Yuying Zhao

Tianjin Medical University General Hospital

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Co-Authors

Chuanzhu Yan

Qilu Hospital of Shandong University

Kunqian Ji

Qilu Hospital of Shandong University

Tingjun Dai

Qilu Hospital of Shandong University

Yan Lin

Qilu Hospital of Shandong University

Pengfei Lin

Shandong University

Fuchen Liu

Yale University

Dandan Zhao

Qilu Hospital of Shandong University

Xuebi Xu

Wenzhou Medical University

Bing Wen

Yuhuangding Hospital

Wei Wang

Qilu Hospital of Shandong University

Cooperative Institutions

Qilu Hospital of Shandong University

129

Shandong University

102

Chinese Academy of Sciences

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Fudan University

Peking University

Harbin Medical University

Capital Medical University

Huazhong University of Science and Technology

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Muscle injury induced by different types of contractions in dystrophic mdx mice

Journal of Muscle Research and Cell Motility (2012)

Jian-Wei Lou Wenbo Bi Wei Li Yuying Zhao Shuping Liu

mdx mouse

10.1007/s10974-012-9284-y

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Citations (7)

Correction to: Comprehensive genetic characteristics of dystrophinopathies in China

Orphanet Journal of Rare Diseases (2021)

Peipei Ma Shu Zhang Hao Zhang Siying Fang Yuru Dong

An amendment to this paper has been published and can be accessed via the original article.

Human genetics

10.1186/s13023-021-01853-x

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A randomized controlled trial evaluating the effects of transversus abdominis plane block with compound lidocaine hydrochloride injection on postoperative pain and opioid consumption and gastrointestinal motility in patients undergoing gynecological laparotomy

Frontiers in Molecular Neuroscience (2023)

Linlin Zhang Zhen Jia Tianyu Gao Yigang Wang Yuying Zhao

Incorporation of transversus abdominis plane (TAP) block into multimodal analgesia has been emphasized in Enhanced Recovery protocols (ERPs). However, benefit is limited in clinical practice. A potential explanation is the short duration of analgesia of standard local anesthetics. Herein, this randomized, double-blind, controlled trial evaluated whether TAPB with long-acting compound lidocaine hydrochloride injection reduces postoperative pain.164 patients undergoing elective gynecological laparotomy under sevoflurane anesthesia randomly received ultrasound-guided TAP block with either saline, or ropivacaine, or compound lidocaine before anesthesia induction. The postoperative pain intensity (primary outcome) was evaluated by pain 11-point numerical rating scale. We also recorded sufentanil consumptions, time to first flatus, side-effects and hospital stay after surgery.We reported that pain scores at rest at postoperative 3h in group 0.375% ropivacaine was lower than that in group saline [mean 2.4 (SD 1.2) vs. 3.0 (1.0), p = 0.036]. Compared with saline, 0.4% and 0.6% compound lidocaine caused lower pain scores at rest at postoperative 12h [2.8 (0.9) vs. 2.1 (0.9) and 2.0 (0.9), p = 0.016 and p = 0.006]. Sufentanil usage for the first postoperative 48h was lower in group 0.6% compound lidocaine than group saline [24.2 (5.4) vs. 45.6 (7.5) µg, p < 0.001]. Time to first flatus and hospital stay after surgery was shortest and the incidence of postoperative nausea was lowest in patients receiving 0.6% compound lidocaine.TAP block with 0.6% compound lidocaine hydrochloride injection attenuates postoperative pain, reduces opioid consumption, accelerates gastrointestinal function recovery, and shortens length of hospital stay in patients after gynecological laparotomy.ClinicalTrials.gov, identifier: NCT04938882.

10.3389/fnmol.2023.967917

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Citations (13)

20 nm polysilicon gate patterning and application in 36 nm complementary metal–oxide–semiconductor devices

Journal of Vacuum Science & Technology B Microelectronics and Nanometer Structures Processing Measurement and Phenomena (2003)

Qiuxia Xu Qian He Ming Liu Yuying Zhao Baoqing Chen

Plasma etching with high selectivity and anisotropy for 20 nm poly-Si gate patterning on EOT of 1.4 nm gate oxynitride is developed in a Cl2/HBr/O2 gas mixture successfully. Direct write e-beam lithography is used for an SAL601 chemically amplified negative resist pattern. Using a combination of resist ashing and TEOS hard mask trimming process, sub-25 nm TEOS SiO2 mask patterns are obtained in the control. Various gas mixtures based on Cl2, HBr, and O2 have been used to study the etching characteristics of poly-Si on EOT of 1.4 nm gate oxynitride. The O2 content as well as HBr are very sensitive to etch rate, selectivity, and the protection of the sidewalls of polysilicon, owing to SiO2-like film, SiOxBry, formed on the etched surface confirmed by x-ray photoelectron spectroscopy. And the ratio of Cl2/HBr/O2 in gas mixture is also tightly related to the etching profile. Using a four-step etching process under optimum conditions the selectivity of poly-Si to oxide is much higher than 500:1, in fact, after polysilicon etching the net deposition of oxide is observed, and no damage on the active area beside the gates for EOT of 1.4 nm gate oxide is observed, too. The etching profile of the 20 nm poly-Si gate pattern is perfectly vertical and an overall narrowing by an estimated 5 nm is observed for oxide masked poly-Si gate etching. The possible mechanism is discussed. This etching process combined with resist ashing and the TEOS hard mask trimming process are implemented successfully to the fabrication of high performance 36 nm gate length complementary metal–oxide–semiconductor (CMOS) devices and 42 nm gate length 32 frequency dividers with 57 stage/201 stage CMOS ring oscillators embedded, the EOT of gate oxynitrid is 1.4 nm, and very good results are obtained.

