Ke Yang

Zhejiang Cancer Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Xin Zhu

Zhejiang Cancer Hospital

Peng Yu

Tianjin University of Science and Technology

Kui Lu

Tianjin University of Science and Technology

Zijun Zhang

City University of Hong Kong

Xiaotong Song

Research Center for Eco-Environmental Sciences

Cuilian Zhang

Henan Provincial People's Hospital

Feng Wan

Chengdu University of Traditional Chinese Medicine

Guojun Pan

Shandong First Medical University

Chenhui Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Chengcheng Zhou

Beijing Forestry University

Cooperative Institutions

Tianjin University of Science and Technology

Zhejiang Cancer Hospital

China International Science and Technology Cooperation

Huazhong University of Science and Technology

Chinese Academy of Sciences

Fudan University

Wenzhou Medical University

Zhengzhou University

University of Chinese Academy of Sciences

Henan University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Supplementary Material for: Evaluation of the Associations of GC and CYP2R1 Genes and Gene-Obesity Interactions with Type 2 Diabetes Risk in a Chinese Rural Population

Figshare (2020)

Yanling Zhao G. Wang Yuguo Li Xihui Liu Li Liu

Introduction: Group-specific component (GC) and cytochrome P450 family 2 subfamily R member 1 (CYP2R1) gene polymorphisms and obesity have been associated with an increased risk for development of type 2 diabetes mellitus (T2DM) in Asian populations. Objective: This study assessed the associations of interactions between GC gene variants and CYP2R1 gene variants and between genes and obesity with T2DM risk. Methods: A study that included 2,271 subjects was performed. Eight single nucleotide polymorphisms in the GC and CYP2R1 genes were genotyped. Interaction analysis was performed using rs7041 in the GC gene and rs1993116 in the CYP2R1 gene. The effects of multiplicative and additive gene-gene and gene-environment interactions on T2DM risk were assessed. Results: The T2DM risk was significantly associated with being overweight/obese, abdominal obesity, rs7041, and rs1993116. A significant additive interaction between rs1993116 and rs7041 was associated with T2DM. In addition, there was a significant multiplicative interaction between rs7041 and body mass index (BMI) associated with elevated blood glucose levels, and at a higher BMI (>28.47), the G allele carrier showed a stronger effect than the TT genotype. Conclusions: The interactions between GC rs7041-CYP2R1 rs1993116 and GC rs7041-BMI may explain the mechanisms by which these factors increase the risk of T2DM development.

10.6084/m9.figshare.12998411

Cite

Citations (0)

Metabolomics reveals the implication of acetoacetate and ketogenic diet therapy in radioiodine-refractory differentiated thyroid carcinoma

The Oncologist (2024)

Jiaqi Wang Qian-Qian Xu Ziyang Xuan Yuting Mao Xi Tang

Patients with radioiodine-refractory (RAIR) differentiated thyroid carcinoma (DTC; RAIR-DTC) have a poor prognosis. The aim of this study was to provide new insights and possibilities for the diagnosis and treatment of RAIR-DTC.

Ketogenic Diet

Radioiodine therapy

Refractory (planetary science)

10.1093/oncolo/oyae075

Cite

Citations (0)

A Systematic Review about Treating Pneumonia with QinKaiLing Injection

Gansu Journal of Traditional Chinese Medicine (2011)

Ke Yang

Objective To systematically evaluate the efficacy of QinKaiLing injection for pneumonia.Methods We searched the PubMed(1966-2010.4),EMbase(1974-2010.4),Cochrane library2010(4),Chinese Science and Technology Academic Journal(1989-2010.4),CJFD(1994-2010.4),Chinese Biomedical Literature Database(1978-2010.4) and the related conference papers,collecting random and quasi-randomized controlled trials about treating pneumonia with QinKaiLing injection.In accordance with a simple evaluation method reviewed by cochrane systematic manual,to rigorously evaluate the methodological quality of included studies,do Meta-analysis using RevMan 5.0 17 software for homogeneous studies.Results: 5 studies,440 patients were included.Meta analysis showed that: compared with conventional treatment,conventional therapy combined with QinKaiLing injection can increase the total clinical effective rate [RR = 1.31,95% CI(1.09,1.57)],shorter cooling time [MD =-1.24,95% CI(-1.56,-0.92)],stopping cough time [MD =-1.09,95% CI(-1.73,-0.45)] and eliminating pulmonary rales(wheezing) time [MD =-1.68,95 % CI(-2.82,-0.54)].Conclusion:The current study shows that treating pneumonia with QinKaiLing injection combined conventional treatment can improve the efficiency,but in view of having only domestic research and low quality,the demonstrate strength restricted to a certain extent,more high quality,large sample,multi-Center double-blind randomized controlled trial results needed to confirm this conclusion.

