Yali Song

Zhengzhou University of Light Industry

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Jigang Wang

Southern Medical University

Wenting Ye

Ministry of Education of the People's Republic of China

Chuanbin Yang

Southern University of Science and Technology

Lili Zhou

Chinese Academy of Agricultural Sciences

Song Quan

Southern Medical University

Tingting Xie

Xiangya Hospital Central South University

Junhui Chen

First Affiliated Hospital of Henan University

Jing Liu

Southern Medical University

Fu-qi Xing

Southern Medical University

Pengchen Chen

Southern University of Science and Technology

Cooperative Institutions

Southern Medical University

Nanfang Hospital

Jinan University

Southern University of Science and Technology

Chinese Academy of Medical Sciences & Peking Union Medical College

Dongguan People’s Hospital

Sun Yat-sen University

Central South University

Chinese Academy of Sciences

Peking University

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The role of androgen and its related signals in PCOS

Journal of Cellular and Molecular Medicine (2020)

Wenting Ye Tingting Xie Yali Song Lili Zhou

Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the development and progression of PCOS. However, the actual role of androgen and the related signals in PCOS and PCOS‐related complications have not yet been clarified. In this review, we surveyed the origin and effects of androgen on PCOS and the related complications, highlighted the cellular signals affecting androgen synthesis and summarized the pathological processes caused by hyperandrogenism. Our review well reveals the important mechanisms referring the pathogenesis of PCOS and provides important clues to the clinic strategies in patients with PCOS.

Hyperandrogenism

Pathogenesis

Androgen insensitivity syndrome

10.1111/jcmm.16205

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Citations (113)

Klotho accelerates the progression of polycystic ovary syndrome through promoting granulosa cell apoptosis and inflammation

Biology of Reproduction (2024)

Wenting Ye Siyu Xia Tingting Xie Huiyun Ye Yi Yang

Abstract The morbidity of polycystic ovary syndrome (PCOS) is in highly increasing rate nowadays. PCOS not only affects the fertility in women, but also threatens the health of whole life. Hence, to find the prognostic risk factors is of great value. However, the effective predictors in clinical practice of PCOS are still in blackness. In this study, we found Klotho (KL) was increased in follicular fluid (FF) and primary luteinized granulosa cells (GCs) from PCOS patients with hyperandrogenism. Furthermore, we found follicular KL was negatively correlated with numbers of mature oocytes, and positively correlated with serum testosterone, LH, and LH/FSH levels menstrual cycle and number of total antral follicles in PCOS patients. In primary luteinized GCs, the increased KL was accompanied with upregulation of cell apoptosis and inflammation-related genes. In ovaries of PCOS mice and cultured human KGN cell line, KL was up-regulated and accompanied by apoptosis, inflammation, and mitochondrial dysfunction. Therefore, our findings suggest new mechanisms for granulosa cell injury and revealed to target inhibit KL maybe a new therapeutic strategy for treatment of PCOS.

Klotho

Antral follicle

Granulosa cell

Hyperandrogenism

10.1093/biolre/ioae094

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Citations (1)

Progress in localization of pulmonary nodules

International Journal of Surgery (2020)

Lü Lyu Xiaopeng Yan Zhixuan Zhang Yali Song Shuangyan Li

Microcoil

Nodule (geology)

10.3760/cma.j.issn.1673-4203.2020.03.011

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The Role of Abnormal Uterine Junction Zone in the Occurrence and Development of Adenomyosis

Reproductive Sciences (2021)

Tingting Xie Xiya Xu Yang Yi Cangui Wu Xiaohan Liu

Adenomyosis

10.1007/s43032-021-00684-2

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Citations (12)

Association of seminal angiotensinogen with sperm motility and morphology in male infertility

Andrologia (2019)

Xi Zhu Tingting Xie Xiaomin Zhan Li Liu Xiaoping Yang

Many researchers have shown that renin–angiotensin system (RAS) is involved in various important aspects of male reproduction. In this study, we assessed whether abnormal levels of seminal angiotensinogen (AGT) may be associated with semen parameters in infertile males. A total of 115 male patients were recruited, and semen parameters, seminal AGT and the electrolytes including K+, Na+, Cl−, P and Ca were evaluated. According to the World Health Organization (WHO) 2010 criteria, the patients were divided into two groups: G1 group with normal semen parameters (n = 42) and G2 group with subnormal semen parameters (n = 73). The level of seminal AGT was significantly higher in G2 group compared with G1 group. Moreover, the level of AGT was negatively correlated with the percentage of total motility (r = −.322, p = .000), progressive motility (PR) (r = −.339, p = .000) and morphologically normal forms (r = −.263, p = .004). This study suggests that elevated seminal AGT level is associated with increased risk of asthenospermia and teratozoospermia.

