Dehui Li

Hebei University of Chinese Medicine

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Huanfang Fan

Hospital of Hebei Province

Yifan Su

Hebei University of Chinese Medicine

Sun Chunxia

Hospital of Hebei Province

Xukuo Liu

Hebei University of Chinese Medicine

Chuanzhi Xu

Kunming Medical University

Yuanyuan Xiao

Jinan University

Harvey A. Risch

Yale University

Dianliang Zhang

Qingdao University

Yingjian Jiang

Qingdao Municipal Hospital

Jian Lu

Kunming Medical University

Cooperative Institutions

Hebei University of Chinese Medicine

Central South University

Affiliated Hospital of Hebei University

Xiangya Hospital Central South University

Huazhong University of Science and Technology

Hospital of Hebei Province

Sun Yat-sen University

Jinan University

Chinese Academy of Agricultural Sciences

Ministry of Agriculture and Rural Affairs

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Organizing pneumonia secondary to pulmonary tuberculosis: A case report

World Journal of Clinical Cases (2024)

Liu Min Xi-Yang Dong Zhi-Xiang Ding Qinghai Wang Dehui Li

BACKGROUND Organizing pneumonia secondary to pulmonary tuberculosis is rare. Moreover, the temporal boundary between pulmonary tuberculosis and secondary organizing pneumonia has not been defined. We report a case of secondary organizing pneumonia associated with pulmonary tuberculosis occurring after nine months of antituberculosis treatment. CASE SUMMARY A 54 years old man, previously diagnosed with pulmonary tuberculosis and tuberculous pleurisy, underwent nine months of antituberculosis treatment. Follow-up lung computed tomography revealed multiple new subpleural ground-glass opacities in both lungs, and a lung biopsy confirmed organizing pneumonia. Treatment continued with anti-tuberculosis agents and hormone therapy, and subsequent dynamic pulmonary computed tomography exams demonstrated improvement in lesion absorption. No disease recurrence was observed after corticosteroid therapy discontinuation. CONCLUSION When treating patients with active pulmonary tuberculosis, if an increase in lesions is observed during anti-tuberculosis treatment, it is necessary to consider the possibility of tuberculosis-related secondary organizing pneumonia, timely lung biopsy is essential for early intervention.

Discontinuation

Lung biopsy

10.12998/wjcc.v12.i26.5974

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The diagnostic value of prenatal ultrasound in fetal Holoprosencephaly

Chinese Journal of Family Planning & Gynecotokology (2011)

Dehui Li

Objective To study the diagnostic and differential diagnostic value of prenatal ultrasound on fetal holoprosencephaly(HPE).Methods The data of abnormal 2D-ultrasound imaging characteristic and the results after induced abortion in 13 cases with fetal HPE were analyzed retrospectively.Results Thirteen cases with fetal HPE diagnosed by prenatal ultrasound and autopsy after induced abortion were confirmed and the accuracy rate was 100%.The characteristic ultrasound findings in HPE showed the single primitive ventricle,fused thalami,absence of midline structures such as the falx cerebri and corpus callosum and facial abnormalities.Conclusion Prenatal ultrasound has important value in the diagnosis for fetal HPE,the characteristic ultrasound findings of the intracranial and facial abnormalities are helpful for the diagnosis and differential diagnosis of fetal HPE.

Falx cerebri

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Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer

Research Square (Research Square) (2019)

Yuanyuan Xiao Haijun Yang Jian Lu Dehui Li Chuanzhi Xu

Abstract Background: Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association between serum GGT measured at diagnosis and overall survival (OS) in patients with metastatic PC. Methods: We identified 320 patients with histopathologically confirmed metastatic pancreatic ductal adenocarcinoma (PDAC) diagnosed during 2015 and 2016 at a specialized cancer hospital in southwestern China. Univariate and multivariate Cox proportional-hazards models were used to determine associations between serum GGT and OS in metastatic PDAC. Results: Controlled for possible confounding factors, serum GGT was significantly associated with OS: serum GGT >48 U/L yielded a hazard ratio of 1.53 (95%CI: 1.19-1.97) for mortality risk. A significant dose-response association between serum GGT and OS was also observed. Subgroup analysis showed a possible interaction between GGT and blood glucose level. Conclusion: Serum GGT could be a potential indicator of survival in metastatic PDAC patients. Underlying mechanisms for this association should be investigated.

