Citations (1)