Hong Zhang

Jilin University

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Ling Zhang

Peking University

Bin Jiang

Xiamen University

Jiaqi Yang

Shanxi University of Traditional Chinese Medicine

Yanfeng Sun

Qingdao University of Science and Technology

Geyu Lu

State Key Laboratory on Integrated Optoelectronics

Huimin Li

Qinghai University

Masanori Ichihashi

National Institutes for Quantum and Radiological Science and Technology

Keisuke Takahata

National Institutes for Quantum and Radiological Science and Technology

Yuko Kataoka

National Institutes for Quantum and Radiological Science and Technology

Ke Zhuang

First People's Hospital of Yunnan Province

Cooperative Institutions

National Institutes for Quantum and Radiological Science and Technology

John Wiley & Sons (United States)

Hudson Institute

Jilin University

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Kunming University of Science and Technology

State Key Laboratory on Integrated Optoelectronics

Nanjing Medical University

Sun Yat-sen University

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Sn4+ Doping Zno Gas Sensor Based on Mesoporous Hierarchical Structure for Acetone and Ethanol Selective Detection

Hong Zhang Ling Zhang Jiaqi Yang Bin Jiang Yanfeng Sun

10.2139/ssrn.4899166

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Formulation and efficacy of gel bait against cockroaches

Hong Zhang

Objective To develop an effective,hypo-toxic,non-contaminative gel bait against cockroaches. Methods The indoor effect were tested with related national standard.Results The gel bait had good stability and palatability.The LT50 for Blattella germanica was 1.34 d,and the mortality was above 92% within 4 days.The efficacy could last for 30 to 60 days.Conclusion The gel bait was effective with lasting effect and easy to be used.

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Development and Performance Assessment of a Novel Plasma p-Tau181 Assay Reflecting Tau Tangle Pathology in Alzheimer’s Disease

medRxiv (Cold Spring Harbor Laboratory) (2023)

Kenji Tagai Harutsugu Tatebe Sayo Matsuura Hong Zhang Naomi Kokubo

Abstract Several blood-based assays for phosphorylated tau (p-tau) have been developed to detect brain tau pathologies in Alzheimer’s disease (AD). However, plasma p-tau measured by currently available assays is influenced by brain amyloid and, therefore, could not accurately reflect brain tau deposits. Here, we devised a novel immunoassay that can quantify N- and C-terminally truncated p-tau fragments (mid-p-tau181) in human plasma. We measured plasma p-tau181 levels in 164 participants who underwent both amyloid and tau positron emission tomography (PET) scans using mid-p-tau181 and conventional p-tau181 assays. The mid-p-tau181 assay displayed stronger correlations with tau PET accumulation than the conventional assay in the AD continuum and accurately distinguished between tau PET-positive and -negative cases. Furthermore, the mid-p-tau181 assay demonstrated a trajectory similar to tau PET alongside cognitive decline. Consequently, our mid-p-tau181 assay could be useful in evaluating the extent of brain tau burden in AD.

Tangle

Tau Pathology

Amyloid (mycology)

10.1101/2023.09.15.23295595

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Graphene Quantum Dots Modulate Stress Granule Assembly and Prevent Abnormal Phase Transition of Fused in Sarcoma Protein

ACS Nano (2023)

Hong Zhang Jinge Gu Yiling Zhang Huazhang Guo Shengnan Zhang

Protein liquid–liquid phase separation (LLPS) plays a crucial role in mediating dynamic assembly of different membraneless organelles such as stress granules (SGs). Dysregulation of dynamic protein LLPS leads to aberrant phase transition and amyloid aggregation which is closely associated with neurodegenerative diseases. In this study, we found that three types of graphene quantum dots (GQDs) exhibit potent activity in preventing SG formation and promoting SG disassembly. We next demonstrate that GQDs can directly interact with the SGs-containing protein fused in sarcoma (FUS), inhibit and reverse FUS LLPS, and prevent its abnormal phase transition. Moreover, GQDs display superior activity in preventing amyloid aggregation of FUS and disaggregating preformed FUS fibrils. Mechanistic study further demonstrates that GQDs with different edge-site exhibit distinct binding affinity to FUS monomers and fibrils, which accounts for their distinct activities in modulating FUS LLPS and fibrillation. Our work reveals the potent capability of GQDs in modulating SG assembly, protein LLPS, and fibrillation and sheds light on rational design of GQDs as effective modulators of protein LLPS for therapeutics application.

