Ni Zhao

Guizhou Normal University

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Michele C. Hayward

University of North Carolina at Chapel Hill

Matthew D. Wilkerson

Uniformed Services University of the Health Sciences

Vonn Walter

Penn State Milton S. Hershey Medical Center

Leigh B. Thorne

University of North Carolina at Chapel Hill

Mark C. Weissler

University of North Carolina at Chapel Hill

Trevor Hackman

University of North Carolina at Chapel Hill

Carol G. Shores

University of North Carolina at Chapel Hill

Karen Fritchie

Mayo Clinic

W. Shockley

University of North Carolina at Chapel Hill

Xiaoying Yin

Qingdao University

Cooperative Institutions

University of North Carolina at Chapel Hill

Johns Hopkins University

Johns Hopkins Medicine

Bloomberg (United States)

Sidney Kimmel Comprehensive Cancer Center

Chinese Academy of Sciences

UNC Lineberger Comprehensive Cancer Center

University of Baltimore

Sun Yat-sen University

Indiana University School of Medicine

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Supplementary Figures from Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non–Small Cell Lung Cancer

Jiajia Zhang Zhicheng Ji Justina X. Caushi Margueritta El Asmar Valsamo Anagnostou

Figures S1-S8

Dynamics

Neoadjuvant Therapy

10.1158/1078-0432.22478583.v1

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Supplementary Figure 1 from High XRCC1 Protein Expression Is Associated with Poorer Survival in Patients with Head and Neck Squamous Cell Carcinoma

Mei‐Kim Ang Mihir R. Patel Xiaoying Yin Sneha Sundaram Karen Fritchie

PDF file - 157KB

XRCC1

10.1158/1078-0432.22443198

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The complete chloroplast genome and phylogenetic analysis of Emilia prenanthoidea (Asteraceae)

Mitochondrial DNA Part B (2025)

Yacheng Huang Ni Zhao Min Liang Xuying Wang Shudong Zhang

Emilia prenanthoidea (Emilia prenanthoidea DC. Prodr. (DC.), 1838) belongs to the Asteraceae family and is a popular Miao medicinal plant in Guizhou, China. It has anti-inflammatory and antitumor properties. It is often used as a medication for healing injury, clearing heat and detoxifying, boosting blood circulation and eliminating blood stasis, and lowering inflammation and diuresis. This is the first reported study on the complete chloroplast genome of E. prenanthoidea. The E. prenanthoidea chloroplast genome is 151, 406 bp long, contains a pair of inverted repeats (IRs 24,705 bp), and is separated into a large single-copy (84,010 bp) and a short single-copy (17,986 bp) region. One hundred thirty genes were predicted, including 85 protein-coding genes, 37 tRNA genes, and eight rRNA genes. Nine protein-coding genes (rps16, rpoC1, atpF, petB, petD, rpl16, rpl2, ndhB, ndhA) had a single intron, two protein-coding genes (ycf3, clpP) had two, and the remainder had none. The phylogenetic analysis found Emilia prenanthoidea and Emilia sonchifolia clustered on a single branch, with Pericallis hybrida as its sister group. This study enhances our understanding of the evolutionary relationships within the Asteraceae family and provides valuable insights for developing germplasm-specific molecular markers.

Phylogenetic relationship

10.1080/23802359.2025.2449686

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Correction: Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes

PLoS ONE (2018)

Vonn Walter Xiaoying Yin Matthew D. Wilkerson Christopher R. Cabanski Ni Zhao

In S7 Fig, the names of cell lines are incorrectly matched to the underlying data.

10.1371/journal.pone.0194674

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Polygenetics Risk Analysis Reveals Potential Genetic Pathogenic Factors of Budd-Chiari Syndrome in Chinese Population

Xiaojun Hu Xiaosen Jiang Jia Li Ni Zhao Hairun Gan

Background & Aims: Budd-Chiari syndrome (BCS) is characterized by hepatic venous outflow obstruction and in severe cases, is even life-threatening. In the past few decades, the risk factors related to BCS, including inherited and acquired hypercoagulable states or other predisposing factors, have been reported. However, a large number of patients have no identiﬁable etiological factors. And, there are different causes for BCS in the West and East. In China, segmental or membranous inferior vena cava obstruction is the main manifestation of BCS. The prevalence of prothrombotic disorders seems to be relatively low. Methods: In this study, 500 BCS patients and 696 normal individuals were recruited for whole-exome sequencing. We carried out whole-exome sequencing and developed polygenic risk scoring (PRS) model based on the PLINK, LASSOSUM, BLUP, and BayesA method. We further performed the BCS risk prediction by intersecting the BCS PRS model with the venous thromboembolism and vascular malformations model. Results: BCS-related mutations, such as rs1042331, rs34370305, and rs73739662, were discovered by BCS genome-wide association studies. By comparing different polygenic risk scoring algorithms, the optimal model produced by the BayesA algorithm was determined. By testing additionally recruited experimental samples, it was found that area under the ROC curve>0.9. Conclusion: Further interpretation of the model also provides new insights to explain the difference in genetic risk for BCS between China and the West. In addition, we also found that BCS, venous thromboembolism, and vascular malformations might share some common genetic risks, which might provide new insights into the pathogenesis of BCS.

