Topikal antibiyotikler başta dermatologlar olmak üzere genel cerrahi, aile hekimi, dahiliye ve pediatri gibi çok sayıda disiplin tarafından yaygın şekilde kullanılmaktadır. Derinin çok sayıda mikroorganizmaya maruz kalması, florada yerleşik fırsatçı patojenler ve girişimsel işlemler sonrası deri bütünlüğünün bozulması gibi nedenlerle deri enfeksiyona açık hale gelmekte ve topikal antibiyotiklere ihtiyaç olmaktadır. Bazı inflamatuvar hastalıklarda da etyolojide yer alan bakteriler nedeniyle topikal antibiyotikler kullanılmakta ve antiinflamatuvar etkilerinden yararlanılmaktadır. Oksitetrasiklin hidroklorür, fusidik asit, mupirosin, retapamulin ve klindamisin gibi topikal antibiyotikler deri enfeksiyonlarının tedavisinde sık kullandığımız etken maddelerdendir.
AMA Polat M, Bugdayci G, Sahin A, Kaya H, Sezer T, Ozturk S. Can pregnancy-associated plasma protein-A be a marker for the assessment of atherosclerosis risk in patients with chronic plaque psoriasis?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(5):340-344. doi:10.5114/ada.2016.62839. APA Polat, M., Bugdayci, G., Sahin, A., Kaya, H., Sezer, T., & Ozturk, S. (2016). Can pregnancy-associated plasma protein-A be a marker for the assessment of atherosclerosis risk in patients with chronic plaque psoriasis?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(5), 340-344. https://doi.org/10.5114/ada.2016.62839 Chicago Polat, Mualla, Guler Bugdayci, Asli Sahin, Hatice Kaya, Tuna Sezer, and Serkan Ozturk. 2016. "Can pregnancy-associated plasma protein-A be a marker for the assessment of atherosclerosis risk in patients with chronic plaque psoriasis?". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 33 (5): 340-344. doi:10.5114/ada.2016.62839. Harvard Polat, M., Bugdayci, G., Sahin, A., Kaya, H., Sezer, T., and Ozturk, S. (2016). Can pregnancy-associated plasma protein-A be a marker for the assessment of atherosclerosis risk in patients with chronic plaque psoriasis?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(5), pp.340-344. https://doi.org/10.5114/ada.2016.62839 MLA Polat, Mualla et al. "Can pregnancy-associated plasma protein-A be a marker for the assessment of atherosclerosis risk in patients with chronic plaque psoriasis?." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 33, no. 5, 2016, pp. 340-344. doi:10.5114/ada.2016.62839. Vancouver Polat M, Bugdayci G, Sahin A, Kaya H, Sezer T, Ozturk S. Can pregnancy-associated plasma protein-A be a marker for the assessment of atherosclerosis risk in patients with chronic plaque psoriasis?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(5):340-344. doi:10.5114/ada.2016.62839.
INTRODUCTION: Pruritus is themostcommon skin problem inhemodialysispatientsand is an importantsymptomaffectingquality of life.An importantcause of pruritus is inflammation.Neutrophil/lymphocyteratio is used as an inflammatory marker in chronicdiseases.Weaimedtoinvestigatewhetherthere is anyrelationshipbetweenitchingandneutrophil/ lymphocyteratio in hemodialysispatients.
Acne is one of the most common skin diseases in the adolescent period. Bisphenol A (BPA) is the most frequently observed endocrine-disrupting chemicals that we are exposed to in daily life. BPA can affect acne pathogenesis with similar biological activity on androgenic receptors.To investigate whether BPA levels play a role in the development and severity of acne in adults.Fifty-one adults with acne and 50 healthy controls, whose ages varied between 18 and 25 years and applied to our dermatology outpatient clinic, were evaluated. A questionnaire containing dietary and lifestyle habits for BPA exposure was filled. BPA and BPA glucuronides were analyzed in the LC-MS/MS system in the first-morning urine samples of the patients. Statistical significance was set at p < 0.05.The median levels of total BPA were significantly higher in the acne group compared with the control group (7.94 (4.69-20.32) vs. 5.62 (1.52-21.05) µg/g creatinine, respectively; p = 0.04)). The acne severity was positively associated with the BPA values (p = 0.00 rs = 0.534). Higher BPA level was noticed in younger acne onset age (p = 0.012 r = -0.349) When the inquiry questions were evaluated, no difference was found between the study groups regarding BPA exposure risk (p > 0.05).BPA could be a factor in acne development and its severity. Therefore, it may be beneficial to prevent BPA exposure and raise awareness in the adolescence and post-adolescence period, in which industrial products such as junk food and plastic bottled water are used more frequently.
After the emergence of the pandemic caused by the COVID-19 virus, vaccination with various vaccines has started to be implemented across the world. To identify dermatological reactions developing after the COVID-19 vaccines administered in Turkey and determine their clinical features and risk factors that may play a role in their development.The study included patients aged ≥18 years, who presented to 13 different dermatology clinics in Turkey between July 2021 and September 2021 after developing dermatological reactions following the administration of the COVID-19 vaccine. After providing written consent, the patients were asked to complete a standard survey including questions related to age, gender, occupation, comorbidities, the regular medication used, the onset of cutaneous reactions after vaccination, and localization of reactions. Dermatological reactions were categorized according to whether they developed after the first or second dose of the vaccine or whether they occurred after the inactivated or messenger RNA (mRNA) vaccine. The relationship between dermatological reactions and some variables such as gender and comorbidities was also evaluated.A total of 269 patients [116 women (43.1%), 153 men (56.9%)] were included in the study. It was observed that the dermatological diseases and reactions that most frequently developed after vaccination were urticaria (25.7%), herpes zoster (24.9%), maculopapular eruption (12.3%), and pityriasis rosea (4.5%). The rate of dermatological reactions was 60.6% after the administration of the mRNA vaccine and 39.4% after that of the inactivated vaccine. There was a statistically significantly higher number of reactions among the patients that received the mRNA vaccine (p = 0.001).The most common reactions in our sample were urticaria, herpes zoster, and maculopapular eruption. Physicians should know the dermatological side effects of COVID-19 vaccines and their clinical features.
