Hao Zheng

First Affiliated Hospital of Anhui Medical University

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Jinlan Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

Menglin Li

Peking University People's Hospital

Mohammad Zahid Hossain

International Centre for Diarrhoeal Disease Research

Jian Cheng

First Affiliated Hospital of Zhengzhou University

Hung Chak Ho

City University of Hong Kong

Ning Sheng

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhe Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhiwei Xu

Griffith University

Ning Wang

First Affiliated Hospital of Jiangxi Medical College

Qiuyan Zhu

Yunnan Center for Disease Control And Prevention

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Institute of High Energy Physics

243

Chinese Academy of Sciences

123

University of Chinese Academy of Sciences

Anhui Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

China Center of Advanced Science and Technology

Shanghai Jiao Tong University

Zhejiang University

Peking University

University of Science and Technology of China

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Performance of HDL-C measurements assessed by a 4-year trueness-based EQA/PT program in China

Clinical Chemistry and Laboratory Medicine (CCLM) (2022)

Weiyan Zhou Wenbo Luo Songlin Yu Hongxia Li Donghuan Wang

Abstract Objectives A trueness-based EQA/PT program for high density lipoprotein cholesterol (HDL-C) was initiated. We analyzed the 4 year EQA/PT program to overview the measurement standardization for HDL-C in China. Methods Two levels of freshly frozen, commutable serum external quality assessment/proficiency testing (EQA/PT) materials were prepared and determined by reference measurement procedure each year. The samples were delivered to clinical laboratories and measured 15 times in 3 days. The precision [coefficient of variation (CV)], trueness (bias), and accuracy [total error (TE)] were calculated and used to evaluate measurement performance. The pass rates of individual laboratories and peer groups were analyzed using the acceptable performance from the National Cholesterol Education Program (NCEP) and biological variation as the evaluation criteria. Results More than 60% of laboratories use heterogeneous systems, and there was a decrease in the percentage from 2016 to 2019. About 95, 78, and 33% of laboratories met the minimum, desirable and optimum TE criteria derived from biological variation. The pass rates were 87.0% (84.7–88.8%), 58.7% (55.3–62.4%), and 97.3% (95.6–98.3%) that met the acceptable performance of TE, bias, and CV of NCEP. The homogeneous systems had higher pass rates of TE, bias, and CV than the heterogeneous groups in 2016, but they did not show apparent advantages in 2017–2019. Conclusions The trueness-based EQA/PT program can be used to evaluate the accuracy, reproducibility, and trueness of results. For some IVD manufacturers and individual laboratories, accuracy, especially trueness, are still problems. Efforts should be made to improve the situation and achieve better HDL-C measurement standardization.

Coefficient of variation

10.1515/cclm-2020-0658

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Citations (2)

TS-TCD: Triplet-Level Cross-Modal Distillation for Time-Series Forecasting Using Large Language Models

arXiv (Cornell University) (2024)

Pengfei Wang Hao Zheng Silong Dai Wenjing Yue Wei Zhu

In recent years, large language models (LLMs) have shown great potential in time-series analysis by capturing complex dependencies and improving predictive performance. However, existing approaches often struggle with modality alignment, leading to suboptimal results. To address these challenges, we present a novel framework, TS-TCD, which introduces a comprehensive three-tiered cross-modal knowledge distillation mechanism. Unlike prior work that focuses on isolated alignment techniques, our framework systematically integrates: 1) Dynamic Adaptive Gating for Input Encoding and Alignment}, ensuring coherent alignment between time-series tokens and QR-decomposed textual embeddings; 2) Layer-Wise Contrastive Learning}, aligning intermediate representations across modalities to reduce feature-level discrepancies; and 3) Optimal Transport-Driven Output Alignment}, which ensures consistent output predictions through fine-grained cross-modal alignment. Extensive experiments on benchmark time-series datasets demonstrate that TS-TCD achieves state-of-the-art results, outperforming traditional methods in both accuracy and robustness.

