Zhi Wang

Shanghai University of Traditional Chinese Medicine

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Co-Authors

Nianping Feng

Shanghai University of Traditional Chinese Medicine

Yongtai Zhang

Shanghai University of Traditional Chinese Medicine

Ying Liu

Harbin Medical University

Zhiyuan Ren

Southern University of Science and Technology

Zehui He

Shanghai University of Traditional Chinese Medicine

Zifei Jiang

Shanghai University of Traditional Chinese Medicine

Yongkang Xu

Second Affiliated Hospital of Nanchang University

F. H. Sarkar

Wayne State University

Huálín Wáng

Chinese Academy of Sciences

Yi Shao

Northeast Agricultural University

Cooperative Institutions

Chinese Academy of Sciences

Shanghai University of Traditional Chinese Medicine

Sichuan University

Wuhan Institute of Virology

University of Chinese Academy of Sciences

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

Fudan University

Sun Yat-sen University

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Pancreatic cancer stem cells and EMT in drug resistance and metastasis.

PubMed (2009)

F. H. Sarkar Yiwei Li Zhi Wang Dong Kong

Pancreatic cancer (PC) is an aggressive malignancy with one of the worst outcomes among all cancers. It is the fourth leading cause of cancer death in the United States with a very low five-year survival rate. The high mortality of PC could, in part, be due to their drug resistance characteristics and high propensity for metastasis. Recently, cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT)-type cells, which shares molecular characteristics with CSCs, have been believed to play critical roles in drug resistance and cancer metastasis as demonstrated in several human malignancies including PC. Thus, the discovery of molecular knowledge of drug resistance and metastasis in relation to CSCs and EMT in PC is becoming an important area of research, and such knowledge is likely to be helpful in the discovery of newer drugs as well as designing novel therapeutic strategies for the treatment of PC with better outcome. In this brief review, we will summarize the current knowledge regarding the CSCs and EMT in the context of drug resistance and metastasis in PC, the molecular events occurring in CSCs and EMT, and the design of novel therapeutic strategies targeting CSCs and EMT-type cells to increase drug sensitivity and suppression of metastasis toward better treatment outcome of patients diagnosed with PC.

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Citations (156)

Identification and characterization of three monoclonal antibodies targeting the SFTSV glycoprotein and displaying a broad spectrum recognition of SFTSV-related viruses

PLoS neglected tropical diseases (2024)

Xiaoli Wu Abulimiti Moming Yanfang Zhang Zhi Wang Tao Zhang

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne viral pathogen that causes severe fever with thrombocytopenia syndrome (SFTS). The disease was initially reported in central and eastern China, then later in Japan and South Korea, with a mortality rate of 13–30%. Currently, no vaccines or effective therapeutics are available for SFTS treatment. In this study, three monoclonal antibodies (mAbs) targeting the SFTSV envelope glycoprotein Gn were obtained using the hybridoma technique. Two mAbs recognized linear epitopes and did not neutralize SFTSV, while the mAb 40C10 can effectively neutralized SFTSV of different genotypes and also the SFTSV-related Guertu virus (GTV) and Heartland virus (HRTV) by targeting a spatial epitope of Gn. Additionally, the mAb 40C10 showed therapeutic effect in mice infected with different genotypes of SFTSV strains against death by preventing the development of lesions and by promoting virus clearance in tissues. The therapeutic effect could still be observed in mice infected with SFTSV which were administered with mAb 40C10 after infection even up to 4 days. These findings enhance our understanding of SFTSV immunogenicity and provide valuable information for designing detection methods and strategies targeting SFTSV antigens. The neutralizing mAb 40C10 possesses the potential to be further developed as a therapeutic monoclonal antibody against SFTSV and SFTSV-related viruses.