Gamma-glutamyltransferase

Univariate analysis

10.21203/rs.2.10892/v3

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Based on BATMAN-TCM to Explore the Molecular Mechanism of Xihuang Pill Regulating Immune Function to Treat Breast Precancerous Lesions

Breast Cancer Targets and Therapy (2021)

Dehui Li Huanfang Fan Jing‐fei Dong Sun Chunxia Yifan Su

The specific mechanism of Xihuang Pill in the treatment of breast precancerous lesions and breast cancer has not yet been elucidated.In our study, BATMAN-TCM (a Bioinformatics Analysis Tool for Molecular mechanisms of Traditional Chinese Medicine) was used to forecast the relationship among chemical components, immune targets, and diseases of each herb in Xihuang Pill and constructed a component-target-disease network. Taking breast precancerous lesion model rats as the research object, the molecular mechanism of Xihuang Pill regulating immunity was analyzed.BATMAN-TCM prediction showed that 309 genes were enriched in the biological process of "immune system response", which was the target of Xihuang Pill to regulate the immune system. The target of breast cancer disease and the genes related to Xihuang Pill's immune system response were crossed, and 88 cross genes were obtained. According to the enrichment results of GO/KEGG pathway, T cell activation was found to be the most relevant. We select Th1 cells (IL-2, IFN-γ) and Th2 cells (IL-4, IL-10) among them for animal experiment verification. The results show that Xihuang Pill can upregulate the serum IFN-γ and IL-2 levels, reduce the IL-4 and IL-10 levels, and regulate the balance of Th1/Th2 cells in the peripheral blood of rats with breast precancerous lesions.Xihuang Pill targets a variety of immune-related molecules related to breast precancerous lesions and is a traditional Chinese medicine formula that effectively regulates immune function.

Pill

KEGG

10.2147/bctt.s339607

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Effect of ceramide-1-phosphate transfer protein on intestinal bacterial translocation in severe acute pancreatitis

Clinics and Research in Hepatology and Gastroenterology (2016)

Jiang Wang Chang Li Yingjian Jiang Hongmei Zheng Dehui Li

Bacterial translocation

10.1016/j.clinre.2016.08.003

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Acupuncture Combined with Three-Step Analgesic Drug Therapy for Treatment of Cancer Pain: A Systematic Review and Meta-Analysis of Randomised Clinical Trials

Evidence-based Complementary and Alternative Medicine (2021)

Dehui Li Yifan Su Huanfang Fan Na Guo Sun Chunxia

Objective. The purpose of this study was to systematically evaluate the efficacy and safety of acupuncture combined with the WHO three-step analgesic drug ladder for cancer pain. Methods. The Cochrane Library, PubMed, and CNKI Database of Systematic Reviews were searched. Using the Cochrane Register for Randomized Controlled Trials, the quality of the included literature was evaluated, and the meta-analysis was carried out with RevMan 5.3 software. Results. Compared with three-step analgesia alone, acupuncture combined with three-step analgesia for cancer pain increased pain relief response rates (RR = 1.12, 95% CI: 1.08∼1.17,

P < 0.00001

), reduced NRS score (SMD = −1.10, 95% CI: −1.86∼−0.35,

P = 0.004

), reduced the rate of side effects (RR = 0.45, 95% CI: 0.38∼0.53,

P < 0.00001

), including nausea (

P < 0.00001

), vomiting (

P = 0.008

), constipation (

P < 0.00001

), and dizziness (

P = 0.010

), reduced the burst pain rate (SMD = −1.38; 95% CI: −2.44∼−0.32,

P = 0.01

), shortened analgesia effect onset time (

P = 0.004

), and extended the duration of response (

P < 0.0001

). Conclusion. For the treatment of cancer pain, acupuncture combined with three-step analgesic drugs is better than using only three-step analgesic drugs.

10.1155/2021/5558590

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Dynamic serum alkaline phosphatase is an indicator of overall survival in pancreatic cancer

BMC Cancer (2019)

Yuanyuan Xiao Jian Lu Wei Chang Ying Chen Xiaomei Li

The prognostic role of serum alkaline phosphatase (ALP) has been found in several kinds of solid malignant tumor, but has never been extensively discussed in pancreatic cancer, especially through the application of dynamic survival model which incorporates the varying nature of ALP measurements.We conducted a retrospective study which successfully collected 551 histopathologically confirmed pancreatic ductal adenocarcinoma (PDAC) patients from a cancer specialized hospital in southwest China. The association between variant ALP which measured during the whole survival period and the overall survival (OS) of PDAC patients was evaluated by using dynamic Anderson-Gill (AG) model. Exhaustive sensitivity analysis was performed by adopting continuous cut-offs of ALP.After adjusted for possible confounding of serum albumin, total bilirubin and leukocyte counts, AG model revealed that, serum ALP during the survival period was nonlinearly associated with the OS of PDAC: for resected patients, compared with those whose ALP results ranged within the first quartile (P75) quartiles were observed 1.14 (95% CI: 0.29-4.56), 3.93 (95% CI: 1.23-12.60), 3.87 (95% CI: 1.32-11.36) folds of death hazard; whereas in un-resected PDAC patients, the hazard ratios (HRs) were 1.15 (95% CI: 0.79-1.68), 1.92 (95% CI: 1.32-2.78), and 1.97 (95% CI: 1.30-2.98), respectively. Sensitivity analysis revealed that, for both resected and un-resected patients, the results of AG model were robust with regard to various cut-offs of ALP, and an increased ALP was in general associated with significantly increased hazard of death.Serum ALP during the survival period was significantly associated with the OS of PDAC patients, especially for resected early stage PDAC patients. Future studies with expanded sample size and refined prospective design should be implemented to corroborate our major findings. Besides, the underlying mechanism for this possible hazardous role of ALP should also be investigated.

