Reza Hosseinzadeh

Islamic Azad University Islamshahr Branch

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Khatereh Khorsandi

George Washington University

Ghader Hosseinzadeh

University of Bonab

Parvaneh Maghami

Islamic Azad University, Science and Research Branch

F. Shahidi

Academic Center for Education, Culture and Research

Hossein Rasoulnezhad

Materials and Energy Research Center

Elham Chamani

Birjand University of Medical Sciences

Ali Akbar Moosavi‐Movahedi

University of Tehran

Naser Ghasemian

University of Bonab

Mahdieh Emadi

Islamic Azad University, Science and Research Branch

Heidi Abrahamse

University of Johannesburg

Cooperative Institutions

University of Tehran

Academic Center for Education, Culture and Research

Tehran University of Medical Sciences

Islamic Azad University, Science and Research Branch

Urmia University

Islamic Azad University, Tehran

Islamic Azad University North Tehran Branch

Tarbiat Modares University

Biotechnology Research Center

Baqiyatallah University of Medical Sciences

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A mechanistic perspective on targeting bacterial drug resistance with nanoparticles

Journal of drug targeting (2021)

Khatereh Khorsandi Saeedeh Keyvani‐Ghamsari F. Shahidi Reza Hosseinzadeh Simab Kanwal

Bacterial infections are an important cause of mortality worldwide owing to the prevalence of drug resistant bacteria. Bacteria develop resistance against antimicrobial drugs by several mechanisms such as enzyme inactivation, reduced cell permeability, modifying target site or enzyme, enhanced efflux because of high expression of efflux pumps, biofilm formation or drug-resistance gene expression. New and alternative ways such as nanoparticle (NP) applications are being established to overcome the growing multidrug-resistance in bacteria. NPs have unique antimicrobial characteristics that make them appropriate for medical application to overcome antibiotic resistance. The proposed antibacterial mechanisms of NPs are cell membrane damage, changing cell wall penetration, reactive oxygen species (ROS) production, effect on DNA and proteins, and impact on biofilm formation. The present review mainly focuses on discussing various mechanisms of bacterial drug resistance and the applications of NPs as alternative antibacterial systems. Combination therapy of NPs and antibiotics as a novel approach in medicine towards antimicrobial resistance is also discussed.

Efflux

Membrane permeability

Pathogenic bacteria

10.1080/1061186x.2021.1895818

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Citations (24)

Effect of rutin as flavonoid compound on photodynamic inactivation against P. aeruginosa and S. aureus

Photodiagnosis and Photodynamic Therapy (2020)

Mahroo Motallebi Khatereh Khorsandi Abbas Akhavan Sepahy Elham Chamani Reza Hosseinzadeh

Methylene blue

Phototoxicity

10.1016/j.pdpdt.2020.102074

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Citations (19)

Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment

Inflammation and Regeneration (2022)

Khatereh Khorsandi Reza Hosseinzadeh HomaSadat Esfahani Kavosh Zandsalimi F. Shahidi

Abstract Cellular metabolisms produce reactive oxygen species (ROS) which are essential for cellular signaling pathways and physiological functions. Nevertheless, ROS act as “double-edged swords” that have an unstable redox balance between ROS production and removal. A little raise of ROS results in cell proliferation enhancement, survival, and soft immune responses, while a high level of ROS could lead to cellular damage consequently protein, nucleic acid, and lipid damages and finally cell death. ROS play an important role in various pathological circumstances. On the contrary, ROS can show selective toxicity which is used against cancer cells and pathogens. Photodynamic therapy (PDT) is based on three important components including a photosensitizer (PS), oxygen, and light. Upon excitation of the PS at a specific wavelength, the PDT process begins which leads to ROS generation. ROS produced during PDT could induce two different pathways. If PDT produces control and low ROS, it can lead to cell proliferation and differentiation. However, excess production of ROS by PDT causes cellular photo damage which is the main mechanism used in cancer treatment. This review summarizes the functions of ROS in living systems and describes role of PDT in production of controllable ROS and finally a special focus on current ROS-generating therapeutic protocols for regeneration and wound healing.

