Numerous studies have confirmed that the apolipoprotein E4 allele (APOE4) gene and arteriosclerosis (AS) have a combined effect on the occurrence of cognitive function impairment, and dyslipidaemia levels are significantly correlated with APOE4 levels and AS. Few studies have focused on the combined effect of the APOE4 gene and AS on cognitive function. Therefore, this study aimed to investigate the effect of APOE4 gene and AS acting together on cognitive function through dyslipidaemia levels, which could provide certain scientific research value for future studies.A multi-stage cluster sampling method was used to investigate older adults aged 60 years and above in rural areas of Guizhou, China. The demographic sociological characteristics were collected, and laboratory tests, blood lipid measurements, and physical examinations were performed. Mini-Mental State Examination (MMSE) was used to determine cognitive function. Analysis of variance with two-factor factorial design was used to analyse the interaction between the APOE4 gene and AS on cognitive function and its domains.A total of 549 elderly subjects were eligible for this study. The result of the factorial design analysis revealed there was a significant interaction between the APOE4 gene and AS in terms of attention and numeracy (F = 6.878, P = 0.009).The combination of the APOE4 gene and AS leads to a decrease in the level of attention and numeracy domains, and certain attention should be focused on such populations in the future.
Studies have shown that the prognosis of dental implant treatment in patients with diabetes is not as good as that in the non-diabetes population. The nerve plays a crucial role in bone metabolism, but the role and the mechanism of peripheral nerves in regulating peri-implant osteogenesis under Type 2 diabetes mellitus (T2DM) situation remains unclear. In this study, it was shown that high glucose-stimulated Schwann cells (SCs) inhibited peri-implant osteogenesis via their exosomes. SCs-derived exosomes were analyzed for their miRNA cargo, identifying miR-15b-5p as significantly downregulated in high glucose conditions. T2DM rats and patients exhibited decreased miR-15b-5p expression, correlating with impaired bone microarchitecture. Luciferase assays and Western blotting confirmed TXNIP as a direct miR-15b-5p target, implicating its involvement in ROS signaling and inflammation-related osteogenesis suppression. Furthermore, normal SCs exosomes improved bone parameters around dental implants in T2DM rats. These findings underscore the therapeutic potential of miR-15b-5p and normal SCs exosomes in mitigating poor peri-implant bone regeneration of T2DM patients, offering insights into the molecular mechanisms of peripheral nerves governing bone regeneration in diabetic conditions.
Summary Background An increasing number of studies have indicated that the central and autonomic nervous systems play roles in the genesis of sleep bruxism ( SB ). The role of specific neurochemicals in SB has been a subject of interest. Objective In this study, we use proton magnetic resonance spectroscopy ( 1 H‐ MRS ) to determine whether the levels of γ‐aminobutyric acid ( GABA ) and glutamate (Glu) are different in the brainstem and bilateral cortical masticatory area ( CMA ) between possible sleep bruxism ( SB ) patients and controls, and discuss whether the brainstem or cortical networks which may affect the central masticatory pathways are under the genesis of SB . Methods Twelve possible SB patients and twelve age‐ and gender‐matched controls underwent 1 H‐ MRS using the “ MEGA ‐Point Resolved Spectroscopy Sequence” ( MEGA ‐ PRESS ) technique in the brainstem and bilateral CMA . Proton magnetic resonance spectroscopy data were processed using LCM odel. Because the signal detected by MEGA ‐ PRESS includes contributions from GABA , macromolecules (primarily proteins) and homocarnosine, the GABA signal is referred to as “ GABA +”. The glutamate complex (Glx) signal contains both glutamate (Glu) and glutamine (Gln), which mainly reflect glutamatergic metabolism. Results Edited spectra were successfully obtained from the bilateral CMA in all subjects. There were no significant differences in neurochemical levels between the left and right CMA in possible SB patients and controls. In the brainstem, significantly lower GABA + levels were found in possible SB patients than in controls ( P = .011), whereas there was no significant difference ( P = .307) in Glx levels between the 2 groups. Conclusions SB patients may possess abnormalities in the GABA ergic system of brainstem networks.
Objective:To observe the curative effect of monosialotetrahexosylganglioside,GM1 injection combines with xingnaojing injection therapy the acute stroke.Methods:64 cases of the acute stroke were randomly divided into a treatment group and a control group,32 cases in each group.The treatment group were treated with GM1 injection combines with xingnaojing injection,the control group were treated with xinaojing injection.To observe the curative effect of after a period of treatment(ten days).Results:The total effective rate was 90.6% in the treatment group and 68.8% in the control group,the treatment group being better than the group(P0.01).Conclusion:Its effect on therapy the acute stroke was better in the therapy group than in the control group.
Objective To discuss the diagnosis and treatment of hypertensive brainstem encephalopathy. Methods The clinical and imaging data of 3 cases of hypertensive brainstem encephalopathy were summarized and analyzed for the purpose of improving the acumen in diagnosis and treatment. Results All the 3 patients showed relatively mild clinical symptoms, and they were misdiagnosed in different degrees during the treatment, but their clinical symptoms were improved by rapid and effective antihypertensive therapy. Cerebral CT and MRI scans revealed extensive abnormal signals in brain stem, with or without supratentorial lesions and brain stem hemorrhage. The lesions as revealed by imaging were improved significantly after treatment. Conclusions Clinical-radiographic dissociation is the classic feature of hypertensive brainstem encephalopathy. The clinical symptoms and lesions as shown by imaging could be improved after active treatment.
DOI: 10.11855/j.issn.0577-7402.2015.06.03
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