Budd–Chiari syndrome

10.2139/ssrn.4323729

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Supplementary Figure Legend from High XRCC1 Protein Expression Is Associated with Poorer Survival in Patients with Head and Neck Squamous Cell Carcinoma

Mei‐Kim Ang Mihir R. Patel Xiaoying Yin Sneha Sundaram Karen Fritchie

PDF file - 73KB

XRCC1

Legend

10.1158/1078-0432.22443195.v1

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Mai et al-2015-RSC Adv - supplement

Jiangquan Mai Tsz‐Ki Lau Ting Xiao Chun-Jen Su U. ser Jeng

Source

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Table S2 from Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non–Small Cell Lung Cancer

Jiajia Zhang Zhicheng Ji Justina X. Caushi Margueritta El Asmar Valsamo Anagnostou

Correlative assays performed on each sample

Complete response

Neoadjuvant Therapy

Dynamics

10.1158/1078-0432.22478577.v1

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Adaptation of a Theory-Based, Clinic-Affiliated Smartphone App to Improve HIV Testing and Pre-exposure Prophylaxis Uptake Among Gay, Bisexual, and Other Men Who Have Sex With Men in Malaysia

Iproceedings (2022)

Aviana O. Rosen Jeffrey A. Wickersham Frederick L. Altice Antoine Khati Jeffrey Ralph Luces

Background In Malaysia, HIV disproportionately affects gay, bisexual, and other men who have sex with men (GBMSM). Homosexuality and substance use are criminalized in Malaysia, making GBMSM bear multilevels of social stigma and discrimination, including in health care. Mobile health (mHealth), particularly smartphone apps, is a promising and cost-effective strategy for reaching stigmatized and hard-to-reach populations like GBMSM and linking them to HIV prevention services (eg, HIV testing and pre-exposure prophylaxis [PrEP]), particularly in the context of COVID-19. Objective This study aimed to adapt the HealthMindr app (Emory University), which was developed with GBMSM in the United States, to improve HIV testing and PrEP uptake for GBMSM in Malaysia. Methods We conducted online focus group discussions (FGDs) between August and September 2021 with 20 GBMSM and 16 community stakeholders (eg, doctors, nurses, pharmacists, and nongovernmental organization staff). Participants were asked questions regarding their preferences for functions and features in mHealth apps among GBMSM and suggestions for adapting the HealthMindr app to the Malaysian context. Each session was digitally recorded and transcribed. Transcripts were inductively coded using Dedoose software (University of California, Los Angeles) and analyzed to identify and interpret emerging themes. Results The FGDs with GBMSM revealed preferences for interfacing with apps to access HIV testing, PrEP, and counseling services. Stakeholders showed strong interest in using the app-based platform to deliver integrated care (eg, HIV and mental health). The key themes mostly focused on adaptation and refinement for the Malaysian context and were related to cultural and stylistic preferences (design and user interface), engagement strategies (reward systems, marketing campaigns, and reminders), and recommendations for new functions (enhanced communication options via chat and discussion forums) in a one-stop hub for all HIV prevention needs (HIV self-testing, PrEP, and postexposure prophylaxis) that minimize privacy and confidentiality risks. Conclusions Our data suggest that a tailored HIV-prevention app would be acceptable for GBMSM in Malaysia. The findings provided detailed recommendations for the successful adaptation and refinement of the existing platform for optimal use in the Malaysian context. Conflicts of Interest None declared.

mHealth

Pre-exposure prophylaxis

10.2196/39358

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A Dynamic Model for Frequency Response Optimization in Photovoltaic Visible Light Communication

arXiv (Cornell University) (2023)

Shuyan Chen Yu Hui Ni Zhao Lian‐Kuan Chen

Photovoltaic (PV) modules are recently employed in photovoltaic visible light communication (PVLC) for simultaneous energy harvesting and visible light communication. A PV-based receiver features large signal output, easy optical alignment, and self-powered operation. However, PV modules usually have a severe bandwidth limitation when used as passive photodetectors. In this paper, we systematically investigate the internal impedance dynamic of PV modules and how that affects their frequency response characteristics under different illuminances. We propose a simplified yet accurate dynamic PV mode AC detection model to capture the frequency response characteristics of a PVLC receiver. The model is validated with the impedance spectroscopy characterization methodologies. Experimental results show that a PV module's internal resistance and capacitance depend on incident illuminance, affecting PV's frequency response. The bandwidth is exacerbated under indoor environments with low illuminance levels due to the increment of internal resistance for PV modules. The RC constant can be reduced for PVLC receivers working near open-circuit voltage conditions by adding a moderate local light to decrease the internal resistance value. For practical implementation, PVLC receivers will employ a load for data recovery. We show that adjusting the forward bias conditions can simultaneously reduce the resistance and capacitance values. With the optimization of equivalent trans-impedance, the data rate of a Cadmium telluride (CdTe) PV module achieves a 3.8 times enhancement under 200 lux. We also demonstrate that the BER of a 5-Mbit/s eight-level pulse amplitude modulation (PAM8) signal can be reduced from 9.8*10-2 to 1.4*10-3 by maximizing the transimpedance gain-bandwidth product.

Cadmium telluride photovoltaics

Internal resistance

10.48550/arxiv.2305.00800

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