Chengyu Lu

Guangdong Medical College

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Jian-Qiang Liu

Guangdong Medical College

Ying Pan

Guangdong Medical College

Alireza Nezamzadeh–Ejhieh

Islamic Azad University of Shahreza

Abhinav Kumar

Southmead Hospital

Yingnan Yang

University of Tsukuba

Guoping Chen

University of Tsukuba

Naoki Kawazoe

National Institute for Materials Science

Lanlan Liu

Shenzhen Third People’s Hospital

Ai-Qing Ma

Shenzhen Institutes of Advanced Technology

Donghui Liao

Guangdong Medical College

Cooperative Institutions

Guangdong Medical College

Guangdong Pharmaceutical University

Chinese Academy of Sciences

Dongguan People’s Hospital

Shanghai Jiao Tong University

Shenzhen Institutes of Advanced Technology

University of Tsukuba

University of Chinese Academy of Sciences

National Institute for Materials Science

Central South University

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Cancer Cell Membrane‐Biomimetic Oxygen Nanocarrier for Breaking Hypoxia‐Induced Chemoresistance

Advanced Functional Materials (2017)

Hao Tian Zhenyu Luo Lanlan Liu Mingbin Zheng Ze Chen

The inadequate oxygen supply in solid tumor causes hypoxia, which leads to drug resistance and poor chemotherapy outcomes. To solve this problem, a cancer cell membrane camouflaged nanocarrier is developed with a polymeric core encapsulating hemoglobin (Hb) and doxorubicin (DOX) for efficient chemotherapy. The designed nanoparticles (DHCNPs) retain the cancer cell adhesion molecules on the surface of nanoparticles for homologous targeting and possess the oxygen‐carrying capacity of Hb for O 2 ‐interfered chemotherapy. The results show that DHCNPs not only achieve higher tumor specificity and lower toxicity by homologous targeting but also significantly reduce the exocytosis of DOX via suppressing the expressions of hypoxia‐inducible factor‐1α, multidrug resistance gene 1, and P‐glycoprotein, thus resulting in safe and high‐efficient chemotherapy. This work presents a new paradigm for targeted oxygen interference therapy by conquering hypoxia‐involved therapeutic resistance and achieves effective treatment of solid tumors.

Nanocarriers

Hypoxia

Tumor Hypoxia

10.1002/adfm.201703197

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Citations (224)

CCDC 1497129: Experimental Crystal Structure Determination

The Cambridge Structural Database (2016)

Jun Lin Nga-Yuen Chau Jia‐Ling Liao Wai‐Yeung Wong Chengyu Lu

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1m7wh7

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CCDC 1497131: Experimental Crystal Structure Determination

The Cambridge Structural Database (2016)

Jun Lin Nga-Yuen Chau Jia‐Ling Liao Wai‐Yeung Wong Chengyu Lu

10.5517/ccdc.csd.cc1m7wk9

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Antitumor activity of DABA-containing carboxylate Zn complexes on breast cancer cell line MCF-7

Research Square (Research Square) (2023)

Wei Liu Hongmei Lu Xun Xu Kangrui Yuan Xinyi Yang

Abstract The coordination polymer [Zn 2 (DABA) 3 (CH 3 OH)] (DABA=4-dimethylaminobenzoic acid) (ZP) was obtained by hydrothermal synthesis using DABA and Zn(NO 3 ) 2 ·6H 2 O as substrates. The exact structure of ZP was confirmed by thermogravimetric analysis (TGA), Fourier transforms infrared spectroscopy (FTIR)， and single-crystal X-ray diffraction. The Cell Counting Kit-8 (CCK-8) assay was used to detect the cytotoxicity of ZP on the following cell types (A549, HepG2, Huh-7, MCF-7, LO2 cells), and the results showed that the complex was significantly toxic to MCF-7 cell line and less toxic to normal hepatocytes LO2. In addition, the cell cycle and mitochondrial membrane potential of the MCF-7 cell line were further measured by flow cytometry, and the experimental results indicated that different concentrations of the drug blocked the cell cycle in the S phase and significantly reduced the mitochondrial membrane potential. Western Blot experiments illustrated that ZP was able to upregulate the expression levels of cleaved PARP, cleaved caspase and bax protein and downregulate the expression level of bcl-2. These results suggest that ZP inhibits tumor cell apoptosis through a mitochondria-mediated pathway, accompanied by the regulation of bcl-2 and caspase family proteins.

