Zhen Tan

Arizona State University

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Jimei Liu

Chinese Academy of Medical Sciences & Peking Union Medical College

Jungui Dai

Chinese Academy of Medical Sciences & Peking Union Medical College

Jinlian Zhao

First People's Hospital of Yunnan Province

Aiming Liu

Meteorological Bureau of Shenzhen Municipality

Shupeng Li

Peking University

Kebo Xie

Chinese Academy of Medical Sciences & Peking Union Medical College

Yongxin Li

Qinghai University Affiliated Hospital

Fawad Ali Shah

Prince Sattam Bin Abdulaziz University

Cailei Zhao

Shenzhen Children's Hospital

Ridao Chen

Chinese Academy of Medical Sciences & Peking Union Medical College

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

Shenzhen Children's Hospital

Chinese Academy of Sciences

First Affiliated Hospital of Xi'an Jiaotong University

Ningbo University

Sun Yat-sen University

Southern Medical University

Peking Union Medical College Hospital

Army Medical University

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Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity

Archives of Toxicology (2016)

Min Luo Zhen Tan Manyun Dai Danjun Song Jiao Lin

Metabolome

10.1007/s00204-016-1779-7

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Citations (21)

Semantic understanding of point clouds based on density-adaptive sampling and position-sensitive feature extraction

Yuhan Bao Xiaobin Wang Tianlei Wang Zhen Tan Yanling Pu

Semantic understanding of point clouds is a major task in 3D scenes. Due to the enormous number of points within point clouds, it is strait to process point clouds directly. Generally, previous work follow a sampler-extractor structure to get high-level semantic features. Previous sampling strategies in the sampler stuck in upholding local density while guaranteeing a predetermined number of sampled points. We propose a density-adaptive sampling strategy. In the extractor, PointNN introduces a non-parameter framework. However, it ignores the positional distance among points. We introduce a position-sensitive feature extraction module inspired by PointNN. We conduct comprehensive experiments to validate the effectiveness of our method.

Position (finance)

Feature (linguistics)

Semantic feature

10.1117/12.3031457

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Two New Sesquiterpenoids from Celastrus rosthornianus

Journal of Natural Products (1992)

Tu Yong Qiang Zhen Tan Wu Tong Xing Zhang Gong Chen

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo New Sesquiterpenoids from Celastrus rosthornianusTu Yong Qiang, Tan Zhen, Wu Tong Xing, and Zhang Gong ChenCite this: J. Nat. Prod. 1992, 55, 1, 126–128Publication Date (Print):January 1, 1992Publication History Published online1 July 2004Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/np50079a018https://doi.org/10.1021/np50079a018research-articleACS PublicationsRequest reuse permissionsArticle Views139Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

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10.1021/np50079a018

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A new anthraquinone from mangrove endophytic fungus Aspergillus sp. 16-5C

Natural Product Research (2021)

Ze’en Xiao Shao’e Lin Zhigang She Yongjun Lu Zhen Tan

A new anthraquinone, asperquinone A (1), and four known anthraquinone derivatives 2–5 were isolated from the mangrove endophytic fungus Aspergillus sp. 16-5C. These structures were elucidated by spectroscopic analysis and the absolute configuration of 1 was unambiguously determined by ECD calculation. Compounds 1–5 showed no significant inhibitory effect against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB).

Anthraquinones

10.1080/14786419.2021.2001810

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Diagnosis and Treatment of Status Epilepticus in a Pediatric Renal Recipient

Case Reports in Transplantation (2011)

Hongjun Gao Xiangdong Luo Taisheng Liang Shangguang Lu Fangfang Liang

We elaborate on the retrospective analysis of clinical data on a patient afflicted with grand mal seizures following a kidney transplant. The 16-year-old female patient was hospitalized for chronic glomerulonephritis. She experienced an epileptic seizure and was treated with carbamazepine. Renal transplantation was performed; the function of the transplant kidney was normal. However, grand mal seizures, which required intravenous and luminal intramuscular diazepam injections for control, began on the fourth postoperative day and lasted for 3 days, occurring approximately 10 to 20 times per day. On the sixth day, the patient fell into a deep comatose state and developed the inability to move the right side of her body, hypomyotonia, type 1 respiratory failure, and a pulmonary infection. She was given a breathing machine to assist with respiration. At the same time, she was given protection from infection, tranquilization, treatment for dehydration and diuresis, supportive therapy for the right side of her body, and adjustment of her immunosuppressants. On the 12th postoperative day, the patient's consciousness gradually returned; on the 15th day, the breathing machine was removed with recovery of myodynamia; on the 27th day, she was fully cured with no neurological sequelae.

10.1155/2011/706107

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Potent Natural Antioxidant Carveol Attenuates MCAO-Stress Induced Oxidative, Neurodegeneration by Regulating the Nrf-2 Pathway

Frontiers in Neuroscience (2020)

