Samreen Begum

University of Karachi

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Mogili Sumakanth

University College for Women

Summyia Masood

University of Karachi

Khagga Bhavyasri

University College for Women

Warda Rehman

University of Karachi

Zainab Khan

Iqra National University

K. Bhavyasri

University College for Women

B. Aishwarya

Women’s Health Care

Lubna Gulnar

University of Karachi

P Vivek Sagar

Central Institute For Subtropical Horticulture

Shaikh Sirajuddin Nizami

University of Karachi

Cooperative Institutions

University of Karachi

University College for Women

Women’s Health Care

Osmania University

Jawaharlal Nehru Technological University, Hyderabad

Federal Urdu University

University of Peshawar

International Center for Chemical and Biological Sciences

Manipal Academy of Higher Education

Université Nangui Abrogoua

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Method Development and Validation of Velpatasvir and Sofosbuvir by RP-HPLC

International Journal of Pharmaceutical Sciences Review and Research (2023)

Dr.K. Bhavya Sri Samreen Begum B. Aishwarya Dr.Mogili Sumakanth

Aim:The given RP-HPLC technique was found to be clear-cut, specific, exact, and economical for the estimation of Velpatasvir and Sofosbuvir in bulk and tablet dosage form.Methodology: Stationary phase Hypersil C18 column (4.6×150, 5µm) was utilized as chromatographic conditions.Water: Acetonitrile in the ratio of 30:70 was used as a fluid phase.The flow rate was maintained at 1.0ml/min Results: The wavelength of detection was 230 nm.Velpatasvir linearity was found to be 10-50 ppm and Sofosbuvir linearity was found to be 20-100 ppm with r 2 =0.999.Assessment of the formulated market was carried out by using the above method and the percentage of Velpatasvir and Sofosbuvir was found to be 99.6 % and 99.8% respectively. Conclusion:Hence the method can be successfully applied for routine analysis of Velpatasvir and Sofosbuvir in bulk and tablet formulation.

10.47583/ijpsrr.2023.v80i01.001

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Drug-drug and drug-solvent interaction studies of Chloroquine phosphate, Acefylline piperazine and Gentamicin sulfate in polymeric systems

Arabian Journal of Chemistry (2020)

Summyia Masood Warda Rehman Samreen Begum Zainab Khan Lubna Gulnar

The densities of three pharmacologically significantly used drugs i.e., Chloroquine phosphate (CP), Acefylline piperazine (AP) and Gentamicin sulfate (GS) have been carried out in aqueous (aq), aqueous polyethylene glycol (aq-PEG) and aqueous polyvinyl pyrrolidone (aq-PVP) solvent systems within concentration range (0.02–0.1 ± 0.001 mol.dm−3) at different temperatures (293.15–318.15 K) with the interval of 5 K. Density data were used to evaluate volumetric properties of drugs (CP, AP and GS) by apparent molar volume, partial molar volumes, molar expansibilities and isothermal expansion coefficient. ϕE° provides information about the absence or presence of a caging or packing effect. Partial molar transfer volume was also calculated to study the hydrophilic/hydrophobic interactions in aq-PEG and aq-PVP solvent systems. The results are interpreted in terms of drug–solvent and drug-drug interactions and structure making or breaking abilities of drugs in aq, aq-PEG and aq-PVP solvent systems.

Piperazine

Gentamicin Sulfate

PEG 400

10.1016/j.arabjc.2020.05.030

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Novel RP-HPLC Method Development and Validation of Metformin HCl and Repaglinide in bulk and Tablet dosage form

International Journal of Pharmaceutical and Phytopharmacological Research (2023)

Khagga Bhavyasri Samreen Begum Mogili Sumakanth

Repaglinide

10.51847/xc9uhmnyiy

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Synthesis and evaluation of antibacterial activity for a series of N-phthaloylglycine derivatives

European Journal of Chemistry (2014)

Samreen Begum Shaikh Sirajuddin Nizami Sumayya Saied Syed Muhammad Shahid Fatima Z. Basha

Two series of N-p hthaloylglycine derivatives were synthesized under Schotten-Baumann conditions. The first series consists of N-p hthaloylglycine amides (4a-h), and the second one consists of benzimidazole derivatives of N-p hthaloylglycine (6a-d). All the synthesized analogues were evaluated for their in vitro antimicrobial activity by using disc diffusion method. In the first series, compounds 4h (MIC, 0.5 mg/L), 4a (MIC, 0.6 mg/L), and 4e (MIC, 0.7 mg/L) were found to be the most potent against vancomycin-resistant Staphylococcus aureus (VRSA). Furthermore, three compounds i.e . 4g (MIC, 0.8 mg/L), 6b (MIC, 1.5 mg/L), and 4h (MIC, 1.6 mg/L) displayed good activity against methicillin-resistant Staphylococcus aureus (MRSA). All the synthesized compounds exhibited a wide range of antibacterial activity against all of the Staphylococcus aureus resistant strains tested . The structures of the synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR and MS (EI).

Benzimidazole

Proton NMR

10.5155/eurjchem.5.4.557-562.1077

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Quantitative Estimation of Rivaroxaban in Bulk and Pharmaceutical Formulation using High-Pressure Liquid Chromatography in Reverse Phase

International Journal of Pharmaceutical and Phytopharmacological Research (2022)

Khagga Bhavyasri Samreen Begum Bantaram Aishwarya Mogili Sumakanth

Rivaroxaban is prescribed to patients with nonvalvular atrial fibrillation to reduce the risk of stroke and blood clots in blood vessels. It is applied to the management of vascular blood clots. Goal: To create a method for estimating the dosage of Rivaroxaban in tablets and bulk using RP-HPLC that is straightforward, specific, accurate, and exact. The C18 column was used to provide the optimal circumstances. Acetonitrile: water (60:40) with pH adjusted to 4 with formic acid. Flow rate maintaine

10.51847/a8zljjupte

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2-Dimensional Gas Chromatography-Mass Spectroscopy: A Review

International Journal of Pharmaceutical Sciences Review and Research (2022)

K. Bhavyasri Samreen Begum R. Swethasri Mogili Sumakanth

Gas Chromatography separates components in time. Mass spectroscopy provides information that aids in the identification and structural elucidation of each component. Comprehensive 2-Dimensional gas chromatography (GC×GC) is a novel technique. The revolutionary aspect of GC x GC, with respect to classical multidimensional chromatography, is that the entire sample is subjected to two distinct analytical separations. The resulting enhanced separating capacity makes this approach a prime choice when GC analysts are challenged with highly complex mixtures. The combination of a third mass spectrometric dimension to a GC x GC system generates the most powerful analytical tool today for volatile and semi-volatile analytes. The present review is focused on the instrumentation of 2D GC-MS, the difference between GC and 2d GC, application of 2d GC-MS have been discussed.

Two-dimensional gas

Two-Dimensional Chromatography

Instrumentation

10.47583/ijpsrr.2022.v76i01.025

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2 dimensional liquid chromatography-mass spectroscopy: A review

International Journal of Pharmaceutical Research and Development (2024)

Afirin Farahana N Indira Rani K. Sirisha Samreen Begum P Vivek Sagar

10.33545/26646862.2024.v6.i2b.61

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