Objective To evaluate the role of ultrasonography guided needle percutaneous biopsy in the qualitation of internal mammary lymph nodes in breast cancer.Methods Twenty patients with breast cancer and large internal mammary lymph nodes underwent ultrasonography guided percutaneous biopsy.Results The successful rate of the percutaneous biopsy was 85.0%.Sixteen cases got specific pathology diagnosis,in which cancer cells were found.The diagnostic accuracy was 94.1% and no serious complications occurred.Conclusion Ultrasonography guided needle percutaneous biopsy is convenient,safe and efficient for the qualitation of internal mammary lymph nodes in breast cancer.It can offer a basis for clinical diagnosis and therapy.
BACKGROUND: The present article analyses the association between socioeconomic status (includes education, occupation, income and marriage) and alcoholic liver disease (ALD) risk factors (age, gender, obesity, quantity and duration of alcohol intake, alcoholic beverages, drinking patterns) in Taishan area of Shandong province, to provide scientific basis for the prevention of alcoholic liver disease for the people who mostly need it in north China.METHODS: Across-sectional survey of over 18--year-old inhabitants in Shandong Province in 2011 used multistage, randomized clustered sampling to identify 8186 subjects; 7295 (89.12%) of them were interviewed. Questionnaires, designed by co-working of epidemiologists and hepatologists, included demographic characteristics, current medication use, medical history and health-relevant behaviors, i.e. alcohol consumption, dietary habits and physical activities. Anthropometric measurements, biochemical tests and abdominal ultrasonography were carried out. The sample was determined by Chi-square test, covariance analysis and logistic regression analysis.RESULTS: Because of the small number of female drinkers, alcoholic liver disease prevalence of female was obviously lower than that of male, the very study of the male drinkers is more meaningful and can be represent the whole drinkers group to some extent. Among the four socio-economic status (SES) indicators the marriage status seemed to be the most influential factor. People (men or women) without spouse had higher risk of alcoholic liver disease risk factors than those who had spouse. The risk of people who have different occupation is different. The higher education was associated with risk of ALD.CONCLUSION: Marriage status seemed to be the most important measure of the socioeconomic indicators in relation to the alcoholic liver disease risk factors in the study of population. There is obvious relation between occupation status and alcoholic liver disease risk factors in men. The lower occupation had higher alcoholic liver disease risk factors. People with higher income and education had higher levels of drinking risk factors and lower level of obesity risk factors.
The paper Explored two pieces of necessary qualification to improve human-information system(H-IS) interactive efficiency within enterprise computerization environment: first, there are good matching among tasks and human,tasks and IS,human and IS;second,there are good interactive environment during the course of interaction. Established the conceptual model about H-IS interactive efficiency and the three pieces of matching relation of tasks,human,IS and interactive environment.The action mechanism among the three pairs of matching relations and H-IS are analyzed.The results show: the matching between human and tasks,human and IS affect cognitive efficiency and information processing efficiency by cognitive load and psychological load,further affect H-IS interactive efficiency;the matching between tasks and IS affect emotion by anxiety and rationality of IS,further affect cognitive efficiency,and ultimately affect H-IS interactive efficiency.
Objective: To explore the prognostic factors on patients with chronic severe hepatitis treatment by artificial liver support system by analyzing the clinical date of 65 cases with chronic severe hepatitis treatment by artificial liver support system. Methods Clinical data of 65 patients with chronic severe hepatitis treatment by artificial liver support system were analyzed retrospectively. Results Fatality rate in patients with severe hepatitis had no relation to age and sexuality. There is no significant difference between the death rate of patients with single infection of HBV and that of patients with multiple infection of HBV and other type hepatitis virus. Hepatic encephalopathy (86.49%), hepatorenal syndrome(40.54%), severe infection(27.03%)and primary peritonitis (64.86%)in death group were higher than those in curing or improving group(35.71%, 10.71%, 3.57%, 39.29%, P0.05)。.Prothrombrin activity (PTA) (26.29±13.75)and cholesterol (CHOL) (1.27±0.66) in death group was lower than that in curing or improving group(32.93±7.38, 2.21±1.06, P0.05). Conclusion Low PTA, low CHOL, and complicated with hepatic encephalopathy, hepatorenal syndrome, severe infection and primary peritonitis are bad parameters in patients with chronic severe hepatitis treatment by artificial liver support system.
Many transmitted diseases have latent period,and the length of the latent period affects the disease incidence in general.So it considered an age-since-infection epidemic model,the model constructed by two ordinary differential equations and one partial differential equation.Disease-free steady state and epidemic steady state of the model was given,linked by a transcritical bifurcation.A local stability analysis of the equilibria was performed.It is shown that the dynamics of the model is determined by the threshold of the parameters,that is,the basic reproductive number R0.If the threshold value is less than one,i.e.R01,only the disease-free equilibrium exist and it is stable.While the threshold value is greater than one,i.e.R01,there is a unique endemic equilibrium,and it is stable.
