Sanjeev K. Gautam

University of California, Davis

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Birbal Singh

Indian Veterinary Research Institute

Manishi Mukesh

National Bureau of Animal Genetic Resources

Gorakh Mal

Indian Veterinary Research Institute

Vinod Verma

Sanjay Gandhi Post Graduate Institute of Medical Sciences

Kapil Dev

Central Institute of Medicinal and Aromatic Plants

Anita Yadav

Kurukshetra University

Shiv Kumar Giri

Maharaja Engineering College

Anıl Kumar

Maharshi Dayanand University

Neeraj Aggarwal

Kurukshetra University

M. S. Chauhan

National Dairy Research Institute

Cooperative Institutions

National Dairy Research Institute

Kurukshetra University

Indian Council of Agricultural Research

Indian Veterinary Research Institute

National Bureau of Animal Genetic Resources

All India Institute of Medical Sciences

Panjab University

Nepal Agricultural Research Council

Sun Yat-sen University

Maharaja Agrasen University

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<i>In Pursuit</i> of Porcine Pluripotent Stem Cells for Autologous Cell Therapy

Stem Cell Discovery (2014)

Vinod Verma Ashish Mehta Sanjay Pal Manoj Kumar Birbal Singh

Treatments to repair the human heart following regenerative diseases remain a challenge for medical science. Unlike lower vertebrate species the human heart lacks a regenerative pathway meaning that research has to be focused on cell transplantation. Porcines (Sus scrofa) are excellent models for cardiovascular disease and pluripotent stem cells (PSCs) generated from porcines will provide important clinical insights for cardiac cell therapy. This could open a new avenue of research into degenerative conditions as porcine is a more effective human proxy to work with. However, bona fide PSCs are currently available onlyin rodents (mouse, rat) and primates (monkey, human). Attempts to derivepluripotent stem cells (PSCs) from porcine have been going on for more than two decades with slow progress. Despite the fact that the porcine stem cells are under increasing glare of publicity due to milestone achievements in this area of research. Advances in stem cell technology, especially the genetic engineering, innovative cell culturing and induced pluripotency to generate stem cells has dramatically revolutionized the basic and applied investigations and applications of porcine stem cells. This review attempts to summarize the major signaling pathways involved in maintenance of pluripotency and the state of the art conceptual and technical progress for generating bona fide porcine PSCs.

Regenerative Medicine

Cell therapy

Stem Cell Therapy

10.4236/scd.2014.44012

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Therapeutic Effect of Probiotic Dahi on Plasma, Aortic, and Hepatic Lipid Profile of Hypercholesterolemic Rats

Journal of Cardiovascular Pharmacology and Therapeutics (2013)

Dheeraj Mohania Vinod K. Kansal Dilip Shah Ravinder Nagpal Manoj Kumar

This study examined the effects of probiotic dahi prepared by Lactobacillus plantarum Lp9 and dahi culture in buffalo milk on lowering cholesterol in rats fed a hypercholesterolemic basal diet. Male Wistar rats were divided into 3 groups and fed with probiotic dahi, dahi, or buffalo milk for 120 days. Following the consumption of supplements (probiotic dahi, dahi or buffalo milk), the animals were fed a basal hypercholesterolemic diet. Plasma total cholesterol and triglycerides (TAGs) were decreased by 35% and 72% in rats fed with probiotic dahi group, while cholesterol levels increased by 70% and TAGs increased by 97% in buffalo milk and 59% in dahi fed groups. Supplementation of probiotic dahi further lowered plasma low-density lipoprotein (LDL) + very-low-density lipoprotein (VLDL)- cholesterol by 59%, while it elevated plasma high-density lipoprotein (HDL)-cholesterol by 116%. As a result, atherogenic index, the ratio of HDL to LDL + VLDL was markedly improved. Deposition of cholesterol and TAGs in liver and aorta were significantly reduced in rats fed with probiotic dahi. These observations suggest that probiotic dahi may have therapeutic potential to decrease plasma, hepatic and aortic lipid profile, and attenuate diet-induced hypercholesterolemia.

