Alberto Bianchi

Azienda Ospedaliera Universitaria Integrata Verona

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Alessandro Antonelli

University of Verona

Matteo Brunelli

University of Verona

Sebastian Gallina

University of Verona

Maria Angela Cerruto

Azienda Ospedaliera Universitaria Integrata Verona

Antonio Benito Porcaro

University of Verona

Alessandro Tafuri

Ospedale Vito Fazzi

Riccardo Rizzetto

Azienda Ospedaliera Universitaria Integrata Verona

Emanuele Serafin

Azienda Ospedaliera Universitaria Integrata Verona

Rossella Orlando

Azienda Ospedaliera Universitaria Integrata Verona

Filippo Migliorini

RWTH Aachen University

Cooperative Institutions

Queen Elizabeth Hospital Birmingham

212

University of Verona

110

Azienda Ospedaliera Universitaria Integrata Verona

European Association of Urology

University of Birmingham

University of British Columbia

Istituti di Ricovero e Cura a Carattere Scientifico

Radboud University Nijmegen

Radboud University Medical Center

University College London

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Oncologic and Safety Outcomes for Retrograde and Antegrade Endoscopic Surgeries for Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-analysis

European Urology Focus (2022)

Ekaterina Laukhtina Tatsushi Kawada Fahad Quhal Takafumi Yanagisawa Paweł Rajwa

Upper urinary tract

10.1016/j.euf.2022.11.014

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Citations (10)

Prognostic impact of palpable prostate tumors on disease progression after robot-assisted radical prostatectomy: a single center experience

Research Square (Research Square) (2023)

Antonio Benito Porcaro Sebastian Gallina Alberto Bianchi Alessandro Tafuri Emanuele Serafin

Abstract Objective: This study aimed to evaluate the impact of palpable prostate tumors on digital rectal exam (DRE) on the disease progression of prostate cancer (PCa) treated with RARP surgery in a tertiary referral center. Materials and methods: Overall 901 patients were evaluated in a period ranging from January 2013 to October 2020. In the surgical specimen, unfavorable pathology included ISUP grade group ≥3, seminal vesicle invasion (SVI), and pelvic lymph node invasion (PLNI). Disease progression was defined as the occurrence of biochemical recurrence and/or local recurrence and/or distant metastases; its association with the primary endpoint was evaluated by Cox’s proportional model. Results: Palpable prostate tumors were detected in 359 (39.8%) patients. The overall median (IQR) follow-up was 40 months (17-59). PCa progressed in 159 cases (17.6%). Nodularity or induration of the prostate at DRE was significantly associated with features of unfavorable pathology, increased risk of PCa progression (hazard ratio, HR=1.902; 95% CI:1.389–2.605; p <0.0001) and, on multivariable analysis, was an independent prognostic factor for disease progression after adjusting for clinical and pathological variables. Conclusions: Prostate tumors presenting with an abnormal DRE finding have an independent adverse outcome for disease progression after PCa surgery. They provide also independent prognostic information, as they may be more aggressive than impalpable PCa.

Biochemical recurrence

Single Center

Lymphovascular invasion

10.21203/rs.3.rs-2693701/v1

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Citations (0)

Understanding biological conservation strategies: a molecular-genetic approach to the case of myrtle (Myrtus communis L.) in two Italian regions: Sardinia and Calabria

Conservation Genetics (2006)

Caterina Agrimonti Roberto Bianchi Alberto Bianchi Mauro Ballero Ferruccio Poli

Myrtus communis

Outcrossing

Myrtaceae

Genetic Variability

10.1007/s10592-006-9177-y

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Citations (41)

Predictors of anastomotic leak and conduit necrosis after oesophagectomy: Results from the oesophago-gastric anastomosis audit (OGAA)

European Journal of Surgical Oncology (2024)

Ewen A. Griffiths James Halle‐Smith Sivesh K. Kamarajah R.P.T. Evans Dmitri Nepogodiev

Esophagectomy

10.1016/j.ejso.2024.107983

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Citations (3)

Diagnostic Accuracy of Clinical Lymph Node Staging for Upper Tract Urothelial Cancer Patients: A Multicenter, Retrospective, Observational Study

The Journal of Urology (2022)

Maximilian Pallauf David D’Andrea Frederik König Ekaterina Laukhtina Takafumi Yanagisawa