Stress granule

Organelle

10.1021/acsnano.3c00001

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Citations (22)

Cavernous hemangioma in retropubic space: a case report

Chin J Med Ultrasound(Electronic Edition) (2016)

Lanyan Qiu Hong Zhang

10.3877/cma.j.issn.1672-6448.2016.09.017

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Endogenous orbital cellulitis and endophthalmitis induced by Klebsiella can be the first sign of pyaemia origined from not healing cellulitis of groin.

Journal of Pure and Applied Microbiology (2013)

Wensong Zhang Hao Ji-long Hong Zhang Shuyan Gu Hongyan Zhou

Groin

Orbital cellulitis

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Observation of Clinical Efficacy of 32P Applicator Combined with Carteolol Hydrochloride Eye Drops Treatment on Infantile Superficial Hemangiomas

Journal of Sun Yat-sen University (2016)

Fang Fěng Liang Jiu gen Lu Ping Sheng Liu Jiang Ning yi

Hydrochloride

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Laboratory diagnosis of infectious endophthalmitis.

PubMed (2011)

Wenjiang Ma Hong Zhang Shaozhen Zhao

To analyze the lab diagnosis and etiology of infectious endophthalmitis.The medical and microbial records of 36 patients diagnosed with infectious endophthalmitis and 8 patients diagnosed with intraocular lens (IOL)-related inflammation between Nov. 1999 and Dec. 2009 were retrospectively reviewed for lab diagnosis and etiology.The inflammatory cell counts in all aqueous humor specimens from infectious endophthalmitis patients were more than in all aqueous humor specimens from patients with IOL-related inflammation. Sixteen of the 36 aqueous humor samples (44.4%) and 11 of the 24 vitreous humor samples (45.8%) from infectious endophthalmitis patients showed positive results in smears; while 17 aqueous humor samples (47.2%) and 15 vitreous humor samples (62.5%) from infectious endophthalmitis patients showed positive results in culture.The inflammatory cell count may be an important index for infectious endophthalmitis; while, smears can show etiological information earlier.

Etiology

Aqueous humour

Infectious agent

10.3980/j.issn.2222-3959.2011.01.23

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Citations (7)

Analysis of clinical features and imagines in orbital lymphoma

Chinese Journal of Practical Ophthalmology (2010)

Dong Wang Hong Zhang Guo-xiang Song

Objective To investigate the value of ultrsonography,colour doppler image,CT and MRI on diagnosis and differential diagnosis of orbital lymphoma.Methods The clinical and imageologic features of 53 cases(56 eyes)orbital lymphoma were analyzed.Results Any part of orbits could be involved.Most cases showed orbital masses,limitation of ocular movement.Some cases were with visual loss,conjunctiva and lid swelling and exophthalmos.Fifty-three cases(56 eyes)with B-scan ultrasonography revealed irregular shape in 42 eyes,less reflective in 42 eyes,uniformed reflective in 31 eyes,eyeballs were compressed in 11 eyes.Forty cases(43 eyes)of orbital lymphoma were detected with CDI,in which rich blood flow signal were showed in 19 eyes,less blood flow signal in 14 eyes.CT scan were done in 49 cases(52 eyes),in which,showed irregular shape in 41 eyes,regular border in 34 eyes,uniform density in 29 eyes,touched closely with the globe in 25 eyes,orbital walls showed bone dystrophy in 3cases.Fifteen cases(15 eyes)were examined with MRI,11 cases showed isointensity signal on TIWI,slight hyperintense signal in T2WI.Six cases were enhanced moderately by GPDA.Conclusions Clinical and imageologic feature are valuable on the diagnosis and differential diagnosis of orbital lymphoma. Key words: Orbital; Lymphoma; Clinical; Imaging; Diagnosis

Exophthalmos

10.3760/cma.j.issn.1006-4443.2010.06.020

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Effects of Diammonium Phosphate on Free Nicotine Release in Smoke and Sensory Quality of Cigarette

Tobacco Science & Technology (2014)

Hong Zhang Zhihua Liu Xiaoxi Si Fan Ying Kai Wang

Diammonium phosphate

10.16135/j.issn1002-0861.20151106

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