Abstract Background The rate of cosmetic procedures and use of skincare products is considered to be affected during the pandemic period; however, this has not been investigated yet. Objective To determine whether the ongoing pandemic has changed people's habits related to skincare products and cosmetic procedures. Methods We conducted a multicenter survey study covering both private and public hospitals. Sociodemographic characteristics and clinical diagnoses of the patients were noted by dermatologists. A survey was used to determine the type and application areas of skincare products and cosmetic procedures before and during the pandemic, whether the patients were concerned about being infected, and any change in the make‐up habits of female patients. Results Of the 1437 patients, 86.7% presented to the hospital due to dermatological complaints and 13.3% for cosmetic procedures. The rate of those that did not use skincare products was 0.05% before and 0.06% during the pandemic. Of the participants, 43.2% had undergone cosmetic procedures before and 38.1% during the pandemic. For both periods, the most frequent cosmetic procedure applied was laser epilation, followed by skincare treatment and chemical peeling. While undergoing these procedures, 34.9% of the patients were concerned about contracting coronavirus. Conclusion There was no significant difference in the use of skincare products and cosmetic procedures before and during the pandemic. The majority of the patients continued to undergo these procedures despite their fear of being infected. This shows that during the pandemic period, patients are concerned with their appearance and continue to undergo cosmetic procedures and pay attention to their skincare.
Aim: To evaluate the diagnostic yield of pleural fluid total protein, albumin, globulin levels and pleural fluid albumin/globulin ratios in different diseases. Method: Retrospective review. All patients with pleural effusions of whose final diagnoses, pleural fluid and serum total protein, albumin and globulin were enrolled. Globulin levels were calculated as the difference between total proteins and albumin. Patients were grouped based on their diagnosis as; tuberculosis pleurisy (TP), parapneumonic effusion (PPE), malign pleural effusion (MPE) and others. Results: A total of 237 patients were enrolled.The average age was 64±16. Female/male ratio was 39/198. Pleural fluid total protein (p-tprot), albumin (p-alb), globulin (p-glob) levels and pleural fluid albumin/globulin ratios (p-alb/glob) were statistically significantly different between the study groups. Conclusion: Differential diagnosis of pleural effusions is sometimes a challenge for clinicians particularly in endemic areas of tuberculosis. Pleural fluid total protein, albumin and globulin levels and pleural fluid albumin/globulin ratios might have roles in the differential diagnosis of pleural effusions.
Background: Acne vulgaris (AV) is among the common skin diseases for which patients refer to complementary and alternative medicine (CAM). Aims and Objectives: To investigate the approaches to CAM methods and factors believed to increase the disease in 1,571 AV patients. Materials and Methods: The sociodemographic characteristics of the patients and disease severity according to the Food and Drug Administration criteria were recorded. The Cardiff Acne Disability Index (CADI) was used to assess the impact of acne on the patient's life and the history of CAM use was noted. The patients also listed the factors that they thought worsened their disease and reported their gluten-free diet experiences. Results: Of all the patients, 74.41% had a history of using CAM methods. CAM use was significantly higher in women, patients with severe AV, those with a higher CADI score and non-smokers. As a CAM method, 66.37% of the patients reported having used lemon juice. The respondents most frequently applied CAM methods before consulting a physician (43.94%), for a duration of 0–2 weeks (38.97%). They learned about CAM methods on the internet (56.24%) and considered CAM methods to be natural (41.86%). The patients thought that food (78.55%) and stress (17.06%) worsened their disease. They considered that the most common type of food that exacerbated their symptoms was junk food (63.84%) and a gluten-free diet did not provide any benefit in relieving AV (50%). Conclusion: Physicians need to ask patients about their CAM use in order to be able to guide them appropriately concerning treatments and applications with a high level of evidence.
Epidemiological studies have suggested that patients with psoriasis are at an increased risk of developing cardiovascular diseases. Chronic inflammation may play a role in the pathogenesis of atherosclerosis in psoriasis patients. Recent studies have evaluated the expression of plasma endocan and homocysteine levels. Endocan is a marker of vascular endothelial damage, and homocysteine plays a role in the development of atherosclerosis. Plasma endocan and homocysteine levels, as well as echocardiographic parameters, were evaluated in patients with psoriasis to assess cardiovascular disease risk.This was a prospective cohort analysis of 40 patients who were diagnosed with psoriasis and 40 healthy controls matched to the patient group according to demographic and biochemical parameters.Serum endocan and homocysteine concentrations were significantly higher in the psoriasis group than the control group (p < 0.001). Serum endocan concentrations correlated positively with disease duration (p < 0.001; r = 0.725). The Tei index (myocardial performance) was elevated in psoriasis patients (p < 0.001). Additionally, the E/A (mitral valve early diastolic peak flow velocity/mitral valve late diastolic peak flow velocity) and E/Em (early diastolic myocardial velocity) ratios were reduced in psoriasis patients (p < 0.001). Parameters indicative of left ventricular asynchrony were elevated significantly in the psoriasis group versus the control group (p < 0.001).We observed a substantial increase in serum endocan and homocysteine concentrations, and significant differences in key parameters of cardiac function, in psoriasis patients relative to controls. These results are consistent with the hypothesis that subclinical cardiac damage is increased in patients with psoriasis and that psoriasis itself may be a cardiovascular risk factor.