Ta Nguyen

Foreign Trade University

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Gary Dempers

IP Australia

Kavindhran Velen

Aurum Institute

Clive Seymour

IP Australia

Guy B. Marks

Woolcock Institute of Medical Research

Gregory J. Fox

University of Sydney

Wei Peng

Sichuan University

Jie Liu

Center for High Pressure Science and Technology Advanced Research

Xu He

Nanjing Forestry University

Jian Yu

Queen's University

Chang Liu

Fudan University

Cooperative Institutions

Chinese Academy of Sciences

Peking University

Nanjing University of Posts and Telecommunications

Huazhong University of Science and Technology

Sichuan University

University of Chinese Academy of Sciences

Sun Yat-sen University

Tsinghua University

Shanghai Jiao Tong University

Beijing University of Posts and Telecommunications

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Geotechnical data from optical and acoustic televiewer surveys

The AusIMM bulletin/AusIMM bulletin (2014)

Farrin de Fredrick Ta Nguyen Clive Seymour Gary Dempers

Diamond drill core is typically the only available source of geotechnical information during the investigation phase of mining projects. In recent years downhole surveys using optical (OTV) and acoustic (ATV) televiewer tools have been increasingly used as a complementary source of data for the identification and orientation of structures. The array of data collected from these tools however, have not been applied in a manner that enables the comprehensive assessment of the geotechnical environment.

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Geotechnical investigation

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Citations (6)

EVALUATING THE EFFECTIVENESS OF THE IMPLEMENTATION OF POLICY DOCUMENTS RELATED TO DISEASES PREVENTATION BY WILDLIFE PROTECTION IN PERIOD 2010 - 2020

Tạp chí Y học Việt Nam (2024)

H. N. Nguyen Duy Chinh Nguyen Ta Nguyen Thi Khuyen Tran

The project was conducted to evaluate the effectiveness of the implementation of policies on wildlife protection on the awareness and practice of party members. Within the framework of the study, 261 party members in 3 clusters were questioned with a set of quantitative questions. The results showed that policy documents were covered at a high rate in a variety of forms. However, the level of awareness and practice of the participants is not commensurate with this coverage, and there are differences between groups. 78,2% of respondents identified violations specified in policy documents related to wildlife consumption and use. The reason for not carrying out wildlife trade was chosen by 91,6% of respondents; Reasons for protecting wildlife; prevention of diseases transmitted from animals to humans; Ensuring the implementation of international commitments has 83,1% respectively; 71,3% and 65,9% identified. The rate of good practice accounted for the highest rate with 67,1%. The rates of good and bad practice were 26,8% and 6,5%, respectively. Changes in the form and method of dissemination are needed to improve the effectiveness of wildlife protection policy documents implementation.

10.51298/vmj.v544i2.11976

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Adapting a TB contact investigation strategy for COVID-19

The International Journal of Tuberculosis and Lung Disease (2020)

Ta Nguyen Quoc Nguyen Cuong A. L. T. Kim T. N. Huong H.N. Nguyen

2019-20 coronavirus outbreak

10.5588/ijtld.20.0169

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Active case‐finding in contacts of people with TB

The International Journal of Tuberculosis and Lung Disease (2021)

Greg J. Fox James C. Johnston Ta Nguyen S. S. Majumdar Justin T. Denholm

BACKGROUND: Exposure to people with TB substantially elevates a person's risk of tuberculous infection and TB disease. Systematic screening of TB contacts enables the early detection and treatment of co‐prevalent disease, and the opportunity to prevent future TB disease. However, scale‐up of contact investigation in high TB transmission settings remains limited. METHODS: We undertook a narrative review to evaluate the evidence for contact investigation and identify strategies that TB programmes may consider when introducing contact investigation and management. RESULTS: Selection of contacts for priority screening depends upon their proximity and duration of exposure, along with their susceptibility to develop TB. Screening algorithms can be tailored to the target population, the availability of diagnostic tests and preventive therapy, and healthcare worker expertise. Contact investigation may be performed in the household or at communal locations. Local contact investigation policies should support vulnerable patients, and ensure that drop‐out during screening can be mitigated. Ethical issues should be anticipated and addressed in each setting. CONCLUSION: Contact investigation is an important strategy for TB elimination. While its epidemiological impact will be greatest in lower‐transmission settings, the early detection and prevention of TB have important benefits for contacts and their communities.

Contact tracing

Case finding

10.5588/ijtld.20.0658

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The impact of innovation and renewable energy on CO2 emission in Asian developing countries

Journal of International Economics and Management (2024)

Xuan Truong Pham Cam Nhung Nguyen Ta Nguyen

This study examines the impact of innovation and renewable energy on CO2 emissions in a sample of 15 developing Asian countries from 2000 to 2020. Using panel data regression analysis, it identifies two key findings. First, innovation - measured by research and development (R&D) expenditures and the number of patents - leads to an increase in CO2 emissions, likely driven by the scale effect, whereby economic growth and technological advancements initially result in higher emissions. Second, a higher share of renewable energy consumption significantly reduces emissions, underscoring the critical role of clean energy in mitigating environmental impacts. The findings also support the Environmental Kuznets Curve (EKC) hypothesis, suggesting that as income levels rise, emissions initially grow but eventually decline as economies transition toward greener technologies. Additionally, the study highlights population growth and afforestation as significant factors influencing CO2 emissions. By offering empirical evidence, this research provides valuable guidance for policymakers in developing Asian nations, emphasizing the need to balance innovation with greater investments in renewable energy to achieve sustainable development and lower carbon emissions.

