Chunling Hu

Shihezi University

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Maolin Pang

Guangxi Normal University

Sainan Liu

Changchun Institute of Applied Chemistry

Lihan Cai

Dalian University

Yuwei Liang

North China Electric Power University

Jichang Liu

East China University of Science and Technology

Ying Zhou

Chongqing Medical University

Qi Li

Harbin Engineering University

Xueyan Zhao

Ningbo University

Yanlong Tai

Chinese Academy of Sciences

Jianning Wu

Shihezi University

Cooperative Institutions

Chinese Academy of Sciences

Changchun Institute of Applied Chemistry

University of Science and Technology of China

Shihezi University

Xinjiang Production and Construction Corps

National Taiwan University of Science and Technology

Soochow University

University of Chinese Academy of Sciences

Jilin University

State Key Laboratory of Rare Earth Resources Utilization

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Photocatalytic Selective Oxidation of Hmf to Dff Based on Hollow CDS Qds/Mil-101 Composites Under Visible Light

Yuwei Liang Chunling Hu Peng Chen Qi Li Jianning Wu

Download This Paper Open PDF in Browser Add Paper to My Library Share: Permalink Using these links will ensure access to this page indefinitely Copy URL Copy DOI

Visible spectrum

10.2139/ssrn.4775371

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Covalent Organic Framework-Based Nanocomposite for Synergetic Photo-, Chemodynamic-, and Immunotherapies

ACS Applied Materials & Interfaces (2020)

Sainan Liu Ying Zhou Chunling Hu Lihan Cai Maolin Pang

Cancer deaths are mainly caused by tumor metastases. However, tumor ablation therapies can only target the primary tumor but not inhibit tumor metastasis. Herein, a multifunctional covalent organic framework (COF)-based nanocomposite is designed for synergetic photo-, chemodynamic- and immunotherapies. Specifically, the synthesized COF possesses the ability to produce singlet oxygen under the 650 nm laser irradiation. After being metallized with FeCl3, p-phenylenediamine is polymerized on the surface of COF with Fe3+ as the oxidant. The obtained poly(p-phenylenediamine) can be used for photothermal therapy. Meanwhile, the overexpressed H2O2 in the tumor would be further catalyzed and decomposed into hydroxyl radicals (•OH) by the Fe3+/Fe2+ redox couple via Fenton reaction. Intriguingly, the increase of temperature caused by photothermal therapy can accelerate the production of •OH. Moreover, the tumor-associated antigen induced a robust antitumor immune response and effectively inhibited tumor metastasis in the presence of anti-PD-L1 checkpoint blockade. Such a COF-based multifunctional nanoplatform provides an efficacious treatment strategy for both the primary tumor and tumor metastasis.

Tumor ablation

Covalent organic framework

Immune checkpoint

10.1021/acsami.0c12824

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Facile Fabrication of Nanoscale Porphyrinic Covalent Organic Polymers for Combined Photodynamic and Photothermal Cancer Therapy

ACS Applied Materials & Interfaces (2019)

Yanshu Shi Sainan Liu Ying Liu Chunqiang Sun Mengyu Chang

Photodynamic therapy (PDT) of cancers is usually inefficient due to the relatively low level of oxygen in cancer cells; therefore, it needs to combine with other treatment strategies such as chemotherapy or photothermal therapy (PTT) to achieve the best anticancer efficacy. Although porphyrin-containing materials have been widely studied for PDT, the photothermal effect is rarely reported. Herein, nanoscale porphyrin-containing covalent organic polymers (PCOPs) were produced via a room temperature solution-based aging method. The resulting nanoparticles possess high photothermal conversion efficiency (21.7%) and excellent photodynamic effect. For the first time, the in vitro and in vivo tests indicated an enhanced antitumor efficacy for PCOP with combined PDT and PTT. This study provides an efficient approach to fabricate nanoCOP and also demonstrates the great potential of porphyrin-containing COP for biomedical applications.

10.1021/acsami.9b00361

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Tracking and memorizing mechanism in machine translation

RIAO Conference (2000)

Chunling Hu Huang Heyan Zhaoxiong Chen

Improving the machine intelligence and the quality of machine translation is always an important and hard problem in natural language processing. This paper analyzes the disadvantages of present translation systems, and proposes a track-memorizing mechanism that is based on machine learning. Then, the principles of the mechanism are elaborated. At the end, we describe and discuss the utilization of the approach in Russian-Chinese translation system.

Memorization

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The Sphere-end-mill-cutter Sharpend on Four-axis CNC

Chunling Hu

Because the resharpening of an end-cutting-edge of sphere-end-mill-cutter must be completed on five-axis NC tool-grinding machine, a model of four-axisCNC sharpening process is set and error analysis is made, on the basis of which, this model is verified by some experiments.

