Jong Sung Park

Dong-A University Hospital

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Young–Rak Cho

Asan Medical Center

Moo Hyun Kim

Dong-A University Hospital

Tae‐Ho Park

Dong-A University Hospital

Kyungil Park

Seoul National University

Dong‐Gyu Jo

Sungkyunkwan University

Moon‐Hyoung Lee

Yonsei University

Young‐Dae Kim

Dong-A University Hospital

Edward Abraham

New York Medical College

Seongwook Han

Keimyung University

Dae-Kyeong Kim

Inje University Busan Paik Hospital

Cooperative Institutions

Laboratoire Lorrain de Recherche en Informatique et ses Applications

447

Yonsei University

147

Sungkyunkwan University

139

Seoul National University

132

University of Liverpool

103

Dong-A University

University of Ulsan

Johns Hopkins University

Liverpool Heart and Chest Hospital

Dong-A University Hospital

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Measures of Improvement and Development of New Qualification Items in the Area of Educational Service

Journal of Skills and Qualifications (2013)

Jeong Yoon Cho Hyangjin Jung Jong Sung Park

Source

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Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry

Journal of Thrombosis and Thrombolysis (2023)

Wern Yew Ding Ameenathul M. Fawzy Giulio Francesco Romiti Marco Proietti Daniele Pastori

Abstract The 2MACE score was specifically developed as a risk-stratification tool in atrial fibrillation (AF) to predict cardiovascular outcomes. We evaluated the predictive ability of the 2MACE score in the GLORIA-AF registry. All eligible patients from phase II/III of the prospective global GLORIA-AF registry were included. Major adverse cardiac events (MACEs) were defined as the composite outcome of stroke, myocardial infarction and cardiovascular death. Cox proportional hazards were used to examine the relationship between the 2MACE score and study outcomes. Predictive capability of the 2MACE score was investigated using receiver-operating characteristic curves. A total of 25,696 patients were included (mean age 71 years, female 44.9%). Over 3 years, 1583 MACEs were recorded. Patients who had MACE were older, with more cardiovascular risk factors and were less likely to be managed using a rhythm-control strategy. The median 2MACE score in the MACE and non-MACE groups were 2 (IQR 1–3) and 1 (IQR 0–2), respectively (p < 0.001). The 2MACE score was positively associated with an increase in the risk of MACE, with a score of ≥ 2 providing the best combination of sensitivity (69.6%) and specificity (51.6%), HR 2.47 (95% CI, 2.21–2.77). The 2MACE score had modest predictive performance for MACE in patients with AF (AUC 0.655 (95% CI, 0.641–0.669)). Our analysis in this prospective global registry demonstrates that the 2MACE score can adequately predict the risk of MACE (defined as myocardial infarction, CV death and stroke) in patients with AF. Clinical trial registration: http://www.clinicaltrials.gov . Unique identifiers: NCT01468701, NCT01671007 and NCT01937377

Mace

10.1007/s11239-023-02866-y

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Acute Myocardial Infarction in a Patient with an Anomalous Origin of the Right Coronary Artery from the Left Anterior Descending Coronary Artery

Korean Journal of Medicine (2014)

Dong Yeol Lee Hyejung Lee Sang Hyeon Kang Eun Seok Kim Dong Hyun Lee

A 55-year-old male underwent coronary artery intervention for an acute myocardial infarction of the inferior or lateral wall. The initial left coronary angiogram showed total occlusion of the proximal left circumflex artery (LCX). There was an abnormal coronary artery originating from the mid-portion of the left anterior descending artery (LAD) and running to the right ventricular side. However, we could not identify the anomalous right coronary artery (RCA). We tried to find the RCA in the right coronary cusp to confirm the infarction-related artery, but failed. A focused left coronary angiogram in the posteroanterior projection revealed the entire anatomy of the anomalous RCA. An anomalous origin of the RCA from the LAD is a rare coronary artery anomaly that might affect the physician’s decision during coronary intervention. We report an anomalous origin of the RCA from the mid-LAD and discuss the anatomy and clinical significance. (Korean J Med 2014;86:618-622)

Left coronary artery

10.3904/kjm.2014.86.5.618

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Secretases as therapeutic targets for Alzheimer’s disease

Biochemical and Biophysical Research Communications (2010)

Ha‐Na Woo Sang‐Ha Baik Jong Sung Park A‐Ryeong Gwon Sung-Hee Yang

Amyloid (mycology)

10.1016/j.bbrc.2010.11.132

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Citations (31)

DOES THE AMOUNT OF RADIOFREQUENCY ENERGY DELIVERY OR ABLATION TECHNIQUE AFFECT POST-ABLATION 3RD MONTH HEART RATE VARIABILITY OR CLINICAL OUTCOME?

