Shuo Geng

Guizhou University

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Ran Lu

Jilin Medical University

Jingze Wang

Shanghai Chest Hospital

Bo Sun

University of California, San Francisco

Yaxin Sang

Hebei Agricultural University

Kemin Mao

Hebei Agricultural University

Bo Sun

Chinese Academy of Sciences

Jie Gao

Hebei Agricultural University

Bo Sun

Hebei Medical University

Xiyu Li

University of Science and Technology of China

Rongqian Ning

Guizhou University

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Anhui Medical University

Hebei Agricultural University

Ministry of Education of the People's Republic of China

Guizhou University

Harbin Institute of Technology

Chinese Academy of Sciences

Sichuan University

Sun Yat-sen University

Peking University

Shanghai Jiao Tong University

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Microstructure and mechanical properties of double-sided welded joints in MX246A high-temperature alloy

Jianmin Li Dongyun Zhang Shuo Geng Yujing Chi Denghao Yi

In this paper, the microstructure and properties of MX246A alloy laser double-sided welding were studied. Different alloy welding structures were obtained under different laser powers, and the fine-grain zone, columnar-grain zone, and equiaxed-grain zone in the welding structure were analyzed. According to the results of SEM, it was found that the width of the surface fine-grain zone was generally thin, which had little effect on the quality and properties of the welded joint. The quality and properties of the welded joint mainly depended on the proportion of columnar-grain zone and equiaxed- grain zone, as well as the grain size. Moreover, with the increase of laser power density, the number of columnar grains decreased, while the number of equiaxed grains increased. The grain size of equiaxed grains became smaller, and the structure became denser, resulting in better mechanical properties. The double-sided welding was subjected to high-temperature and room-temperature tensile tests. The Laser welding double-sided tensile properties test showed that the tensile strength was 555 MPa at room temperature and 400 MPa at 1000 °C under the laser power intensity of 1704 W/mm² . The study revealed that MX246A alloy exhibited superior tensile properties and microhardness than the substrate, while the microstructure demonstrated excellent high-temperature durability.

Equiaxed crystals

Tensile testing

10.1117/12.2685437

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用超重力技术强化O 3 /Fe(II)工艺深度氧化降解苯胺废水

秦月娇 Qin Yue-jiao 耿烁 Shuo Geng 焦纬洲

针对传统反应器存在臭氧传质效率低的问题, 将旋转填料床(RPB)的超重力技术与O 3 /Fe(Ⅱ)高级氧化法相耦合(RPB-O 3 /Fe(Ⅱ))用于含苯胺(AN)废水的深度氧化降解, 考察了超重力因子 β 、催化剂Fe(Ⅱ)投加量、O 3 浓度, 体系pH值及苯胺初始浓度对AN降解率和TOC去除率的影响, 用液相色谱-质谱联用仪分析了AN降解过程的中间产物, 探讨了AN的降解机理。结果表明, 超重力因子的提高有利于AN的深度降解; 体系pH值会影响臭氧化直接与间接反应以及催化剂Fe(Ⅱ)的存在形式, RPB-O 3 /Fe(Ⅱ)体系拓宽了臭氧使用的pH范围; O 3 浓度增加有利于提高AN降解效能, 但臭氧利用效率降低。在超重力因子 β 为100, Fe(Ⅱ)浓度为0.8 mmol·L -1 , O 3 浓度为36 mg·L -1 , pH值为3, AN初始浓度为200 mg·L -1 时, 12 min苯胺去除率达100%, 60 min时TOC去除率可达73%。氧化降解苯胺过程的中间产物主要有硝基苯、对苯醌、马来酸和草酸, 并推断了臭氧催化氧化降解苯胺的可能途径。

10.11943/j.issn.1006-9941.2018.05.013

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Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12

International Journal of Biological Sciences (2024)

Xian‐Zheng Zhang Ziwei Zhang Yuchen Zhao Lin Jin Yu Tai

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and the production of autoantibodies.Previous studies have indicated an association between high-salt diets (HSD) and an increased risk of RA, yet the underlying mechanisms remain unclear.Macrophage pyroptosis, a pro-inflammatory form of cell death, plays a pivotal role in RA.In this study, we demonstrate that HSD exacerbates the severity of arthritis in collagen-induced arthritis (CIA) mice, correlating with macrophage infiltration and inflammatory lesions.Given the significant alterations observed in macrophages from CIA mice subjected to HSD, we specifically investigate the impact of HSD on macrophage responses in the inflammatory milieu of RA.In our in vitro experiments, pretreatment with NaCl enhances LPS-induced pyroptosis in RAW.264.7 and THP-1 cells through the p38 MAPK/NF-κB signaling pathway.Subsequent experiments reveal that Slc6a12 inhibitors and SGK1 silencing inhibit sodium-induced activation of macrophage pyroptosis and the p38 MAPK/NF-κB signaling pathway, whereas overexpression of the SGK1 gene counteracts the effect of sodium on macrophages.In conclusion, our findings verified that high salt intake promotes the progression of RA and provided a detailed elucidation of the activation of macrophage pyroptosis induced by sodium transportation through the Slc6a12 channel.

