Yuqiang Liu

Changzhi Medical College

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Shou-Jun Nie

Suihua University

Hui-Lin Chang

Jiangsu University

Qian Cai

Liaoning University of Traditional Chinese Medicine

Pengcheng Yan

Sichuan University

Yubao Chen

East China Normal University

Ling Jiang

Nanjing Agricultural University

Tianqing Zheng

Institute of Crop Sciences

Shiwei Gao

Shandong Agricultural University

Guilong Zhao

Shanghai Institute of Materia Medica

Tian-Tian Xu

Anhui University of Science and Technology

Cooperative Institutions

Chinese Academy of Sciences

Shandong University

Nanjing Agricultural University

Chinese Academy of Agricultural Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Ministry of Agriculture and Rural Affairs

Sun Yat-sen University

Second Hospital of Shandong University

Peking University

Shanghai Jiao Tong University

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Transcutaneous electrical stimulation of somatic afferent nerves in the foot relieved symptoms related to postoperative bladder spasms

BMC Urology (2017)

Chanjuan Zhang Zhiying Xiao Xiulin Zhang Liqiang Guo Wendong Sun

Bladder spasm is a common side effect of urological surgery. Main treatment modalities include opioids or anticholinergic medication; however, bladder spasms still occur even after these interventions. Recent studies indicate that transcutaneous stimulation of the foot can result in 50% increase in bladder capacity in healthy adults, and inhibit bladder detrusor overactivity in spinal cord injured patients. In this study, we examined the effects of transcutaneous electrical stimulation of the foot on bladder spasms related symptoms. Sixty-six male patients who underwent prostate or bladder surgeries due to benign prostatic hyperplasia or bladder diseases were randomly divided into two groups: the control group (n = 36) and the treatment group (n = 30). The control group received the routine postoperative care. The treatment group received daily transcutaneous electrical stimulation of the foot during 3 days after surgery; each time lasted for 60 min. All patients were evaluated by the Visual Analogue Scale for pain sensation, frequency of bladder spasm episodes, and a total score of bladder spasms symptoms. In the control group, the patients with bladder surgery had a higher Visual Analogue Scale score than patients with prostate surgery (P = 0.024). In both treatment and control groups, the Visual Analogue Scale score, spasm frequency, and total score of bladder spasm symptoms decreased from day 1 to day 3 (P <0.001). The Visual Analogue Scale score at day 2, total score of bladder spasm symptoms at day 2 and day 3 were significantly lower in the treatment group than in the control group (P <0.05). These results provided preliminary evidence suggesting beneficial effects of stimulating somatic afferent nerves in the foot on postoperative bladder spasms. The study was registered with Chinese Clinical Trial Registry on June 13 2016 ( http://www.chictr.org.cn/ ) (Identifier: ChiCTR-INR-16008635)

10.1186/s12894-017-0248-9

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Citations (7)

Retracted Article: Circular RNA PTK2 modifies the progression and radiosensitivity in gastric cancer via miR-369-3p/ZEB1 axis

RSC Advances (2020)

Yuqiang Liu Kun Yao Ke Zhang Jianping Wang Qiang Dai

Circular RNA PTK2 regulates the cell proliferation, apoptosis, mobility and radiosensitivity via ZEB1 by sponging miR-369-3p in gastric cancer.

Radiosensitivity

10.1039/c9ra08525d

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Citations (4)

Annotated genes based on Suijing18 Denovo assembly version 1

Figshare (2017)

Shou-Jun Nie Yuqiang Liu Chun-Chao Wang Shiwei Gao Tian-Tian Xu

Mask the repeats by RepeatMask with parameter setting as “-nolow -no_is -norna” and then annotate the genome by multiple tools including GENEID with parameters for rice, GeneMark with setting of --ES --cores 24 --min_contig 100, SNAP with default setting, and AUGUSTUS 21 with –species = rice. We compared the CDS and protein sequences from other rice genome by using PASA with default setting and GeneWise with setting of “splice_gtag -sum -gff –quiet”. All the results were integrate and screened by using EVidenceModeler (EVM).

