A retrospective analysis of the patients being given Panimun Bioral (microemulsion cyclosporine) after renal transplantation was done at IKRDC, (Institute of Kidney Diseases & Research Centre), Ahmedabad. A total of 21 patients were included for analysis. Patients were evaluated for various parameters e.g. weight, cyclosporine levels, S. Creatinine and BUN at three time schedules as 0 to > or = 30 days, > 30 to > or = 60 days and > 60 to 120 days after renal transplantation. The analysis of data obtained indicates the kidney function tests improved in these patients and therapeutically safe blood cyclosporine levels were achieved in all the three timeschedules.
Introduction: Pancreatic dermoid cyst is a rare, benign germ cell tumour and part of differential diagnosis for cystic neoplasm of pancreas, where it shows a slight preference for the pancreatic head. Case Report: We report a case of dermoid cyst of pancreas in a 17-year-old female patient. Patient presented with epigastric pain, anorexia and lump in epigastric region. CECT showed a well marginated cystic lesion with tiny speck of calcification in wall and fatty component anteriorly in epigastric region in midline and towards right arising from anterior aspect of head of pancreas. The fat planes surrounding the lesion are normal. The CBD was seen lying on posterior aspect of the lesion. Conclusion: Pre-operative diagnosis is difficult and it is usually diagnosed intraoperatively or by histopathological examination of the specimen.
To compare glomerular filtration rate measured by technetium-99m ([Tc99m]) DTPA clearance with estimated creatinine clearance (CrCl) (Cockcroft and Gault (C&G) method) in patients with serum creatinine (Scr) levels <0.06 mmol l−1, and determine the effect of rounding serum creatinine to 0.06 mmol l−1. Patients with serum creatinine values <0.06 mmol l−1 at the time of [Tc99m] clearance determination were identified. Creatinine clearance was calculated by the C&G method using both actual and rounded Scr values. A total of 419 adults had GFR measured by technetium-99m diethyl triamine penta-acetic acid ([Tc99m] DTPA) clearance. Out of this group, 26 patients had a serum creatinine value <0.06 mmol l−1. The C&G estimates of renal function using actual serum creatinine resulted in an overall overestimation of 12.9% when compared to [Tc99m] DTPA clearance. When the value of serum creatinine was rounded to 0.06 mmol l−1, the formula underestimated renal function by −7.0%. Analysis of estimated creatinine clearance for different levels of renal function showed significant differences to [Tc99m] DTPA clearance. Rounding up of serum creatinine to 0.06 mmol l−1 improved the predictive ability of the C&G method for the patients with [Tc99m] DTPA clearance ⩽100 ml min−1, but worsened the effect in those >100 ml min−1. This work indicates that when bedside estimates of renal function are calculated using the C&G formula actual Scr should be used first to estimate CrCl. If the resultant CrCl is ⩽100 ml min−1, then the Scr should be rounded up to 0.06 mmol l−1 and CrCl recalculated. Further assessment of this approach is warranted in a larger cohort of patients.
Abstract Background: Artificial Intelligence (AI) powered tools have transformed the field of healthcare. A recently launched large language model, ChatGPT has gained significant traction due to its communicative interface and relevance of the responses generated. This tool could be utilized in dentistry for dental education, and possibly as a clinical decision support system. Hence, it is imperative to evaluate the accuracy of the model in relation to the responses generated for dental-related queries. Methods: This multi-centric study involved 27 subject experts from nine dental specialties of various institutions and 2 heads of institutions. A total of 243 questions were formulated and the answers generated by ChatGPT (version: 3.5) were rated in terms of accuracy (6-point Likert), completeness (4-point Likert), and relevance (5-point Likert). Results: The mean accuracy of the ChatGPT-generated answers was 4.61 (SD 1.575), with a median of 5.33. For completeness, mean score was 2.01 (SD 0.793), and the median was 2.33. Regarding relevance, a mean of 3.13 (SD 1.590) and median of 3.67 were obtained. The highest ratings were observed for answers related to Oral Medicine and Radiology, as well as for open-ended questions, and questions labelled as easy in terms of difficulty. Conclusion: The promising results observed in the study promote the application of ChatGPT for retrieving dental information. However, it is crucial to exercise caution and seek advice from a qualified healthcare for dental health-related queries. Further large-scale testing of the model is necessary before incorporating it into dental clinical practice.
Background: Diabetic foot ulcer disease is one of the most common complications of diabetes, especially in developing nations like India. Management and successful treatment of diabetic ulcers have been under rigorous research and interventions for the past few decades now. This study is an attempt to analyze the effects of a relatively newer treatment modality for diabetic foot ulcers. Aims and Objectives: The primary objective of this study was to determine results after treating patients of diabetic foot ulcers with local insulin injection therapy and compare with the placebo group after 1 week of treatment. Materials and Methods: In this study, 50 patients with diabetic foot ulcer disease were enrolled, of which 25 patients were randomly selected for the intervention group and the rest were kept in a control group. In the intervention group, patients were treated by injecting insulin preparation at the ulcer site whereas in control group, normal saline was used. Wound assessment was done by measuring the ulcer size and by determining the ankle peak systolic velocity (APSV) using color Doppler technique before and after the treatment in both intervention and control groups. Results: Mean ulcer size before the treatment (7.19 cm2) was higher than post-treatment size (3.48 cm2) and the difference was statistically highly significant (P=0.00) while there was no significant difference in ulcer size post-treatment by insulin or non-insulin (normal saline) group (P=0.274). Mean APSV before the treatment (30.75 cm/s) was lower than post-treatment velocity (43.50 cm/s) and the difference was statistically highly significant (P=0.00) while there was no significant difference in APSV post-treatment by insulin or non-insulin (normal saline) group (P=0.061). Conclusion: It meant that insulin and normal saline were equally effective in reducing ulcer size and improving APSV without being superior to one another.
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