Jiapeng Yin

Shanghai Center for Brain Science and Brain-Inspired Technology

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Zhenmin Zhao

Peking University

Haizhou Tong

Plastic Surgery Hospital

Feng Gao

Shandong University

Yongqian Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Tao Song

McLean Hospital

Ningbei Yin

Chinese Academy of Medical Sciences & Peking Union Medical College

Xiaomei Sun

Xi'an Jiaotong University

Lixin Liao

Lanzhou University Second Hospital

Pang Chen

Hebei University of Technology

Ningbei Yin

Chinese Academy of Medical Sciences & Peking Union Medical College

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Peking Union Medical College Hospital

Shandong University

Center for Excellence in Brain Science and Intelligence Technology

Shandong Provincial Hospital

Plastic Surgery Hospital

Peking University

University of Chinese Academy of Sciences

First Affiliated Hospital of Xiamen University

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Single Nucleotide Polymorphisms of nucleotide excision repair and homologous recombination repair pathways and their role in the risk of osteosarcoma

Pakistan Journal of Medical Sciences (2015)

G.-X. Jin Min Wang Weida Chen Wei Shi Jiapeng Yin

To evaluate the influence of polymorphisms in nucleotide excision repair (NER) and homologous recombination repair (HRR) pathways on the development of osteosarcoma patients.Genotypes of ERCC1 rs11615 and rs3212986, ERCC2 rs1799793 and rs13181, NBN rs709816 and rs1805794, RAD51 rs1801320, rs1801321 and rs12593359, and XRCC3 rs861539 were conducted by Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) assay.Total 148 osteosarcoma patients and 296 control subjects were collected from Taizhou First People's Hospital. Conditional logistic regression analyses found that individuals carrying with GA+AA genotype of ERCC2 rs1799793 and GC+CC genotype of NBN rs1805794 were significantly associated with increased risk of osteosarcoma, and the ORs(95%CI) were 1.58(1.03-2.41) and 2.66(1.73-4.08), respectively. We found that GA+AA genotype of ERCC2 rs1799793 or GC+CC genotype of NBN rs1805794 were associated with an increased risk of osteosarcoma in females, with ORs(95%CI) of 2.42(1.20-4.87) and 2.01(1.07-4.23), respectively.Our results suggest that ERCC2 rs1799793 and NBN rs1805794 polymorphisms were associated with an increased risk for osteosarcoma, which suggests that NER and HRR pathways modulate the risk of developing osteosarcoma.

ERCC2

XRCC3

ERCC1

Primer (cosmetics)

10.12669/pjms.312.6569

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Reinforcement of Neuropixels probes for high-density neural recording in non-human primates

Qifan Wang Jiapeng Yin He Cui

The improvements of electrode techniques in recent years make it possible to record hundreds of neurons simultaneously. Neuropixels probe as a type of high-density linear silicon probe, is widely used in rodents' studies to record brain-wide neural activity. However, in vivo electrophysiological recording in non-human primates (NHPs) faces different challenges than in small animals. The challenges faced by the Neuropixels probe of NHPs' recording are addressed in this paper. With targeted improvements, the probe's structure was enhanced to make it more suitable for the acute recording in NHPs. The reinforced probe's shank shows strong stability during different mechanical insertion testing. Furthermore, the recordings were tested on the macaque using standard acute recording procedures which made it possible to densely record hundreds of neurons of different cortical layers in behaving NHPs.

10.1109/ner49283.2021.9441229

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Autogenous Septal Cartilage to Extend the Nasal Part and Shape Nasal Tip

Journal of Tissue Engineering and Reconstructive Surgery (2007)

Jiapeng Yin Logos Plastic

Objective Use autogenous septal cartilage to extend the nasal part and shape nasal tip to the patient with foreshorted nasal deformation. The operation is technically simple and widely used by western countries. But for the difference of anatomic structure and beautiful outlook appreciation, how to make this operation method suit the oriental is a motive of many plastic surgeons. Method Since the year of 1998, this technique was performed in 326 patients, 298 women and 28 men, with the incision of nostril side or columella nasi to get the autogenous septal cartilage, and use it to extend the nasal length. And use some cartilage which has been carved to shape nasal tip. Use or not use the silicon post to fill the back of nose. Result The result is satisfied. The nose part can be extended 5mm in average; The time of operation is about one hour and fifty minutes. Follow-up 3 years in average, we don't find absorption, deformation, infection and rejection phenomenon. Conclusion It is an effective and safe method to use autogenous septal cartilage to extend the nasal part and shape nasal tip to the patient with foreshorted nose deformation.