An SIRS epidemic model with an age-dependent vaccination is considered.By using the theory of differential or integral equation,an explicit formula for the vaccine-dependent reproductive number R(ψ) is first obtained.Next,it is showed that the disease-free steady state is locally asymptotically stable if R(ψ) is less than one and unstable if R(ψ) is larger than one.If R(0)1,then the disease-free equilibrium is global attractor.Moreover,there exists an endemic steady state in this model which is unstable under the condition R(ψ)1.Finally,the condition for the local stability of the endemic equilibrium is given.
Objective
To investigate the role of serum thymidine kinase 1 (STK1) in public screening for early carcinoma of precancerous diseases.
Methods
STK1 concentrations were measured in 8869 participants by using an enhanced chemiluminescent blot assay.
Results
The mean STK1 value (n=514)(5.8%) of the risk group (STK1>2 pmol/L) was (3.8±2.2) pmol/L.Only one individual with hepatoma was found.However, 85.2% of the subjects in the risk group developed precancerous diseases (gall-bladder or kidney proliferative lesions), suspected liver or lung malignant tumor lesions, anemia disease, over-weight, benign tumor of gall-bladder, liver and lung, fatty liver and hepatitis B. Those (n=4333) who had long-term direct exposure to oil-related pollutants (drilling, transportations, geological prospecting) showed a higher positive rate of STK1 (7.8%) in comparison to those (n=4536) responsible for pre-drilling prepared technology or services (3.9%) (χ2=55.53, P<0.05). Furthermore, those who had proliferating lesions and suspected malignant tumor lesions were mainly found in the former group (78.4%), which might be associated with direct exposure to oil mists in the working environment.
Conclusions
Serum TK1 may be a reliable marker of tumor proliferating, enabling timely discovery of early carcinoma in patients with precancerous diseases.
Key words:
Thymidine kinase; Precancerous conditios; Physical examination
To investigate and study the related risk factors of gastric cancer (GC) patients, to establish a high-risk scoring model of GC by multiple logistic regression analysis, and to explore the establishment of a GC screening mode with clinical opportunistic screening as the main method, and by using the pattern of opportunistic screening to establish the screening of high-risk GC patients and the choice of screening methods in the clinical outpatient work.Collected the epidemiological questionnaire of 99 GC cases and 284 non-GC patients (other chronic gastric diseases and normal) diagnosed by the General Hospital of Ningxia Medical University from October 2017 to March 2019. Serum pepsinogen (PG) levels were measured by enzyme-linked immunosorbent assay (ELISA) and confirmed Helicobacter pylori (Hp) infection in gastric mucosa tissues by Giemsa staining. Determined the high-risk factors and established a scoring model through unconditional logistic regression model analysis, and the ROC curve determined the cut-off value. Then, we followed up 26 patients of nongastric cancer patients constituted a validation group, which validated the model.The high-risk factors of GC included age ≥ 55, male, drinking cellar or well water, family history of GC, Hp infection, PGI ≤ 43.6 μg/L, and PGI/PGII ≤ 2.1. Established the high-risk model: Y = A × age + 30 × gender + 30 × drinking water + 30 × Hp infection + 50 × family history of GC + B × PG level. The ROC curve determined that the cut-off value for high-risk GC population was ≥155, and the area under the curve (AUC) was 0.875, the sensitivity and specificity were 87.9% and 71.5%.According to the risk factors of GC, using statistical methods can establish a high-risk scoring model of GC, and the score ≥ 155 is divided into the screening cut-off value for high-risk GC population. Using this model for clinical outpatient GC screening is cost-effective and has high sensitivity and specificity.
Objective To investigate the value of ultrasound in diagnosis of primary gastric lymphoma(PGL).Methods The ultrasonographic images of 25 cases with PGL were analyzed.Results In 25 cases of PGL,there were 20 cases of thickness of stomach wall type,and wave changes appeared in mucous membrane,5 cases of mass type,and arch bridge appeared in mucous membrane. Peristalsis was decreased in early stage,The stomach remained distensibility without obvious stenosis. Peristalsis disappeared in late stage,and whole gastric wall and peripheral tissue were invaded. There were 15 cases combined with ulcer. Blood flow was not abundant in diseased region.In 20 cases of thickening stomach wall type,8 cases were diagnosed by ultrasound,9 cases were misdiagnosed as gastric cancer,and 3 cases as acute gastritis.In 5 cases of mass type,3 cases were diagnosed by ultrasound,2 cases were misdiagnosed as gastric smooth muscle tumor. The coincidence rate of ultrasound in diagnosis of PGL was 44%.Conclusion The sonograms of PGL have special characteristic,which has important reference value in clinical diagnosis of PGL.
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