Qianqian Duan

Taiyuan University of Technology

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Shengbo Sang

Taiyuan University of Technology

Juanjuan Xue

Taiyuan University of Technology

Boye Zhang

Shanxi Medical University

Pengcui Li

Second Hospital of Shanxi Medical University

Dong Zhao

Taiyuan University of Technology

Wendong Zhang

North University of China

Xing Guo

Taiyuan University of Technology

Muyue Jia

Taiyuan University of Technology

Yuanhang Liu

Taiyuan University of Technology

Xiaoyuan Wang

East China University of Science and Technology

Cooperative Institutions

Biocat

Taiyuan University of Technology

Shanxi Medical University

Second Hospital of Shanxi Medical University

Chinese Academy of Sciences

BridgeBio (United States)

Central South University

Shanghai Jiao Tong University

Huazhong University of Science and Technology

RWTH Aachen University

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Development of a Terrestrial Modeling System: The China-wide Demonstration

AGUFM (2010)

Qianqian Duan Yun-fang Dai Xinli Zheng A. Ye Z. Chen

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A magnetoelastic biosensor based on E2 glycoprotein for wireless detection of classical swine fever virus E2 antibody

Scientific Reports (2017)

Xing Guo Shengbo Sang Jinyu Guo Aoqun Jian Qianqian Duan

A wireless magnetoelastic (ME) biosensor immobilized with E2 glycoprotein was first developed to detect classical swine fever virus (CSFV) E2 antibody. The detection principle is that a sandwich complex of CSFV E2 - rabbit anti-CSFV E2 antibody - alkaline phosphatase (AP) conjugated goat anti-rabbit IgG formed on the ME sensor surface, with biocatalytic precipitation used to amplify the mass change of antigen-antibody specific binding reaction, induces a significant change in resonance frequency of the biosensor. Due to its magnetostrictive feature, the resonance vibrations and resonance frequency can be actuated and wirelessly monitored through magnetic fields. The experimental results show that resonance frequency shift increases with the augmentation of the CSFV E2 antibody concentration. Scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS) and fluorescence microscopy analysis proved that the modification and detection process were successful. The biosensor shows a linear response to the logarithm of CSFV E2 antibody concentrations ranging from 5 ng/mL to 10 μg/mL, with a detection limit (LOD) of 2.466 ng/mL and the sensitivity of 56.2 Hz/μg·mL

10.1038/s41598-017-15908-2

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A New Staining Method Using Different Targeted Fluorescent Carbon Dots For Tissue Sections Analysis and Diagnosis

Qianqian Duan Qingxia Guo Yanfeng Xi Hong Su Juanjuan Xue

Fluorescent staining

10.2139/ssrn.5024739

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A novel flexible Magnetoelastic Biosensor Based on PDMS/FeSiB/QDs composite film for the Detection of African Swine Fever Virus P72 protein

Analytical Methods (2024)

Yuanhang Liu Shengbo Sang Dong Zhao Yang Ge Juanjuan Xue

A novel flexible magnetoelastic biosensor based on PDMS/FeSiB/QDs was proposed to detect the P72 protein of African swine fever virus. The novel assay shows high sensitivity, stability and selectivity for ASFV detection.

10.1039/d4ay01057d

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Highly Stable and Biocompatible CsPbBr₃ Nanocrystals Synthesized by Different Methods for Bioimaging Applications

ACS Applied Nano Materials (2024)

Juanjuan Xue Danyang Chen Huamei Zhang Li Xin Guo Pengcui Li

The low stability and high toxicity of CsPbBr3 perovskite nanocrystals (PNCs) greatly limit their application in the biological field. Here, six different CsPbBr3 PNCs were prepared by ligand-assisted reprecipitation (LARP) and hot injection using oleic acid (OA), oleamine (OAm), (3-Aminopropyl) triethoxysilane (APTES) modification and SiO2 coating, respectively. Different ligands, shells, and synthesis methods give CsPbBr3 PNCs diverse optical properties, stability, and biocompatibility. Among them, OA-OAm-APTES-CsPbBr3@SiO2 has the highest photoluminescence quantum yield (PLQY) (80.74%) and higher stability (fluorescence intensity remains 70% after 15 days in an atmospheric environment). OA-OAm-APTES-CsPbBr3@SiO2 (30 μg/mL) was cocultured with liver cancer cells for 12 h, and the survival rate was 80%, indicating high biocompatibility. Under the observation of the microplate reader, bright green fluorescence appeared in the cytoplasm, indicating that OA-OAm-APTES-CsPbBr3@SiO2 has great application potential in the field of bioimaging.

