Lihua Sun

Air Force Medical University

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Chuan Qin

Chinese Academy of Medical Sciences & Peking Union Medical College

Wensheng Wang

Sichuan University

Fuliang Zhang

Beijing University of Chemical Technology

Baosheng Chen

Ningxia Water Conservancy

Guifang Zhang

Shandong Tumor Hospital

Jill D. Jacobson

Children's Mercy Hospital

Lan Huang

Yangzhou University

Shunli Shu

Yao-zeng Lu

Chinese Academy of Medical Sciences & Peking Union Medical College

Hao Fei

Pennsylvania State University

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Sichuan University

Wuhan University

Institute of Laboratory Animal Science

Capital Medical University

Harbin Medical University

Army Medical University

University of Chinese Academy of Sciences

Fudan University

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Detection of the t(2; 5)(p23; q35) chromosomal translocation in large B-cell lymphomas other than anaplastic large cell lymphoma

Human Pathology (1996)

Daniel A. Arber Lihua Sun Lawrence M. Weiss

Anaplastic large-cell lymphoma

Large cell

10.1016/s0046-8177(96)90167-7

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Citations (46)

Clinical and Epidemiological Features of Pancreatic Neuroendocrine Neoplasm in China,20012010

Zhongguo Zhongliu (2016)

Yuqing Zhang Li Ma Yutong He Lihua Sun You‐Lin Qiao

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Effect of ANEPIII, a New Recombinant Neurotoxic Peptide Derived from Scorpion Peptide, on mRNA Expression of Voltage-gated Potassium Channel Subunits in Cultured Rat Hippocampal and Cortical Neurons

亚洲传统医药 (2007)

Chunli Li Baofeng Yang Jinghai Zhang Lihua Sun Ling Wang

Voltage-gated potassium channel

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Priority Research Areas of Produce Technology for Farm Products Quality and Safety in Tianjin

Tianjin Agricultural Sciences (2005)

Lihua Sun

The quality and safety of farm products is the focus issue nowadays,which has been concerned by the whole world.In this paper,the key technology which affects the farm products quality and safety has been analyzed,as well as the develop trends.Meanwhile,based on the analysis of four key problems of agricultural produce in Tianjin,the priority research areas of farm products quality and safety produce have been suggested.

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Cyclical Expression of GnRH and GnRH Receptor mRNA in Lymphoid Organs

Neuroendocrinology (1998)

Jill D. Jacobson Leslie J. Crofford Lihua Sun Ronald L. Wilder

Gonadotropin-releasing hormone (GnRH) is known to possess direct immunomodulatory effects. We have previously demonstrated that the administration of GnRH analogues modulates the expression of murine lupus independently of effects on gonadal steroids. We speculate that GnRH exerts direct actions at the level of the immune cells. GnRH receptors have been identified on lymphocytes. Because GnRH and GnRH receptor (GnRH-R) expression varies with the estrous cycle at the levels of the hypothalamus and pituitary, we speculated that similar cyclicity might be demonstrable in lymphoid tissue. In this report, we used competitive reverse transcription PCR to quantitate the expression of GnRH and GnRH-R mRNA in lymphoid organs throughout the estrous cycle in mice. We demonstrate that the pattern of expression of GnRH-R mRNA in spleen agrees closely with the pattern in the pituitaries of the same mice and the pattern previously reported in the rat pituitary, with significantly increased levels of expression seen on the afternoon of proestrus compared to the morning of metestrus. A similar pattern is seen with GnRH-R mRNA expression in the thymus. Furthermore, we show that the expression of GnRH mRNA in both thymus and spleen agrees closely with the pattern of expression of its receptor, with significantly increased levels of expression seen on the afternoon of proestrus compared to the morning of metestrus. Additional in vitro studies demonstrate that both GnRH and estradiol significantly increase the expression of GnRH-R mRNA in immune cells. These findings support an active role for GnRH in the immune system.

