Jianjian Zhang

Ministry of Education of the People's Republic of China

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Lulu Ning

Shaanxi University of Science and Technology

Xiao‐Feng Yang

Fujian Medical University

Kanyi Pu

Nanyang Technological University

Haixia Zhang

Lanzhou University

Xiaoyan Liu

Fujian Medical University

Xinyue Zhu

Shanghai University of Traditional Chinese Medicine

Yuan Guo

Northwest University

Jianxi Wang

Shijiazhuang Tiedao University

Xu Zhen

Canadian Forest Service

Qingqing Miao

University of Science and Technology of China

Cooperative Institutions

Northwest University

Ministry of Education of the People's Republic of China

Chinese Academy of Sciences

Nanyang Technological University

Zhejiang University

University of Chinese Academy of Sciences

Sichuan University

Southwest University

China University of Mining and Technology

University of Electronic Science and Technology of China

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pH-/Viscosity-Activatable NIR Fluorescent Probes via Acceptor Engineering of Hemicyanine Dyes for High-Contrast Bioimaging

Analytical Chemistry (2025)

Da Feng Li Guo Yihan Zhao Yuan Fang Lulu Ning

Real-time monitoring of the lysosomal microenvironment using small-molecule probes is critical for understanding the complex interactions between organelles and diseases associated with lysosomal dysfunction. Most traditional fluorescent-dye-based lysosome probes rely on the protonation of the nitrogen atom in the morpholine unit to visualize the lysosomal microenvironment by inhibiting the photoinduced electron transfer (PET) effect. However, these probes often face selectivity issues within the complex cellular microenvironment. For instance, classic hemicyanine dyes (HD) show nonspecific fluorescence responses in the liver due to inappropriate pKa value, leading to low imaging contrast and the risk of false positives. Herein, a series of novel pH/viscosity-activatable, lysosomal-targeted near-infrared (NIR) fluorescent probes were developed by incorporating naphthalimide dye with hemicyanine dyes. These probes exhibit no fluorescence at physiological pH and weak fluorescence under acidic conditions (key 1), with substantial fluorescence activation triggered by abnormal viscosity in pathological tissues (key 2). Notably, NpCy-4 demonstrated a superior signal-to-background ratio (SBR) for cellular imaging and proved effective for real-time in situ diagnosis of acute gastritis.

Acceptor

10.1021/acs.analchem.4c05680

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Characterization of Chemical Constituents of Oxytropis microphylla (Pall.) DC. by Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole-Time-of Flight Tandem Mass Spectrometry

Separations (2022)

Mengqi Xia Min Yao Junmao Li Jianjian Zhang Yayun Yu

Oxytropis microphylla (Pall.) DC. is a traditional Tibetan medicine used as an external preparation for clearing heat and detoxification, healing sore muscles, astringent vein hemostasis, defecation, and treating plague, constipation, anthrax, and swollen and painful furuncles. It remains a challenge to comprehensively analyze and identify the chemical constituents of Oxytropis microphylla (Pall.) DC. In this study, a new analytical method using a combination of ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS) and effective data mining techniques was established to identify the chemical constituents of Oxytropis microphylla. A total of 127 compounds were identified in O. microphylla extract, including 92 flavonoids, 15 indole alkaloids, and 20 others. After the oral administration of the extract to rats, 22 metabolites were identified in the plasma. The primary in vivo metabolic reactions that occurred after the administration of O. microphylla extract were glucuronidation and sulfation. Therefore, we successfully devised a high-efficiency method to distinguish compounds and used it as a source of post-study to identify the active biological components of O. microphylla extract.

