// Dazhi Fan 1, 2 , Shuzhen Wu 1, 2 , Li Liu 3, 5 , Qing Xia 3, 6 , Guo Tian 5 , Wen Wang 2 , Shaoxin Ye 1, 2 , Lijuan Wang 2 , Jiaming Rao 1, 7 , Xiao Yang 3, 8 , Zhen Yu 9 , Lihong Xin 10 , Song Li 11 , Zhenghua Duan 12 , Tianchen Zhang 13 , Song Wu 4 , Xiaoling Guo 1, 2 and Zhengping Liu 1, 2 1 Foshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, Guangdong, 528000, China 2 Department of Obstetrics, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, Guangdong, 528000, China 3 Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China 4 School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, China 5 Department of Library, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China 6 Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia 7 Department of Epidemiology, Medical College of Jinan University, Guangzhou, Guangdong, 510632, China 8 Changzhou Center for Disease Control and Prevention, Changzhou, Jiangsu, 213003, China 9 Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China 10 Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China 11 Chaohu Hospital Affiliated Anhui Medical University, Chaohu, Anhui, 238000, China 12 Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan, 610041, China 13 Department of Communicable Diseases Control, Jiangxi Provincial Center for Disease Control and Prevention, Nanchang 330000, Jiangxi, China Correspondence to: Zhengping Liu, email: liuzphlk81@outlook.com Xiaoling Guo, email: fsguoxl@163.com Keywords: non-syndromic orofacial clefts; perinatal infants; prevalence; meta-analysis; China Received: June 27, 2017 Accepted: December 05, 2017 Published: January 13, 2018 ABSTRACT Non-syndromic orofacial clefts (NSOFC), which include cleft lip and palate (CLP), cleft lip only (CLO), and cleft palate only (CPO), contains a range of disorders affecting the lips and oral cavity. No systematic review and meta-analysis has been carried out to synthesize the prevalence of NSOFC in Chinese perinatal infants. We aimed to quantify and understand the variation of prevalence national and regional levels. Four English databases and four Chinese databases were searched using a comprehensive search strategy from inception to April 2017. The random effect model was used for this meta-analysis. To determine the sources of heterogeneity, subgroup analyses and meta-regression were conducted based on different categories. The protocol has been pre-registered in the PROSPERO, number CRD42017062293. 110 studies, including 15,094,978 Chinese perinatal infants, were eligible for inclusion. The pooled prevalence rate for NSOFC was 1.67‰ (95% CI 1.53–1.82), varying with provinces. The pooled prevalence estimate was 0.56‰ (0.50–0.63) for CLO, 0.82‰ (0.73–0.90) for CLP, and 0.27‰ (0.24–0.30) for CPO. Significant associations were found between overall prevalence estimates and survey year and study region. The prevalence of NSOFC was severe in Chinese perinatal infants, varying with provinces. The results will serve as a baseline for future assessment of the overall effectiveness of NSOFC control, and will also support and inform health policy for planning and helping health debates.
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