Qin Xu

East China University of Science and Technology

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Min Shi

Shanghai Institute of Organic Chemistry

Yongzhuo Huang

Shanghai Institute of Materia Medica

Changsheng Deng

Guangzhou University of Chinese Medicine

Yueming Yuan

Huazhong Agricultural University

Jianping Song

Guangzhou University of Chinese Medicine

Jianping Song

Guangzhou University of Chinese Medicine

Hongying Zhang

Nanchang University

Yin Wei

Chinese Academy of Sciences

Qi Wang

Shanghai Institute of Materia Medica

Xinan Huang

Guangzhou University of Chinese Medicine

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Guangzhou University of Chinese Medicine

185

Chinese Academy of Sciences

151

Capital Medical University

Sichuan Agricultural University

East China University of Science and Technology

Peking University

Shanghai Jiao Tong University

Sun Yat-sen University

Shanghai Institute of Materia Medica

University of Chinese Academy of Sciences

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[Chemosensitivity testing of oral and maxillofacial cancer with biopsy specimens].

PubMed (2002)

Wantao Chen Xiaojian Zhou Qin Xu Wei Guo Lisong Lin

To determine the chemosensitivity in fresh biopsy specimen of human oral and maxillofacial cancer, and the differential chemosensitivity among those drugs used popularly in clinic.Human biopsy cancer cells were obtained from 150 oral and maxillofacial malignant tumors. The antitumor drugs tested using modified MTT assay were cisplatin (CDDP), 5-fluorouracil (5-Fu), Pinyangmycin (PYM), Paclitaxel (Taxol), Teniposide (Vm-26), Epi-adriamycin (E-ADM), Vindesin (VDS) and Methortrexatum (MTX).The success rate of the MTT assay was 93.33% (140 of the 150 cases). At a drug concentration of Cmax x 5, the inhibition rates of oral tumor cells were 63.76% for Vm-26, 25.93% for CDDP, 25.86% for E-ADM, 23.52% for Taxol, 22.97% for PYM, 22.08% for 5-Fu, 18.42% for VDS and 18.93% for MTX. The inhibition rate of VM26 was significantly higher than any of other seven chemotherapeutic drugs (P < 0.05). Over forty percent patients with squamous cell carcinoma showed moderate chemosensitivity to VM-26, CDDP and E-ADM, and over forty percent cases with adenoid carcinoma showed moderate chemosensitivity to Vm-26, Taxol and E-ADM.Most oral and maxillofacial cancers showed chemosensitivity to Vm-26, CDDP, E-ADM and Taxol. Vm-26, E-ADM and Taxol were more potent drugs than VDS, 5-Fu and MTX against oral and maxillofacial cancer cells. Chemosensitivity testing using modified MTT assay was useful in selecting antitumor drugs for patients with oral and maxillofacial cancers.

Chemosensitivity assay

MTT assay

Teniposide

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Citations (4)

CONTENTS

De Gruyter eBooks (2022)

Xifan Li Jing Cao Qinghui Cao Shouxiang Chen Yonglin Li

10.1515/9783110790887-toc

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Citations (0)

Regio- and diastereoselective construction of 1′,2′-(dihydrospiro[indoline-3,3′-pyrrol]-2′-yl)acrylates through phosphine-catalyzed [4 + 1] annulation of Morita–Baylis–Hillman carbonates with oxindole-derived α,β-unsaturated imines

RSC Advances (2015)

Lei Yu Xiaonan Zhang Xueyan Yang Qin Xu Min Shi

Phosphine-catalyzed [4 + 1] annulation of Morita–Baylis–Hillman carbonates with oxindole-derived imines has been developed.

Annulation

Oxindole

Indoline

10.1039/c5ra09147k

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Citations (25)

A model of pregnancy-associated malaria for inducing adverse pregnancy outcomes in ICR mouse

Experimental Parasitology (2023)

Yingying Zhang Zhiming Liang Haoyu Xing Chuyi Yu Jianming Liang

Plasmodium berghei

Cerebral Malaria

10.1016/j.exppara.2023.108686

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Citations (0)

Gold‐Catalyzed Cascade Oxidative Cyclization and Arylation of Allenoates

European Journal of Organic Chemistry (2013)

Rui Zhang Qin Xu Kai Chen Peng Gu Min Shi

Abstract An Au I /Au III catalytic system was found to be effective for the cascade oxidative arylation and cyclization of allenoates with arylboronic acids to give the corresponding cyclic adducts in moderate yields. This reaction system constitutes a new method for the synthesis of β‐aryl‐γ‐butenolides under mild conditions. Based on the previous mechanistic studies, a proposed Au I /Au III redox catalytic cycle has been outlined.