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Columella

Nasal cartilages

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A Clinical Study of Various Buccinator Musculomucosal Flaps for Palatal Fistulae Closure After Cleft Palate Surgery

Journal of Craniofacial Surgery (2014)

Fang Lin Mingyong Yang Chunyan Wang Tingting Ma Zhenmin Zhao

This retrospective study describes various buccinator musculomucosal flaps for the repair of palatal fistulae. Twenty-two palatal fistulae were repaired at our institution between 2002 and 2012 by buccinator musculomucosal flaps with superior-anterior or posterior pedicles. Seventeen patients were treated with posteriorly pedicled flaps, 7 of whom had lengthening of the soft palate and 10 of whom had simultaneously repaired severe lateral palatal scarring. Five patients with anterior or midpalatal fistulae were treated with superior-anteriorly pedicled flaps. All but 4 of the 22 patients had satisfactory results. Four patients had recurrent fistulae, 2 resulting from flap tip necrosis and 2 from wound dehiscence. Follow-up was from 5 to 72 months. None of the patients had facial nerve injury, limited mouth opening, or difficulty chewing. We evaluated the factors that could cause complications, such as flap pattern, location of fistula, and size of palate defect. No statistically significant differences were found in the complication rates among different groups. In conclusion, the buccinator musculomucosal flap is reliable and versatile, with rich vascularity and flexible design. The flap is a good option for fistula repair, especially for larger fistulae at the anterior portion of the hard palate or at the junction of hard and soft palate, where surrounding soft tissues are stiff, scarred, and difficult to mobilize.

Soft palate

Vascularity

Wound dehiscence

10.1097/scs.0000000000000411

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Intraoral Prosthetic Chin Augmentation With Vertical Incisions

Journal of Craniofacial Surgery (2018)

Jiapeng Yin Shuqiang Fan Xuhong Wu Shi Pan Lixin Liao

To explore a new surgical approach for chin augmentation using a prosthesis with 3 intraoral vertical incisions whereby placement of the prosthesis is more convenient and accurate, with fewer postoperative complications. Following the anatomic characteristics of the chin, a bilateral mucosal vertical incision and a median observation incision are made. The V-shaped mark on the upper side of the prosthesis can be seen through the observation incision after it is placed from the lateral incision into the predesigned compartment. The incision can be sutured if there is no bleeding in the operation area. Surgery performed in all 19 patients with mild microgenia with 6 to 12 months of follow-up resulted in satisfactory chin and face shape without any complications. The application of this novel method can correct McCarthy type I microgenia with more accurate positioning, less possibility of bilateral sideways and/or up/down movement, and fewer complications.

10.1097/scs.0000000000004252

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An Adaptive Direction-Dependent Polarization State Configuration Method for High Isolation in Polarimetric Phased Array Radar

Zhanling Wang Jiapeng Yin Pang Chen Yongzhen Li Xuesong Wang

<div>High cross-polarization isolation (CPI) is crucial to the accurate polarization measurement using polarimetric phased array radar (PPAR). In this paper, we propose an adaptive direction-dependent polarization state configuration (AD2PSC) method to improve the polarization isolation. Compared with conventional fixed polarization state of radiated wave whether it is linear, circular or elliptical polarization state, our AD2PSC approach configures the polarization state on basis of beam steering. To achieve the adaptive configuration of magnitude and phase of the dual-polarization antenna, an improved steepest descent algorithm is put forward. To facilitate the uniform representation for the polarization measurement application of PPAR, the universal expressions of intrinsic and measured backscatter matrices are derived for arbitrary polarization state. The dualpolarization dipole array is used to assess the priority of our proposed method. Compared with the conventional approaches,</div><div>our approach could obtain higher CPI while being available for a larger scanning range. The configured CPI meets the specific polarization requirement for PPAR.</div>

10.36227/techrxiv.13186769.v1

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Transsutural Distraction Osteogenesis Applied to Maxillary Complex With New Internalized Distraction Device

Journal of Craniofacial Surgery (2015)

