Yifan Jiang

First Affiliated Hospital Zhejiang University

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Feng Zhu

University of British Columbia

Shusen Zheng

National Clinical Research Center for Digestive Diseases

Peng Guo

First Affiliated Hospital of Xi'an Jiaotong University

Shengguo Xue

Shaanxi University of Science and Technology

Jianbin Ma

Qujiang People's Hospital

Kaihua Xue

First Affiliated Hospital of Xi'an Jiaotong University

Jiawei Hong

Zhejiang University

Ji‐Yu Bai

First Affiliated Hospital of Xi'an Jiaotong University

Feng Li

Beijing Forestry University

Linping Cao

Zhejiang University

Cooperative Institutions

Zhejiang University

First Affiliated Hospital Zhejiang University

Blood Center of Zhejiang Province

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Central South University

First Affiliated Hospital of Xi'an Jiaotong University

Peking Union Medical College Hospital

Ministry of Education of the People's Republic of China

Sun Yat-sen University

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Validation the DNA Methylation Landscape of TFF1/TFF2 in Gastric Cancer

Ze Qian Yifan Jiang Chunhui Shou Jinghua Yu Dongdong Huang

Gastric cancer (GC) is one of the most common malignancies around the world, and the incidence of GC is increasing in the past decades. In addition to genetic modifications, epigenetic alterations catalyzed by DNA methyltransferases (DNMTs) are a well-characterized epigenetic hallmark in gastric cancer. Nowadays, DNA methylation landscape is essential for maintaining the silence of tumor suppressor genes (TSGs). As an important group of peptide, TFF family has been confirmed to function as a TSG in various kinds of cancers. However, whether TFFs could be modified by DNA methylation in gastric cancer remains unknown. In this study, we initially screened out two expression profiles about GC from Gene Expression Omnibus (GEO) database. The higher expressions of TFF1 and TFF2 were observed in GC tumor tissues than normal tissues. Additionally, we illustrated that the expressions of TFF1/TFF2 were associated to the overall survival (OS) and tumor free survival (TFS) of GC patients via through the Kaplan-Meier analysis. Subsequently, the integrative analysis was performed to estimate the DNA methylation level of each site in TFF1/TFF2 CpG islands. Importantly, our findings indicated that hyper-methylation of cg01886855 and cg26403416 were separately responsible for the downregulation of TFF1 and TFF2 in GC samples. Besides, utilizing the gain of function assay, we demonstrated that TFF1/TFF2 could suppress the proliferation of GC cells. Based on these results, We identified that TFF1 and TFF2 acted as the putative tumor suppressors in gastric cancer, which suggested that TFFs could be two candidate biomarkers for predicting tumor recurrence in gastric cancer patients. Furthermore, these findings highlight a potential therapeutic approach in targeting the TFFs for the treatment of gastric cancer.

CpG site

DNA methyltransferase

10.20944/preprints202210.0305.v1

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Principles and Practices of Effective Food Safety Risk Communication – Introducing the Asia-Pacific Economic Cooperation Food Safety Risk Communication Framework

European Journal of Nutrition & Food Safety (2023)

Hong Jin Lateef Adewoye Eleonora Dupouy Jun Cheng Er Frank Geraghty

This paper describes the principles and practices of effective food safety risk communication developed under the “Asia-Pacific Economic Cooperation Food Safety Risk Communication Framework and Associated Guidelines”. The framework recommends that effective food safety risk communication needs to be centered on the clear goal of protecting consumer health by ensuring transparency and timeliness, and communication on food safety matters should be conducted in a two-way process. It emphasizes the need to provide the public with credible information based on science and evidence and highlights that food safety is a shared responsibility among all stakeholders, including industry, government agencies, media organizations and consumers. It further highlights that food safety risk communication needs to be conducted in a consistent, systematic, inclusive, consultative, and preventative manner. The framework also indicates that effective food safety risk communication needs to pay attention to the backgrounds, experiences, and needs of concerned audiences. It stresses the importance of continuous improvement of the communication system to ensure food safety risk communication to be effective. Focusing on effective communications in response to food safety incidents, emergency or crisis situations, as well as everyday food safety communications, these principles and practical guidelines will help food safety regulators, food industry, food safety educators and other stakeholders improve their communications with target audiences.