Basal (medicine)

Lipid Profile

10.1177/1074248413487431

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Citations (32)

Reproduction Advances in Buffaloes

Springer eBooks (2019)

Birbal Singh Gorakh Mal Sanjeev K. Gautam Manishi Mukesh

Bubalus

Cloning (programming)

10.1007/978-3-030-21309-1_12

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Reproductive biotechniques in buffaloes (Bubalus bubalis): status, prospects and challenges

Reproduction Fertility and Development (2009)

Birbal Singh M. S. Chauhan S. K. Singla Sanjeev K. Gautam Vinod Verma

The swamp buffalo holds tremendous potential in the livestock sector in Asian and Mediterranean countries. Current needs are the faster multiplication of superior genotypes and the conservation of endangered buffalo breeds. Recent advances in assisted reproductive technologies, including in vitro embryo production methodologies, offer enormous opportunities to not only improve productivity, but also to use buffaloes to produce novel products for applications to human health and nutrition. The use of molecular genomics will undoubtedly advance these technologies for their large-scale application and resolve the key problems currently associated with advanced reproductive techniques, such as animal cloning, stem cell technology and transgenesis. Preliminary success in the application of modern reproductive technologies warrants further research at the cellular and molecular levels before their commercial exploitation in buffalo breeding programmes.

Bubalus

10.1071/rd08172

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Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)

Genetics and Molecular Biology (2011)

Ruheena Javed Sanjeev K. Gautam Ramesh Kumar Vijh Madhu Sudan Tantia

More than 40 million households in India depend at least partially on livestock production. Buffaloes are one of the major milk producers in India. The prolactin receptor (PRLR) gene and peroxisome proliferators activated receptor-γ coactivator 1-alpha (PPARGC1A) gene are reportedly associated with milk protein and milk fat yields in Bos taurus. In this study, we sequenced the PRLR and PPARGC1A genes in the water buffalo Bubalus bubalis. The PRLR and PPARGC1A genes coded for 581 and 819 amino acids, respectively. The B. bubalis PRLR gene differed from the corresponding Bos taurus at 21 positions and four differences with an additional arginine at position 620 in the PPARGC1A gene were found in the amino acid sequence. All of the changes were confirmed by cDNA sequencing. Twelve buffalo-specific single nucleotide polymorphisms (SNPs) were identified in both genes, with five of them being non-synonymous.

Bubalus

PPARGC1A

Prolactin receptor

10.1590/s1415-47572011005000037

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Citations (9)

Synthetic Biology

Springer eBooks (2019)

Birbal Singh Gorakh Mal Sanjeev K. Gautam Manishi Mukesh

10.1007/978-3-030-21309-1_36

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Citations (1)

Career Opportunities in Animal Biotechnology

Springer eBooks (2019)

Birbal Singh Gorakh Mal Sanjeev K. Gautam Manishi Mukesh

Animal health

Intellect

Animal agriculture

10.1007/978-3-030-21309-1_48

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Citations (1)

Anaerobic Gut Fungi—A Biotechnological Perspective

Springer eBooks (2019)

Birbal Singh Gorakh Mal Sanjeev K. Gautam Manishi Mukesh

Alimentary tract

10.1007/978-3-030-21309-1_3

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Citations (1)

CYP1A1 Gene Polymorphisms: Modulator of Genetic Damage in Coal-Tar Workers

Asian Pacific Journal of Cancer Prevention (2012)

Shiv Kumar Giri Anita Yadav Anıl Kumar Kapil Dev Sachin Gulati

Aim: It is well known that polycyclic aromatic hydrocarbons (PAHs) such as benzo (a) pyrene have carcinogenic properties and may cause many types of cancers in human populations. Genetic susceptibility might be due to variation in genes encoding for carcinogen metabolizing enzymes, such as cytochrome P-450 (CYP450). Our study aimed to investigate the effect of genetic polymorphisms of CYP1A1 (m1 and m2) on genetic damage in 115 coal-tar workers exposed to PAHs at their work place. Methods: Genetic polymorphisms of CYP1A1 were determined by the PCR-RFLP method. Comet and buccal micronucleus assays were used to evaluate genetic damage among 115 coal tar workers and 105 control subjects. Results: Both CYP1A1 m1 and CYP1A1 m2 heterozygous and homozygous (wt/mt+mt/mt) variants individually as well as synergistically showed significant association (P<0.05) with genetic damage as measured by tail moment (TM) and buccal micronuclei (BMN) frequencies in control and exposed subjects. Conclusion: In our study we found significant association of CYP1A1 m1 and m2 heterozygous (wt/mt)+homozygous (mt/mt) variants with genetic damage suggesting that these polymorphisms may modulate the effects of PAH exposure in occupational settings.

Buccal swab

Genetic predisposition

10.7314/apjcp.2012.13.7.3409

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Citations (15)

Influence of GSTM1 and GSTT1 genotypes and confounding factors on the frequency of sister chromatid exchange and micronucleus among road construction workers

Chemosphere (2011)

Anıl Kumar Anita Yadav Shiv Kumar Giri Kapil Dev Sanjeev K. Gautam

Sister chromatid exchange

10.1016/j.chemosphere.2011.04.008

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Citations (8)