Sen Wei

Binzhou People's Hospital

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Jun Chen

Tianjin Medical University General Hospital

Qinghua Zhou

Sichuan University

Qinghua Zhou

Sichuan University

Guang Yang

Dalian Medical University

Xiaofang Liu

Heilongjiang University

Zhidong Wang

Beijing Normal University

Gang Chen

Tongji Hospital

Song Xu

Tianjin Medical University General Hospital

Zuoqing Song

Tianjin Medical University General Hospital

Xiaofeng Yao

Dalian Medical University

Cooperative Institutions

Tianjin Medical University General Hospital

Sichuan University

Dalian Medical University

Peking University

Tianjin Medical University

Chinese Academy of Sciences

Tianjin Medical University Cancer Institute and Hospital

Shanghai Jiao Tong University

Soochow University

Chinese Academy of Medical Sciences & Peking Union Medical College

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RETRACTED ARTICLE: Repression of lncRNA-SVUGP2 mediated by EZH2 contributes to the development of non-small cell lung cancer via brisking Wnt/β-catenin signal

Artificial Cells Nanomedicine and Biotechnology (2019)

Sen Wei Jinghao Liu Xin Li Xingyu Liu

To grab the possible impact of lncRNA-SVUGP2 in the biology and process of non-small cell lung cancer (NSCLC). Sixty paired NSCLC tumour and the adjacent non-tumour lung tissues were collected for detection of lncRNA-SVUGP2. lncRNA-SVUGP2 expression in NSCLC cells (SK-MES-1, A549, SPC-A1, and NCI-H1975) was also detected. lncRNA-SVUGP2 was overexpressed and depressed in A549 and H1975 cells, and the effects of lncRNA-SVUGP2 dysregulation on cell biological performances including viability, colony formation, apoptosis, migration and invasion were grabbed. Furthermore, the regulatory association of lncRNA-SVUGP2 vs. EZH2 in H1975 cells, as well as the association between lncRNA-SVUGP2 and Wnt/β-catenin pathway, was explored. lncRNA-SVUGP2 was depressed in NSCLC tissues and cells. Overexpression of lncRNA-SVUGP2 depressed proliferation, induced apoptosis, and suppressed migration and invasion of A549 and H1975 cells. In addition, lncRNA-SVUGP2 was repressed by EZH2 and was inversely correlated with EZH2 levels in H1975 cells. Repression of lncRNA-SVUGP2 potentially participated in the oncogenic function of EZH2. Besides, overexpression of lncRNA-SVUGP2 depressed the briskness of Wnt/β-catenin signal in H1975 cells. Our data reveal that lncRNA-SVUGP2 is under-expressed in NSCLC cells and the reduced expression of lncRNA-SVUGP2 may enhance the development and process of NSCLC by interacting with EZH2 and activating Wnt/β-catenin pathway.

10.1080/21691401.2019.1648279

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Citations (12)

Effects of BTG2 on proliferation inhibition and anti-invasion in human lung cancer cells

Tumor Biology (2012)

Sen Wei Chunfang Hao Xin Li Honglin Zhao Jun Chen

The objective of the study was to investigate the impact of the B cell translocation gene 2 (BTG2) on lung cancer cell growth, proliferation, metastasis, and other biological characteristics and to provide experimental evidence for the biological treatment of human lung cancer. A pcDNA3.1-BTG2 eukaryotic expression vector was constructed and transfected into the human lung cancer cell line A549. The biological changes in the BTG2-expressing cells were analyzed using growth curves, the MTT (tetrazolium) assay, propidium iodide (PI) staining, and the Transwell invasion chamber. Additionally, Western blotting was used to determine the impact of BTG2 on the protein expression of cyclin D1, MMP-1, and MMP-2. Compared to the empty vector-transfected A549 cells or the mock-transfected A549 cells, the pcDNA3.1-BTG2-transfected A549 cells grew significantly slower. No significant differences were detected between the empty vector-transfected group and the mock-transfected A549 cells. The growth curve analysis and the PI staining showed that the pcDNA3.1-BTG2-transfected cells grew significantly slower than the empty vector-transfected A549 cells (P < 0.05). The cell invasion assay results suggested that the invasion rate of the pcDNA3.1-BTG2-transfected A549 cells was significantly slower than the invasion rate of the empty vector-transfected group and the mock-transfected group (P < 0.05). The overexpression of BTG2 may inhibit the protein expression of cyclin D1, MMP-1, and MMP-2 in A549 cells. The overexpression of BTG2 may inhibit the growth, proliferation, and invasiveness of the A549 human lung cancer cell line.