Haizhou Tong Feng Gao Jiapeng Yin Xiangyu Zhang Chen Zhang

The purposes of this study were to evaluate the effects of transsutural distraction osteogenesis applied to the maxillary complex with a new internalized distraction device and to analyze the long-term osteogenesis outcome.Three-month-old beagle dogs were treated with a self-designed internalized distractor. The feasibility was evaluated, and the effects of the maxillary growth were measured using radiography and computed tomography (CT). The regenerated bone was examined with micro-CT, biomechanical testing, and histology 1 year after the distraction.The experimental group showed significantly larger forward displacement of maxillary during the distraction. One year after the distraction, the micro-CT showed more incompact structure and bone volume/total volume was significantly less in the experimental group. Biomechanical testing also showed a significantly lower yield but with no difference in stiffness. Histologic staining found osteoclasts deposited in the region of the suture and osteoblasts on the bone surface. The immunohistochemical staining of osteoprotegrin and receptor activator of nuclear factor-κ B ligand showed evidence of expression in suture area components and osteocytes with no difference between the groups.Transsutural distraction osteogenesis using an internalized distractor with skull anchorage demonstrated feasibility. It is expected that this device may provide new thoughts in developing an appropriate appliance for clinical use in young patients with midfacial hypoplasia. Moreover, the long-term osteogenesis analysis findings suggest that the metabolism of sutural area still remained active, which enhanced our understanding of bone remodeling in the sutural area to manage maxillary relapse after transsutural distraction osteogenesis.

10.1097/scs.0000000000001263

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Seasonal Variation in Birth Months of Patients With Oral-Facial Clefts

Journal of Craniofacial Surgery (2013)

Jiapeng Yin Ningbei Yin Lei Liu Zhenmin Zhao Di Wu

Background Seasonality of the incidence of congenital anomalies has provided useful clues in etiological research. However, seasonality of oral-facial clefts is inconsistent in many countries, including native China. The aim of this study was to determine whether births of patients with oral-facial clefts follow a seasonal pattern in a native Chinese population. Methods Patients with oral-facial clefts treated at the Plastic Surgery Hospital between January 2002 and December 2011 were retrospectively investigated. The controls comprised all living births from the obstetric department of the Third Affiliated Hospital of Peking University from January 2002 to December 2011. Seasonal variations in birth months were analyzed using the χ2 test. Results A total of 6193 patients with oral-facial clefts and 13,254 healthy living newborns were included in this study. Birth time peaks of the patients occurred in autumn and winter, especially in October and January, compared with the nadir in the summer (P < 0.05). The birth time peaks of male patients occurred in autumn and winter, especially in October, February, and January. The birth time peaks of female patients occurred in autumn and winter, especially in January, October, and November. There was a statistical difference in birth distribution among the different months (P < 0.05) and 4 seasons (P < 0.05) in female patients. No statistical difference was found in male patients (P > 0.05). Conclusions There is a possible seasonality in birth months and a difference between sexes of patients with oral-facial clefts in this native Chinese population. This approach could be useful to study the etiology and pathogenesis of oral-facial clefts.

Etiology

Seasonality

Statistical Analysis

10.1097/scs.0b013e3182670045

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Changes in the Zygomaticomaxillary Suture During Aging

Journal of Craniofacial Surgery (2015)

Jiapeng Yin Lixin Liao Lu Lin Haizhou Tong Xiangyu Zhang

Trans-sutural distraction osteogenesis (TSDO) has been successfully used to correct midfacial hypoplasia in growing patients for years. The effects of TSDO, however, remain difficult to predict in adult patients. The aim of this study was to determine the biologic basis for the age-related increase in difficulty of performing TSDO. A total of 45 male Sprague Dawley (SD) rats were obtained in 3 age groups: 4 weeks old (4W, N = 15), 3 months old (3M, N = 15), and 13 months old (13M, N = 15). The zygomaticomaxillary sutures (ZMS) were dissected, and their morphology was evaluated by histology and micro-computed tomography (micro-CT). Quantitative real-time polymerase chain reaction of the ZMS and blood samples taken from the abdominal aorta were also used to assess the effects of age at the molecular level. Compared with the 4W rats, the number of fibroblasts in the ZMS was decreased, the bone plate adjacent to the ZMS was thicker, and the texture was denser in the 13M rats. Micro-computed tomography analysis showed the density of the ZMS was significantly increased in the 13M group (P < 0.05). The density ratio of the ZMS to the adjacent bone was increased from 0.14:1 in the 4M group to 0.54:1 in the 13M group. The gene expression of osteocalcin (OC) was significantly lower at 13M than at 3M (P < 0.05). The OC and alkaline phosphatase (ALP) serum levels were significantly lower at 13M than at 4W (P < 0.05). During aging, the decreased osteogenesis activity both systemically and locally may be the biologic effect that limits the application of TSDO in older patients.

10.1097/scs.0000000000002141

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ESM for Yin et al July 06 2015

Jiapeng Yin Hongliang Gong An Xu Zheyuan Chen Yiliang Lu

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