Journal of the American College of Cardiology (2011)

Jaemin Shim Boyoung Joung Hye Jin Hwang Jong Sung Park Jong‐Youn Kim

Affect

10.1016/s0735-1097(11)60136-8

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PEGylated TRAIL ameliorates experimental inflammatory arthritis by regulation of Th17 cells and regulatory T cells

Journal of Controlled Release (2017)

Jong Sung Park Yumin Oh Ogyi Park Catherine A. Foss Sung Mook Lim

Inflammatory arthritis

Proinflammatory cytokine

Fas ligand

10.1016/j.jconrel.2017.10.004

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Citations (22)

Exploration of Factors Affecting Re－Participation Intention of Companies Involved in Apprenticeship

Korean Business Education Review (2020)

Han-Jin Jo Seon-Hwa Lee Jong Sung Park

[연구목적] 기존 일학습병행에 참여한 학습기업의 재참여 활성화 방안에 앞서 학습기업의 재참여에 미치는 영향 요인을 구명하여, 학습기업 재참여 활성화 방안에 정책적 기초자료를 제공하는 것이다.
[연구방법] 독립변수는 총 11개로 범주형 4문항과 연속형 7문항으로 구성되어 있고, 종속변수는 범주형 1문항으로 구성되어 이분형 로지스틱 회귀분석을 적용하였다.
[연구결과] 전체적으로 학습기업의 재참여 의사에 영향을 미치는 요인은 참여 동기, 일학습병행 전반적인 만족, 현장훈련 시간 단축 필요성, 기업현장교사 양성교육 기간 적절성, 일학습병행 훈련과정 종료 후 유지 계획 유무, 참여유형의 6가지 변수로 나타났다. 참여유형을 재직자단계와 재학생단계로 나누어 분석한 결과는 다음과 같다. 첫째, 재직자단계에서 학습기업의 재참여 의사에 영향을 미치는 요인은 참여 동기, 일학습병행 전반적인 만족, 현장훈련 시간 단축 필요성, 기업현장교사 양성교육 기간 적절성, 일학습병행 훈련과정 종료 후 유지 계획 유무의 5가지로 나타났다. 둘째, 재직자단계에서 학습기업의 재참여 의사에 영향을 미치는 요인은 참여 동기, 학습기업 선정 절차 적절성, 학습기업 선정기준 적절성, 일학습병행 전반적인 만족, 일학습병행 훈련과정 종료 후 유지계획 유무의 5가지로 나타났다.
[연구의 시사점] 일학습병행의 내실화를 위하여 학습기업의 재참여 활성화 방안을 위한 정책적 시사점을 제공하였다.

Apprenticeship

10.23839/kabe.2020.35.2.287

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Long-Term Outcomes of Unprotected Left Main Coronary Artery Disease: Comparison of Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention

Deleted Journal (2020)

Kai Song Moo Hyun Kim Jia Xin Li Soo Jin Kim Kwang Min Lee

We compared the long-term outcomes of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) disease in a real-world population.

10.25270/jic/19.00292

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Citations (1)

Involvement of phosphatidylinositol 3-kinase γ in neutrophil apoptosis

Cellular Signalling (2002)

Kuang‐Yao Yang John J. Arcaroli John Kupfner Todd M. Pitts Jong Sung Park

10.1016/s0898-6568(02)00063-3

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Citations (53)

Tyrosine kinase inhibitor neratinib attenuates liver fibrosis by targeting activated hepatic stellate cells

Scientific Reports (2020)

Yong Joo Park Hyoung‐Tae An Jong Sung Park Ogyi Park Alexander J. Duh

Liver fibrosis, a common outcome of chronic liver disease characterized by excessive accumulation of extracellular matrix (ECM), is a leading cause of mortality worldwide. The tyrosine kinase inhibitor neratinib is a human epidermal growth factor receptor 2 (HER2) inhibitor approved by the FDA for HER2-positive breast cancer treatment; however, it has not yet been evaluated for liver fibrosis treatment. We elucidated the anti-fibrotic effects of neratinib in hepatic stellate cells (HSCs) and in vivo models of CCl4-induced liver fibrosis. HSC activation is a key step in liver fibrogenesis and has a crucial role in collagen deposition, as it is primarily responsible for excessive ECM production. The effect of neratinib on HSC was evaluated in transforming growth factor (TGF-β)-incubated LX-2 cells and culture-activated primary human HSCs. In vivo study results indicated that neratinib inhibited the inflammatory response, HSC differentiation, and collagen accumulation induced by CCl4. Moreover, the anti-fibrotic effects of neratinib were not associated with the HER2 signaling pathways. Neratinib inhibited FGF2 expression in activated HSCs and serum FGF2 level in the model, suggesting that neratinib possessed therapeutic potency against liver fibrosis and the potential for application against other fibrotic diseases.

Neratinib

Hepatic stellate cell

10.1038/s41598-020-71688-2

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Citations (10)