10.48550/arxiv.2409.14978

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Observation of a Broad1--Resonant Structure around1.5 GeV/c2in the Physical Review Letters (2006)

F. De Mori J. Z. Bai Y. Ban X. Cai H. F. Chen

A broad peak is observed at low K+K− invariant mass in J/ψ→K+K−π0 decays found in a sample of 5.8×107 J/ψ events collected with the BESII detector. The statistical significance of the broad resonance is much larger than 5σ. A partial wave analysis shows that the JPC of this structure is 1--. Its pole position is determined to be [1576−55+49(stat)−91+98(syst)] MeV/c2−i2[818−23+22(stat)−133+64(syst)] MeV/c2. These parameters are not compatible with any known meson resonances.Received 21 June 2006DOI:https://doi.org/10.1103/PhysRevLett.97.142002©2006 American Physical Society

10.1103/physrevlett.97.142002

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Citations (40)

Proteomics Profiling of Plasma Exosomes in VKH Patients

Current Molecular Medicine (2020)

Hao Zheng Fuhua Yang Vicki Ea Lei Zhou Lingzi Wu

Vogt-Koyanagi-Harada syndrome is common autoimmune uveitis that can cause blindness. Recent studies have shown that plasma exosomes carry disease-related proteins that may serve as biomarkers. Here, we aimed to find candidate biomarkers of Vogt-Koyanagi-Harada disease using proteomic analysis of plasma exosomes.Exosomes were isolated from the plasma of normal controls and Vogt- Koyanagi-Harada patients in the following groups: a) initial inflammatory attack (active stage), b) remission after one month of treatment (unstable stage), and c) stationary phase after three months of treatment (stable stage). Groups were analyzed by mass spectrometry using isobaric tags for relative and absolute quantitation. After functional analysis, proteins of interest were verified by ELISA.463 proteins were identified in the exosomes. Forty-three were upregulated at the active inflammation stage, including inflammation-associated proteins. Thirty-one were downregulated. Gene ontology and pathway analyses revealed differential proteins related to cell adhesion, cell phagocytosis, cytoskeleton movement, leukocyte migration across endothelial cells, and platelet activation. By ELISA, Carbonic anhydrase 2 and Ras-related protein Rap-1b were verified as more plentiful at the active stage compared to the normal control and stationary phase in exosomes, but not, however, in microvesicles or plasma.Plasma exosomes of Vogt-Koyanagi-Harada patients contain many proteins related to the degree of inflammation. The levels of Carbonic anhydrase 2 and Ras-related protein Rap-1b in exosomes can be used as biomarkers for active inflammation in Vogt-Koyanagi-Harada disease. Further investigation could help study the pathogenesis of Vogt-Koyanagi-Harada disease and identify therapeutic targets.

Pathogenesis

Proteome

Vogt–Koyanagi–Harada disease

10.2174/1566524020666200719021653

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Citations (8)

Lipoprotein proteome profile: novel insight into hyperlipidemia

Clinical and Translational Medicine (2021)

Miao Lin Menglin Li Hao Zheng Haidan Sun Jinlan Zhang

Hyperlipidemia

Proteome

10.1002/ctm2.361

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Citations (7)

Quantitative Proteomics and Targeted Fatty Acids Analysis Reveal the Damage of Triptolide in Liver and Kidney

PROTEOMICS (2017)

Menglin Li Ting Hu Cai Tie Liang Qu Hao Zheng

Abstract Triptolide (TP), the major active component in Tripterygium wilfordii Hook. f., is widely used for the treatment of rheumatoid arthritis and autoimmune diseases. However, organ toxicity, especially hepatotoxicity and nephrotoxicity, limits its clinical application. To fully understand the mechanism underlying TP toxicity, iTRAQ‐based 2D‐LC‐MS/MS proteomics is used to detect differentially expressed proteins in the livers and kidneys of mice administered the LD50 dose of TP. Functional annotation revealed that multiple pathways are involved in TP toxicity, including acute‐phase response signaling, the antigen presentation pathway, FXR/RXR activation, LPS/IL‐1‐mediated inhibition of RXR function, and EIF2 signaling. Members of the cytochrome P450 protein family that are involved in fatty acid (FA) metabolism, such as CYP2E1, show significant differences in expression among groups. Additionally, the proteomics data suggested that FAs are involved in TP‐induced toxicity. FA analysis is conducted using HPLC‐MRM to characterize the differences among various groups exposed to TP for different times. It has been found that 20 FAs in the liver show significant differences in abundance among groups, whereas in the kidneys, six FAs show significant differences in abundance. By integrating the proteomic and targeted FA analyses, it has been found that differently expressed proteins and FAs both participate in pathways including cellular lipolytic activity, peroxisomal fatty acid beta‐oxidation, and so on. Our data contribute to understanding the mechanisms underlying TP‐induced organ toxicity. The results may help to improve the clinical efficacy and safety of TP in the future.