Risk Communication

10.9734/ejnfs/2023/v15i81324

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Intracellular Metabolomics Switching Alters Extracellular Acid Production and Insoluble Phosphate Solubilization Behavior in Penicillium oxalicum

Metabolites (2020)

Yifan Jiang Fei Ge Feng Li Dayi Zhang Songqiang Deng

This research aims to understand the precise intracellular metabolic processes of how microbes solubilize insoluble phosphorus (Insol-P) to increase bio-available P. Newly isolated Penicillium oxalicum PSF-4 exhibited outstanding tricalcium phosphate (TP) and iron phosphate (IP) solubilization performance—as manifested by microbial growth and the secretion of low-molecular-weight organic acids (LMWOAs). Untargeted metabolomics approach was employed to assess the metabolic alterations of 73 intracellular metabolites induced by TP and IP compared with soluble KH2PO4 in P. oxalicum. Based on the changes of intracellular metabolites, it was concluded that (i) the enhanced intracellular glyoxylate and carbohydrate metabolisms increased the extracellular LMWOAs production; (ii) the exposure of Insol-P poses potential effects to P. oxalicum in destructing essential cellular functions, affecting microbial growth, and disrupting amino acid, lipid, and nucleotide metabolisms; and (iii) the intracellular amino acid utilization played a significant role to stimulate microbial growth and the extracellular LMWOAs biosynthesis.

10.3390/metabo10110441

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Identification, Biological Characteristics of Pestalotiopsis diospyri and Its Sensitivity to Fungicides

Journal of Biobased Materials and Bioenergy (2022)

Yiming Zhang Yifan Jiang Yonghong He

Persimmon canker disease on stems caused by pathogens affects its growth and yield, leads to economic losses, thus it is important to investigate the pathogen in detail to find an effective control method. In this paper, samples from diseased persimmon trees in Yunnan were collected to isolate and purify the pathogen, and its biological characteristics were studied. In detail, its morphology was observed and molecular identified. The effects of different carbon and nitrogen sources, temperature, pH and light condition on its growth were analyzed, and the toxicities of 6 fungicides to the pathogen were compared. In the results, the pathogens were identified as Pestalotiopsis diospyri , the optimum conditions for its mycelium growth were on persimmon stem decoction medium, temperature 30 °C, light illumination for 24 h and pH at 4. The most suitable carbon and nitrogen sources were glucose and sodium nitrate, respectively. The sensitivity test of six fungicides to P. diospyri showed different degrees, the EC 50 values of tebuconazole, azoxystrobin, chlorothalonil, difenoconazole, prochloraz, and carbendazim were 0.212, 0.313, 4.921, 0.552, 0.035 and 6.175 μ g/mL, respectively, revealing that P. diospyri was the most sensitive to prochloraz. In conclusion, P. diospyri grow fastest in acidic and well-lit environments, and prochloraz can be used as a protential fungicide for the treatment and prevention of the disease. This paper provides a theoretical basis for further research and field experiment.

Tebuconazole

Pestalotiopsis

Chlorothalonil

Canker

10.1166/jbmb.2022.2169

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Characterization of Volatile Constituents from the Flowers and Leaves of Ailanthus altissima by Dynamic Head-Space Collection/GC-MS

Asian Journal of Chemistry (2014)

Yifan Jiang Jiayan Ye Bao Jiang

Ailanthus altissima

10.14233/ajchem.2014.16665

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Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect

Figshare (2023)