Pyroptosis

SGK1

10.7150/ijbs.93242

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Screening for high virulence strains of Metarhizium anisopliae and yield determination of its extracellular protease

Nongyaoxue xuebao (2013)

Shuo Geng

The virulence of different Metarhizium anisopliae,which screened from orchards soil,was evaluated by using the larvae of Galleria mellonella L.as the test insect in laboratory.Four high virulence strains of M.anisopliae were obtained,the LT50 values were between 1.85 d and 2.56 d.The LD50 values were between 6.11×102 and 1.55×104 spores.Gelatin-AGAR analysis method was used to determine the extracellular protease enzyme levels of the high virulence strains of M.anisopliae.The results showed that the production of extracellular protease among high virulence strains was different,and there was an obvious liner correlation between extracellular protease level and pathogenicity to larvae of G.mellonella.

Galleria mellonella

Metarhizium

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Data from Coleusin Factor, a Novel Anticancer Diterpenoid, Inhibits Osteosarcoma Growth by Inducing Bone Morphogenetic Protein-2–Dependent Differentiation

Shuo Geng Bo Sun Ran Lu Jingze Wang

<div>AbstractColeusin factor is a diterpenoid compound isolated from the root of a tropical plant, Coleus forskohlii. Although Coleusin factor has been reported to suppress proliferation of and induce apoptosis in several types of cancer cells, the effects of Coleusin factor on osteosarcoma and the underlying mechanism are still not fully understood. In this study, we show that Coleusin factor treatment potently inhibits the growth of osteosarcoma cells associated with G1 cell-cycle arrest. Interestingly, apoptosis and cell death are not induced. Instead, Coleusin factor causes osteosarcoma cells to exhibit typical properties of differentiated osteoblasts, including a morphologic alteration resembling osteoblasts, the expression of osteoblast differentiation markers, elevated alkaline phosphatase activity, and increased cellular mineralization. Coleusin factor treatment significantly increases the expression of bone morphogenetic protein-2 (BMP-2), a crucial osteogenic regulator, and runt-related transcription factor 2 (RUNX2), one of the key transcription factors of the BMP pathway. When BMP-2 signaling is blocked, Coleusin factor fails to inhibit cell proliferation and to induce osteoblast differentiation. Thus, upregulation of BMP-2 autocrine is critical for Coleusin factor to induce osteoblast differentiation and exert its anticancer effects on osteosarcoma. Importantly, administration of Coleusin factor inhibits the growth of osteosarcoma xenografted in nude mice without systemic or immunologic toxicity. Osteosarcoma is a highly aggressive cancer marked by the loss of normal differentiation. Coleusin factor represents a new type of BMP-2 inducer that restores differentiation in osteosarcoma cells. It may provide a promising therapeutic strategy against osteosarcoma with minimal side effects. Mol Cancer Ther; 13(6); 1431–41. ©2014 AACR.</div>

10.1158/1535-7163.c.6536257.v1

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Engineering Lattice Oxygen Regeneration of NiFe Layered Double Hydroxide Enhances Oxygen Evolution Catalysis Durability

Angewandte Chemie International Edition (2024)

Fengyu Wu Fenyang Tian Menggang Li Shuo Geng Longyu Qiu

The lattice oxygen mechanism (LOM) endows NiFe layered double hydroxide (NiFe-LDH) with superior oxygen evolution reaction (OER) activity, yet the frequent evolution and sluggish regeneration of lattice oxygen intensify the dissolution of active species. Herein, we overcome this challenge by constructing the NiFe hydroxide/Ni

Oxygen evolution

Lattice (music)

10.1002/anie.202413250

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30. Toilet Tray

Anna Filigenzi Shuo Geng Jianan Fan

Tray

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Supplementary Table 3 from Coleusin Factor, a Novel Anticancer Diterpenoid, Inhibits Osteosarcoma Growth by Inducing Bone Morphogenetic Protein-2–Dependent Differentiation