Yu-Feng Huang

Mackay Memorial Hospital

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Yih‐Giun Cherng

Taipei Medical University-Shuang Ho Hospital

Chun-Chieh Yeh

China Medical University Hospital

Chien‐Chang Liao

Chang Gung University

Chao‐Shun Lin

Taipei Medical University Hospital

Ta-Liang Chen

Taipei Medical University

Barbara E. Kream

UConn Health

Jian Lei

Hubei Academy of Agricultural Sciences

Li-Ying Ji

Huazhong University of Science and Technology

Hu-Dan Pan

Macau University of Science and Technology

Gloria Gronowicz

UConn Health

Cooperative Institutions

Huazhong University of Science and Technology

Taipei Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Taipei Medical University Hospital

Wuhan University

Taipei Medical University-Shuang Ho Hospital

Union Hospital

China Medical University Hospital

Macau University of Science and Technology

Renmin Hospital of Wuhan University

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Effects of levobupivacaine on isolated rat tracheal smooth muscle

Journal of Anesthesia (2015)

Hung-Chi Chang Shin-Yan Chen Yu-Feng Huang Feng-Lin Liu Yih‐Giun Cherng

Levobupivacaine

Methacholine

Tachyphylaxis

10.1007/s00540-015-2026-8

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Citations (2)

Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

Nature Genetics (2011)

Fan Wang Chengqi Xu Qing He Jian‐Ping Cai Xiu-Chun Li

Genome-wide Association Study

Genetic Association

SNP

Minor allele frequency

10.1038/ng.783

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Citations (247)

Full-endoscopic transforaminal procedure to treat the single-level adjacent segment disease after posterior lumbar spine fusion: 1–2 years follow-up

Mathematical Biosciences & Engineering (2019)

Xiaoming Liu Zhonghan Liu Yaqin Pan Yu-Feng Huang Desheng Wu

Adjacent segment disease (ASD) is one of the potential risks after lumbar spine surgery with instrumentation. Revision surgery needs to be performed on patients suffered from ASD. The traditional open surgery takes severe injury to the body. We investigated the clinical outcome of using full-endoscopic transforaminal procedure to treat the single-level adjacent segment diseases after posterior lumbar fusion. 33 patients (average 71 years, ranged 65-84 years old) underwent full-endoscopic transforaminal procedure were involved. The Oswestry Disability Index (ODI), Modified Japanese Orthopedic Association (mJOA) score and visual analogue scale (VAS) score were used to evaluate the clinical effect. The complication, hospital stay, hospitalization costs and blood loss were investigated according to the patient's records. The mean VAS score was 1.8 and mJOA score was 5.4 postoperatively. Improvement rate was 78%. The mean ODI was 14.6 postoperatively. The mean length of hospital stay, hospitalization costs and blood loss was 2.5 days, $3500 and 15 mL, respectively. No complication or recurrence was observed in any of the patients at the final follow-up. Full-endoscopic transforaminal procedure is a safe and effective technique. It is economical, acceptable and mini-invasive. Of course, it also can shorten the length of hospital stay and decrease bleeding. For revision surgery to treat ASD, this technique can achieve good clinical effects.

Oswestry Disability Index

10.3934/mbe.2019393

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Citations (2)

Risk and adverse outcomes of fractures in patients with liver cirrhosis: two nationwide retrospective cohort studies

BMJ Open (2017)

Ta-Liang Chen Chao‐Shun Lin Chun-Chuan Shih Yu-Feng Huang Chun-Chieh Yeh

The aim of this study is to evaluate fracture risk and post-fracture outcomes in patients with and without liver cirrhosis (LC).Retrospective cohort study and nested fracture cohort study.This study was based on Taiwan's National Health Insurance Research Database that included information on: (1) 3941 patients aged 20 years and older newly diagnosed with LC between 2000 and 2003; (2) 688290 hospitalised fracture patients aged 20 years and older between 2006 and 2013.Followed-up events of fracture from 2000 to 2008 were noted from medical claims to evaluate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of fracture associated with LC. Adjusted odds ratios (ORs) and 95% CIs of adverse events after fracture were compared among patients with and without LC RESULTS: The incidences of fracture for people with and without LC were 29.1 and 17.2 per 1000 person-years, respectively. Compared with controls, the adjusted HR of fracture was 1.83 (95% CI 1.67 to 2.01) for patients with LC. Previous LC was associated with risks of septicaemia (OR 1.77, 95% CI 1.60 to 1.96), acute renal failure (OR 1.63, 95% CI 1.33 to 1.99), and 30-day in-hospital mortality (OR 1.61, 95 %CI 1.37 to 1.89) after fracture.LC was associated with higher risk of fracture; patients with LC in particular had more complications and 30-day in-hospital mortality after fracture. Fracture prevention and attention to post-fracture adverse events are needed for these susceptible populations.

