Jun Dong

First Affiliated Hospital of Chongqing Medical University

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Hugh Calkins

Johns Hopkins Medicine

Darshan Dalal

AstraZeneca (Japan)

Ronald D. Berger

Johns Hopkins Hospital

Joseph E. Marine

Johns Hopkins Medicine

Ke Wei

First Affiliated Hospital of Chongqing Medical University

Huan Meng

NOAA National Environmental Satellite Data and Information Service

Alan Cheng

McMaster University

Saman Nazarian

Hospital of the University of Pennsylvania

Ralph Ferraro

University of Maryland, College Park

David Spragg

Johns Hopkins University

Cooperative Institutions

Johns Hopkins University

Johns Hopkins Medicine

Chongqing Medical University

Chinese Academy of Sciences

First Affiliated Hospital of Chongqing Medical University

Capital Medical University

Johns Hopkins Hospital

Sun Yat-sen University

University of Maryland, Baltimore

Technical University of Munich

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Long‐Term Safety and Efficacy of Circumferential Ablation with Pulmonary Vein Isolation

Journal of Cardiovascular Electrophysiology (2006)

Aamir Cheema Jun Dong Darshan Dalal Chandrasekhar R. Vasamreddy Joseph E. Marine

Background: Each of the two main approaches to catheter ablation of atrial fibrillation (AF, segmental and circumferential) is associated with moderate long‐term efficacy. Objective: To report the long‐term outcomes of a modified technique that combines circumferential ablation with pulmonary vein (PV) isolation, determined by a circular mapping catheter and to determine the relationship between complete PV isolation and long‐term efficacy. Methods: The patient population was composed of 64 consecutive patients (47 men [73%]; age 59 ± 11 years) with AF who underwent catheter ablation. AF was paroxysmal in 29 (45%) and nonparoxysmal in 35 (55%). Each patient was followed for a minimum of 12 months. Results: After a mean follow‐up of 13 ± 1 months, the long‐term single‐procedure success rate was 45% (n = 29) with an additional 4% (n = 3) of patients demonstrating improvement. With repeat procedures in 19 patients, the overall long‐term success rate was 62% (n = 40) with 9% (n = 6) demonstrating improvement. All the patients who underwent repeat ablations had recovered PV conduction. Incomplete PV isolation was the only independent predictor of failure. A major complication occurred in four (6%) patients, including three patients with vascular complications and one with cardiac tamponade. Conclusion: Our results suggest that the long‐term single‐procedure efficacy of circumferential ablation with PV isolation in a cohort of patients with predominantly nonparoxysmal AF approaches 50%. Repeat procedures involving re‐isolation of the PVs result in a significant improvement in outcomes. Complete electrical isolation of the PVs has a significant impact on the long‐term efficacy of the procedure.

10.1111/j.1540-8167.2006.00569.x

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Subanesthetic Dose of Ketamine Administered Before Each Electroconvulsive Therapy Session Improves Antidepressant and Sleep Quality Outcomes

Journal of Ect (2023)

Jun Dong Su Min Qibing Chen Haitang Qiu Li Ren

The main purpose of this trial is to explore the effects of subanesthetic dose of ketamine on sleep quality and symptoms in patients with major depressive disorder undergoing bitemporal electroconvulsive therapy (ECT).Seventy-one patients with major depressive disorder and sleep disturbance were randomly divided into 2 groups, namely, the ECT without ketamine group (group ES), receiving routine ECT and saline (3 mL) at each ECT session, and the ECT-assisted ketamine group (group KS), which received ECT and ketamine (3 mL) at each ECT session. The 24 Hamilton Depression Rating Scale was used to assess depressive symptoms and the Chinese Pittsburgh Sleep Quality Index was used to evaluate sleep quality.The patients in group KS required shorter ECT treatment sessions. Patients in group ES had lower sleep efficiency, longer sleep latency, and required more sleep medication than patients in group KS at the end of the ECT course.Subanesthetic dose of ketamine improved sleep quality and enhanced ECT therapeutic effects in patients with sleep disturbance.