Propidium iodide

10.1007/s13277-012-0370-y

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Citations (35)

385. Radical operation of stage IIIB locally advanced non-small cell lung cancer with carina, pericardium, superior vena cava and pulmonary trunk invasion: Our center experience

European Journal of Surgical Oncology (2014)

R.W. Liu Song Xu J.H. Liu Yi-Lin Wu Zuoqing Song

10.1016/j.ejso.2014.08.375

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Synchronous primary intrapulmonary and mediastinal thymoma-A case report

Journal of Cardiothoracic Surgery (2010)

Zuoqing Song Xiaohong Xu Shujun Li Sen Wei Jun Chen

Abstract We report an extremely rare case of Synchronous primary intrapulmonary and mediastinal thymoma in a Chinese patient. We describe the histological and radiological findings, which support the possibility of multicentric thymoma. Resection of the mass in the left anterior superior mediastinum and upper lobectomy of right lung were performed, with lymph Nodes clearance, superior vena cava, left and right brachiocephalic veins resection, reconstruction of left brachiocephalic vein to right auricle and reconstruction of right brachiocephalic vein to superior vena cava.

Brachiocephalic vein

Cardiothoracic surgery

Median sternotomy

Mediastinal tumor

Mediastinal mass

Anterior mediastinum

10.1186/1749-8090-5-69

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Citations (3)

Dickkopf-1 Is Oncogenic and Involved in Invasive Growth in Non Small Cell Lung Cancer

PLoS ONE (2013)

Shujun Li Xuebo Qin Xin Guo Airong Cui Yuzheng He

Dickkopf-1 (DKK1) is an inhibitor of the Wnt/β-catenin signaling pathway. However, the role of DKK1 in the progression of non small cell lung cancer (NSCLC) is not fully understood. In this study, RT-PCR and Western blot were used to examine the expression of DKK1 in a panel of ten human NSCLC cell lines and NSCLC tissues. DKK1 expression was highly transactivated in the great majority of these cancer lines. The expression of DKK1 was upregulated on both mRNA and protein levels in NSCLC tissues compared with the adjacent normal lung tissues. Immunohistochemistry and immunofluoresence revealed that DKK1 was mainly distributed in the cytoplasm in both carcinoma tissues and cell lines. DKK1 protein expression was also evaluated in paraffin sections from 102 patients with NSCLC by immunohistochemistry, and 65(63.73%)tumors were DKK1 positive. Relative analysis showed a significant relationship between DKK1 positive expression and lymph node metastasis(P<0.05). Patients with DKK1-positive tumors had poorer DFS than those with negative ESCC (5-year DFS; 15.4% versus 27%, P = 0.007). To further explore the biological effects of DKK1 in NSCLC cells, we over-expressed DKK1 in NSCLC 95C cell using eukaryotic expression vector pCMV-Tab-2b and performed a knockdown of DKK1 in LTEP-a-2 cell using a short hairpin RNA expression vector pSilencer 5.1. DKK1 did not have any effect on proliferation, but seemed to play a role in migration and invasion capability. Overexpression of DKK1 promotes migratory and invasive activity of 95C, while DKK1 knockdown resulted in the suppression of migration and invasion potentials of LTEP-a-2 cell. Taken together, these results indicate that DKK1 may be a crucial regulator in the progression of NSCLC. DKK1 might be a potential therapeutic target in NSCLC.