10.3390/separations9100297

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A fluorescent probe for hydrazine based on a newly developed 1-indanone-fused coumarin scaffold

Dyes and Pigments (2018)

Yuan Liu Dandan Ren Jianjian Zhang Hua Li Xiao‐Feng Yang

Bathochromic shift

Hydrazine (antidepressant)

Hydrazone

Stokes shift

10.1016/j.dyepig.2018.10.012

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Citations (69)

Imaging of Fluoride Ion in Living Cells and Tissues with a Two-Photon Ratiometric Fluorescence Probe

Sensors (2015)

Xinyue Zhu Jianxi Wang Jianjian Zhang Zhenjie Chen Haixia Zhang

A reaction-based two-photon (TP) ratiometric fluorescence probe Z2 has been developed and successfully applied to detect and image fluoride ion in living cells and tissues. The Z2 probe was designed designed to utilize an ICT mechanism between n-butylnaphthalimide as a fluorophore and tert-butyldiphenylsilane (TBDPS) as a response group. Upon addition of fluoride ion, the Si-O bond in the Z2 would be cleaved, and then a stronger electron-donating group was released. The fluorescent changes at 450 and 540 nm, respectively, made it possible to achieve ratiometric fluorescence detection. The results indicated that the Z2 could ratiometrically detect and image fluoride ion in living cells and tissues in a depth of 250 μm by two-photon microscopy (TPM).

Two-photon excitation microscopy

Fluorescence-lifetime imaging microscopy

10.3390/s150101611

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Citations (22)

合理的に設計されたチオール蛍光プローブ:光誘起電子移動(PET)における位置的異性体

Tetrahedron (2016)

Zhu Xinyue Gao Hong Zan Wenyan Li Yan Jianjian Zhang

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Boundary Extract and Reduction of Mass Data in Reverse Engineering

Cheng Xiao-min Hong Cheng Wei Yang Jianjian Zhang

Boundary extract and reduction of mass data in reverse engineering was studied in this paper by adopting variable precision rough set theory, introducing error factors, building up decision tables of mass data and making attributes reduction. This process would benefit to the valuation of the scan boundary data and result in the boundary extract and reduction as well as the 3D reconstruction of mass data. As an experimental sample, an art dog was used to discuss this improved process, which fundamentally proved that the partial intelligence and 3D reconstruction precision could be successfully realized.

Reverse engineering

Data Reduction

10.1109/isdpe.2007.18

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The Study of Reduced-order in Determinant Computation

Journal of Lanzhou Polytechnic College (2005)

Jianjian Zhang

In this paper, a series of reduced-order theories are deduced by block-matrix and product-matrix,which can be used to make the determinant change from the higher-order to lower one so as to be calculated.The method is particularly convenient to calculate a certain type determinant especially characteristic polynomial.For the determinant of ｜D+CA~(-1)B｜and｜λE_n-AB｜,the relevant conclusion and illustration are given in this paper.

Matrix (chemical analysis)

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Toeplitz-structured measurement for compressed channel feedback in FDD massive MIMO system

Kai Wang Liu Jingzhi Bo Zhang Jianjian Zhang Kai Wang

By exploiting the correlations of the massive MIMO channel, Compressed Sensing (CS) has been applied to develop efficient channel feedback scheme. The existing CS-based channel feedback schemes, however, adopt Gaussian random matrices to compress the channel, which will impose an unreachable memory and computation requirement on user equipment (UE). In this paper, a new Toeplitz-structured measurement matrix is proposed to perform efficient channels compression in massive MIMO system. Instead of containing entries of are independent realizations of random variables with certain distributions, Toeplitz matrices have constant diagonals, leading a significant reduction of UE requirement for storing and computation. Based on such matrices, we introduce novel feedback mechanism improving further the feedback efficiency for frequency division duplex (FDD) massive MIMO systems. Simulation results show that the Toeplitz-structured matrices perform comparably with Gaussian random matrices while requiring less independent random variables and computation complexity.

Matrix (chemical analysis)

10.1109/iccsn.2017.8230164

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Citations (1)

Water-soluble fluorescent unimolecular micelles: ultra-small size, tunable fluorescence emission from the visible to NIR region and enhanced biocompatibility for in vitro and in vivo bioimaging

Chemical Communications (2018)

Xiaoqian Ma Xiaoxiao Shi Shuang Bai Jianjian Zhang Meili Hou

Water-soluble fluorescent unimolecular micelles with ultra-small size and various fluorescence emission for multicolor imaging.

Biocompatibility

10.1039/c8cc02261e

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Citations (20)