Phlebovirus

10.1371/journal.pntd.0012216

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Citations (2)

Protective effects of TRPV1 inhibition against sevoflurane-induced cell death

Neuroscience Letters (2019)

Yuqiang Liu Yang Han Chengsan Sun Zhi Wang Zhiheng Liu

Neurotoxicity

10.1016/j.neulet.2019.05.024

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Citations (3)

<p>Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer</p>

International Journal of Nanomedicine (2019)

Ying Liu Pei‐Wen Huang Xuefeng Hou Fei Yan Zifei Jiang

Background: Oral route of administration is preferred for treating breast cancer, especially when continued disease management with good tolerability is required; however, orally administered chemotherapeutics combined with near-infrared (NIR) dyes are hindered by the low bioavailability, insufficient for the desired therapeutic efficacy. In this study, we developed a hybrid self-microemulsifying drug delivery system for co-loading curcumin-phospholipid complex and NIR dye IR780 (CUR/IR780@SMEDDS), to achieve combined phototherapeutic and chemotherapeutic effects against lung metastasis of breast cancer. Methods: CUR/IR780@SMEDDS were characterized. The efficacy against breast cancer metastasis was evaluated by photothermal and photodynamic assessment, cytotoxicity, invasion, and migration in metastatic 4T1 breast cancer cells in vitro, and in vivo oral bioavailability study in rats and pharmacodynamics studies in tumor-bearing nude mice. Results: CUR/IR780@SMEDDS improved oral bioavailability of curcumin and IR780 in rats compared with curcumin and IR780 suspensions. CUR/IR780@SMEDDS exhibited remarkable photothermal and photodynamic effects in vitro. In metastatic 4T1 breast cancer cells, CUR/IR780@SMEDDS combined with localized NIR laser irradiation induced significant cytotoxicity and inhibited invasion and migration of 4T1 cells, an outcome attributable to cumulative effects of IR780-induced hyperthermia and pharmacological effects of curcumin. In orthotopic 4T1 tumor-bearing nude mice, combination of oral administration of CUR/IR780@SMEDDS with local NIR laser irradiation inhibited tumor progression and suppressed lung metastasis.

10.2147/ijn.s200847

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Citations (25)

Discovery of prolyl hydroxylase 2 inhibitors with new chemical scaffolds as in vivo active erythropoietin inducers through a combined virtual screening strategy

Chemical Biology & Drug Design (2019)

Yu Zhan Zhihong Li Quanwei Yu Zhi Wang Huilin Song

Abstract Hypoxia‐inducible factor (HIF) is identified to be a promising target to mediate the response to hypoxia. Its stability and activation are negatively controlled by prolyl hydroxylase 2 (PHD2). Thus, PHD2 inhibition has been perceived as a promising anti‐anemia therapy. In this study, we carried out a structure‐based virtual screening followed by in vitro and in vivo biological validation, with the goal to identify novel PHD2 inhibitors. As a result, a set of hits with new chemical scaffolds were revealed to be active in vitro for PHD2 inhibition. Compounds 2 and 3 were revealed to be capable of stabilizing HIF‐α and stimulating erythropoietin (EPO) expression in cell‐based assays. Notably, further in vivo assays revealed that 2 was capable of elevating the EPO plasma levels in C57BL/6 mice model. These findings provide new chemical scaffolds for further development of PHD2 inhibitors.

Hypoxia

Hypoxia-Inducible Factors

Inducer

10.1111/cbdd.13640

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Citations (9)

Does the Region of the Spine Involved with Metastatic Tumor Affect Outcomes of Surgical Treatments?

World Neurosurgery (2021)

Van Tri Truong Fidaa Al-Shakfa Philippe Phan Nicholas Newman Ghassan Boubez

Univariate analysis

10.1016/j.wneu.2021.09.014

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Citations (13)

[Molecular epidemiological characteristics of newly diagnosed HIV-1 cases in Fujian Province in 2020].

PubMed (2023)

Mingxing Xie Li‐Rong Lin Zhi Wang Ying Qiu Xiaoxia Lü

To investigate the HIV-1 genotype and distribution of newly diagnosed HIV-1 cases in Fujian Province in 2020, so as to provide insights into formulation of the precise AIDS control strategy in the province.