Quartile

Surgical oncology

CA19-9

10.1186/s12885-019-6004-7

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Compound Kushen Injection combined with Chemotherapy in Advanced Gastric Cancer

Yifan Su Dehui Li Huanfang Fan Sun Chunxia

Objective: To evaluate the clinical efficacy and safety of compound Kushen injection combined with chemotherapy in the treatment of advanced gastric cancer. Methods: A computerized search through PubMed, MEDLINE, CNKI, Web of Science and Baidu Scholar electronic databases was performed to obtain randomized controlled trials (RCTs) that compared the efficacy and safety of compound Kushen injection plus chemotherapy in patients with advanced gastric cancer with chemotherapy alone, covering all papers published up to 20 January 2020. The quality of the included literature was evaluated using the Cochrane-rereviewer's Handbook 5.1 evaluation criteria, and the data was analyzed by Rev-Man5.3 analysis software. Results: a total of 1744 patients with advanced gastric cancer were enrolled in 21 RCT studies. Meta analysis results show that: Compared with chemotherapy alone, compound Kushen injection combined with chemotherapy improved the total effective rate (OR=1.89; 95% CI:1.56-2.31, P<0.00001), pain relief rate (OR=3.15; 95% CI: 1.81-5.50, P<0.0001), and thrombocytopenia rate (OR=0.51; 95% CI:0.31-0.85, P=0.009) in the treatment of advanced gastric cancer. Conclusion: Compound Kushen injection combined with chemotherapy in the treatment of advanced gastric cancer can effectively improve the clinical efficacy, relieve pain, reduce chemotherapy-induced thrombocytopenia and other adverse reactions, which is worthy of clinical application.

Clinical efficacy

10.1145/3399637.3399653

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Citations (1)

Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer

Research Square (Research Square) (2019)

Yuanyuan Xiao Haijun Yang Jian Lu Dehui Li Chuanzhi Xu

Abstract Background Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, a prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association between serum GGT measured at diagnosis and overall survival (OS) in patients with metastatic PC. Methods We identified 320 patients with histopathologically confirmed metastatic pancreatic ductal adenocarcinoma (PDAC) diagnosed during 2015 and 2016 at a specialized cancer hospital in southwest China. Univariate and multivariate Cox proportional hazards models were used to determine associations between serum GGT and OS in metastatic PDAC. Results Under control for possible confounding factors, serum GGT was significantly associated with OS: serum GGT >48 U/L yielded a hazard ratio of 1.53 (95%CI: 1.19-1.97) for mortality risk. Significant dose-response between serum GGT and OS was also observed. Subgroup analysis showed some evidence for an interaction between GGT and blood glucose level. Conclusion Serum GGT could be a promising indicator of survival in metastatic PDAC patients. Underlying mechanisms for this association should be investigated.

Gamma-glutamyltransferase

Univariate analysis

10.21203/rs.2.10892/v1

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Traditional Chinese Medicine for Breast Cancer: A Review

Breast Cancer Targets and Therapy (2023)

Rui-Qi Feng Dehui Li Xukuo Liu Xiaohui Zhao Qian-Er Wen

Abstract: A total of 18% of global breast cancer (BC) deaths are attributed to BC in China, making it one of the five most common cancers there. There has been a steady rise in BC morbidity and mortality in women in the last few years and it is now a leading cancer among Chinese women. Conventional treatments for BC are currently effective but have several limitations and disadvantages, and Traditional Chinese medicine (TCM) plays a vital role in the overall process of cancer prevention and therapy. It is known that TCM can treat a variety of conditions at a variety of sites and targets. In recent years, increasingly, research has been conducted on TCM's ability to treat BC. TCM has shown positive results in the treatment of breast cancer and the adverse effects of radiotherapy and chemotherapy. This review describes the progress of clinical observation and mechanism research of TCM in the treatment of breast cancer in recent years. It provides some ideas and theoretical basis for the treatment of BC with TCM. Keywords: formulas, acupuncture, mechanism of action, therapy

10.2147/bctt.s429530

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Citations (7)