Semen Analysis

Normal group

10.1111/and.13421

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Citations (6)

Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation

Acta Pharmaceutica Sinica B (2022)

Zhaodi Che Yali Song Chengfang Xu Wei Li Zhiyong Dong

Chronic alcohol consumption causes liver steatosis, cell death, and inflammation. Melatonin (MLT) is reported to alleviate alcoholic liver disease (ALD)-induced injury. However, its direct regulating targets in hepatocytes are not fully understood. In the current study, a cell-based screening model and a chronic ethanol-fed mice ALD model were used to test the protective mechanisms of MLT. MLT ameliorated ethanol-induced hepatocyte injury in both cell and animal models (optimal doses of 10 μmol/L and 5 mg/kg, respectively), including lowered liver steatosis, cell death, and inflammation. RNA-seq analysis and loss-of-function studies in AML-12 cells revealed that telomerase reverse transcriptase (TERT) was a key downstream effector of MLT. Biophysical assay found that epidermal growth factor receptor (EGFR) on the hepatocyte surface was a direct binding and regulating target of MLT. Liver specific knock-down of Tert or Egfr in the ALD mice model impaired MLT-mediated liver protection, partly through the regulation of nuclear brahma-related gene-1 (BRG1). Long-term administration (90 days) of MLT in healthy mice did not cause evident adverse effect. In conclusion, MLT is an efficacious and safe agent for ALD alleviation. Its direct regulating target in hepatocytes is EGFR and downstream BRG1-TERT axis. MLT might be used as a complimentary agent for alcoholics.

Steatosis

10.1016/j.apsb.2022.06.015

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Citations (13)

Specificity of regulatory T cells that modulate vascular inflammation

Autoimmunity (2014)

Alessandra Franco Ranim Touma Yali Song Chisato Shimizu Adriana H. Tremoulet

Intravenous immunoglobulin therapy (IVIG) is the treatment of choice for many immune-mediated diseases, yet its mechanisms of action are incompletely elucidated. We investigated the possibility that IVIG played a direct role in the expansion of regulatory T cells (Treg) that recognize the heavy chain constant region of immunoglobulin G (Fc) as a mechanism for the recovery of Kawasaki disease (KD), a T cell mediated pediatric vasculitis of the coronary arteries. We successfully generated Fc-specific Treg clones from sub-acute KD subjects that did not develop arterial complications after IVIG and defined an unusual functional phenotype: Fc-specific Treg secrete IL-10 and small amounts of IL-4 but not TGF-β. Antigen presentation studies demonstrated that these Treg clones can be activated by autologous B cells that express IgG on their cell surface in the absence of exogenous Fc. The IgG molecule has to be canonically processed and presented by autologous MHC molecules to be recognized by Treg. In support of the importance of this novel Treg population in downsizing vascular inflammation, KD patients with dilated coronary arteries or aneurysms despite IVIG treatment failed to expand Fc-specific Treg. Our results point to a specificity of a previously un-described Treg population for the clinical benefit provided by IVIG therapy in children.

Systemic vasculitis

10.3109/08916934.2013.860524

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Citations (61)

Biochemical mechanisms of tributyltin chloride-induced cell toxicity in Sertoli cells

Ecotoxicology and Environmental Safety (2023)

Pengchen Chen Junhui Chen Wei Zhang Li Tang Guangqing Cheng

Tributyltin chloride (TBTCL) is a widely used fungicide and heat stabilizer in compositions of PVC. TBTCL has been detected in human bodies and potentially causes harmful effects on humans' thyroid, cardiovascular and other organs. As one of the first examples of endocrine disruptors, the toxicity effects of TBTCL on the male reproduction system have aroused concerns. However, the potential cellular mechanisms are not fully explored. In the current study, by using Sertoli cells, a critical regulator of spermatogenesis as a cell model, we showed that with 200 nM exposure for 24 h, TBTCL causes apoptosis and cell cycle arrest. RNA sequencing analyses suggested that TBTCL probably activates endoplasmic reticulum (ER) stress, and disrupts autophagy. Biochemical analysis showed that TBTCL indeed induces ER stress and the dysregulation of autophagy. Interestingly, activation of ER stress and inhibition of autophagy is responsible for TBTCL-induced apoptosis and cell cycle arrest. Our results thus uncovered a novel insight into the cellular mechanisms for TBTCL-induced toxicology in Sertoli cells.

Reproductive toxicity

Endocrine disruptor

10.1016/j.ecoenv.2023.114725

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Citations (4)

Application of Nerve Blockade in Surgeries of Single Leg in Aged

Inner Mongolia Medical Journal (2009)

Xizhe Zhang Sun Young Yi BU Hong-qing Shumin Ma Qi Zhou

Objective:To compare the complications of anesthesia between nerve blockade and intraspinal anesthesia in surgeries of single leg in aged.Methods:66 cases for surgeries of single leg,who aged between 65 and 85 years old with ASA in grade Ⅰ to Ⅲ were randomly divided into group with epidural anesthesia(E group) and group with nerve blockade(NB group).NB group was divided into two subgroups: S+F group(n=22) and F+L group(n=22).NB group received nerve blockade located by nerve stimulator,sciatic nerve combined with femoral nerve blockade for surgery in inferior knee joint,or sciatic nerve combined with lumbar plexus blockade for surgery in hip joint and shaft of femur.E group received lidocayin through puncture between L3 and L4 and controlling anesthesia in T10.Before anesthesia and at 15,30,60 min after anesthesia and ended time,the BP,HR and SpO2 were observed.The onset time of anesthesia was recorded,and the duration of analgesia and residence time of motion was followed up.The occurrence of toxic effect and hypotension during operation and complications including urine retention and nausea and vomiting were observed.The efficacy of anesthesia was evaluated based on criteria of nerve blockade grading.Results:In NB group,the hemodynamics was steady.The surgeries were successful with less postoperative complications and better maintaining analgesia.Conclusion: Nerve blockade is safe and feasible technique for aged patients receiving surgies of single leg,with stable circulation,perfect anesthetic effect and less adverce effect and quick recovery.

Lumbar plexus

Nerve stimulator

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

Science China Life Sciences (2024)

Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun Jing Cai

10.1007/s11427-024-2638-9

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Citations (1)