Sharpening

End mill

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Research on the Development and Utilization of Archives Information Resources Based on User's Perspective

Liying Cui Chunling Hu

Archives information resource is an important part of information resources, which contains abundant information.With the advent of the information age, the importance of the value of archives is becoming more and more popular.

10.2991/emim-17.2017.321

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Design of TiO2-X nanotubes with controllable oxygen vacancy concentration and performance study of selective oxidation of benzyl alcohol

Journal of Materials Science (2024)

Chunling Hu Peng Chen Qi Li Keliang Wu Yuwei Liang

Benzyl alcohol

10.1007/s10853-024-10101-z

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Covalent Organic Framework–Titanium Oxide Nanocomposite for Enhanced Sonodynamic Therapy

Bioconjugate Chemistry (2021)

Lihan Cai Chunling Hu Sainan Liu Ying Zhou Zhendong Liu

Sonodynamic therapy (SDT) has attracted wide attention for its high tissue-penetration depth capacity. However, developing new kinds of sonosensitizers that are capable of generating large amounts of reactive oxygen species (ROS) still remains a challenge. Herein, covalent organic framework-titanium oxide nanoparticles (COF-TiO2 NPs) were successfully synthesized by using COF as a template. Under ultrasound (US) irradiation, large quantities of ROS can be generated, and compared with pure TiO2 NPs, the SDT performance of COF-TiO2 nanoparticles was significantly improved due to the narrower band gap. Both in vitro and in vivo experiments demonstrated the great tumor inhibitory effect via COF-TiO2-mediated SDT. This work broadens the biomedical applications of COF-based composites.

Sonodynamic therapy

Covalent organic framework

Titanium oxide

10.1021/acs.bioconjchem.1c00039

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A covalent organic framework as a nanocarrier for synergistic phototherapy and immunotherapy

Journal of Materials Chemistry B (2020)

Ying Zhou Sainan Liu Chunling Hu Lihan Cai Maolin Pang

As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumors, but they cannot inhibit extensive tumor metastasis and local recurrence. Herein, in order to prevent intermolecular accumulation and improve photostability, indocyanine green (ICG) is spontaneously adsorbed onto a covalent organic framework (COF) with high affinity through π-π conjugation, and then chicken ovalbumin (OVA) is coated on the surface of COF@ICG via an electrostatic interaction force. The resultant COF@ICG@OVA can ablate primary tumors under 650 nm and 808 nm laser irradiation due to its high photothermal conversion efficiency (η = 35.75%) and ability to produce reactive oxygen species (ROS). Tumor-associated antigens are also produced after combinational PTT/PDT therapy. By further combining with anti-PD-L1 checkpoint blockade therapy, it can effectively eliminate primary tumors and inhibit the metastasis of cancer cells by generating strong immune responses. Taken together, COF@ICG@OVA nanoparticles offer an efficient synergistic therapeutic modality for the treatment of tumor metastasis.

Nanocarriers

10.1039/d0tb00679c

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Compression, Energy Absorption, and Electromagnetic Shielding Properties of Carbon Nanotubes/Al Composite Foams

Advanced Engineering Materials (2022)

Wenda Shao Xudong Yang Chunling Hu Yuanxing Zheng

Herein, pre‐dispersed ball‐milling and space‐holder methods are used to prepare carbon nanotubes (CNTs) reinforced aluminum (Al) matrix composite foams (C‐AMCFs). Systematic research is conducted on the mechanical and electromagnetic shielding properties of C‐AMCFs as well as the optimal ball‐milling time. The results demonstrate a quasi‐linear relationship between CNTs contents and optimal ball‐milling time. With the addition of CNTs, the compressive performances of C‐AMCFs first increase and subsequently decrease. The 2.5 wt% C‐AMCFs have the best mechanical performance, whose yield strength (19.25 MPa), plateau stress (20.87 MPa), and energy absorption capacity (8.874 MJ m −3 ), are both 1.72, 1.72, and 1.79 times than those of AFs, respectively. In the X‐band (8.2–12.4 GHz), the addition of CNTs in C‐AMCFs can increase their electromagnetic shielding effectiveness. The greatest electromagnetic shielding effectiveness of the 2.0 wt% C‐AMCFs is 30–40 dB. By enhancing the reflection loss at the first interface as well as the absorption and reflection loss inside the cell walls, CNTs play an important role in improving the electromagnetic shielding performance of C‐AMCFs.

Reflection loss

10.1002/adem.202201240

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Citations (7)