10.6084/m9.figshare.5258125

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Citations (0)

Protective effects of TRPV1 inhibition against sevoflurane-induced cell death

Neuroscience Letters (2019)

Yuqiang Liu Yang Han Chengsan Sun Zhi Wang Zhiheng Liu

Neurotoxicity

10.1016/j.neulet.2019.05.024

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Citations (3)

Development of recombinant COVID-19 vaccine based on CHO-produced, prefusion spike trimer and alum/CpG adjuvants

Vaccine (2021)

Haitao Liu Chenliang Zhou Jiao An Yujiao Song Pin Yü

COVID-19 pandemic has severely impacted the public health and social economy worldwide. A safe, effective, and affordable vaccine against SARS-CoV-2 infections/diseases is urgently needed. We have been developing a recombinant vaccine based on a prefusion-stabilized spike trimer of SARS-CoV-2 and formulated with aluminium hydroxide and CpG 7909. The spike protein was expressed in Chinese hamster ovary (CHO) cells, purified, and prepared as a stable formulation with the dual adjuvant. Immunogenicity studies showed that candidate vaccines elicited robust neutralizing antibody responses and substantial CD4+ T cell responses in both mice and non-human primates. And vaccine-induced neutralizing antibodies persisted at high level for at least 6 months. Challenge studies demonstrated that candidate vaccine reduced the viral loads and inflammation in the lungs of SARS-CoV-2 infected golden Syrian hamsters significantly. In addition, the vaccine-induced antibodies showed cross-neutralization activity against B.1.1.7 and B.1.351 variants. These data suggest candidate vaccine is efficacious in preventing SARS-CoV-2 infections and associated pneumonia, thereby justifying ongoing phase I/II clinical studies in China (NCT04982068 and NCT04990544).

Vero cell

10.1016/j.vaccine.2021.10.066

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Citations (30)

Further discussion of the direction in gold prospecting in the Jiao-Lai basin

Chinese Geology (2001)

Yuqiang Liu

Through1∶200000and partly1∶50000comprehensive information ore deposit pre-diction and interpretations of geological,geophysical,geochemical and remote-sensing data,the author thinks that the hidden basement area of the Jiao-Lai basin has geological condi-tions of gold deposit formation similar to those of the exposed basement area in the Jiaobei uplift.On the basis of the construction of a statistical and prediction model of the known gold deposit concentration area in the Jiaobei uplift,qualitative,positioning and quantitative predictions were made.The predictions show that the Jiao-Lai basin has a great gold poten-tial and particularly the northeastern and northwestern margins of the basin,have the best gold prospects.According to the sequencing,it is suggested that priority should be given to exploration and evaluation of gold deposits in five targets.

Prospecting

Basement

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Signal transduction by M3 muscarinic acetylcholine receptor in prostate cancer

Oncology Letters (2015)

Liqiang Guo Yuqiang Liu Zhibo Ding Wendong Sun Mingzhen Yuan

The present study aimed to investigate the potential mechanisms used during signal transduction by M3 muscarinic acetylcholine receptor (CHRM3) in prostate cancer. The microarray datasets of GSE3325, including 5 clinically localized primary prostate cancers and 4 benign prostate tissues, were downloaded from the Gene Expression Omnibus database. The differentially‑expressed genes (DEGs) in primary prostate cancer tissues compared with benign controls were screened using the Limma package. Gene Ontology and pathway enrichment analyses were performed using the Database for Annotation Visualization and Integrated Discovery. Next, a protein‑protein interaction (PPI) network was constructed. Additionally, microRNAs (miRNAs) associated with DEGs were predicted and miRNA‑target DEG analysis was performed using a Web‑based Gene Set Analysis Toolkit. Finally, the PPI network and the miRNA‑target DEG network were integrated using Cytoscape. In total, 224 DEGs were screened in the prostate cancer tissues, including 113 upregulated and 111 downregulated genes. CHRM3 and epidermal growth factor (EGF) were enriched in the regulation of the actin cytoskeleton. EGF and v‑myc avian myelocytomatosis viral oncogene homolog (Myc) were enriched in the mitogen‑activated protein kinase (MAPK) signaling pathway. EGF with the highest degree of connectivity was the hub node in the PPI network, and miR‑34b could interact with Myc directly in the miRNA‑target DEG network. EGF and Myc may exhibit significant roles in the progression of prostate cancer via regulation of the actin cytoskeleton and the MAPK signaling pathway. CHRM3 may activate these two pathways in prostate cancer progression. Thus, these two key factors and pathways may be crucial mechanisms during signal transduction by CHRM3 in prostate cancer.