Kaihua Xue Yifan Jiang Ji‐Yu Bai Dize Zhang Yuhang Chen

Metabolic alteration drives renal cell carcinoma (RCC) development, while the impact of melatonin (MLT), a neurohormone secreted during darkness, on RCC cell growth and underlying mechanisms remains unclear. We detected concentration of metabolites through metabolomic analyses using UPLC-MS/MS, and the oxygen consumption rate was determined using the Seahorse Extracellular Flux analyzer. We observed that MLT effectively inhibited RCC cell growth both in vitro and in vivo. Additionally, MLT increased ROS levels, suppressed antioxidant enzyme activity, and induced apoptosis. Furthermore, MLT treatment upregulated key TCA cycle metabolites while reducing aerobic glycolysis products, leading to higher oxygen consumption rate, ATP production, and membrane potential. Moreover, MLT treatment suppressed phosphorylation of Akt, mTOR, and p70 S6 Kinase as well as the expression of HIF-1α/VEGFA in RCC cells; these effects were reversed by NAC (ROS inhibitors). Conversely, MLT synergistically inhibited cell growth with sunitinib and counteracted the Warburg effect induced by sunitinib in RCC cells. In conclusion, our results indicate that MLT treatment reverses the Warburg effect and promotes intracellular ROS production, which leads to the suppression of Akt/mTOR/S6K signaling pathway, induction of cell apoptosis, and synergistically inhibition of cell growth with sunitinib in RCC cells. Overall, this study provides new insights into the mechanisms underlying anti-tumor effect of MLT in RCC cells, and suggests that MLT might be a promising therapeutic for RCC.

Reversing

Warburg Effect

10.6084/m9.figshare.24049798

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PFOS and Its Commercial Alternative, 6:2 Cl-PFESA, Induce Multidrug Resistance in Pancreatic Cancer

Environmental Science & Technology (2024)

Jiawei Hong Keyi Du Weichen Zhang Yifan Jiang Hanxi Yu

Per- and polyfluoroalkyl substances (PFAS), specifically perfluorooctanesulfonate (PFOS) and its alternative, 2-[(6-chloro-1,1,2,2,3,3,4,4,5,5,6,6-dodecafluorohexyl)oxy]-1,1,2,2-tetrafluoroethanesulfonic acid (6:2 Cl-PFESA), are associated with environmental health concerns and potential cancer progression. However, their impact on multidrug resistance (MDR) in pancreatic cancer (PC) chemotherapy remains unclear. Here, we employed drug-sensitivity assays, including IC

10.1021/acs.est.4c08669

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New Insight into Carboxylic Acid Metabolisms and pH Regulations During Insoluble Phosphate Solubilisation Process by Penicillium oxalicum PSF-4

Current Microbiology (2020)

Yifan Jiang Jiang Tian Fei Ge

Malic acid

Oxalic Acid

Gluconic acid

Organic acid

10.1007/s00284-020-02238-2

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Citations (30)

ST6GALNAC4 promotes hepatocellular carcinogenesis by inducing abnormal glycosylation

Journal of Translational Medicine (2023)

Da Man Yifan Jiang Deguo Zhang Jingjing Wu Bo Ding

Abstract Hepatocellular carcinoma (HCC) is one of the most lethal tumor types worldwide. Glycosylation has shown promise in the study of tumor mechanisms and treatment. The glycosylation status of HCC and the underlying molecular mechanisms are still not fully elucidated. Using bioinformatic analysis we obtained a more comprehensive characterization of glycosylation of HCC. Our analysis presented that high glycosylation levels might correlate with tumor progression and poor prognosis. Subsequent Experiments identified key molecular mechanisms for ST6GALNAC4 promoting malignant progression by inducing abnormal glycosylation. We confirmed the contribution of ST6GALNAC4 to proliferation, migration, and invasion in vitro and in vivo. Mechanistic studies revealed that ST6GALNAC4 may be induced abnormal TGFBR2 glycosylation, resulting in the higher protein levels of TGFBR2 and TGF $$\beta$$ β pathway increased activation. Our study also provided a further understand of immunosuppressive function of ST6GALNAC4 through T antigen-galectin3+ TAMs axis. This study has provided one such possibility that galectin3 inhibitors might be an acceptable treatment choice for HCC patients with high T antigen expression.

Tumor progression

N-linked glycosylation

10.1186/s12967-023-04191-7

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Ca-driven stable regulatory of alkalinity within desilication products: Experimental, modeling, transformation mechanism and DFT study

The Science of The Total Environment (2023)

Yujun Wu Dandan Deng Jun Jiang Feng Li Jiaqing Zeng

Sodalite

Alkalinity

Sodium aluminosilicate

Calcium aluminosilicate

10.1016/j.scitotenv.2023.161708

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Citations (20)