10.1136/bmjopen-2017-017342

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Citations (21)

A population-based cohort study of mortality of intensive care unit patients with liver cirrhosis

BMC Gastroenterology (2020)

Yu-Feng Huang Chao‐Shun Lin Yih‐Giun Cherng Chun-Chieh Yeh Ray‐Jade Chen

The impact of liver cirrhosis on the outcomes of admission to intensive care unit (ICU) is not completely understood. Our purpose is to identify risk factors for mortality in ICU patients with liver cirrhosis.Using reimbursement claims from Taiwan's National Health Insurance Research Database from in 2006-2012, 1,250,300 patients were identified as having ICU stays of more than 1 day, and 37,197 of these had liver cirrhosis. With propensity score-matching for socioeconomic status, pre-existing medical conditions, and cirrhosis-related morbidities, 37,197 ICU patients without liver cirrhosis were selected for comparison. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of cirrhosis associated with 30-day, ICU, and one-year mortality were calculated.Compared with control, cirrhotic patients had higher 30-day mortality (aOR 1.60, 95% CI 1.53 to 1.68), particularly those with jaundice (aOR 2.23, 95% CI 2.03 to 2.45), ascites (aOR 2.32, 95% CI 2.19 to 2.46) or hepatic coma (aOR 2.21, 95% CI 2.07 to 2.36). Among ICU patients, liver cirrhosis was also associated with ICU mortality (aOR 144, 95% CI 1.38 to 1.51) and one-year mortality (aOR 1.40, 95% CI 1.35 to 1.46). Associations between cirrhosis of liver and increased 30-day mortality were significant in both sexes and every age group.Liver cirrhosis was associated with 30-day mortality in ICU patients. Jaundice, ascites, hepatic coma, more than 4 admissions due to cirrhosis, and more than 30 days of hospital stay due to cirrhosis were exacerbated factors in cirrhotic ICU patients.

Liver disease

10.1186/s12876-020-1163-1

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Citations (15)

Osteopenia in transgenic mice with osteoblast-targeted expression of the inducible cAMP early repressor

Bone (2008)

Taranpreet Chandhoke Yu-Feng Huang Fei Liu Gloria Gronowicz Douglas J. Adams

10.1016/j.bone.2008.03.012

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Citations (20)

A study on the localization and distribution of GnRH and its receptor in rat submaxillary glands by immunohistochemical, in situ hybridization and RT–PCR

Life Sciences (2003)

Bing Yao WeiQuan Huang Yu-Feng Huang YingXia Chui Lei Wang

Submaxillary gland

10.1016/s0024-3205(03)00194-2

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Citations (18)

Risk and mortality of gastrointestinal hemorrhage in patients with thrombocytopenia: Two nationwide retrospective cohort studies

European Journal of Internal Medicine (2015)

Po-Han Lo Yu-Feng Huang Chuen‐Chau Chang Chun-Chieh Yeh Chia-Yau Chang

Gastrointestinal bleeding

10.1016/j.ejim.2015.10.007

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Citations (7)

The Scientific Foundation of Chinese Herbal Medicine against COVID-19

Engineering (2020)

Elaine Lai-Han Leung Hu-Dan Pan Yu-Feng Huang Xing-Xing Fan Wan-Ying Wang

The recent coronavirus disease 2019 (COVID-19) pandemic outbreak has caused a serious global health emergency. Supporting evidence shows that COVID-19 shares a genomic similarity with other coronaviruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), and that the pathogenesis and treatment strategies that were applied 17 years ago in combating SARS-CoV and other viral infections could be taken as references in today's antiviral battle. According to the clinical pathological features of COVID-19 patients, patients can suffer from five steps of progression, starting with severe viral infection and suppression of the immune system and eventually progressing to cytokine storm, multi-organ damage, and lung fibrosis, which is the cause of mortality. Therefore, early prevention of disease progression is important. However, no specific effective drugs and vaccination are currently available, and the World Health Organization is urging the development of novel prevention and treatment strategies. Traditional Chinese medicine could be used as an alternative treatment option or in combination with Western medicine to treat COVID-19, due to its basis on historical experience and holistic pharmacological action. Here, we summarize the potential uses and therapeutic mechanisms of Chinese herbal formulas (CHFs) from the reported literature, along with patent drugs that have been recommended by institutions at the national and provincial levels in China, in order to verify their scientific foundations for treating COVID-19. In perspective, more basic and clinical studies with multiple high-tech and translational technologies are suggested to further confirm the therapeutic efficacies of CHFs.

Cytokine Storm

Pandemic

Coronavirus

10.1016/j.eng.2020.08.009

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Citations (39)