Catalytic cycle

10.1002/ejoc.201300896

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Citations (14)

Regulation of the Keap1-Nrf2 Signaling Axis by Glycyrrhetinic Acid Promoted Oxidative Stress-Induced H9C2 Cell Apoptosis

Evidence-based Complementary and Alternative Medicine (2022)

Zhangyu Jiang Yanqing Wang Xiuli Xi Weibin Cai Changhui Liu

Excessive reactive oxygen species (ROS) could interfere with the physiological capacities of H9C2 cells and cause cardiomyocyte apoptosis. Glycyrrhetinic acid (GA), one of the main medicinal component of Glycyrrhetinic Radix et Rhizoma, shows toxic and adverse side effects in the clinic setting. In particular, some studies have reported that GA exerts toxic effects on H9C2 cells. The purpose of this study is to assess the effect of GA-induced oxidative stress on cultured H9C2 cells and reveal the relevant signaling pathways. LDH assay was used to assess cell damage. Apoptosis was detected using Hoechst 33242 and a propidium iodide (PI) assay. An Annexin V-fluorescein isothiocyanate/PI double-staining assay was utilized to investigate GA-induced apoptosis in H9C2 cells. The expression level of specific genes/proteins was evaluated by RT-qPCR and Western blotting. Flow cytometry and DCFH-DA fluorescent testing were used to determine the ROS levels of H9C2 cells. The potential mechanism of GA-induced cardiomyocyte injury was also investigated. GA treatment increased ROS generation and mitochondrial membrane depolarization and triggered caspase-3/9 activation and apoptosis. GA treatment also caused the nuclear translocation of NF-E2-related factor 2 after its dissociation from Keap1. This change was accompanied by a dose-dependent decline in the expression of the downstream target gene heme oxygenase-1. The findings demonstrated that GA could regulate the Keap1-Nrf2 signaling axis and induce oxidative stress to promote the apoptosis of H9C2 cells.

Propidium iodide

KEAP1

10.1155/2022/2875558

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Citations (1)

Immunogenicity and toxicokinetics assessment of the mono-PEGylated recombinant human interleukin-11 in cynomolgus monkeys

Life Sciences (2020)

Xiaobo Li Pui-Shi Pang Suxing Zhang Li Ru Zheng Yuan

PEGylation

10.1016/j.lfs.2020.118244

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Citations (2)

Effects of intrauterine growth retardation and Bacillus subtilis PB6 supplementation on growth performance, intestinal development and immune function of piglets during the suckling period

European Journal of Nutrition (2016)

Liang Hu Peng Xie Hong Chen Chuan Yan Liu Yan

Growth retardation

10.1007/s00394-016-1223-z

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Citations (55)

Switchable adsorption/desorption Bisphenol A and its derivatives by Allyl-β-cyclodextrin functionalized intelligent molecularly imprinted polymer membrane

New Journal of Chemistry (2025)

Wenzheng Xie Kangping Ning Zhipeng Chen Jingwen Xia Сейтхан Азат

Endocrine-disrupting chemicals (EDCs) in natural waterways have significant risks to both ecological systems and human health. The development of effective removal strategies for EDCs that are selective, economical, efficient, and...

Molecularly imprinted polymer

10.1039/d4nj04714a

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Visible-Light-Promoted [5 + 1] Annulation Initiated by Electron-Donor–Acceptor Complexes: Synthesis of Perfluoroalkyl-s-Triazines

Organic Letters (2019)

Rui Wang Lili Wang Qin Xu Baoyi Ren Fushun Liang

A visible-light-promoted electron-donor–acceptor (EDA) complex-initiated [5 + 1] annulation between biguanides and perfluoroalkyl halides for the construction of perfluoroalkyl-s-triazines has been developed. It was found that both visible light and dioxygen in the air are favorable for the reaction. A radical–polar crossover mechanism was proposed, in which sequential SET, radical combination, HF elimination, electrocyclization, and aromatization are involved.

Annulation

Aromatization

Visible spectrum

Acceptor

Electron acceptor

10.1021/acs.orglett.9b00655

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Citations (49)