ErbB

10.3892/ol.2015.3830

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Citations (9)

Influencing factors of bentonite for the directional electric repair of landfill HDPE membrane leakage in calcium ion solution

Waste Management Bulletin (2024)

Guangyuan Yao Yuqiang Liu Ya Xu Jing‐Cai Liu Can Qian

Bentonite

Leakage (economics)

High-density polyethylene

10.1016/j.wmb.2024.10.001

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Citations (0)

Effect analysis of surgical treatment for ankle osteoarthritis under arthroscopy

Yuqiang Liu Xupeng Wang Ning Liu Liang Zhen-lei

Objective To discuss the clinical effect of surgical treatment for ankle osteoarthritis under arthroscopy. Methods Forty-eight cases with ankle osteoarthritis patients admitted at the Orthopaedic Hospital of Zhengzhou from January 2012 to June 2014 were selected and all of them were given the treatment of focal cleaning under arthroscopy.The clinical effect of surgical treatment were judged by modified McGuire ankle rating system, the United States after ankle surgery AOFAS ankle-full score and Mazur ankle rating system respectively. Results At the time of the last follow-up, modified McGuire ankle rating system((85.64±16.52) points vs.(52.46±10.25) points, t=-8.465), the United States after ankle surgery AOFAS ankle-full score [(85.24±11.46) points vs.(53.68±9.48) points, t=-7.548) and Mazur ankle rating system((86.45±12.57) points vs.(58.49±8.64) points, t=-6.596) all increased than that of pre-operation, the differences were statistically significant(P 0.05). Conclusion The clinical effect of surgical treatment for ankle osteoarthritis under arthroscopy is remarkable and it causes light damage to the body.It is especially suitable for patients with low-grade lesions and is worth popularization and application. Key words: Ankle; Osteoarthritis; Arthroscopy; Effect

10.3760/cma.j.issn.1008-6315.2017.02.016

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One-Step, Multiplexed Fluorescence Detection of microRNAs Based on Duplex-Specific Nuclease Signal Amplification

Journal of the American Chemical Society (2012)

Bin‐Cheng Yin Yuqiang Liu Bang‐Ce Ye

Traditional molecular beacons, widely applied for detection of nucleic acids, have an intrinsic limitation on sensitivity, as one target molecule converts only one beacon molecule to its fluorescent form. Herein, we take advantage of the duplex-specific nuclease (DSN) to create a new signal-amplifying mechanism, duplex-specific nuclease signal amplification (DSNSA), to increase the detection sensitivity of molecular beacons (Taqman probes). DSN nuclease is employed to recycle the process of target-assisted digestion of Taqman probes, thus, resulting in a significant fluorescence signal amplification through which one target molecule cleaves thousands of probe molecules. We further demonstrate the efficiency of this DSNSA strategy for rapid direct quantification of multiple miRNAs in biological samples. Our experimental results showed a quantitative measurement of sequence-specific miRNAs with the detection limit in the femtomolar range, nearly 5 orders of magnitude lower than that of conventional molecular beacons. This amplification strategy also demonstrated a high selectivity for discriminating differences between miRNA family members. Considering the superior sensitivity and specificity, as well as the multiplex and simple-to-implement features, this method promises a great potential of becoming a routine tool for simultaneously quantitative analysis of multiple miRNAs in tissues or cells, and supplies valuable information for biomedical research and clinical early diagnosis.

Molecular beacon

Nuclease

Duplex (building)

Multiplex

TaqMan

10.1021/ja300721s

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Citations (501)