Hypothalamic–pituitary–gonadal axis

Gonadotropin-releasing hormone receptor

10.1159/000054306

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A comparison of the accuracy of the CapitalBio Mycobacterium real-time polymerase chain reaction and the Xpert MTB/RIF assay for the diagnosis of tuberculous meningitis

International Journal of Infectious Diseases (2020)

Lihua Sun Liwei Yao Genlian Fu Lihua Lin Enlan Zhu

We aimed to compare the efficiency of the CapitalBioMycobacterium real-time polymerase chain reaction (PCR) detection test with the standard Xpert MTB/RIF assay for the diagnosis of tuberculous meningitis (TBM).We analyzed cerebrospinal fluid (CSF) from 163 patients with suspected TBM that were collected between January 1, 2018, and December 31, 2019. For both tests, we determined the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC). Next, we compared the diagnostic accuracy of the two techniques using clinical diagnosis as a reference standard.The sensitivity, specificity, PPV, NPV, and AUC, of the CapitalBio Mycobacterium detection test were 48.5%, 100%, 100%, 29.6%, and 0.74, respectively, when used for the diagnosis of TBM. In comparison, the Xpert MTB/RIF assay returned values of 47.0%, 100%, 100%, 29.0%, and 0.74, respectively. Our analysis showed that the diagnostic accuracies of the CapitalBio Mycobacterium detection test and the Xpert MTB/RIF assay were very similar; the accuracy of both tests for detecting mycobacteria was significantly higher than that associated with acid-fast staining.The CapitalBio Mycobacterium real-time PCR detection test has moderate sensitivity and very high specificity for TBM; results are very similar to those generated by the Xpert MTB/RIF assay. We recommend that the CapitalBio PCR test should be used as an initial screening method for TB.

Gold standard (test)

Tuberculous Meningitis

10.1016/j.ijid.2020.12.044

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Apoptosis of diaphragmatic muscle cell in Chronic obstructive pulmonary disease

Lihua Sun

Objective To investigate the influence of lipopolysaccharide and cigarette on apoptosis of diaphgramatic muscle cell in rats with COPD.Methods 30 Wistar rats were randomly divided into control group and COPD group.The rat model of COPD was established by exposure to cigarette smoke for 28 days,and lipopolysaccharide was injected intratracheally on the fisrt and 14 th day.On the 1 st,14 th and 28 th day,5 rats of each group were sacrificed. The rate of apoptosis,Caspase-3,Fas protein and Fas gene expression of diaphgramatic muscle cell were detected.The pulmonary function of rats was measured on the 28th day before they were sacrificed.Results On the 28th day,destruction of alveolar walls and enlargement of alveolar space were observed on COPD group.Pulmonary function of COPD group was less than contorl group.They were the same as pathological changes of lung tissues in COPD.On the 14th and 28th day,rate of apoptosis in COPD group [(23.40±1.72)% and (34.60±1.25)%] was increased than control group [(1.04±0.10)% and (1.07±0.11)%]. Caspase-3,Fas gene and protein expression in COPD group were also significantly increased (P0.01).Conclusion Abnormal apoptosis of diaphgramatic muscle cell was present in rats with COPD,which was related to the changes of lung function or pathological changes of lung tissues.Fas/FasL mediated apoptosis way was involved in diaphragm apoptosis.

Diaphragm (acoustics)

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The Value of Color Doppler in Detecting Atherosclerosis of Carotid Artery in Patients with Cerebral Infarction

Zhongguo linchuang yixue (2008)

Lihua Sun

Objective:To evaluate the changes and clinical value of color Doppler in detecting atherosclerosis of caroid artery in patients with cerebral infarction.Methods:Color Doppler ultrasonography was performed in 42 patients with clinically proved cerebral infact and 38 healthy controls. Results: The incidence of carotid atherosclerosis and its plague formation in patient group (78.6%) was significantly higher than that in control group (18.4%). Carotid atherosclerosis plagues were more common in the left side, CCA bifurcate CCA trunk ICA origination segment ECA origination segment, and it was continuously increased with aging.Conclusion:There is significant positive linear correlation between carotid atherosclerosis and carotid infarction. The ultrasonic examinations of carotid atherosclerosis have an important significance for predicting the prognosis of patients with cerebral infarct and for selecting the treatment protocol.

Color doppler

Stroke

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Reconstruction and expression of ORF2 gene of porcine circovirus type 1 in Escherichia coli.

Zhongguo dongwu jianyi (2009)

Fuliang Zhang Lihua Sun Changxu Song

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Rising attention to the market to ratio meet demand of improvingefficiency of pharmaceutical circulation——Based on complicated variety and specification of drugs

China Journal of Chinese Materia Medica (2010)

Zhaoxing Chen Lihua Sun

Analyzing the complicated variety and specification of drugs and the objective demand of pharmaceutical circulation, to seek out the key factors in improving the efficiency of pharmaceutical circulation, for putting forward suggestions to promote the development of pharmaceutical circulation in China. The conclusion is drawed from industrial organization theory and successful experience of foreign countries, high market attention met with the demand of complicated variety and specification of drugs in pharmaceutical circulation.

Circulation (fluid dynamics)

10.4268/cjcmm20101031

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