Source

Cite

Citations (0)

Expression and clinical significance of Runt-related transcription factor 3 gene methylation in gastric cancer tissue

Rubo Cao Ke Yang Jun Xue Qian Ding Jing Huang

Objective To investigate the clinical significance of Runt-related transcription factor 3 (RUNX3) gene methylation in gastroscope biopsy specimens of patients with gastric cancer.Methods Sixty patients with primary gastric cancer (36 males and 24 females) at the age of (55.6 ± 10.1) years admitted to our hospital from January 2010 to January 2012 were selected as experimental group,and 60 healthy volunteers (35 males and 25 females) at the age of (55.2 ± 9.8) during the same period served as control group.Methylation specific polymerase chain reaction (MSP) was used to detect the methylation status of Runx3 gene promoter in the gastroscope biopsy specimens of 60 gastric cancer patients and normal controls.The results were analyzed by using SPSS software.Results The methylation ratio of Runx3 gene promoter was significantly higher in gastric cancer patients (61.7％,37/60) than in normal controls (3.3％,2/60,P ＜ 0.05).The Runx3 gene promoter methylation ratio was was related with gender,age,location and HP infection (P ＞ 0.05),but with Lauren's classification,histological grade,tumor size,lymph node metastasis,distant metastasis and TNM staging (P ＜ 0.05).Conclusion Runx3 gene promoter methylation in gastroscope biopsy specimens may be related with histological classification,tumor size,metastasis and TNM staging. Key words: Gastric cancer; Runt-related transcription factor 3

Clinical Significance

10.3760/cma.j.issn.1001-9030.2013.09.066

Cite

Citations (0)

Vale of ADA in differential diagnosis of hydrothorax

Journal of Clinical Pulmonary Medicine (2006)

Ke Yang

Objective To observe the value of ADA in differential diagnosis of hydrothorax. Methods We detected ADA pleural fluid in 188 patients with pleural effusion. The patients were divided into three groups of malignant hydrothorax, tuberculous hydrothorax and transudative hydrothorax. The data of the three groups were compared. The value of ADA in any one of the groups was significantly different from the other two. ADA was great in identifying tuberculous and malignant hydrothorax. Detection of ADA can be routinely performed. It is very useful and can help clinicians greatly.

Hydrothorax

Source

Cite

Citations (0)

Synthesis & α-Glucosidase Inhibitory & Glucose Consumption-Promoting Activities of Flavonoid–Coumarin Hybrids

Future Medicinal Chemistry (2018)

Hua Sun Xiaotong Song Yunchang Tao Ming Li Ke Yang

Aim: The research of novel and potent antidiabetic agents is urgently needed for the control of the exploding diabetic population. We previously reported the synthesis and antidiabetic activity of natural 8-(6"-umbelliferyl)-apigenin (1), but its antidiabetic targets are not known. Therefore, four series of derivatives were synthesized and evaluated for their antidiabetic activities. Results & methodology: Compounds (5a) and (14a) were identified as new α-glucosidase and α-amylase dual inhibitors. The kinetic analysis of the most potent α-glucosidase inhibitor of each series of compounds revealed that they inhibited α-glucosidase in irreversible modes. In addition, compounds (5a) and (14a) showed potent glucose consumption-promoting activity. Conclusion: Compounds (5a) and (14a) could be regarded as promising starting points for the development of antidiabetic candidates.

10.4155/fmc-2017-0293

Cite

Citations (22)

Study on effects and effects of expanded testing in found HIV.

The Chinese Journal of Dermatovenereology (2018)

Ke Yang Yang ZhengPei Cheng ZhouHeng He LongMing Yang Li-qiong

Source

Cite

Citations (0)

[Clinical characteristics and genetic analysis of a patient with Acephalic spermatozoa syndrome due to variant of PMFBP1 gene].

PubMed (2024)

Ke Feng Yanqing Xia Xiaowei Qu Feng Wan Ke Yang

To analyze the clinical characteristics and genetic basis of a male patient with primary infertility caused by Acephalic spermatozoa syndrome.

Genetic Analysis

10.3760/cma.j.cn511374-20220323-00199

Cite

Citations (0)

Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma

Evidence-based Complementary and Alternative Medicine (2021)

Ke Yang Ke Wu Jianguo Feng Yutian Ling Xin Zhu

To investigate the antitumor effect of andrographolide on the ATC cell lines 8505C and CAL62 and to explore the possible mechanism of the effect.

Andrographolide

10.1155/2021/5526581

Cite

Citations (2)

The Rat Chronic Toxicity Test of Sishun Qingliangyin

Lishizhen Medicine and Materia Medica Research (2006)

Zhu Liang Xing Shao-jing Wang Yi-fei Ke Yang Jiuxiang Li

ObjectiveTo observe the effects of Sishun Qingliangyin on the rat chronic toxicity test.MethodsThe rats were orally given for 3 weeks with the doses of 40,28 and 19.6 g/kg(being 44.8,31.4 and 22 times of clinic dose) and for 6 days of stopping administration,the rat weights,organ coefficients,the indexes of hematology and biochemistry were determined,and the pathological examination were carried out.ResultsThe outer appearance and behavior,weights, organ coefficients,the indexes of hematology and biochemistry in rats has no significant difference by comparing with control group;the pathological examination was not discovered significant pathological changes with relation of drug toxicity and the delayed toxicity reaction in stopping administration later.ConclusionThe Sishun Qingliangyin has no significant toxicity for long-term administration in rats,and infers that the drawing up doses in clinic will be safe.

Hematology

Chronic toxicity

Source

Cite

Citations (0)