Mitochondrial ROS

10.1186/s41232-022-00226-6

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Citations (88)

Interaction of vitamin B₁ with bovine serum albumin investigation using vitamin B₁-selective electrode: potentiometric and molecular modeling study

Journal of Biomolecular Structure and Dynamics (2015)

Reza Hosseinzadeh Khatereh Khorsandi

Vitamin B1 or thiamin is one of the B vitamins. All B vitamins help the body to convert food (carbohydrates) into fuel (glucose), which produces energy. The B vitamins are necessary for healthy skin, eyes, hair, and liver. It also could help the nervous system function properly, and is necessary for brain functions. Drug interactions with protein can affect the distribution of the drug and eliminate the drug in living systems. In this study, the binding of thiamine hydrochloride (vitamin B1) to bovine serum albumin (BSA) was evaluated using a new proposed vitamin B1 (thiamine)-selective membrane electrode under various experimental conditions, such as pH, ionic strength, and protein concentration; in addition molecular modeling was applied as well. The binding isotherms plotted based on potentiometric data and analyzed using the Wyman binding potential concept. The apparent binding constant was determined and used for the calculation of intrinsic Gibbs free energy of binding. According to the electrochemical and molecular docking results, it can be concluded that the hydrophobic interactions and hydrogen binding are major interactions between BSA and vitamin B1.

Bovine serum albumin

Binding constant

10.1080/07391102.2015.1094414

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Photodynamic treatment with anionic nanoclays containing curcumin on human triple‐negative breast cancer cells: Cellular and biochemical studies

Journal of Cellular Biochemistry (2018)

Khatereh Khorsandi Reza Hosseinzadeh F. Shahidi

Photodynamic treatment is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with activation of a photosensitizer agent at a specific light. Little is known, however, about the phototoxic properties of curcumin, as a natural phenolic compound, against different types of cancers. It is generally accepted that cellular damage occurs during photo treatment. There is a limitation in using of curcumin as a drug due to its low solubility, but nanoparticles such as anionic nanoclays or layered double hydroxide (LDH) could overcome it. The aim of this study was to investigate cellular responses to curcumin-LDH nanoparticles after photodynamic treatment of MDA-MB-231 human breast cancer cells. For this purpose, the MDA-MB-231 human breast cancer cell line treated with curcumin-LDH nanoparticle and then irradiated (photodynamic treatment). After irradiation, lactate dehydrogenase assay, clonogenic cell survival, cell death mechanisms such as autophagy and apoptosis were determined. Cell cycle distribution after photodynamic therapy (PDT) and also intracellular reactive oxygen species (ROS) generation were measured. The result showed that curcumin-LDH-PDT has a cytotoxic and antiprolifrative effect on MDA-MB-231 human breast cancer cells. Curcumin-LDH-PDT induced autophagy, apoptosis, and G0/G1 cell cycle arrest in human breast cancer cell line. Intracellular ROS increased in MDA-MB-231 cancer cell line after treatment with curcumin-LDH along with irradiation. The results suggest that curcumin-LDH nanoparticle could be considered as a novel approach in the photodynamic treatment of breast cancer.

Clonogenic assay

10.1002/jcb.27775

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Spectroscopic investigation on molecular aspects and structural and functional effects of tetraethyl pyrophosphate organophosphorus insecticide interaction with adult human hemoglobin

Journal of Biomolecular Structure and Dynamics (2021)

Aida Doroudian Reza Hosseinzadeh Parvaneh Maghami Khatereh Khorsandi

Organophosphates are extremely toxic compounds that use extensively in agriculture and household as insecticides. However, their binding mechanism to bio-macromolecules especially blood proteins is not clearly understood. In this research, various spectroscopic techniques utilized to analyze the effect of Tetraethyl Pyrophosphate (TEPP), as an organophosphorus insecticide, on the structure, function, stability, and aggregation of adult human hemoglobin and also hemolysis potential of the TEPP on red blood cells (RBCs) examined. Molecular docking was used for TEPP binding to human Hemoglobin (Hb), too. The results demonstrated that the TEPP insecticide has the potential for lysing RBCs. UV-Vis experiment indicated that globin part and heme group influenced by TEPP. Oxygen affinity measurements revealed the formation of deoxy-Hb and met-Hb, also decreased in oxygen affinity of Hb upon interaction with TEPP that is due to heme destruction. Fluorescence spectroscopy confirmed the production of heme degradation species after interaction of Hb with TEPP, which is inconsistent with oxygen affinity measurements. Thermal and aggregation studies indicated that TEPP induced aggregation of Hb in a concentration manner and Tm of protein reduced to lower temperatures. Docking's study also showed that TEPP interacts with Hb through hydrophobic interactions, which confirms UV-Vis results. ATR-FTIR study also revealed that TEPP can induce changes in the alpha helix element of Hb's secondary structure. Totally, Experimental and theoretical results indicate that tetraethyl pyrophosphate has unfavorable effects on hemoglobin structure and function.Communicated by Ramaswamy H. Sarma.