Dry etching

Photoresist

Silicon oxynitride

Metal gate

Buffered oxide etch

10.1116/1.1620514

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Citations (10)

Characteristics of human encephalitis caused by pseudorabies virus: A case series study

International Journal of Infectious Diseases (2019)

Xue Yang Hongzhi Guan Chen Li Ying Li Shengjun Wang

Pseudorabies virus (PRV) has been thought to cause diseases only in animals. However, recent studies have shown that PRV can also cause illnesses in humans.This was a case series study. The cases of five patients with clinical symptoms of acute encephalitis, which were confirmed to be caused by PRV infections, were reviewed.The five patients all had jobs involving the handling of pigs. They had acute onset and rapid progression of clinical presentations, which were consistent with central nervous system infections. Four of them had respiratory failure, which required ventilator support. Brain magnetic resonance imaging showed abnormal signals in the bilateral temporal lobes and insular cortex in all five patients, bilateral frontal lobes in one patient, and caudate nucleus in one patient. Cerebrospinal fluid analysis results were consistent with a viral infection. Next-generation sequencing of the cerebrospinal fluid confirmed the presence of PRV. All patients received human immunoglobulin, glucocorticoids, antiviral agents, and symptomatic supportive treatments. All patients survived until discharge, but suffered from various sequelae. Pneumonia was the most common complication during the disease course.PRV encephalitis should be included in the differential diagnosis of patients with a clinical presentation of central nervous system infection, especially for those who have had recent contact with pigs.

Pseudorabies

Viral encephalitis

10.1016/j.ijid.2019.08.007

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Citations (97)

Common Alterations in Parallel Metabolomic Profiling of Serum and Spinal Cord and Mechanistic Studies on Neuropathic Pain following PPARα Administration

Neuropharmacology (2024)

Yuying Zhao Zijun Wu Shu-jing Hao Beibei Dong Yuxin Zheng

Allodynia

10.1016/j.neuropharm.2024.109988

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Robust boron nanoplatform provokes potent tumoricidal activities via inhibiting heat shock protein

Asian Journal of Pharmaceutical Sciences (2022)

Yuying Zhao Ning Liu Piaoxue Liu Taojian Fan Rui Ma

Near-infrared (NIR)-light-triggered photothermal therapy (PTT) is a promising treatment for breast cancer. However, its therapeutic efficiency is often compromised due to the heat-induced up-regulation of heat shock proteins, which confer photothermal resistance. To solve this urgent problem, PEGylated two-dimensional boron nanosheets (B-PEG)—which allow both multimodal imaging and photothermal conversion—were loaded with gambogic acid (GA), which can inhibit heat shock protein 90 (Hsp90). Experimental findings indicated that this combination of B-PEG and GA could serve as an integrated drug delivery system for cancer diagnosis and treatment. It could be used to administer mild PTT as well as chemotherapy for breast cancer, provide improved anti-tumor effects, and reduce the toxicity of PTT, all while inhibiting breast cancer growth. This drug delivery system could offer a novel tool for administering chemotherapy combined with PTT while avoiding the adverse effects of traditional PTT.

Gambogic acid

PEGylation

10.1016/j.ajps.2022.06.003

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Citations (3)

Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of Cancer

Frontiers in Oncology (2021)

Yuying Zhao Piaoxue Liu Hanxu Tan Xiaojia Chen Qi Wang

Exosomes are composed of a lipid bilayer membrane, containing proteins, nucleic acids, DNA, RNA, etc., derived from donor cells. They have a size range of approximately 30-150 nm. The intrinsic characteristics of exosomes, including efficient cellular uptake, low immunogenicity, low toxicity, intrinsic ability to traverse biological barriers, and inherent targeting ability, facilitate their application to the drug delivery system. Here, we review the generation, uptake, separation, and purification methods of exosomes, focusing on their application as carriers in tumor diagnosis and treatment, especially in brain tumors, as well as the patent applications of exosomes in recent years.

Exosome

10.3389/fonc.2021.743189

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Citations (29)

Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA plus syndrome

JCI Insight (2024)

Yan Lin Dongdong Wang Busu Li Jiayin Wang Ling Xu

Autosomal dominant optic atrophy plus (ADOA+) is characterized by primary optic nerve atrophy accompanied by a spectrum of degenerative neurological symptoms. Despite ongoing research, no effective treatments are currently available for this condition. Our study provided evidence for the pathogenicity of an unreported c.1780T>C variant in the OPA1 gene through patient-derived skin fibroblasts and an engineered HEK293T cell line with OPA1 downregulation. We demonstrated that OPA1 insufficiency promoted mitochondrial fragmentation and increased DRP1 expression, disrupting mitochondrial dynamics. Consequently, this disruption enhanced mitophagy and caused mitochondrial dysfunction, contributing to the ADOA+ phenotype. Notably, the Drp1 inhibitor, mitochondrial division inhibitor-1 (Mdivi-1), effectively mitigated the adverse effects of OPA1 impairment. These effects included reduced Drp1 phosphorylation, decreased mitochondrial fragmentation, and balanced mitophagy. Thus, we propose that intervening in DRP1 with Mdivi-1 could correct mitochondrial abnormalities, offering a promising therapeutic approach for managing ADOA+.

Fragmentation

Geographic atrophy

10.1172/jci.insight.180582

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Citations (4)

Mitochondrial Dysfunction due to Novel COQ8A Variation with Poor Response to CoQ10 Treatment: A Comprehensive Study and Review of Literatures

The Cerebellum (2024)

J. Wang Yan Lin Zhihong Xu Chuanzhu Yan Yuying Zhao

Coenzyme Q10

Mitochondrial disease

Idebenone

10.1007/s12311-024-01671-4

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Citations (0)