Molecular Epidemiology

10.16250/j.32.1374.2023003

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Citations (1)

Written Сommunication in Chinese on the International University Сampus

Litera (2023)

Polina Povalko Jiaxian Zhang Zhi Wang

The article examines the place and role of the Chinese language in the linguistic landscape of the campus of the Peoples' Friendship University of Russia named after Patrice Lumumba. The subject of the study is written public texts in Chinese, posted on the university campus (announcements, signs, posters, etc.). The material collected by the continuous sampling method was analyzed from the positions of the addressees of the texts, their subject matter and multilingualism, and also evaluated from the point of view of compliance with the norms of the Chinese language in the texts. The effectiveness of Chinese-language written communication was assessed using a survey of Chinese-speaking students. The place of the Chinese language in the linguistic landscape of the university campus is described; it is noted that written communication in Chinese on campus plays an important role both in the educational process and in everyday interaction. At the same time, conclusions about the insufficient representation and limited thematic diversity of Chinese-language texts were drawn. Recommendations for improving written communication in Chinese are proposed, which will help optimize the process of adaptation of students from China, increase their awareness, which will generally have a positive impact on the ergonomics of the communicative space, as well as increase the status of the Chinese language in the language landscape of an internationally oriented university.

Linguistic Landscape

Written language

Chinese language

10.25136/2409-8698.2023.10.44083

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Citations (0)

Piceatannol as an Antiviral Inhibitor of PRV Infection In Vitro and In Vivo

Animals (2023)

Zhi Wang Xiaojing Cai Zhiyuan Ren Yi Shao Yongkang Xu

Pseudorabies virus (PRV) belongs to the family Herpesviridae. PRV has a wide host range and can cause cytopathic effects (CPEs) in PK-15 cells. Therefore, PRV was used as a model to study the antiviral activity of piceatannol. The results showed that piceatannol could restrain PRV multiplication in PK-15 cells in a dose-dependent manner. The 50% inhibitory concentration (IC50) was 0.0307 mg/mL, and the selectivity index (SI, CC50/IC50) was 3.68. Piceatannol could exert an anti-PRV effect by reducing the transcription level of viral genes, inhibiting PRV-induced apoptosis and elevating the levels of IL-4, TNF-α and IFN-γ in the serum of mice. Animal experiments showed that piceatannol could delay the onset of disease, reduce the viral load in the brain and kidney and reduce the pathological changes in the tissues and organs of the mice to improve the survival rate of the mice (14.3%). Therefore, the anti-PRV activity of piceatannol in vivo and in vitro was systematically evaluated in this study to provide scientific data for developing a new alternative measure for controlling PRV infection.

Piceatannol

Pseudorabies

IC50

Ex vivo

Cytopathic effect

10.3390/ani13142376

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Citations (3)

Arthroscopic bone autografting for treatment of atrophy nonunion of long bone fractures

Zhong Li Liying Shen Hongbin Yang Yuanhui Wang Zhi Wang

Objective To introduce preliminary experiences using arthroscopic debridement and bone autografting to treat atrophy nonunion of long bone fractures, especially those with severely damaged soft tissues. Methods There were 13 patients (8 males and 5 females) with atrophy nonunion of long bone fractures, of whom seven patients were associated with severely damaged soft tissues. Under guid-ance of radiography, two portals for insertion of arthroscope were created towards the nonunion site.Then, debridement of the fracture and bone autografting were performed under arthroscope. Results The operation lasted for mean 65 minutes, with mean blood loss of 15 ml. No severe complications at the nonunion site during and after operation were found except for complications related to the iliac crest donor site. All fractures were healed, without pain, instability or loss of functional range of movements. The du-ration of fracture healing was 3-7 months (mean 5.2 months). Conclusions Arthroscopic bone auto-graphing in treatment of atrophy nonunion of long bone fractures is proved to be an minimally invasive sur-gery, with high fracture healing rate, and is especially suitable for those with severely damaged soft tis-sues. Key words: Fractures,ununited; Arthroscopes; Tibial fractures; Femoral fractures; Humeral fractures

Iliac crest

Debridement (dental)

10.3760/cma.j.issn.1001-8050.2009.11.315

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