Sleep

Depression

10.1097/yct.0000000000000938

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Citations (2)

Mars orbit optical remote sensor

CRC Press eBooks (2018)

Qingliang Meng Da Wang Jun Dong

The high- and medium-resolution integrated stereo camera (HiMeRISC) is a two-component system consisting of a high-resolution camera (HRC) and a medium-resolution stereo camera (MRSC) designed for stereo mapping of the Martian surface and high-spatial-resolution imaging of selected regions. An off-axis three-mirror system is used in the HRC, with a focal length of 5000 mm, a field-of-view of 2° and an F-number of 12.5. Over 10-km-wide areas can be imaged in a resolution of 0.5 m pix-1 (at 300-km orbit altitude by the HRC). The MRSC has a focal length of 32 mm, a field-of-view of 66°, an F-number of 6.8 and a working wavelength range of 450–750 nm. Areas with widths of 250 km can be imaged in a resolution of 50 m pix-1 (at 300-km orbit altitude). MRSC was aligned, and the test results showed good image quality. HiMe-RISC can provide various imaging modes with the combination of the two cameras, and it will be particularly useful in the geological research in Mars-exploring experiments.

Orbit (dynamics)

10.1201/9780429505997-6

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Prospective randomized study comparing amiodarone vs. amiodarone plus losartan vs. amiodarone plus perindopril for the prevention of atrial fibrillation recurrence in patients with lone paroxysmal atrial fibrillation

European Heart Journal (2006)

Yuehui Yin Darshan Dalal Zengchang Liu Jinjin Wu Dong Liu

The purpose of this trial was to compare the long-term efficacy of low-dose amiodarone with losartan and perindopril (both combined with low-dose amiodarone) for the prevention of atrial fibrillation (AF) recurrence in patients with lone paroxysmal AF.One-hundred and seventy-seven patients with lone paroxysmal AF were randomly assigned to three treatment groups: group 1 received low-dose amiodarone alone, group 2 received low-dose amiodarone plus losartan, and group 3 received low-dose amiodarone plus perindopril. Left atrial diameter was measured with transthoracic echocardiogram at baseline and 6, 12, 18, and 24 months after randomization. The primary endpoint was the incidence of AF documented by 12-lead ECG or Holter after 14 days and within 24 months after randomization. The primary endpoint was reached in 24 patients (41%) in group 1, 11 (19%) in group 2, and 14 (24%) in group 3 (P = 0.02). The Kaplan-Meier survival analysis demonstrated a significant reduction in AF recurrence in group 2 (P = 0.006, log-rank test) as well as in group 3 (P = 0.04, log-rank test) when compared with group 1. No difference in the AF recurrence-free survival was found between group 2 and group 3. After 24 months follow-up, the left atrial diameter in group 2 and group 3 was significantly smaller than that in group 1 (36 +/- 2.3 and 35 +/- 2.4 vs. 38 +/- 2.4 mm, P < 0.001 for both comparisons).The results of this study suggest that the combination of perindopril or losartan with low-dose amiodarone is more effective than low-dose amiodarone alone for the prevention of AF recurrence in patients with lone paroxysmal AF. Adding losartan or perindopril to amiodarone can inhibit left atrial enlargement in this group of patients.

Perindopril

Paroxysmal atrial fibrillation

10.1093/eurheartj/ehl135

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Citations (119)

Application of Random forest Algorithm to Detect Snowfall from ATMS Measurements

Vilnius University Proceedings (2020)

Justinas Kilpys Huan Meng Yalei You Jun Dong Ralph Ferraro

10.15388/klimatokaita.2020.37

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Ultrasound-guided Modified Thoracoabdominal Nerve Block for Postoperative Analgesia in Laparoscopic Renal Cyst Decompression: A Randomized Double-blind Controlled Trial

Research Square (Research Square) (2024)

Man Pun Wan Ke Wei Jun Dong Juying Jin Jun Cao

Abstract Background Laparoscopic renal cyst decompression (LRCD) is a common procedure in urology, but postoperative pain remains a significant challenge. While regional nerve blocks provide more targeted pain relief, there is no universally accepted pain management strategy for LRCD. The ultrasound-guided modified thoracoabdominal nerve block (M-TAPA) may offer effective analgesia by blocking the anterior and lateral branches of the intercostal nerves (T5-T12). However, its efficacy in LRCD has not been thoroughly evaluated. Objective This study aimed to assess the efficacy and safety of unilateral M-TAPA in reducing postoperative pain and opioid consumption in patients undergoing LRCD, and to evaluate its potential benefits in enhancing recovery. Methods In this randomized, double-blind, controlled trial, 61 patients undergoing LRCD were assigned to either the M-TAPA group (n = 31) or the Control group (n = 30). The M-TAPA group received ultrasound-guided nerve block, while the Control group received a placebo injection following general anesthesia. Postoperative pain was assessed using the numerical rating scale (NRS) over a 48-hour period. Additional outcomes included opioid consumption and opioid-related side effects, such as nausea and vomiting. Results The M-TAPA group had significantly lower NRS scores at all time points compared to the Control group, with the largest difference observed at 6 hours postoperatively (4.27 ± 0.83 in the Control group vs. 2.19 ± 0.54 in the M-TAPA group). Repeated measures ANOVA revealed a significant interaction between time and treatment (F = 20.813, p < 0.001). Opioid consumption was reduced by 22% in the M-TAPA group over 48 hours (P < 0.001), and the need for antiemetic drugs was significantly lower (P = 0.020). No M-TAPA-related complications were observed. Conclusion M-TAPA was found to be an effective method for reducing postoperative pain and opioid consumption in patients undergoing LRCD.