Imran Riaz Malik Fawad Ali Shah Tahir Ali Zhen Tan Abdullah Alattar

Ischemic stroke is a severe neurological disorder with a high prevalence rate in developed countries. It is characterized by permanent or transient cerebral ischemia and it activates syndrome of pathological events such as membrane depolarization, glutamate excitotoxicity, and intracellular calcium buildup. Carveol is widely employed as anti-inflammatory and antioxidant in traditional Chinese medicine. In the present study, the neuroprotective effects of post-treated carveol were demonstrated against transient middle cerebral artery occlusion (MCAO) induced focal ischemic cerebral injury. Male Sprague Dawley (SD) rats were subjected to two different experimental protocols to determine the dose and effects of carveol, and to demonstrate the underlying role of the nuclear factor E2-related factor (Nrf2) pathway. Our results showed that MCAO induced marked neuronal injury in the ipsilateral cortex and striatum associated with higher inflammatory cytokines expression, along with apoptotic markers such as caspase-3 and the phosphorylated c-Jun N-terminal kinase (JNK). Furthermore, MCAO induced a marked increase in oxidative stress as evidenced by high lipid peroxidase (LPO) content accompanied by the depressed antioxidant system. Carveol significantly reversed the oxidative stress and downregulated inflammatory cascades by enhancing endogenous antioxidant mechanisms including the Nrf2 gene, which critically regulates the expression of several downstream antioxidants. Further, to determine the possible involvement of Nrf2 in carveol mediated neuroprotection, we antagonized Nrf2 by all-trans retinoic acid (ATRA), and such treatment abrogated the protective effects of carveol accompanied with exaggerated neuronal toxicity as demonstrated by higher infarction area. The target effects of carveol were further supported by molecular docking analysis of drug-protein interactions. Together, our findings suggest that carveol could activate endogenous master anti-oxidant Nrf2, which further regulates the expression of downstream antioxidants, eventually ameliorating MCAO-induced neuroinflammation and neurodegeneration.

Excitotoxicity

10.3389/fnins.2020.00659

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Effect of Angiotensin-(1-7) on Pulmonary Arterial Hypertension Induced by Monocrotaline

Journal of Sun Yat-sen University (2009)

Zhen Tan

【Objective】 To investigate the effect and mechanism of Ang-(1-7) on pulmonary arterial hypertension induced by MCT. 【Methods】 Eighty Sprague-Dawley rats were randomly divided into four groups: control group, MCT group, MCT + Ang-(1- 7) group, and control + Ang-(1-7) group. Twenty-four hours after injection of MCT, the rats in MCT + Ang-(1-7) group and MCT group were allocated to intravenous infusion of either Ang-(1-7) (24 μg·kg-1·h-1) or saline by osmotic minipumps. Twenty- four hours after injection of saline, rats in control + Ang-(1-7) group and control group were allocated to intravenous infusion of either Ang-(1-7) (24 μg·kg-1·h-1) or saline by osmotic minipumps. After 4 weeks of treatment, right ventricular systolic pressure (RVSP) and right ventricular hypertrophy index (RVHI) were measured. Percentage of wall thickness (WT%) and percentage of wall area (WA%) of pulmonary arterioles were evaluated. AngiotensinⅡ(AngⅡ) concentration in plasma and lung were measured by radioimmunoassay. ERK1 / 2 activation was analyzed by Western blotting. 【Results】 After four weeks, these parameters of RVSP, RVHI, WT%, WA%, pulmonary AngⅡconcentration and the level of phosphorylation of ERK1 / 2 in MCT group were significantly increased compared with control group (P 0.01). The parameters of RVSP, RVHI, WT%, WA%, and the level of phosphorylation of ERK1 / 2 in MCT + Ang-(1-7) group were significantly decreased compared with MCT group (P 0.01). There were no significant difference concerned RVSP, RVHI, WT%, WA%, and the level of phosphorylation of ERK1 / 2 among control group, MCT + Ang-(1-7) group, and control + Ang-(1-7) group (P 0.05). 【Conclusion】 Down-regulation of the level of phosphorylation of ERK1 / 2, Ang-(1-7) can inhibit pulmonary vascular remodeling and prevent the development of pulmonary arterial hypertension.

Right ventricular hypertrophy

Ventricular pressure

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Simultaneous multi-component quantitation of Chinese herbal injection Yin-zhi-huang in rat plasma by using a single-tube extraction procedure for mass spectrometry-based pharmacokinetic measurement

Journal of Chromatography B (2014)

Le Zeng Meiling Wang Yuan Yu Bin Guo Jing Zhou

Chlorogenic Acid

Protein precipitation

Baicalin

Salvia miltiorrhiza

Flos

10.1016/j.jchromb.2014.07.037

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Citations (25)

Nesfatin-1 antagonized rotenone-induced neurotoxicity in MES23.5 dopaminergic cells

Peptides (2015)

Zhen Tan Huamin Xu Xiaoli Shen Hong Jiang

Rotenone

Neurotoxicity

10.1016/j.peptides.2015.04.019

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Citations (21)

Alterations in Spontaneous Brain Activity and Functional Network Reorganization following Surgery in Children with Medically Refractory Epilepsy: A Resting-State Functional Magnetic Resonance Imaging Study

Frontiers in Neurology (2017)

Yongxin Li Zhen Tan Jian‐Ping Wang Wang Ya Yungen Gan

For some patients with medically refractory epilepsy (MRE), surgery is a safe and effective treatment for controlling epilepsy. However, the functional consequences of such surgery on brain activity and connectivity in children remain unknown. In the present study, we carried out a longitudinal study using resting-state functional magnetic resonance imaging in 10 children with MRE before and again at a mean of 79 days after surgery, as well as in a group of 28 healthy controls. Compared with the controls, children with epilepsy exhibited abnormalities in intrinsic activity in the thalamus, putamen, pallidum, insula, hippocampus, cerebellum, and cingulate gyrus both before and after surgery. Longitudinal analyses showed that the amplitude of low frequency fluctuations (ALFF) increased in the parietal-frontal cortex and decreased in the deep nuclei from pre- to post-surgery. The percentage changes in ALFF values in the deep nuclei were positively correlated with the age of epilepsy onset. Functional connectivity (FC) analyses demonstrated a reorganization of FC architecture after surgery. These changes in brain activity and FC after surgery might indicate that the previously disrupted functional interactions were reorganized after surgery. All these results provide preliminary evidence that the age of epilepsy onset may have some potential to predict the outcome of brain functional reorganization after surgery in children with MRE.

Refractory (planetary science)

Functional Imaging

10.3389/fneur.2017.00374

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Citations (23)