Methemoglobin

10.1080/07391102.2021.1902398

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Potentiometric study of cetylpyridinium chloride cooperative binding to anionic azo-dyes

Journal of the Brazilian Chemical Society (2007)

Reza Hosseinzadeh Abdol‐Khalegh Bordbar Amir Abbas Matin Ramin Maleki

The binding of cetylpyridinium chloride (CPC) with some azo dyes (X6G, 3-BL, DY-42) has been extensively studied at various concentration of dyes, using cetylpyridinium-selective membrane electrode as a fast and accurate method. Klotz logarithmic plots have been constructed from EMF measurements. These plots indicated cooperativity in all of interactions. The accurate binding isotherms have been obtained and analyzed using Hill equation. The values of Hill equation parameters have been estimated and determined by considering this fact that saturation parameter of binding in the Hill equation (y) can be determined from the ratio of electromotive force (EMF) measurements in the presence and absence of dye. In all of the interactions Hill coefficients indicate cooperative binding in CPC-dye interactions due to the combination of both electrostatic and hydrophobic interactions. Intrinsic Gibbs energies of binding processes have been also calculated and interpreted on basis of interaction mechanism.

Cetylpyridinium chloride

Electromotive force

Cooperativity

Scatchard plot

Cooperative binding

10.1590/s0103-50532007000200017

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Citations (14)

Nanomaterials as drug delivery systems with antibacterial properties: current trends and future priorities

Expert Review of Anti-infective Therapy (2021)

Khatereh Khorsandi Reza Hosseinzadeh Homa Sadat Esfahani Saeedeh Keyvani‐Ghamsari Saeed Ur Rahman

Introduction:Despite extensive advances in the production and synthesis of antibiotics, infectious diseases are one of the main problems of the 21st century due to multidrug-resistant (MDR) distributing in organisms. Therefore, researchers in nanotechnology have focused on new strategies to formulate and synthesis the different types of nanoparticles (NPs) with antimicrobial properties.Areas covered:The present review focuses on nanoparticles which are divided into two groups, organic (micelles, liposomes, polymer-based and lipid-based NPs) and inorganic (metals and metal oxides). NPs can penetrate the cell wall then destroy permeability of cell membrane, the structure and function of cell macromolecules by producing of reactive oxygen species (ROS) and eventually kill the bacteria. Moreover, their characteristics and mechanism in various bacteria especially MDR bacteria and finally their biocompatibility and the factors affecting their activity have been discussed.Expert opinion:Nanotechnology has led to higher drug absorption, targeted drug delivery and fewer side effects. NPs can overcome MDR through affecting several targets in the bacteria cell and synergistically increase the effectiveness of current antibiotics. Moreover, organic NPs with regard to their biodegradability and biocompatibility characteristics can be suitable agents for medical applications. However, they are less stable in environment in comparison to inorganic NPs.

Biocompatibility

Nanomaterials

10.1080/14787210.2021.1908125

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Citations (53)

Biological and Molecular Effects of Pesticides on Human Health

IntechOpen eBooks (2022)

Aida Doroudian Mahdieh Emadi Reza Hosseinzadeh Parvaneh Maghami

Pesticides are widely used in agriculture and are practical and economical to improve the quality of food safety for the permanent population around the world. Even though insecticides are beneficial to cropping views, their extensive use may result in severe consequences due to their biocompatible and permanent nature. Various pesticides can cause serious health risks of direct or indirectly contaminated air, water, soil, and the general ecosystem. The effect of pesticides on blood in the mammalian cell is significant because blood can act as a target and carrier for pesticides. However, the mechanism by which they bind to biopolymers, particularly blood proteins, is not clearly understood yet. This chapter investigates the molecular effects of pesticides on biomacromolecules, especially hemoglobin.

10.5772/intechopen.104811

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Citations (2)

Interaction of Diclofenac with Bovine Serum Albumin Investigated by Diclofenac-Selective Electrode

Acta chimica slovenica (2007)

Reza Hosseinzadeh Ramin Maleki Amir Abbas Matin

The binding of sodium diclofenac (SD) with bovine serum albumin (BSA) has been extensively studied at various concentration of BSA, using diclofenac-selective membrane electrodes constructed in our laboratory. The accurate binding isotherms have been obtained and analyzed in terms of binding capacity concept. The results represent two binding set system for all of studied conditions. The values of Hill equation parameters have been estimated and used for calculation of intrinsic Gibbs free energy of binding.

Bovine serum albumin

Diclofenac Sodium

Diclofenac

Serum Albumin

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Citations (20)