Placebo-controlled study

10.21203/rs.3.rs-5322411/v1

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Biological variations of serum lipoprotein subfractions and high-density lipoprotein cholesterol esterification rate

Zhonghua jianyan yixue zazhi (2011)

Hanbang Guo Hongxia Li Man Yong Shu Wang Jun Dong

Objective To investigate the biological variations ( CVI,CVG ) of serum high-density (HDL2-C,HDL3-C ) and low-density (LDLa-C,LDLb-C ) lipoprotein subfractions and high-density lipoprotein cholesterol esterification rates (FERHDL and MERHDL ).Methods Twenty healthy volunteers,10 males and 10 females,were recruited for this study from September to October,2010.Blood was collected four times from each individual with a 2-week interval between each sampling.Serum lipoprotein subfraction cholesterol levels were measured by ultracentrifugation/HPLC,FERHDL and MERHDL were measured by HPLC.Within-subject ( CVI) and between-subject ( CVG.) biological variations and quality specifications for precision,bias and total error were calculated.Results The average CVI of this group were 5.5％ and 7.2％ for HDL3-C and HDL2-C,11.2％ and 18.7％ for LDLa-C and LDLb-C,11.95％ and 12.3％ for FERHDL and MERHDL,respectively.The CVG for HDL2-C was 45.5％,much higher than that of HDL3-C (8.7％),and FERHDL(49.5％ ) had a higher CVG than MERHDL (30.6％ ).For each analyte,there was a considerable variation of CVI among individuals.Conclusions Biological variations of lipoprotein subfractions,FERHDI and MERHDL have been estimated.These rsults will play an important role in quality specifications and cardiovascular disease risk assessment. Key words: Lipoproteins, HDL; Lipoproteins, LDL; Cholesterol, HDL; Esterification; Variation(genetics)

High-density lipoprotein

Low-density lipoprotein

Plasma lipoprotein

10.3760/cma.j.issn.1009-9158.2011.12.021

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Effects of the nontourniquet combined with controlled hypotension technique on pain and long-term prognosis in elderly patients after total knee arthroplasty: a randomized controlled study

Journal of Anesthesia (2019)

Jun Dong Su Min Kaihua He Lihua Peng Jun Cao

10.1007/s00540-019-02671-z

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Citations (19)

[Mechanisms of action of transportation of liposomes and chitosan-coated liposomes containing leuprolide across intestine and Caco-2 cell].

PubMed (2005)

Zhixiong Guo Qineng Ping Jun Dong Zhengrong Li Chao‐Jun Li

To investigate the mechanisms of action of transportation of liposomes and chitosan-coated liposomes containing leuprolide across rat intestine and Caco-2 cell.Everted-gut technique and Caco-2 cell were used to study the transport properties of free leuprolide, liposomes and chitosan-coated liposomes containing leuprolide. Caco-2 cell was used to study the effect of chitosan concentration and the order of addition on the permeation of liposomes.The transport of leuprolide was passive diffusion. Probably because the entrapment by liposomes prevents the transport of leuprolide across the rat intestine and Caco-2 cell, the permeation amount of leuprolide from liposomes was lower than that of the free drug. However, liposomes protected the leuprolide from degradation. Chitosan promoted the transport of leuprolide from liposomes and there was no obvious difference in enhancement effect from the concentration of 0.1% to 0.5%. On the other hand, the incubation of chitosan with liposomes may weak the enhancement effect of chitosan.Chitosan-coated liposomes showed both protection and enhancement effect, therefore, they may promote the oral absorption of leuprolide.

Caco-2

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Abnormal Sympathetic Innervation of Viable Myocardium and the Substrate of Ventricular Tachycardia After Myocardial Infarction

Journal of the American College of Cardiology (2008)

Tetsuo Sasano M. Roselle Abraham Kuan‐Cheng Chang Hiroshi Ashikaga Kevin J. Mills

10.1016/j.jacc.2008.02.062

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Citations (171)