MCF-7

10.21203/rs.3.rs-2437557/v1

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Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer

Nano Research (2022)

Lishan Zhang Ting Yin Baozhen Zhang Chong Yan Chengyu Lu

Sonodynamic therapy

10.1007/s12274-021-4039-y

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Recent advances of the core–shell MOFs in tumour therapy

International Journal of Pharmaceutics (2022)

Yana Zeng Guihua Xu Xiangyang Kong Gaomin Ye Jian Guo

10.1016/j.ijpharm.2022.122228

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Citations (41)

GFP-based Escherichia coli in establishment of the visual model in rats of bacterial prostatitis

Zhongguo yaolixue tongbao (2013)

Chengyu Lu

Aim To induce an experimental model in rats by E.coli tagged with GFP to investigate the significance of the invasion pathway of bacteria and the immune response in abacterial prostatitis and to establish a direct quantitative analysis method of pathogen.Methods After injecting 0.05 ml of of E.coli K88-GFP(1.49×109cfu·ml-1) liquid into the left dorsal lobe of SD rat prostate,a visualized method of bacterial prostatitis model was established through surface fluorescence image and tissue sections observed by fluorescence microscopy.Results ① The pathway of invasion and infection and the pathology changes of gland were confirmed.② A preliminary direct quantitative analysis method of pathogen was established.Conclusion Through constructing a visualized method of bacterial prostatitis model tagged with GFP,a direct quantitative analysis method of pathogen would be established and it provides a novel approach to further study of PK/PD for antibacterial.

Quantitative Analysis

Source

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Manganese complexes and manganese-based metal-organic frameworks as contrast agents in MRI and chemotherapeutics agents: Applications and prospects

Colloids and Surfaces B Biointerfaces (2022)

Rouqiao Zheng Jun-Ru Guo Xinyi Cai Lianjie Bin Chengyu Lu

Biocompatibility

Rational design

MRI contrast agent

10.1016/j.colsurfb.2022.112432

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Citations (83)

MOF-Based Platform for Kidney Diseases: Advances, Challenges, and Prospects

Pharmaceutics (2024)

Lier Deng Manli Guo Yijun Deng Ying Pan Xiaoxiong Wang

Kidney diseases are important diseases that affect human health worldwide. According to the 2020 World Health Organization (WHO) report, kidney diseases have become the top 10 causes of death. Strengthening the prevention, primary diagnosis, and action of kidney-related diseases is of great significance in maintaining human health and improving the quality of life. It is increasingly challenging to address clinical needs with the present technologies for diagnosing and treating renal illness. Fortunately, metal-organic frameworks (MOFs) have shown great promise in the diagnosis and treatment of kidney diseases. This review summarizes the research progress of MOFs in the diagnosis and treatment of renal disease in recent years. Firstly, we introduce the basic structure and properties of MOFs. Secondly, we focus on the utilization of MOFs in the diagnosis and treatment of kidney diseases. In the diagnosis of kidney disease, MOFs are usually designed as biosensors to detect biomarkers related to kidney disease. In the treatment of kidney disease, MOFs can not only be used as an effective adsorbent for uremic toxins during hemodialysis but also as a precise treatment of intelligent drug delivery carriers. They can also be combined with nano-chelation technology to solve the problem of the imbalance of trace elements in kidney disease. Finally, we describe the current challenges and prospects of MOFs in the diagnosis and treatment of kidney diseases.

Kidney disorder

10.3390/pharmaceutics16060793

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Recent Advances of Fe(III)/Fe(II)-MPNs in Biomedical Applications

Pharmaceutics (2023)

Weipeng Chen Miao Liu Hanping Yang Alireza Nezamzadeh–Ejhieh Chengyu Lu

Metal–phenolic networks (MPNs) are a new type of nanomaterial self-assembled by metal ions and polyphenols that have been developed rapidly in recent decades. They have been widely investigated, in the biomedical field, for their environmental friendliness, high quality, good bio-adhesiveness, and bio-compatibility, playing a crucial role in tumor treatment. As the most common subclass of the MPNs family, Fe-based MPNs are most frequently used in chemodynamic therapy (CDT) and phototherapy (PTT), where they are often used as nanocoatings to encapsulate drugs, as well as good Fenton reagents and photosensitizers to improve tumor therapeutic efficiency substantially. In this review, strategies for preparing various types of Fe-based MPNs are first summarized. We highlight the advantages of Fe-based MPNs under the different species of polyphenol ligands for their application in tumor treatments. Finally, some current problems and challenges of Fe-based MPNs, along with a future perspective on biomedical applications, are discussed.

10.3390/pharmaceutics15051323

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Citations (33)