Biocompatible material

10.1021/acsanm.3c05605

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Heparin detection based on the fluorescent turn-on probe of amino carbon quantum dots

Carbohydrate Research (2021)

Qianqian Duan Muyue Jia Lan Ma Tao Wang Xiaoyuan Wang

Turn (biochemistry)

Carbon fibers

Linear range

Carbon Quantum Dots

10.1016/j.carres.2021.108487

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Study on the photothermal performance of supra-(carbon nanodots) developed with dicyandiamide N-doped

Colloids and Surfaces A Physicochemical and Engineering Aspects (2022)

Qianqian Duan Si Si Shengbo Sang Jialin Wang Boye Zhang

Nanodot

Photothermal effect

10.1016/j.colsurfa.2022.129346

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MicroRNA-1 small nucleic acid drugs attenuate the progression of osteoarthritis by downregulating Indian hedgehog

Research Square (Research Square) (2022)

Pengcui Li Yangyang Gao Hang Wang Xianda Che Lingling Cong

Abstract Objective To verify whether MicroRNA-1 (miR-1) small nucleic acid drugs can delay the progression of osteoarthritis (OA) by downregulating Indian hedgehog (Ihh). Methods Costal chondrocytes were isolated from male Sprague-Dawley rats aged 2–3 days. Second-generation chondrocytes were transfected with miR-1 mimic and empty vector with lipo3000 for 6 h and then stimulated with 10 ng/mL IL-1β for 24 h. OA-related genes and cartilage matrix genes were quantified using real-time quantitative polymerase chain reaction (RT–qPCR). Two-month-old Sprague-Dawley rats were divided into three groups: sham operation group + 50 µL saline, anterior cruciate ligament transection (ACLT) group + 50 µL agomiR-1 small nucleic acid drug, and control group ACLT + 50 µL agomiR-1. Treatment was started one week after the operation. All animals were euthanized eight weeks after the operation. X-rays and CT scans were used to detect imaging changes in the articular cartilage. Safranin O staining was used to detect morphological changes in articular cartilage. Immunohistochemistry was used to detect changes in Col2, Col10, metalloproteinase-13 (MMP-13), and other indicators. RT-qPCR was used to detect changes in indicators such as miR-1, Col2, Col10, MMP-13, Ihh, Smo, Gli1, Gli2, and Gli3. Results Overexpression of miR-1 in IL-1β-stimulated chondrocytes reduced the levels of Ihh, MMP-13, and Col10 but increased the levels of Col2 and aggrecan. Intra-articular injection of miR-1 small nucleic acid drugs reduced osteophyte formation and prevented histological cartilage damage. RT-qPCR results indicated that the miR-1 small nucleic acid drug increased articular cartilage anabolism. Conclusions miR-1 small nucleic acid drugs can delay the progression of OA by downregulating Ihh.

Aggrecan

Indian hedgehog

10.21203/rs.3.rs-1763564/v1

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A global optimization approach for a class of MINLP problems with applications to crude oil scheduling problem

The Journal of Nonlinear Sciences and Applications (2015)

Qianqian Duan Genke Yang Guanglin Xu Xueyan Duan

A global optimization algorithm is proposed to solve the crude oil schedule problem.We first developed a lower and upper bounding model by using a multiparametric disaggregation method.Secondly, the lower and the upper bounding models combined with finite state method (FSM) are incorporated to solve the bilinear programing problem jointly.The advantage of using FSM is that we can generate promising substructure and partial solution.Furthermore, the FSM can guarantee that the entire solution space is uniformly covered.Therefore, the algorithm has better global performance than some existing algorithms.Finally, a real-life crude oil scheduling problem from the literature is used for conducting simulation.The experimental results validate that the proposed method outperforms commercial solvers.

10.22436/jnsa.008.05.22

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Citations (2)

Chidamide, a Novel Histone Deacetylase Inhibitor, Alleviates Renal Fibrosis by Suppressing the Pi3k/Akt Signaling Pathway

Yumei Liu Yanbing Tang Lianghao Mao Xiaowen Huang Cunjin Su

Histone deacetylase inhibitor

HDAC1

10.2139/ssrn.5028378

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