DKK1

10.1371/journal.pone.0084944

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Citations (35)

Thymoma With Pure Red Cell Aplasia and Good's Syndrome

The Annals of Thoracic Surgery (2011)

Jun Chen Yongbo Yang Daxing Zhu Gang Chen Sen Wei

Aplasia

10.1016/j.athoracsur.2010.10.010

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Citations (28)

The Effects of (11R)-13-(6-Nitroindazole)-11,13-Dihydroludartin on Human Prostate Carcinoma Cells and Mouse Tumor Xenografts

Medical Science Monitor (2020)

Longning Wang Lei Wang Sen Wei Xiaodong Wang Daqing Shen

BACKGROUND This study aimed to investigate the effects of the 6-nitroindazole compound and amino analog of ludartin, (11R)-13-(6-nitroindazole)-11,13-dihydroludartin (NDHL), on human prostate carcinoma cells in vitro and in mouse tumor xenografts in vivo. MATERIAL AND METHODS DU-145 and LNCaP human prostate carcinoma cells were cultured with increasing concentrations of NDHL. Cell viability was measured using the MTT assay, and cell apoptosis was measured by fluorescence flow cytometry. Mouse tumor xenografts were created by implanting 2×10⁶ of DU-145 cells subcutaneously in the left flank. On the second day following DU-145 cell implantation, the mice in the treatment groups were injected intraperitoneally with 2, 5, and 10 mg/kg of NDHL. RESULTS Treatment of DU-145 and LNCaP cells with NDHL (range, 2.5-20.0 μM) significantly reduced cell proliferation in vitro (P<0.05). The proliferation rate of DU-145 and LNCaP cells was reduced to 27% and 24%, respectively, following treatment with 20.0 μM of NDHL. Treatment with NDHL significantly increased cell apoptosis and the formation of reactive oxygen species (ROS) formation in DU-145 cells at 48 h (P<0.05). NDHL significantly increased the proportion of DU-145 cells in the G1 phase of the cell cycle and significantly increased the expression of cyclin D1 and p21 (P<0.05). Treatment of the mice in the xenograft tumor model with NDHL significantly increased survival and suppressed tumor growth (P<0.02). CONCLUSIONS NDHL inhibited cell proliferation, increased apoptosis, and caused cell cycle arrest in human prostate carcinoma cells in vitro and inhibited mouse tumor xenograft growth in vivo.

Viability assay

MTT assay

10.12659/msm.920389

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Citations (2)

Survival and bronchial carcinoid tumors: Development of surgical techniques in a 30‐year experience of 82 patients in China

Thoracic Cancer (2011)

Sen Wei Chunfang Hao Lei Gong HU Cheng-guang Jianhong Lian

We aimed to identify the factors determining long-term survival after surgical management for bronchial typical carcinoid (TC) and atypical carcinoids (AC) and to compare the clinical outcome of the different surgical strategies used in the two periods of 1980-1994 and 1995-2005.Records of 82 patients with an initial pathological diagnosis of bronchial carcinoid tumor who underwent surgical management from January 1980 to December 2009 were reviewed. Tumors were classified as TC or AC using the 2004 World Health Organization criteria.There were 60 TC and 22 AC. Surgical procedures included lobectomies, sleeve or bronchoplastic resections, pneumonectomies, wedge resections, and segmental resections. Significantly fewer pneumonectomies and more sleeve and bronchoplastic resections were performed after 1994. The prognosis was more favorable for TC than AC. Comparing lymph node status N0 with N1 + N2, 5- and 10-year survival was 92% and 85% vs. 61% and 41%. No patient with lymph node involvement survived more than 15 years.Tumor subtype and lymph node status have the greatest impact on long-term survival following surgery. AC and/or regional lymph node metastases have the worst prognosis. Formal anatomic and tissue-saving lung resection plus systematic radical mediastinal lymphadenectomy for TC and AC should be standard.

Lymphadenectomy

Mediastinal lymph node

Carcinoid tumors

10.1111/j.1759-7714.2011.00080.x

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Citations (5)

Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis

Chemosphere (2019)

Ye Tao Tianming Qiu Xiaofeng Yao Liping Jiang Ningning Wang

Hepatic stellate cell

10.1016/j.chemosphere.2019.124959

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