Triptolide

Toxicogenomics

Fatty Acid Metabolism

Tripterygium wilfordii

Nephrotoxicity

Biological pathway

10.1002/pmic.201700001

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Citations (22)

Identification of chemicals and rat metabolites of Biqi capsule by liquid chromatography-tandem mass spectrometry following a network pharmacological analysis

International Journal of Mass Spectrometry (2018)

Hao Zheng Zhe Wang Wenwei Liu Tiankun Ren Jinlan Zhang

Capsule

10.1016/j.ijms.2018.09.021

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Altered Blood Oxygen Level-Dependent Signal Stability in the Brain of Patients with Major Depressive Disorder Undergoing Resting-State Functional Magnetic Resonance Imaging

Neuropsychobiology (2024)

Hao Zheng Siyu Fan Xiaonan Pang Qiang Wei Yue Wu

Introduction: Major depressive disorder (MDD) is a common, relapse-prone psychiatric disorder with unknown pathogenesis. Previous studies on resting-state functional magnetic resonance imaging of MDD have mostly focused on the spontaneous activity of blood oxygen level-dependent (BOLD) signals; however, a few studies have investigated BOLD signal stability. Methods: We conducted a resting-state functional study in 42 patients with MDD and 42 healthy controls (HC) matched for age and sex. This included the BOLD signal stability, resting-state functional connectivity (RSFC) analysis, correlation analysis, and support vector machine (SVM) analysis. Results: The BOLD signal stability of the left fusiform gyrus, right inferior temporal gyrus, right temporal pole superior temporal gyrus, and left thalamus was significantly lower in the MDD group compared to the HC group. Further RSFC analysis revealed that the connectivity between right inferior temporal gyrus and both left inferior temporal gyrus and left supramarginal gyrus was significantly reduced in the MDD group. Additionally, the RSFC levels of left thalamus and right thalamus were decreased. Combining BOLD signal stability and RSFC, the SVM-based classification model achieved an accuracy of 80.95% (sensitivity: 78.57%; specificity: 83.33%; receiver-operating characteristic area under the curve: 0.8793). Conclusion: The integration of the BOLD signal stability index and RSFC index demonstrates a robust capability to differentiate between individuals with MDD and HC subjects. We tentatively believe that a combination of the BOLD signal stability index and RSFC can be used to diagnose MDD.

Blood-oxygen-level dependent

Gyrus

10.1159/000541720

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Observation of a Threshold Enhancement in thepΛ¯Invariant-Mass Spectrum

Physical Review Letters (2004)

F. De Mori J. Z. Bai Y. Ban J. G. Bian X. Cai

An enhancement near the mp+MΛ mass threshold is observed in the combined pΛ¯ and p¯Λ invariant-mass spectrum from J/ψ→pK−Λ¯+c.c. decays. It can be fit with an S-wave Breit-Wigner resonance with a mass m=2075±12(stat)±5(syst) MeV and a width of Γ=90±35(stat)±9(syst) MeV; it can also be fit with a P-wave Breit-Wigner resonance. Evidence for a similar enhancement is also observed in ψ′→pK−Λ¯+c.c. decays. The analysis is based on samples of 5.8×107J/ψ and 1.4×107ψ′ decays accumulated in the BES II detector at the Beijing Electron-Positron Collider.Received 19 May 2004DOI:https://doi.org/10.1103/PhysRevLett.93.112002©2004 American Physical Society

10.1103/physrevlett.93.112002

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Citations (54)

Chemoproteomics identifies Ykt6 as the direct target of schisandrin A for neuroprotection

Chinese Chemical Letters (2022)

Tiantian Wang Yu Zhou Hao Zheng Tao Shen Dongmei Wang

10.1016/j.cclet.2022.107887

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Citations (1)