Basing on the existing(t,n) secret sharing scheme,a dynamic proactive secret sharing scheme which can be applied to access structure is proposed by introducing the concept of adversary structure.The access structure can be changed when the shadows are renewed.The detailed process of the distribution and renewal of the shadows is given,and the validity of the scheme is proved perfectly.The comparisons with the existing schemes show that the proposed scheme is more flexible and its computational cost is less.
Abstract Introduction: Casitas B-lineage lymphoma b (Cbl-b), a RING finger E3 ligase and a member of a highly conserved family of Cbl proteins, catalyzes the ubiquitination of substrate proteins to regulate multiple signaling events in a variety of cell types, including immune cells. In T cells, Cbl-b negatively regulates adaptive immune system signaling by establishing the threshold for the activation of antigen receptors. Additionally, Cbl-b regulates the function of other immune cell types, including NK cells, dendritic cells (DC) and monocytes. Cbl-b deficient T cells no longer require a costimulatory signal to be fully activated. Cbl-b KO mice spontaneously reject tumors via an enhanced immune response. Taken together, these findings point to Cbl-b inhibitors as having the potential to be highly efficacious immuno-oncology agents. Experimental Procedures: A structure-based drug design approach was used to identify potent inhibitors of Cbl-b. Biochemical and cellular binding assays, a cellular NFAT-luciferase reporter assay, as well as primary in vitro human and mouse T cell activation assays measuring IL-2 production were used to profile inhibitor compounds. In vivo activity of Cb-b inhibitors was evaluated using an anti-CD3 mouse model and a CT-26 syngeneic mouse model Results: Cbl-b inhibitor NTX-001 potently binds to Cbl-b, preventing Cbl-b phosphorylation and binding to E2. In cells, NTX-001 treatment results in enhanced phosphorylation of ZAP-70, a protein proximal to the TCR and reported to be a direct substrate of Cbl-b. Additionally, inhibition of Cbl-b potently enhances cytokine secretion from primary human and mouse T cells. In vivo, an increase in cytokines and T cell activation markers was observed after a single dose of NTX-001. Repeated dosing of NTX-001 showed dose-dependent anti-tumor activity in the colorectal CT-26 syngeneic model. Conclusions: NTX-001 is a potent Cbl-b inhibitor that demonstrated strong T cell activation and anti-tumor activity in a syngeneic tumor model. These data support Cbl-b inhibitors as a promising therapeutic opportunity for cancer treatment. Citation Format: Fred Csibi-Levin, Silvana Leit, David L. Laughton, Tom Baker, Suzanne L. Jacques, Beth Browning, Angela V. Toms, Samantha Garside, Simon D'Archivio, Katarzyna Kopycka, Xiaohua Zhu, Allan M. Jordan, Stuart Thomson, Christine Loh, Peter Tummino, David N. Ciccone. Discovery of NTX-001, a potent Cbl-b inhibitor with antitumor activity in syngeneic models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 589.
We prove that on a Fano \mathbf{G} -manifold (M,J) , the Gromov–Hausdorff limit of the Kähler–Ricci flow with initial metric in 2\pi c_{1}(M) must be a \mathbb{Q} -Fano horosymmetric variety M_{\infty} which admits a singular Kähler–Ricci soliton. Moreover, M_{\infty} is the limit of a \mathbb{C}^{*} -degeneration of M induced by an element in the Lie algebra of the Cartan torus of \mathbf{G} . A similar result can be proved for Kähler–Ricci flows on any Fano horosymmetric manifolds. As an application, we generalize our previous result about the existence of type II singularities of Kähler–Ricci flows on Fano \mathbf{G} -manifolds to Fano horosymmetric manifolds.
In this paper, we study the uniformly strong convergence of K\"ahler-Ricci flow on a Fano manifold with varied initial metrics and smooth deformation complex structures. As an application, we prove the uniqueness of K\"ahler-Ricci solitons in sense of diffeomorphism orbits. The result generalizes Tian-Zhu's theorem for the uniqueness of of K\"ahler-Ricci solitons on a compact complex manifold, and it is also a generalization of Chen-Sun's result of for the uniqueness of of K\"ahler-Einstein metric orbits.
Objective To investigate the typing,positive rate and significance of human papilloma virus(HPV)from the lesions of the patients with condyloma acuminata(CA).Methods The typing and positive rate of HPV was detected by fluorescence quantitative polymerase chain reaction(FQ-PCR).The female patients were also detected by cervix pathological biopsy.Results Thirty seven cases(84.09%) were confirmed to be HPV-DNA positive among 44 male patients with CA by FQ-PCR,and the main types of infection was HPV6/11(91.89%).Twenty six cases(78.78%) were confirmed to be HPV-DNA positive in cunnus among 33 female patients with CA by FQ-PCR,while 19 cases(57.57%) were positive by cervix biopsy.The main types of infection was HPV6/11(53.84%)in cunnus and 57.89% in cervix.Conclusion HPV6/11 are the main types causing CA.FQ-PCR can be taken as an index in CA diagnosis.
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