10.38203/jiem.024.3.0093

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Les infections respiratoires aigues en milieu tropical; importance, prise en charge

Michel Le Bras L Eyckmans H Tiendrebiogo Julia Adou Ta Nguyen

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Improvement of Cyclophosphamide Activation by CYP2B6 Mutants: From in Silico to ex Vivo

Molecular Pharmacology (2008)

Ta Nguyen M. Tychopoulos F. Bichat C. Zimmermann Jp Flinois

Cyclophosphamide (CPA) is a chemotherapeutic agent that is primarily activated in the liver by cytochrome P4502B6 (CYP2B6) and then transported to the tumor via blood flow. To prevent deleterious secondary effects, P450-based gene-directed enzyme prodrug therapy (GDEPT) consists of expressing CYP2B6 in tumor cells before CPA treatment. Given the relatively low affinity of CYP2B6 for CPA, the aim of our work was to modify CYP2B6 to increase its catalytic efficiency (V(max)/K(m)) to metabolize CPA into 4'-OH CPA. A molecular model of CYP2B6 was built, and four residues in close contact with the substrate were subjected to mutagenesis. Canine CYP2B11 exhibiting a particularly low K(m) to CPA, the amino acids exclusively present in the CYP2B11 substrate recognition sequences were substituted in human CYP2B6. All mutants (n = 26) were expressed in Saccharomyces cerevisiae and their enzymatic constants (K(m), V(max)) evaluated using CPA as substrate. Five mutants exhibited a 2- to 3-fold higher catalytic efficiency than wild-type CYP2B6. A double mutant, comprising the two most effective mutations, showed a 4-fold increase in K(m)/V(max). Molecular dynamic simulations of several mutants were found to be consistent with the observed modifications in catalytic efficiency. Finally, expression of the CYP2B6 114V/477W double mutant, contrary to wt CYP2B6, allowed switching of a resistant human head and neck cancer cell line (A-253) into a sensitive cell line toward CPA. Thus, we were able to obtain a new efficient CYP2B6 mutant able to metabolize CPA, an important step in the GDEPT strategy for human cancer treatment.

Ex vivo

10.1124/mol.107.042861

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Citations (42)

Using drone photogrammetry to optimise geotechnical analysis through efficient data collection

Ta Nguyen Gary Dempers Clive Seymour Mike Harris

This paper presents the application of drone photogrammetry to acquire high-resolution data to conduct geotechnical analysis.The application of this technology enables the collection of data with significant time and cost savings when compared to conventional methods.The employment of drones in mapping and pit inspection services yields many advantages.Whether through manual flight or pre-planned flight paths, efficient data collection becomes possible; covering areas that are inaccessible for visual inspection by personnel.Furthermore, the acquisition of high-resolution data through drone photogrammetry enhances the quality and quantity of gathered information.By leveraging the collected photogrammetric data, 3D textured meshes of pit walls can be generated, facilitating the identification and mapping of defects as well as significant large-scale structures.Drone photogrammetry ensures operator safety by enabling geotechnical data collection from secure locations.Operators can remotely gather data without the need for physical mapping, thereby eliminating exposure to potential hazards.Additionally, drones can operate at altitudes that do not interfere with ongoing pit operations, minimising disruptions and sustaining productivity.The methodology employed in drone photogrammetry for open pit mines can be extended to other large-scale excavations with restricted access.Inactive quarries, road cuttings and cliff faces are prime examples of scenarios where drone-based geotechnical analysis can prove invaluable, providing detailed information that could not otherwise be obtained.

Drone

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Orthophoto

10.36487/acg_repo/2335_31

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Table of contents

Jinghan Xu Fuji Ren Yanwei Bao Ta Nguyen Binh Duong

Table (database)

10.1109/ccis.2018.8691307

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The effect of medication event reminder monitoring on treatment adherence of TB patients

The International Journal of Tuberculosis and Lung Disease (2023)

Kavindhran Velen Ta Nguyen Cao Dang Su Pham Ha Trang Le Hoa Binh Nguyen

BACKGROUND: TB control remains a serious public health problem, compounded by poor treatment adherence, which increases the likelihood of onward transmission. We evaluated the effectiveness of medication event reminder monitoring (MERM) upon treatment adherence in a high TB burden setting.METHODS: We conducted an open-label parallel group randomised controlled trial among pulmonary TB adults. Participants were provided with a MERM device to store their medications. In the intervention arm, the devices were set to provide daily medication intake reminders. Primary outcome was the proportion of patient-months in which at least 6/30 doses were missed. Secondary outcomes included 1) the proportion of patient-months in which at least 14/30 doses were missed, and 2) the proportion of doses missed.RESULTS: Of 2,142 patients screened, 798 (37.3%) met the inclusion criteria and 250 participants were enrolled. The mean ratio (MR) for poor adherence between the intervention and control groups was 0.72 (95% CI 0.55-0.86). The intervention was also associated with a reduction in the proportion of patients missing at least 14/30 doses (MR 0.61, 95% CI 0.54-0.68) and the percentage of total doses missed (MR 0.75, 95% CI 0.68-0.80).CONCLUSION: MERM is effective in improving TB treatment adherence in a resource-limited environment.

Directly Observed Therapy

10.5588/ijtld.22.0500

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