To survey the serum uric acid (SUA) levels and associated risk factors of hyperuricemia among youth and middle-aged residents in Guangzhou. A total of 1420 subjects, aged from 20 to 60 years, receiving health check-up at our hospital in 2010 were enrolled. The total prevalence of hyperuricemia was 22.04%, 32.01% in males and 14.07% in females. The average SUA was (388±78) μmol/L in males and (288±63) μmol/L in females. The prevalence of hyperuricemia in males was 30.11% before 40 years of age and 33.81% between 40 and 60 years of age. The average level of SUA in males was significantly higher than that of females. logistic regression analysis showed that BUN, body mass index (BMI) and hypertriglyceridemia were the independent risk factors of disease while HDL-C and gender (females) the protective factors.
Key words:
Hyperuricemia; Risk factors
Abstract Southern rust, one of the most destructive foliar diseases of sweet corn ( Zea mays convar. saccharata var. rugosa ), is caused by Puccinia polysora Underw. and leads to enormous yield losses and reduced quality of sweet corn in China. Utilization of resistance genes is an effective and environmentally friendly strategy for improving southern rust resistance of sweet corn. However, improvement is hampered by a lack of resistance genes in Chinese sweet corn germplasm. In this study, we used marker-assisted backcross breeding to introgress the southern rust resistance gene RppQ from Qi319, an inbred line of southern rust resistant field corn, into four elite sweet corn inbred lines, 1401, 1413, 1434, and 1445. These are parental inbred lines of the popular sweet corn varieties Yuetian 28, Yuetian 13, Yuetian 16, and Yuetian 27. We developed five RppQ -based markers, M0607, M0801, M0903, M3301, and M3402, and employed these for foreground selection; 92.3 to 97.9% of the recurrent parent genomes were recovered following three or four rounds of backcrossing. The four newly developed sweet corn lines all showed significant improvement of southern rust resistance compared with their respective parent lines. Meanwhile, there was no significant difference in phenotypic data for agronomic traits. In addition, reconstituted hybrids derived from the converted lines retained resistance to southern rust, while other agronomic traits and sugar content remained unchanged. Our study provides an example of successful development of southern rust resistant sweet corn using a resistance gene from field corn.
Hereditary nephropathy is a progressive fatal renal disease caused by genetic changes. In this study, genetic screening was used to reveal mutations in a family in Southern China, in which there are two patients with confirmed hereditary nephropathy, who are alive at the time of publication. Imaging tests, including color Doppler ultrasonography and magnetic resonance imaging (MRI), as well as pathological examinations, including hematoxylin‑eosin staining, electron microscopy and immunohistochemistry were performed. Target sequencing of nephrosis 2 (NPHS2), wilms tumor 1 (WT1), phospholipase C ε 1 (PLCE1), actinin α 4 (ACTN4), angiotensin I converting enzyme (ACE), uromodulin (UMOD) and nephrocystin 1 (NPHP1) was also carried out. This study indicated that heterozygous genetic variants of NPHS2, WT1, ACTN4, PLCE1 and UMOD found in the patients were gene polymorphisms. A renal biopsy showed sclerosing glomerulonephritis, dilated tubules and lymphocyte/monocyte infiltration in the interstitium of the index patients. Genetic analysis showed vertical transmission of the disease‑causing mutations, including a homozygous deletion in NPHP1 and a nonsense mutation in ACE found via PCR‑based single nucleotide polymorphism screening. Further network analysis identified direct and indirect co‑location genes between NPHP1 and ACE. To conclude, familial adolescent nephronophthisis was diagnosed in two index patients in this study. It is recommended that comprehensive gene mutation screening is used in the diagnosis of complex hereditary diseases.
This study analyzed the effects of thermal processing on volatiles and fatty acids in sweet corn. There were 27 volatiles measured in fresh samples, and 33, 21, and 19 volatiles identified in the steaming, blanching, and roasting groups, respectively. Relative odor activity values (ROAVs) showed that characteristic aroma-active volatiles of sweet corn after thermal treatments included: (E)-2-nonenal, 1-octen-3-ol, beta-myrcene, dimethyl trisulfide, 1-(4,5-dihydro-2-thiazolyl)-ethanone, and d-limonene. Thermal treatments significantly increased the unsaturated fatty acids (oleic acid and linolenic acid) of sweet corn by 110 to 183% compared to fresh samples. Meanwhile, many characteristic volatiles were found that derived from the oxidative cleavage of fatty acids. The sweet corn aroma obtained by steaming for 5 min was considered the closest to fresh corn. Our research provided insight into aroma composition of different thermally processed sweet corn and laid the foundation for further exploring the sources of aroma compounds in thermally processed sweet corn.
Haute couture is a specific profession which originated in Paris of French two centuries ago,and has gradually formed strict guild regulations.Its development course had truly reflected the great change of the western society in the past 150 years.Also its social effects have changed along with its own development,from the initial pure commercial carrier,through the absorption,merge with kinds of historical and cultural elements,evolved unceasingly until today.In France,haute couture is endued with lofty cultural connotation——Art.However,speaking of the pure commercial significance,the present haute couture has already lost independent marketoperation ability,begins to attaches to its derivation industry department which had been its attached industry before.This article divides the development course of haute couture into five historical stages.Thus according to these five stages,the writter analyzes the main development characteristic and its evolution.
To solve problems in the traditional anatomy museum, such as difficulties in the human body specimen preservation, limited teaching resources and capabilities, as well as lack of innovation cultivation and other issues, this paper proposes the digital and innovative anatomy museum based on the digitalization of exhibited human body specimen and exhibition hall, and digital anatomy operating platform, and student's innovative practice platform. The digital anatomy operating platform is composed by Chinese digital human anatomy teaching system and VH Dissector system. The student's innovative practice platform is composed by radiographic imaging system and anatomy 3D printing system. For commemoration of the great selfless dedication of the body donors to establishment of the anatomy museum, we also build the body donation memorial website.
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