Treatment options for the management of upper tract urothelial cancer are based on accurate staging. However, the performance of conventional cross-sectional imaging for clinical lymph node staging (N-staging) remains poorly investigated. This study aims to evaluate the diagnostic accuracy of conventional cross-sectional imaging for upper tract urothelial cancer N-staging.This study was a multicenter, retrospective, observational study. We included 865 nonmetastatic (M0) upper tract urothelial cancer patients treated with curative intended surgery and lymph node dissection who had been staged with conventional cross-sectional imaging before surgery. We compared clinical (c) and pathological (p) N-staging results to evaluate the concordance of node-positive (N+) and node-negative (N0) disease and calculate cN-staging's diagnostic accuracy.Conventional cross-sectional imaging categorized 750 patients cN0 and 115 cN+. Lymph node dissection categorized 641 patients pN0 and 224 pN+. The cN-stage was pathologically downstaged in 6.8% of patients, upstaged in 19%, and found concordant in 74%. The sensitivity and specificity of cN-staging were 25% (95% CI 20; 31) and 91% (95% CI 88; 93). Positive and negative likelihood ratios were 2.7 (95% CI 2.0; 3.8) and 0.83 (95% CI 0.76; 0.89). The area under the receiver operating characteristics curve (0.58, 95% CI 0.55; 0.61) revealed low diagnostic accuracy.Conventional cross-sectional imaging had low sensitivity in detecting upper tract urothelial cancer pN+ disease. However, cN+ increased the likelihood of pN+ by almost threefold. Thus, conventional cross-sectional imaging is a rule-in but not a rule-out test. Lymph node dissection should remain the standard during extirpative upper tract urothelial cancer surgery to obtain accurate N-staging. cN+ could be a strong argument for early systemic treatment.

Concordance

Cross-sectional study

Cancer staging

T-stage

10.1097/ju.0000000000003085

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Citations (16)

Preliminary clinical and radiological evaluation with transfibular total ankle replacement

Foot and Ankle Surgery (2017)

Alberto Bianchi Jacopo Flore G Romeo Elena Sartorelli Nicolò Martinelli

10.1016/j.fas.2017.07.335

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Citations (0)

Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients

Current Urology (2022)

Antonio Benito Porcaro Nelia Amigoni Riccardo Rizzetto Filippo Migliorini Alessandro Tafuri

To test hypothesized associations between the ABO blood group (ABO-bg) system and the pathological features of prostate cancer (PCa).Between January 2013 and September 2019, 1173 patients underwent radical prostatectomy. Associations between ABO-bg levels and pathological features were evaluated using statistical methods.Overall, 1149 consecutive patients were evaluated using the ABO-bg system, which was represented by O-bg (42.8%) and A-bg (41.3%), followed by B-bg (11.1%) and AB-bg (4.8%). Only positive surgical margins (PSMs) was correlated with ABO-bg (Pearson correlation coefficient, r = 0.071; p = 0.017), and the risk was increased in group-O (odds ratio [OR], 1.497; 95% confidence interval, 1.149-1.950; p = 0.003) versus non-O-bg. In clinical and pathological models, O-bg was at increased risk of PSM after the adjustment for prostate-specific antigen, percentage of biopsy-positive cores, and high surgical volume (adjusted OR, 1.546; 95% confidence interval, 1.180-2.026; p = 0.002); however, the adjusted OR did not change after the adjustment for tumor load and stage as well as high surgical volume.In clinical PCa, the risk of PSM was higher in O-bg versus non-O-bg patients after the adjustment for standard predictors. Confirmatory studies are needed to confirm the association between ABO-bg and unfavorable PCa features.

Biochemical recurrence

Prostate biopsy

10.1097/cu9.0000000000000146

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Citations (1)

Surgical experience overcomes the impact of prostatic-urethral anatomy on continence recovery after robotic prostatectomy: comprehensive analysis on 366 cases

World Journal of Urology (2024)

Alessandro Veccia Riccardo Bertolo Francesco Artoni Alberto Bianchi Vincenzo De Marco

Nephrology

Urinary continence

10.1007/s00345-024-05381-8

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Citations (0)

Morphology and development of secretory structures in Hypericum perforatum and H. richeri

Nordic Journal of Botany (2003)

Luciano Maffi Lorenzo Camoni R. Baroni Fornasiero Alberto Bianchi

Secretory organs are a specialised anatomical feature of plants, these tissues function in the production and/or storage of specific chemical substances, which often have pharmacological properties. The genus Hypericum is characterised by the presence of specialised secretory structures such as black nodules, translucent glands and secretory canals. The presence of these structures is not homogeneous for all the species or between the various floral and vegetative parts of the plants. In this study, we have compared the distributions, morphology and development of secretory structures in the leaves of H. perforatum and H. richeri. Whilst, black nodules occurred in both species, translucent glands followed different development stages depending on the leaf age.

Morphology

Hypericum

10.1111/j.1756-1051.2003.tb00419.x

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Citations (4)

Natural history of cN+ bladder cancer treated with radical cystectomy with or without perioperative treatment

European Urology (2024)

Markus von Deimling Marc A. Furrer Andrea Mari L.S. Mertens Anshu Khanna

Urothelial cancer

10.1016/s0302-2838(24)00294-x

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Citations (0)