Obesity is a risk factor for endometrial cancer.Recently, visceral fat has been found to be strongly associated with obesity-related carcinogenesis, more than subcutaneous fat.In this study, we hypothesized that the visceral fat measured by computed tomography (CT) contributes to the occurrence of endometrial cancer.A retrospective chart review of patients undergoing primary surgery for endometrial cancer was conducted.The volume of visceral fat was measured by CT scans performed at the fourth lumbar level for all participants.To compare body fat distributions assessed by a direct method in 52 endometrial cancer cases with age-and BMI-matched healthy community controls.Case group showed significantly higher mean visceral fat area (VFA; 76.2 ± 25.0 vs. 62.2 ± 13.9 cm 2 , p = 0.007).The mean total fat area (TFA; 270.3 ± 99.9 vs. 238.9± 53.8 cm 2 , p = 0.137) and subcutaneous fat area (SFA;194.2± 86.5 vs. 176.7 ± 45.8 cm 2 , p = 0.315), however, presents no significant differences.VFA and BMI correlation (r 2 = 0.299, p<0.001) was lower than to SFA (r 2 = 0.528, p <0.001) and TFA (r 2 = 0.584, p<0.001).In receiver operator characteristic (ROC) curve, at the value of 70.8 cm 2 , sensitivity and specificity of the case group was 55.8% and 75%, respectively.The study suggests that increased visceral fat is associated with endometrial cancer.Furthermore, VFA acts as the most independent factor to BMI, it may provide additional information to the representative risks of endometrial cancer.
Abstract Introduction The SK hynix Employee Cohort (SHE cohort) was launched in 2017 to identify the causes of occupational diseases in the semiconductor industry and to conduct various research activities to promote the health of its members. The SHE cohort is a dynamic cohort with 25,505 participants as of December 2022. Methods In order to prevent occupational diseases in the semiconductor industry and improve the health of employees, SK hynix organized the Committee for Advanced and Sustainable Occupational Health in 2017 and analyzes the prevalence of chronic diseases annually. As a control group for comparison, data from the Korea National Health and Nutrition Examination Survey from 2017 to 2021 were standardized by age and gender to obtain the prevalence rate ratio (PRR), which was analyzed using the empirical quantile method for five-year trends. Results The average PRR for hypertension over the five-year period was 0.49, with an annual percent change(APC) value of -2.44. The mean PRR and APC for diabetes prevalence was 0.78 and 2.30 respectively and the mean PRR and APC for dislipidemia prevalence was 0.66 and 5.53 respectively. The mean PRR for obesity was 0.97 with an APC of -0.49, and the mean PRR for metabolic syndrome was 0.72 with an APC of -1.17. Discussion and conclusion There were no statistically significant trends. For all chronic diseases, a low PRR can be interpreted as a health worker effect. Obesity had a relatively high PRR, which should be considered when prioritizing the allocation of healthcare resources in the workplace.
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