Shouhai Yang

Jiangsu Ocean University

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Dihai Gu

Southeast University

Guanghao Zeng

Huaiqiu Wang

Min Ge

University of Science and Technology of China

Mingwei Fu

Institute of Hematology & Blood Diseases Hospital

Zhouer Cai

Southeast University

Yong-Hai Zhou

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Lai Wei

The Ohio State University

Yonghai Zhou

Tokyo University of Science

Wei Lai

Zhejiang University of Technology

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Southeast University

Huazhong University of Science and Technology

Wenzhou Medical University

Sichuan University

University of Science and Technology of China

Tongji University

Tongji Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhejiang University of Technology

First Affiliated Hospital of Wenzhou Medical University

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Comparing Microcrystal Electron Diffraction (MicroED) and X-Ray Crystallography as Methods for Structure Determination of Oseltamivir Phosphate

Shuwang Ge Mingwei Fu Dihai Gu Zhuoer Cai Wei Lai

Oseltamivir phosphate is a pharmaceutical used in the treatment of influenza viruses. Panče Naumov et al. took two years of dedicated single crystal cultivation and successfully obtained low-quality single crystals through a diffusion method. Cultivation of Oseltamivir phosphate single crystals was proved to be difficult and can extend over several months or more. We employed microcrystalline electron diffraction (MicroED) for direct powder measurements, eliminating the need for lengthy single-crystal cultivation, and the time to obtain the molecular structure of Oseltamivir phosphate was shortened from several months to five hours. Comparative analyses of single crystal (Crystal 1) and MicroED (Crystal 2) results revealed equivalent crystal structures, with minimal differences in hydrogen bond distances, identical powder X-ray diffraction patterns, and negligible variations in Hirshfeld surface analysis. The differential scanning calorimetry (DSC) analysis showcased a higher melting point of Oseltamivir phosphate (206.0 °C) than Oseltamivir (110.7 °C), indicating that Oseltamivir phosphate had high-temperature stability, and may result in the selection of Oseltamivir phosphate as a formulation form. The study establishes and verifies a congruence between MicroED detection and traditional single-crystal detection methods and may be applied in the elucidation of compound structures and the surveillance of drug polymorphism.

10.2139/ssrn.4720294

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The Radiation Protection Design of PWR Spent Fuel Dry Storage Facility

Liming Huang Shouhai Yang Jie Liu

Radiation safety is an important part of safety assessment of spent fuel dry storage technology. This paper describes the radiation protection design of PWR spent fuel dry storage facility for radiation safety completed by China General Nuclear Power Corporation. Considering the special site conditions, Monte Carlo method is used to complete the precise calculation of the three-dimensional radiation dose field in the spent fuel storage building. Through the spent fuel storage module and the storage building with shielding function, radiation shielding design is completed to meet China’s regulatory requirements, which ensures radiation safety for workers and the public during the transport and storage of spent fuel. It will provide a reference for construction of spent fuel dry storage facility of CPR1000 and HPR1000.

Spent fuel pool

10.1115/icone26-81552

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The Synchronization between Processes or Threads of Windows Operation System

Journal of Inner Mongolia University for Nationalities (2004)

Shouhai Yang

Windows is a multi-processes and multi-threads operation system.Visual C++ is a main tool of developing program. The article analysis the machinism of synchronization between processes or threads in Windows.

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Application of MC-MC Coupled Method in Neutron Shielding Analysis of Reactor Pit in Reactor Building

Springer proceedings in physics (2023)

Guanghao Zeng Qianqian Huang Shouhai Yang Yong-Hai Zhou Jun Xiong

Abstract As one of the areas with highest radiation risk in nuclear power plant with neutron and gamma ray radiation emitted from the reactor core, the reactor pit in reactor building has great radiation impact on personnel radiation safety by neutron. In order to further improve the shielding design effort of reactor pit, the MC-MC coupled method is developed. By applying the MCNP code and SuperMC code, the variance of the effective dose rate and thermal neutron flux inside the reactor pit is lower than 5% by consuming 6.7 h. The result shows that the MC-MC coupled method can effectively solve neutron shielding problem in large scale or in complex space.

10.1007/978-981-99-1023-6_3

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Two-Dimensional Radiation Shielding Optimization Analysis of Spent Fuel Transport Container

Shouhai Yang

Radiation transport

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Comparing Microcrystal Electron Diffraction (MicroED) and X-ray crystallography as methods for structure determination of Oseltamivir phosphate

Journal of Molecular Structure (2024)

Shuwang Ge Mingwei Fu Dihai Gu Zhouer Cai Lai Wei